[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgery-scheduled\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgery-scheduled":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":33,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100594707","the-million-anesthesia-cases-study-macs---a-cohort-study-of-preoperative-fasting-and-perioperative-outcomes-100594707",false,"NCT07022951","The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes","The Million Anesthesia Cases Study (MACS) - Retrospective and Prospective Characterization of Perioperative Fasting Practices and Their Effects on Clinical Outcomes","MACS","Inclusion Criteria:\n\n* Diagnostic or therapeutic procedure with anesthesia care (general anesthesia, regional anesthesia, sedation, or a combination of the above)\n\nExclusion Criteria:\n\n* Not receiving anesthesia care\n* Lack of medical record data in Epic electronic medical record system","ALL",{"count":19,"type":20},1200000,"ESTIMATED","OBSERVATIONAL","Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes through possible effects on patient well-being (anxiety, hunger, thirst), physiology (hypovolemia, hypotension), perioperative aspiration, etc. The research team hypothesized that in addition to known adverse effects on patients' well-being, prolonged preoperative fasting adversely affects circulating blood volume-related (hypotension, decreased urine output etc.) and glucose metabolism-related (e.g., hypo\u002Fhyperglycemia) perioperative physiology. The investigators will also test for an association between the duration of preoperative fasting and the risk of perioperative pulmonary aspiration.\n\nAdditional knowledge on the potential adverse effects of preoperative fasting will inform preoperative fasting policies and research interventions that are relevant to hundreds of millions of patients subjected to preoperative\u002Fpreprocedural fasting worldwide each year.",[24,25,26,27,28,29,30,31,32],"Anesthesia","Sedation","Monitored Anesthesia Care","Procedure","Surgery, Day","Surgery","Surgery Scheduled","Fasting Before Operation","Aspiration; Gastric Contents, Anesthesia",[34,35,36,37,38,39,40,41,42,43],"preoperative fasting","perioperative pulmonary aspiration","perioperative complications","postoperative nausea and vomiting","perioperative hypoglycemia","perioperative hyperglycemia","perioperative hypotension","myocardial injury after noncardiac surgery","perioperative acute kidney injury","clear liquid fasting","RECRUITING","2026-04-02",{"date":47,"type":48},"2026-04-08","ACTUAL",{"date":50,"type":48},"2016-01-01",{"date":52,"type":20},"2030-12-31",{"name":54,"class":55},"Massachusetts General Hospital","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":65,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":78,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":56},"100572355","fissios-and-postoperative-complications-fpoc-trial-100572355","NCT06732193","Fissios© and Postoperative Complications (FPoC Trial)","Clinical Trial Comparing a Face-to-face Perioperative Respiratory Physiotherapy Program Versus the Use of Fissios App© as a Complement to a Respiratory Physiotherapy Program in Patients Diagnosed With NSCLC Undergoing Surgery.","FPoC","Inclusion Criteria:\n\n1. Patients over 18 years of age.\n2. Indication for lung resection surgery due to diagnostic suspicion or histopathological diagnosis of non-small cell lung carcinoma.\n3. Anatomical lung resection surgery: anatomical segmental resection, lobectomies or pneumonectomies, using a conventional or minimally invasive approach (VATS, RATS).\n4. The patient has a smart mobile device compatible with the Fissios App©, has the ability or has the support to use it.\n5. Willingness and commitment to participate in the study.\n6. Ability to complete the informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Medical contraindication to perform respiratory physiotherapy exercises.\n2. Not possessing a smart mobile device compatible with Fissios App©.\n3. Inability of the patient to perform the exercises, either due to a physical or psychological impediment.\n4. Inability to complete the informed consent form for participation in the study.\n5. Refusal to participate in the study.","18 Years",{"count":67,"type":20},560,"INTERVENTIONAL",[70],"NA","Respiratory physiotherapy as part of a pre-operative physical training program may reduce the risk of developing post-operative complications, improving post-operative results and optimizing physical conditions in patients with a diagnosis of non-small cell lung cancer (NSCLC) undergoing lung resection surgery. During the post-operative period, performing physical exercise has also been proved to increase the capacity for exercise, improve health-related quality of life and reduce the feeling of breathlessness. Fissios App is a tool created by thoracic surgeons, physiotherapists and a specialist doctor in physical medicine and rehabilitation, which has been satisfactorily implemented in thoracic surgery patients; this contains a program of standardized respiratory physiotherapy exercises with a defined time and number of repetitions.\n\nThe aim is to compare the effectiveness of use of the Fissios App tool as a complement to a peri-operative respiratory physiotherapy program compared to just attendance at a face-to-face peri-operative respiratory physiotherapy program, to reduce the incidence of post-operative complications.\n\nIt is expected to include 560 patients in the study. Subsequent to evaluation by the investigator and the acceptance of participant to take part in the study, the performing of peri-operative respiratory physiotherapy is prescribed. The participants will be randomly assigned to a study group that uses the tool as a complement to the respiratory physiotherapy program or a control group that should only attend face-to-face respiratory physiotherapy sessions. All the participants should attend face-to-face respiratory physiotherapy classes taught by physiotherapists at the place and time set out in each centre before and after surgery for at least 45 minutes and at least five sessions. Moreover, study group participants may use the Fissios App tool. Investigators should fill in the pre-operative, surgery and post-operative data for each patient on the Fissios Research platform.",[73,74,30,75,76,77],"Surgical Procedure, Unspecified","Non Small Cell Lung Cancer","Thoracic Surgery","Postoperative Complications","Perioperative Care",[79,80,81,82],"Respiratory physiotherapy","Smartphone App","Post-operative complications","Peri-operative physical training","2025-09-10",{"date":85,"type":48},"2025-09-11",{"date":87,"type":48},"2025-03-20",{"date":89,"type":20},"2026-12-31",{"name":91,"class":55},"Carlos Alfredo Fraile Olivero, MD, PhD."]