[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgical-site-infections\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgical-site-infections":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,43,75,111,133,168,198,227],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100635383","the-effect-of-an-arcs-model-based-escape-room-simulation-on-nursing-students-knowledge-motivation-and-self-efficacy-regarding-surgical-site-infections-100635383",false,"NCT07551973","The Effect of an ARCS Model-Based Escape Room Simulation on Nursing Students' Knowledge, Motivation, and Self-Efficacy Regarding Surgical Site Infections","Inclusion Criteria:\n\n* Being a nursing undergraduate student\n* Voluntarily agreeing to participate in the study\n\nExclusion Criteria:\n\n* Being a graduate of any health sciences program\n* Having prior experience with an escape room simulation",true,"ALL","18 Years","30 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The study is designed as a randomized controlled trial with an experimental and control group, using a pre-test, post-test, and follow-up test design.\n\nAll students who agreed to participate in the study will complete the \"Demographic Information Form,\" the \"Knowledge Test on the Prevention of Surgical Site Infections (pre-test),\" the \"Teaching Material Motivation Scale (pre-test),\" and the \"Nursing Students' Academic Self-Efficacy Scale (pre-test).\" Students will be assigned to the experimental and control groups using simple randomization based on their scores on the Surgical Site Infections Prevention Knowledge Test.\n\nStudents in the experimental group will be briefed on the topic of Surgical Site Infections (CAE) prevention by the researcher. Following the training, an escape room simulation designed according to the ARSC Motivation Model will be conducted. Each escape room simulation will be conducted with 6 students and will consist of a pre-briefing session, the escape room simulation activity, and a debriefing session. During the pre-briefing session, the simulation objectives, the purpose of the scenario, the roles within the scenario, and the game rules will be explained, and the escape room and the standard patient will be briefly introduced to the students in the meeting room. Following this, the students will carry out the scenario and game activities (KAHOOT, Board Game, Card Game, Word Cloud, Crossword Puzzle) in the simulation laboratory, which has been set up as an escape room, accompanied by a standard patient. The researcher will serve as a facilitator during the escape room simulation. If the expected steps are not performed correctly or the game activity is not successfully completed during the session, the team has the right to request a hint from the facilitator. Immediately after the escape room simulation is completed, a debriefing session will be held. The debriefing session, lasting approximately 20-30 minutes per team, will take place in the meeting room located directly across from the escape room. During the debriefing session, students will be encouraged to express their feelings and thoughts, and the researcher will provide feedback.\n\nAll students in the control group will receive instruction on the topic of Surgical Site Infection prevention using the traditional teaching method by the researcher.\n\nAfter the training is completed and 1. month, all students will be administered the \"Surgical Site Infection Prevention Knowledge Test (post-test),\" the \"Teaching Material Motivation Scale (post-test),\" and the \"Nursing Students' Academic Self-Efficacy Scale (post-test).\" Research Questions Does an ARCS-model-based escape room simulation increase nursing students' knowledge levels regarding surgical site infections? Does an ARCS-model-based escape room simulation increase nursing students' learning motivation regarding surgical site infections? Does an ARCS-model-based escape room simulation increase nursing students' self-efficacy regarding surgical site infections?",[27,28,29],"Surgical Site Infections","ARSC Motivation Model","Escape Room Simulation","NOT_YET_RECRUITING","2026-04-20",{"date":33,"type":34},"2026-04-27","ACTUAL",{"date":36,"type":21},"2026-05-01",{"date":38,"type":21},"2026-06-30",{"name":40,"class":41},"Ankara Yildirim Beyazıt University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":42},"100602567","incidence-of-depression-and-its-complications-after-surgical-site-infection---isodep-100602567","NCT07125196","Incidence of Depression and Its Complications After Surgical Site Infection - ISODEP.","ISODEP","Inclusion Criteria:\n\n* Patient \\>18 years old\n* Patient treated in infectiology for surgical site infection after orthopedic surgery of the limbs or spine:\n\n  * Prosthetic limb surgery\n  * Spinal surgery\n  * Traumatology: Osteosynthesis of peripheral limbs or spine\n\nExclusion Criteria:\n\n* Patient under guardianship or curatorship,\n* Pregnant, breastfeeding woman\n* Person deprived of liberty by judicial or administrative decision,\n* Person undergoing psychiatric treatment under duress requiring the consent of the legal representative.\n* Person unable to express their consent,\n* Person under legal protection,\n* Patient not affiliated to a social protection scheme.\n* Patient with a history of diagnosed depression, hospitalization for depressive disorders or taking mood-regulating treatments.\n* An initial BMI of less than \\\u003C 18.5, the existence a cancerous pathology, an ongoing inflammatory disease, a pathology responsible for chronic undernutrition",{"count":51,"type":21},300,[24],"Surgical-site infection (SSI) in orthopedic surgery is a serious and frequent complication with many consequences on the patient's quality of life. This study aims to describe the incidence of depression and its complications like malnutrition in patients followed for surgical site infection to allow their best management and prevention",[27,55,56],"Depression","Malnutrition",[58,59,60,61,62,63,64],"surgical site infection","depression","malnutrition","orthopedic surgery","mood disorders","infection management","prospective study","RECRUITING","2026-02-06",{"date":68,"type":34},"2026-02-09",{"date":70,"type":34},"2025-12-11",{"date":72,"type":21},"2029-07",{"name":74,"class":41},"University Hospital, Bordeaux",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":98,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":110},"100562499","prevention-of-edema-after-coronary-artery-bypass-graft-by-customized-pressure-guided-elastic-bandages-100562499","NCT06603961","Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages","Efficacy of Customized Pressure-Guided Elastic Bandages in Preventing Postoperative Edema and Complications in Coronary Artery Bypass Graft (CABG) Patients: A Comparative Study of Compression Therapy and Standard Post-CABG Care.","PEACCE","Inclusion Criteria:\n\n1. All patients scheduled for elective coronary artery bypass grafting (CABG) surgery with saphenous vein harvesting from the leg at Siriraj Hospital.\n2. Patients aged 18 years and older undergoing CABG surgery with saphenous vein harvesting from the leg at Siriraj Hospital, who willingly consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients with an Ankle-brachial pressure index (ABI) \\\u003C 0.8\n2. Patients with severe leg swelling (pitting edema of grade 3 or higher) or with pre-existing or post-operative heart failure that remains uncontrolled despite diuretic therapy.\n3. Patients with occlusive peripheral arterial disease (PAD) or chronic venous insufficiency (CEAP 2s), characterized by significant venous stasis, leg pain, varicose veins, or lymphadenopathy.",{"count":84,"type":21},106,[24],"The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients. While compression therapy, like compressive stockings, has benefits in preventing edema, concerns about affordability persist. CPG-EB provides optimal sub-bandage pressure, proven effective in venous leg ulcers. Implementing CPG-EB post-CABG could enhance venous blood flow, reducing complications and improving outcomes. Patients were divided into two groups: one with CPG-EB and the other standard post-CABG care. Data collected at 1, 2, and 6 weeks post-surgery assessed swelling and wound complications. Comparative analysis used standardized criteria.",[88,27,89,90,91,92,93,94,95,96,97],"Limb Edema","Leg Swelling","Compression Bandages","Coronary Artery Bypass Graft","CABG","Saphenectomy","Saphenous Vein","Delayed Wound Healing","Post Operative Complications","Post Operative Surgical Site Infection",[99,100,101,92,102],"compression bandages","compression therapy","customized pressure-guided elastic bandages","coronary arterial bypass graft",{"date":68,"type":34},{"date":105,"type":34},"2025-01-19",{"date":107,"type":21},"2026-05-31",{"name":109,"class":41},"Siriraj Hospital",2,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":42},"100545166","effectiveness-of-screening-and-decolonization-of-s-aureus-to-prevent-s-aureus-surgical-site-infections-in-surgery-outpatients-100545166","NCT06378359","Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients","Inclusion Criteria:\n\n* Eligible participanst are outpatients in orthopedic, urology, neuro, otolaryngology, plastic and general surgery and OB\u002FGYN clinics who are scheduled to undergo surgery at participating trial sites.\n* Anticipated surgery ≥ 10 days after the date of enrollment, to allow time for completion of baseline cultures and the decolonization protocol.\n* Age ≥ 18 years\n* Ability to complete the decolonization protocol pre-operatively as an outpatient.\n* No antibiotic therapy at the time of, or seven days prior to, baseline cultures, and no subsequent antibiotic therapy prior to the surgical procedure. Standard pre-op antibiotic prophylaxis given.\n* Patients are having skin incisions as part of their scheduled surgical procedure.\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* Surgery anticipated \\\u003C10 days after the baseline cultures",{"count":118,"type":21},250,"OBSERVATIONAL","The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment, chlorhexidine gluconate (CHG) body wash, and CHG mouth rinse), in eradicating SA carriage compared to other SA decolonization approaches. The study will conduct a single center pilot trial to compare efficacy of different SA decolonization approaches in pre-surgical patients, in eradicating SA carriage, after obtaining informed consent.\n\nThe study will compare four different approaches, Arm 1) screen for SA carriage and using the three-drug decolonization bundle for 5 days among patients with SA colonization, non SA carriers in this arm will get two pre-op showers with CHG soap, Arm 2) all participants receive the three drug decolonization bundle, Arm 3) all receive pre-op nasal povidone iodine the day of surgery plus two pre-op showers with CHG soap, and Arm 4) all receive nasal alcohol gel the day of surgery plus two pre op showers with CHG soap.\n\nThe primary efficacy outcome will be eradication of SA colonization at all 5 body sites. Secondary outcomes will be SA surgical site infections (SSIs), all SSIs, and SA healthcare associated infections (HAIs). The study will also compare eradication of SA from each of the 5 body sites as a secondary outcome.",[122,27,123],"Staphylococcus Aureus Colonization","Healthcare Associated Infections","2026-01-12",{"date":126,"type":34},"2026-01-14",{"date":128,"type":34},"2024-01-29",{"date":130,"type":21},"2026-12-31",{"name":132,"class":41},"University of Minnesota",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":145,"conditions":146,"keywords":149,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100606827","phase-4-gut-decolonisation-with-neomycinmetronidazole-or-rifaximin-before-colon-surgery-100606827","NCT07180615","Gut Decolonisation With Neomycin\u002FMetronidazole or Rifaximin Before Colon Surgery","Neomycine\u002FMetronidazole- vs Rifaximin-based Gut Decolonisation Prior to Colon Surgery: a Randomized Multicenter Trial","NeoRiDe","Inclusion Criteria:\n\n* aged ≥ 18 years\n* undergoind planned colon surgery\n* colon surgery will be included in Swissnoso SSI surveillance\n* informed consent\n\nExclusion Criteria:\n\n* contraindications and\u002For intolerance to one of the study compounds\n* patients with underlying active infection (wound contamination class IV) at the timepoint of incision\n* pregnant women\n* unable to follow study protocol",{"count":142,"type":21},458,[144],"PHASE4","The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery. The study includes adult patients who will have colon surgery.\n\nThe main question it aims to answer are:\n\n-Does the Rifaximin treatment prevent surgical site infections as well as the Neomycin\u002FMetronidazole treatment?\n\nOther things the study will look at:\n\n* How often infections happen, stratified on how deep they are, the type of surgery the patients got, or if bowel cleaning was done before surgery.\n* How many people will die after surgery\n* How long people stay in hospital\n\nParticipants will:\n\n* Take either Rifaximin or Neomycin\u002FMetronidazole one day before surgery to clean their gut\n* Keep a diary until the surgery to record medication intake and any side effects\n* Be contacted by phone 30 days after surgery to ask about their condition and any side effects,",[147,148,27],"Surgical Site Infection","Colon Surgery",[150,58,151,152,153,154,155,156,157],"SSI","Metronidazol","flagyl","neomycine","rifaximin","colon surgery","antibiotics","preoperative decolonisation","2025-09-11",{"date":160,"type":34},"2025-09-18",{"date":162,"type":21},"2026-06-01",{"date":164,"type":21},"2029-06-30",{"name":166,"class":41},"Universität Luzern",4,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":184,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":42},"100582031","nopro---norwegian-hernia-prophylaxis-study-100582031","NCT06858020","NoPro - Norwegian Hernia Prophylaxis Study","NoPro - Norwegian Hernia Prophylaxis Study: Onlay Mesh Versus Small Bite Suture Technique Closure of Midline Laparotomies","NoPro","Inclusion Criteria:\n\n* Surgery predominantly done my midline laparotomy\n* Age 18 years old or older\n* Written consent by patient\u002Ffamily\n* Midline laparotomy with delayed closure\n* No exclusion criteria\n\nExclusion Criteria:\n\n* Age under 18 years\n* Pregnancy\n* Previous abdominal midline hernia mesh repair\n* Abdominal compartment syndrome\n* Linea alba closure not possible\n* Life expectancy under six months\n* Hernia in the midline with transverse diameter lager than 2 cm",{"count":177,"type":21},150,[24],"A multicenter randomized controlled trial comparing midline laparotomy closures using the small-bite suture technique alone to those using the small-bite suture technique with an additional onlay prophylactic polypropylene mesh. The primary endpoint is the incidence of incisional hernias in both groups after one year.",[181,182,183,27],"Incisional Hernia After Midline Laparotomy","Quality of Life (QOL)","Burst Abdomen",[185,186,187,188],"prophylactic mesh","onlay","incisional hernia","midline laparotomy","2025-02-28",{"date":191,"type":34},"2025-03-05",{"date":193,"type":34},"2025-02-17",{"date":195,"type":21},"2028-12",{"name":197,"class":41},"Sykehuset Innlandet HF",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":206,"minAge":17,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":215,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":225,"locationsCount":42},"100576094","supplemental-high-flow-oxygen-to-reduce-infections-in-obese-gynecological-cancer-patients-100576094","NCT06780813","Supplemental High Flow Oxygen to Reduce Infections in Obese Gynecological Cancer Patients","Supplemental Administration of High Flow Oxygen to Enhance Postoperative Recovery and Reduce Infections in Obese Gynecological Cancer Patients","SAFE","Inclusion Criteria:\n\n* Obese (BMI\\>30kg\u002Fm2) gynecological cancer patients\n* Optimized preoperative CBC values (hemoglobin \\>11g\u002Fdl, WBC 4.000-11.000 X 109\u002FL, platelets 150,000 to 400,000 X 109\u002FL)\n* In the case of neoadjuvant therapy an interval longer than three weeks between the last cycle and the operation\n\nExclusion Criteria:\n\n* Active immunosuppresion\n* Preexisting infection of the abdominal wall\n* Preexisting sepsis","FEMALE","85 Years",{"count":209,"type":21},400,[24],"The incidence of surgical-site infection (SSI) and complications related to wound healing reaches 10-20% of gynecological cancer patients. Each complication may dramatically prolong the hospitalization period and increase the economic burden of hospital care. Appropriate wound care and tissue oxygenation are of special importance for wound healing. Assuming adequate perfusion, the easiest, safest, and most effective way to improve tissue oxygenation is to increase the fraction of inspired oxygen. However, there is considerable controversy as to whether supplemental oxygen actually reduces SSI and healing-related complications as to date, there is absence of relevant data.",[213,214,27],"Supplemental Oxygen","Gynecological Cancer",[216,217,218],"Supplemental oxygen","Surgical site infections","Gynecological cancer","2025-01-15",{"date":221,"type":34},"2025-01-17",{"date":223,"type":34},"2025-01-10",{"date":36,"type":21},{"name":226,"class":41},"National and Kapodistrian University of Athens",{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":234,"enrollmentInfo":235,"targetDuration":4,"studyType":22,"phases":236,"briefSummary":237,"conditions":238,"keywords":243,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":42},"100519428","barbed-suture-vs-non-barbed-closure-for-emergency-exploratory-laparotomy-rct-100519428","NCT06043414","Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT","Incisional Surgical Site Infection and Fascial Dehiscence After Abdominal Fascial Closure With Triclosan-Coated Barbed Suture vs Polydioxanone Suture After Emergency Exploratory Laparotomy: A Randomized Control Trial","Inclusion Criteria:\n\n* All adult individuals aged 18 years or older who undergo emergent laparotomy via a midline approach for trauma or non-trauma emergency general surgery who undergo complete fascial closure at the time of the index laparotomy operation.\n* Individuals with CDC Class I, II, III and IV type surgical wounds\n\nExclusion Criteria:\n\n* Individuals under 18 years of age\n* Individuals with known immune deficiencies\n* Individuals taking chronic immunosuppressive medications\n* Individuals presenting with nosocomial infections\n* Individuals presenting with pre-existing abdominal wall hernia\n* Individuals requiring multiple operations for sequential fascial closure\n* Individuals incarcerated at time of operation\n* Individuals with known preexisting connective tissue disease\n* Individuals with known preexisting ventral abdominal wall hernia\n* Individuals who are pregnant time of operation\n* Individuals who are deceased prior to conclusion of exploratory laparotomy\n* Individuals lost to follow-up or deceased during the first 30 days after laparotomy.","100 Years",{"count":118,"type":21},[24],"This randomized control trial aims to compare the efficacy of triclosan-coated barbed suture (TCB) versus conventional non-barbed polydioxanone (PDS) suture in the closure of the abdominal fascia after emergency exploratory laparotomy. The study addresses the common complications of incisional surgical site infections (SSI) and fascial dehiscence (FD) following emergency exploratory laparotomy. The primary objective is to assess the effectiveness of triclosan-coated barbed suture and conventional non-barbed suture in reducing the rates of incisional SSI and FD within 30 days postoperatively. The study population comprises adult patients undergoing emergent laparotomy for traumatic injuries or acute intraabdominal pathology. This prospective, single-blinded randomized control trial will be conducted at Los Angeles General Medical Center. Patients will be randomized to receive either triclosan-coated barbed suture or conventional non-barbed suture for abdominal fascial closure, with a standard closure technique employed. Patients will be followed up for 30 days postoperatively to monitor surgical site infections, fascial dehiscence, and other outcomes. Statistical analysis will be conducted to compare outcomes between the study arms, assessing the efficacy of triclosan-coated barbed suture in reducing the incidence of SSI and FD, along with secondary outcomes.",[239,240,27,241,242],"Laparotomy","Dehiscence Wound","Trauma Abdomen","Emergency General Surgery",[244,58,245,246,247,248,249],"fascial dehiscence","laparotomy","ex-lap","STRATAFIX","PDS","triclosan-coated barbed suture","2023-11-27",{"date":252,"type":34},"2023-11-28",{"date":254,"type":21},"2024-01-01",{"date":256,"type":21},"2027-01-31",{"name":258,"class":41},"University of Southern California"]