[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgical-procedure-unspecified\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgical-procedure-unspecified":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,57,84,106,134,155,178,204,236,264,290,316,349,371],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100573804","preoperative-fasting-vs-not-fasting-in-critically-ill-patients-100573804",false,"NCT06751043","Preoperative Fasting vs. Not Fasting in Critically Ill Patients","FEEDS Trial - Fasting Preprocedurally in Enteral Nutrition: Evaluation of Divergent Approaches in Secure Airway","FEEDS","Inclusion Criteria:\n\n1. 1\\. Age ≥ 18\n2. Current admission to ICU\\*\n3. Secure airway\\*\\* with no plans for its removal prior to procedure\n4. Current non-trophic (\\> 10 mL\u002Fhr) tube (enteral) feeding\\*\\*\\* with no plans to discontinue prior to procedure for reasons other than preoperative fasting\n5. Planned eligible procedure (Examples are listed in Appendix C) with anesthesia care or nursing sedation. Eligible procedures are defined as non-emergent diagnostic or therapeutic interventions that:\n\n   * Do NOT have a well-established practice of preoperative fasting. (For example, bedside placement of a vascular catheter \\[arterial, central venous, peripheral venous\\] by the ICU team is NOT eligible for this trial since it has a widely established practice of no preoperative fasting and is not generally scheduled for a specific time.)\n   * Do NOT require fasting for preoperative gastrointestinal tract preparation\n   * Do NOT require removal\u002Freplacement of the endotracheal or tracheostomy tube\n   * Do NOT require prone or Trendelenburg (head-down) positioning.\n   * Typically require procedural sedation or anesthesia care.\n   * Generally, are scheduled for a specific time (although this time can change, or procedure may be cancelled).\n   * Are performed in the operating room, non-operating room procedural areas, or at the patient's bedside.\n\n     * All ICU types are eligible: surgical, medical, cardiac, neurological, trauma, mixed etc.\n\n       * Secure airway is defined as a cuffed endotracheal tube or a cuffed tracheostomy tube.\n\n         * Patients with all types of feeding tubes are eligible, regardless of tube insertion site (nasal, oral, surgically implanted) and tube tip location (pre- and post-pyloric) †As determined by the enrolling physician-investigator\n\nExclusion Criteria\n\n1. Inability to obtain informed consent\n2. Inability to enroll and randomize \\> 8 hours prior to planned procedure time\n3. Inability to deliver trial interventions\n4. Expected survival \\\u003C 48 hours as determined by the enrolling physician-investigator\n5. Critically ill burn patient\n6. Emergency procedure\n7. a. Gastrointestinal tract procedure that requires fasting based on surgical indications or b. airway\u002Flung procedure that requires removal of endotracheal or tracheostomy tube\n8. Plan for prone or Trendelenburg (head down) positioning during most of the procedure\n9. Major impairment of gastrointestinal motility or major structural disease of the gastrointestinal tract (e.g., severe gastroparesis, bowel obstruction, severe ileus, severely compromised lower esophageal sphincter, active gastrointestinal bleeding)\n10. Plan for postoperative extubation in the procedure area\n11. Prisoner\n12. Pregnant woman, woman of childbearing potential without a documented negative urine or serum pregnancy test during the current hospitalization, or woman who is breast feeding\n13. Refusal to enroll patient by treating physician\n14. Extracorporeal Membrane Oxygenation (ECMO) at the time of potential enrollment, except patients scheduled for ECMO decannulation as the study procedure and patients expected to be off of ECMO at the time of study procedure.\n15. Chronic mechanical ventilation at pre-admission level of care","ALL","18 Years",{"count":20,"type":21},1072,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill. The main questions it aims to answer for patients on a breathing machine who are receiving tube feeding are:\n\n* Does the risk of lung complications and death differ between those who are not fasting, which may have a higher chance of allowing tube feeding to enter the lungs, and fasting, which temporarily stops nutrition before a procedure?\n* Is there a difference in recovery times, hospital stays, infection rates, need for organ support, safety, and nutrition for those who either fast or do not fast before a procedure?\n* What is the relationship between nutrition and clinical outcomes?\n\nResearchers will compare not fasting and fasting to see if it has an effect on recovery.\n\nParticipants will:\n\n* Be assigned by chance (like a coin toss) to one of two groups. One group (fasting group) will have their tube feeding stopped at least 8 hours before their procedure. The other group (not fasting group) will have their tube feeding stopped right before their procedure.\n* Be monitored via medical record for amount of protein and calories received, and any complications related to fasting\u002Fnot fasting.\n\n  * Data from routine electronic medical records will be reviewed to determine how participants are doing 3 months after their procedure.\n\n'",[27,28,29,30],"Critical Illness","Surgical Procedure, Unspecified","Pulmonary Aspiration","Fasting",[32,33,34,35,36,37,38,39,40,41,42,43],"pulmonary aspiration","enteral nutrition","tube feeding","preoperative fasting","perioperative medicine","surgery in critically ill","procedures in critically ill","nutrition in critical illness","perioperative safety","preoperative management","preoperative fasting in secure airway","anesthesia in critically ill","RECRUITING","2026-06-10",{"date":47,"type":48},"2026-06-12","ACTUAL",{"date":50,"type":48},"2025-04-28",{"date":52,"type":21},"2028-05",{"name":54,"class":55},"Massachusetts General Hospital","OTHER",19,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100638260","metabolic-control-in-anesthesia-and-surgery-100638260","NCT07573930","Metabolic Control in Anesthesia and Surgery","Deteriorated Metabolic Control in the Perioperative Period in Surgical Patients: What is the Impact of Anesthetic Preparation and Patient Frailty?","MACS","Inclusion Criteria:\n\n* Adult patients (≥18 years) scheduled for elective non cardiac surgery\n* Expected surgery duration \\>1 hour\n* Administration of dexamethasone as part of standard anaesthetic regimen or planned by the responsible anaesthetist to enhance recovery or to limit risk of PONV.\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Not possible to obtain consent or permission\n* Known allergy or adverse reaction to dexamethasone\n* Type 1 diabetes (due to need for insulin titration)\n* Active infection, sepsis, or immunosuppression\n* Contraindications to continuous glucose monitoring (CGM)",{"count":66,"type":21},100,"OBSERVATIONAL","The goal of this observational study is to investigate how a standard dose of the drug dexamethasone affects blood sugar levels during and after non-cardiac surgery in adult patients.\n\nThe main questions it aims to answer are:\n\n* How does dexamethasone influence blood sugar levels in patients undergoing non-cardiac surgery?\n* Does continuous glucose monitoring (CGM) provide a more accurate estimate of blood sugar fluctuations compared to traditional time-specific finger-prick measurements?\n\nParticipants are scheduled to receive dexamethasone as part of standard anesthesia care and will undergo their planned surgery. As part of the study, a continuous glucose monitoring (CGM) device will be placed on their upper arm approximately 12 hours before surgery and will remain in place for up to 10 days after the operation. During this period, their blood sugar levels will be measured using both the CGM device and traditional finger-prick tests. CGM readings are blinded for both participants and clinicians. No additional treatments or changes to their standard care will be made as a result of their participation in the study.\n\nThe study will include 100 adult patients from the Department of Anesthesiology at Sjællands University Hospital, Roskilde.",[70,71,72,73,28],"Anesthesia","Continuous Glucose Monitoring","Hyperglycemia Steroid-induced","Hyperglycemia Stress","2026-05-04",{"date":76,"type":48},"2026-05-07",{"date":78,"type":48},"2026-04-23",{"date":80,"type":21},"2028-12-31",{"name":82,"class":55},"Zealand University Hospital",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":90,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":83},"100565122","continuous-connected-patient-care-ccpc-a-pilot-testing-a-novel-device-for-continuous-vitals-monitoring---department-of-anesthesia-at-phc-100565122","NCT06638073","Continuous Connected Patient Care (CCPC), a Pilot Testing a Novel Device for Continuous Vitals Monitoring - Department of Anesthesia at PHC","Inclusion Criteria:\n\n* 19 years or older\n* Patients that have undergone a non-cardiac surgery at SPH requiring an inpatient hospital stay\n* Peri-op patients who are in the Surgical High Acuity Unit (SHAU) and those followed by Anesthesia Perioperative Outreach team on the ward\n* Living within British Columbia, Canada and in an area that is covered by Bell cellular network\n\nExclusion Criteria:\n\n* Patient refusal\n* Lack of capacity to consent to the study (including having received sedative or general anesthetic within the past 24 hours)\n* Unable to use (or does not have a caregiver who can help put on) study monitoring device at home\n* Unable to complete (or does not have a caregiver who can help complete) study questionnaires by electronic (mobile, tablet, or computer), paper, nor phone\n* No access to cell phone nor landline at home to receive follow-ups\n* Preoperatively known to be discharged to a nursing home or rehabilitation facility\n* Known allergic reactions to any part material of study devices","19 Years",{"count":92,"type":21},50,"To confirm feasibility and accessibility of the CCPC Platform (Oxymotion, Bridge Health Solutions medication adherence software, CloudDX home kit) in two different environments - in hospital and at-home, in patients undergoing non-cardiac surgery.",[28,95],"Intensive Care Units (ICUs)","2026-03-10",{"date":98,"type":48},"2026-03-12",{"date":100,"type":48},"2025-03-13",{"date":102,"type":21},"2026-06-20",{"name":104,"class":105},"Medtronic - MITG","INDUSTRY",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":83},"100457513","minimally-invasive-sinus-lift-through-the-interradicular-septum-100457513","NCT05237570","Minimally Invasive Sinus Lift Through the Interradicular Septum","Minimally Invasive Microsurgical Sinus-lift Through the Interradicular Septum. A Clinical Trial","Inclusion Criteria:\n\n* Patient older than 18 years.\n* Plaque index and bleeding index less than 30%.\n* Invagination of the sinus cavity in the interradicular area of the upper first molar.\n* Upper first molar not restorable and with height of the interradicular remnant less than 5 mm.\n\nExclusion Criteria:\n\n* Presence of systemic disease contraindicating the intervention.\n* Pregnant women.",{"count":114,"type":21},20,[24],"This study aims to describe a new approach for the reconstruction of the alveolar process in the sinus area. This minimally invasive approach will access the maxillary sinus through the alveolar process, elevating the sinus membrane in the area immediately above it. The regeneration may be achieved in the specific area required for dental implant placement, reducing the morbidity of the procedure.",[118,119,120,28],"Bone Loss","Bone Loss, Age-related","Atrophy; Alveolar Process",[122,123,124],"maxillary sinus","sinus lift","xenograft","2026-02-16",{"date":127,"type":48},"2026-02-17",{"date":129,"type":48},"2021-03-02",{"date":131,"type":21},"2027-02-01",{"name":133,"class":55},"Universidad de Murcia",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":141,"minAge":18,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":83},"100583209","electrosurgical-intervention-analysis-comparing-procedure-patterns-100583209","NCT06873347","Electrosurgical Intervention Analysis: Comparing Procedure Patterns","Electrical Fingerprint: Comparison of Characteristic Patterns of Different Surgical Interventions Based on Electrosurgical Unit Data","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Written informed consent\n* Patients undergoing one of the following surgeries:\n\n  * Supra cervical hysterectomy\n  * Total hysterectomy\n  * Breast conserving surgeries: B-plastic + periareolar mastopexy\n  * Breast conserving surgeries: segmental resection\n\nExclusion Criteria:\n\n* Expected lack of patient compliance or inability of the patient to understand the purpose of the clinical trial\n* Lack of patient consent\n* Surgery under local anaesthesia\n* Robot-Assisted Surgery","FEMALE",{"count":143,"type":21},160,"The purpose of this prospective, single center study is to verify the hypothesis that each type of intervention creates a specific data pattern like a digital \"fingerprint\". This fingerprint offers the possibility to identify specific workflows of surgical procedures but also to differentiate between them, what can be used for training purposes. The following clinical study is not covered by the MDR regulation since we do not investigate performance or safety of a device but collect and assign electrical data only.",[28],"2026-01-23",{"date":148,"type":48},"2026-01-26",{"date":150,"type":48},"2024-02-21",{"date":152,"type":21},"2026-06",{"name":154,"class":55},"University Hospital Tuebingen",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":83},"100303469","phase-4-continuous-infusions-vs-scheduled-bolus-infusions-100303469","NCT03230565","Continuous Infusions vs Scheduled Bolus Infusions","A Prospective Comparison of Pain and Analgesia in Patients With Continuous Peripheral Nerve Block Catheters Using Continuous Infusion or Scheduled Bolus Infusion","Inclusion Criteria:\n\n* Adult patients presenting for nerve block catheters for post-operative analgesia\n* ASA physical status I, II, or III.\n\nExclusion Criteria:\n\n* Pregnancy\n* Incarceration\n* Age \\\u003C18\n* BMI \\>35\n* Pre-operative opioid use \\>30 mg morphine equivalents per day\n* Inability to communicate with investigators by telephone\n* Pre-existing neuropathy of the operative extremity.",{"count":163,"type":21},240,[165],"PHASE4","The goal of the study is to compare continuous infusions and scheduled bolus infusions for peripheral nerve blocks and their effect on post-surgical pain.",[28,168],"Pain, Postoperative","2025-12-04",{"date":171,"type":48},"2025-12-08",{"date":173,"type":48},"2018-06-01",{"date":175,"type":21},"2026-12",{"name":177,"class":55},"Stanford University",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":185,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":83},"100565832","improving-surgical-communication-for-patients-in-wisconsin-100565832","NCT06647303","Improving Surgical Communication for Patients in Wisconsin","Better Conversations for Better Informed Consent: A Pilot Study to Automate Surgeon Training and Evaluate Patient-Reported Outcomes","Inclusion Criteria:\n\nSurgeons:\n\n* Surgeons from University of Wisconsin - Madison Department of Surgery who have an outpatient surgical clinic and treat adult patients at UW Health\n\nSurgical candidates:\n\n* Age 18 or older\n* Present to an enrolled surgeon's clinic with a surgical problem\n* Decision making ability\n* Speak English\n\nStakeholders:\n\n* Must have previous experience with surgery (within 10 years)\n* Speak English\n\nExclusion Criteria:\n\nSurgeons:\n\n* Solely treat minors (under age 18)\n\nSurgical candidates:\n\n* Lacking decision making capacity\n* Unable to speak English\n\nStakeholders:\n\n* Unable to speak English",true,{"count":187,"type":21},580,[24],"The purpose of this study is to evaluate a new training program to support communication between surgeons and their patients. The goal of the training program is to help patients get the information they need to make treatment decisions that are right for them.\n\nParticipants will complete surveys, attend a focus group, or receive training on Better Conversations, depending on the type of participant.",[191,28],"Surgeons",[193,194],"decision making","communication","2025-10-20",{"date":197,"type":48},"2025-10-22",{"date":199,"type":48},"2024-11-18",{"date":201,"type":21},"2028-11",{"name":203,"class":55},"University of Wisconsin, Madison",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":222,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":83},"100572355","fissios-and-postoperative-complications-fpoc-trial-100572355","NCT06732193","Fissios© and Postoperative Complications (FPoC Trial)","Clinical Trial Comparing a Face-to-face Perioperative Respiratory Physiotherapy Program Versus the Use of Fissios App© as a Complement to a Respiratory Physiotherapy Program in Patients Diagnosed With NSCLC Undergoing Surgery.","FPoC","Inclusion Criteria:\n\n1. Patients over 18 years of age.\n2. Indication for lung resection surgery due to diagnostic suspicion or histopathological diagnosis of non-small cell lung carcinoma.\n3. Anatomical lung resection surgery: anatomical segmental resection, lobectomies or pneumonectomies, using a conventional or minimally invasive approach (VATS, RATS).\n4. The patient has a smart mobile device compatible with the Fissios App©, has the ability or has the support to use it.\n5. Willingness and commitment to participate in the study.\n6. Ability to complete the informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Medical contraindication to perform respiratory physiotherapy exercises.\n2. Not possessing a smart mobile device compatible with Fissios App©.\n3. Inability of the patient to perform the exercises, either due to a physical or psychological impediment.\n4. Inability to complete the informed consent form for participation in the study.\n5. Refusal to participate in the study.",{"count":213,"type":21},560,[24],"Respiratory physiotherapy as part of a pre-operative physical training program may reduce the risk of developing post-operative complications, improving post-operative results and optimizing physical conditions in patients with a diagnosis of non-small cell lung cancer (NSCLC) undergoing lung resection surgery. During the post-operative period, performing physical exercise has also been proved to increase the capacity for exercise, improve health-related quality of life and reduce the feeling of breathlessness. Fissios App is a tool created by thoracic surgeons, physiotherapists and a specialist doctor in physical medicine and rehabilitation, which has been satisfactorily implemented in thoracic surgery patients; this contains a program of standardized respiratory physiotherapy exercises with a defined time and number of repetitions.\n\nThe aim is to compare the effectiveness of use of the Fissios App tool as a complement to a peri-operative respiratory physiotherapy program compared to just attendance at a face-to-face peri-operative respiratory physiotherapy program, to reduce the incidence of post-operative complications.\n\nIt is expected to include 560 patients in the study. Subsequent to evaluation by the investigator and the acceptance of participant to take part in the study, the performing of peri-operative respiratory physiotherapy is prescribed. The participants will be randomly assigned to a study group that uses the tool as a complement to the respiratory physiotherapy program or a control group that should only attend face-to-face respiratory physiotherapy sessions. All the participants should attend face-to-face respiratory physiotherapy classes taught by physiotherapists at the place and time set out in each centre before and after surgery for at least 45 minutes and at least five sessions. Moreover, study group participants may use the Fissios App tool. Investigators should fill in the pre-operative, surgery and post-operative data for each patient on the Fissios Research platform.",[28,217,218,219,220,221],"Non Small Cell Lung Cancer","Surgery Scheduled","Thoracic Surgery","Postoperative Complications","Perioperative Care",[223,224,225,226],"Respiratory physiotherapy","Smartphone App","Post-operative complications","Peri-operative physical training","2025-09-10",{"date":229,"type":48},"2025-09-11",{"date":231,"type":48},"2025-03-20",{"date":233,"type":21},"2026-12-31",{"name":235,"class":55},"Carlos Alfredo Fraile Olivero, MD, PhD.",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":22,"phases":245,"briefSummary":247,"conditions":248,"keywords":251,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":83},"100561835","phase-1-comparison-between-epidural-analgesia-and-intrathecal-opioid-analgesia-for-pain-management-in-open-nephrectomy-100561835","NCT06595329","Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy","Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy: Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients over the age of 18, scheduled for an open radical or partial nephrectomy due to RCC.\n* American Society of Anesthesiologists (ASA) physical status classification I-III.\n\nExclusion Criteria:\n\n* Patients who refuse to participate in this study.\n* Patients with BMI \\> 35 kg\u002Fm2 or \\\u003C 15 kg\u002Fm2.\n* Patients with renal dysfunction (eGFR \\\u003C15 or requirement of renal replacement therapy), liver dysfunction (Child-Pugh class C), and heart failure (NYHA IV).\n* Patients with ASA physical status classification ≥ IV.\n* Patients with contraindication for the interventions planned for in this study (allergies to anesthetic drugs used in this study, coagulation disorders, and infection at the injection site).\n* Patients with chronic opioid dependence.\n* Patients unable to communicate preoperatively due to severe dementia, language barrier, or neuropsychiatric disorder.\n* Patients for whom it is impossible to carry out the aforementioned interventions for technical reasons.",{"count":244,"type":21},40,[246],"PHASE1","Nephrectomy is a surgical procedure of choice for patients suffering from renal cell carcinoma (RCC). Even though the laparoscopic approach is considered to cause fewer complications and reduce hospital stay, open surgery is still often performed. Open nephrectomy causes significant acute postoperative pain, and it can also lead to the development of chronic postoperative pain. Pain management is important for the overall recovery of patients undergoing major surgery such as open nephrectomy and it is a part of the enhanced recovery after surgery (ERAS) program.\n\nIn this prospective randomized clinical study, we plan to compare two different approaches to pain management regarding the level of acute pain (first 72 hours), side effects, systemic analgesics consumption, and hospital stay.\n\nOur hypothesis are that intrathecal opioid administration significantly reduces acute postoperative pain compared to epidural analgesia in patients undergoing open radical or partial nephrectomy. We also hypothesize that the intrathecal opioid administration is associated with a lower incidence of adverse effects compared to epidural analgesia and shorter ICU length of stay.",[249,250,28],"Pain","Renal Cancer",[252,253,254],"Pain management","open nephrectomy","renal cell carcinoma","2025-03-05",{"date":257,"type":48},"2025-03-10",{"date":259,"type":48},"2025-01-15",{"date":261,"type":21},"2025-12-31",{"name":263,"class":55},"University Hospital of Split",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":17,"minAge":270,"maxAge":271,"enrollmentInfo":272,"targetDuration":4,"studyType":22,"phases":273,"briefSummary":274,"conditions":275,"keywords":276,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":289},"100442703","decreasing-emergence-agitation-with-personalized-music-100442703","NCT05044832","Decreasing Emergence Agitation With Personalized Music","Inclusion Criteria\n\n* patient ages 3-9 (chosen due to high incidence of emergence delirium and presence of musical memory seen in this age group)\n* unilateral or bilateral myringotomy procedure, laser treatment for skin lesions, adenoidectomy without tonsillectomy\n* tonsillectomy with or without adenoidectomy\n\nExclusion Criteria\n\n* Chronic intake of any sedative or analgesic medication\n* Combined surgical procedure not otherwise listed in inclusion criteria\n* Surgical or anesthetic complications (including use of invasive airway device for myringotomy)\n* History of significant hearing loss impeding the ability to hear music\n* Lack of interest in music reported by parents or inability to identify personally meaningful music","3 Years","9 Years",{"count":66,"type":21},[24],"The purpose of the study is to assess the impact of personalized music on emergence agitation (EA), as measured by Pediatric Anesthesia Emergence Delirium scores in pediatric patients recovering from elective procedures under general anesthesia.\n\nPersonalized music may help to decrease EA in children undergoing elective surgeries under general anesthesia by decreasing perioperative anxiety and minimizing perceived pain. The study has the potential to improve perioperative care by improving safety, decreasing the need for postoperative pharmacologic and nursing interventions, thereby shortening the time of recovery and improving caregiver satisfaction.\n\nParticipants participating in this study will be randomly assigned to receive personalized music plus standard of care, or standard of care alone. Those assigned to the music group will receive music in the preoperative holding area as well as in the post-operative care unit.",[28],[277,278,279,280],"eardrum procedures","laser treatment for skin lesions","adenoidectomy without tonsillectomy","tonsillectomy with or without adenoidectomy","2024-11-20",{"date":283,"type":48},"2024-11-22",{"date":285,"type":48},"2021-11-12",{"date":287,"type":21},"2026-11",{"name":177,"class":55},2,{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":297,"targetDuration":299,"studyType":67,"phases":4,"briefSummary":300,"conditions":301,"keywords":302,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":314,"locationsCount":83},"100433625","troms-trainee-reported-outcome-measurement-the-new-era-of-surgical-evaluation-100433625","NCT04926558","TROMS (Trainee Reported Outcome Measurement): the New Era of Surgical Evaluation","TROMS","Inclusion criteria:\n\nAll surgical residents in the department of general and digestive surgery\n\nExclusion criteria:\n\nNot applicable",{"count":298,"type":21},120,"10 Years","TROMS (trainee reported outcome assessment): assessment of surgical training of residents in general surgery",[28],[295,303,304,305,306,307],"PROMS","surgical assessment","learning curve","OSATS","MIR","2024-06-05",{"date":310,"type":48},"2024-06-07",{"date":312,"type":48},"2021-01-01",{"date":261,"type":21},{"name":315,"class":55},"Hospital del Mar",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":324,"targetDuration":326,"studyType":67,"phases":4,"briefSummary":327,"conditions":328,"keywords":336,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":289},"100522998","european-prospective-registry-on-anomalous-aortic-origin-of-the-coronary-arteries-100522998","NCT06089902","European Prospective Registry on Anomalous Aortic Origin of the Coronary Arteries","EUROAAOCA Registry","EUROAAOCA","Inclusion Criteria:\n\n* All patients with a diagnosis of AAOCA (either referred to surgery or to medical follow-up )\n\nExclusion Criteria:\n\n* isolated high-coronary take-off (≥ 5mm above sino-tubular junction), anomalous origin of a circumflex from the right coronary artery, anomalous course with a normal origin, and association to major congenital heart disease (i.e. Tetralogy of Fallot, transposition of the great arteries, anomalous origin of a coronary from the pulmonary artery).",{"count":325,"type":21},500,"5 Years","Anomalous aortic origin of a coronary artery (AAOCA) is a group of rare congenital heart defects with various clinical presentations. The lifetime-risk of an individual living with AAOCA is unknown, and data from multicentre registries are urgently needed to adapt current recommendations and guide optimal patient management. The European Registry for AAOCA (EURO-AAOCA) aims to assess differences with regard to AAOCA management between centres.",[329,330,331,28,332,333,334,335],"Congenital Heart Disease","Coronary Artery Anomaly","Sudden Cardiac Death","Diagnosis","Arrhythmia","Heart Defects, Congenital","Adult Children",[337,338,339],"anomalous","coronary","sudden cardiac death","2023-10-11",{"date":342,"type":48},"2023-10-19",{"date":344,"type":48},"2019-01-01",{"date":346,"type":21},"2029-01-01",{"name":348,"class":55},"University of Padova",{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":356,"enrollmentInfo":357,"targetDuration":4,"studyType":22,"phases":359,"briefSummary":360,"conditions":361,"keywords":4,"overallStatus":362,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":369,"locationsCount":83},"100517028","rae-versus-mie-in-patients-with-esophageal-cancer-after-neoadjuvant-therapy-100517028","NCT06012214","RAE Versus MIE in Patients With Esophageal Cancer After Neoadjuvant Therapy","Robot-assisted Versus Conventional Minimally Invasive Esophagectomy for Locally Advanced Esophageal Squamous Cell Carcinoma After Neoadjuvant Therapy: a Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age ranges from 18 to 75 years;\n2. European Clinical Oncology Group Performance Status (ECOG PS) 0-2;\n3. Histological subtype of esophageal squamous cell carcinoma;\n4. Primary tumors are located at the intrathoracic esophagus;\n5. Pre-treatment stage as cT1b-4aN1-3M0, cT3N0M0 (AJCC\u002FUICC 8th Edition);\n6. With neoadjuvant chemoradiotherapy, chemotherapy and immunotherapy;\n7. Without any anticancer therapy for other malignant diseases;\n8. Written informed consent.\n\nExclusion Criteria:\n\n1. Cervical esophageal cancer and carcinoma of gastro-esophageal junction;\n2. Patients with unresectable or metastatic esophageal cancer;\n3. Histological subtype of esophageal non-squamous cell carcinoma;\n4. History of previous thoracic surgery;\n5. Patients with other malignant tumor (previous or current);\n6. Participation in another clinical trial during this study.","75 Years",{"count":358,"type":21},300,[24],"This is a prospectively randomized controlled trial to compare RAMIE and MIE in the treatment for locally advanced ESCC after neoadjuvant therapy. According to previous studies, long-term survival after RAMIE seemed to be at least comparable to MIE or open esophagectomy. Therefore, the RAMIE-2 study was designed as a non-inferiority trial, which was based on the hypothesis that the 5-year overall survival of patients who received RAMIE is uncompromised to MIE. To achieve the primary endpoint, 260 cases will be recruited in our hospital. Based on the volume of esophagectomy (1000 cases\u002Fyear) and the proportion of patients with neoadjuvant therapy (50%) in our institution, approximately 10 patients will be enrolled for each group per month for this trial. The study will be performed in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice Guidelines. Written informed consent will be obtained from each participant. The flow chart of this trial is also presented.",[28],"NOT_YET_RECRUITING","2023-08-21",{"date":365,"type":48},"2023-08-25",{"date":367,"type":21},"2024-01-01",{"date":80,"type":21},{"name":370,"class":55},"Shanghai Chest Hospital",{"id":372,"slug":373,"hasResults":11,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":11,"sex":17,"minAge":379,"maxAge":380,"enrollmentInfo":381,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":383,"conditions":384,"keywords":388,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":83},"100405180","results-of-surgical-treatment-of-the-hepatobiliopancreatic-surgical-unit-100405180","NCT04556019","Results of Surgical Treatment of the Hepatobiliopancreatic Surgical Unit","Results of the Surgical Treatment of Patients From Hepatobiliopancreatic Surgical Unit at the Complejo Hospitalario de Navarra","HPB","Inclusion Criteria:\n\n* All patients operated by the HPB Surgical Unit in the last 10 years (retrospective)\n* All patients being operated by the HPB Surgical Unit from January 2019 onwards who provide inform consent (prospective).\n\nExclusion Criteria:\n\n* Patients not eligible for surgery\n* Patients not interested in taking part in the study","15 Years","90 Years",{"count":382,"type":21},1000,"The main aims of this study are:\n\n1. \\- to evaluate post-surgical morbidity and mortality outcomes, following the criteria and the definitions from Claven-Dindo and ISGPS international classifications, of the patients operated by the HPB Surgical Unit.\n2. \\- to evaluate survival and disease-free survival rates of the patients operated by the HPB Surgical Unit due to tumoral cause.",[385,386,28,387],"Pancreas Disease","Liver Diseases","Bile Duct Diseases",[389],"Hepatobiliopancreatic surgery","2020-09-15",{"date":392,"type":48},"2020-09-21",{"date":394,"type":48},"2019-01-03",{"date":396,"type":21},"2029-01",{"name":398,"class":55},"Fundacion Miguel Servet"]