[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"surgical-stress-response\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:surgical-stress-response":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,48,83,117,143,175,216,251,287],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100642663","phase-4-the-association-between-bilateral-intermediate-cervical-plexus-block-during-total-thyroidectomy-and-surgical-stress-response-100642663",false,"NCT07600580","The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response","The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary and Serum Biomarkers of Surgical Stress Response During Total Thyroidectomy","Inclusion Criteria:\n\n* patienets of both sexes\n* 18 years of age and older\n* ASA I or ASA II\n* euthyroid status\n* signed informed consent\n\nExclusion Criteria:\n\n* patients who refuse to sign the informed consent form\n* infection at the block injection site\n* hypersensitivity or contraindications to the medications used in the study\n* hypothyroidism or hyperthyroidism at the time of surgery\n* presence of substernal goiter\n* additional surgical interventions during the procedure\n* history of previous neck surgery or radiation\n* coagulopathy\n* uncontrolled respiratory disease\n* diabetes mellitus\n* autoimmune disease\n* chronic corticosteroid therapy\n* smokers\n* pregnant women.","ALL","18 Years",{"count":19,"type":20},48,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of stress and inflammatory biomarkers in the participants' saliva and serum.\n\nThe study will be conducted on 48 subjects divided into two groups of 24: a control group receiving total intravenous anesthesia (TIVA) and an experimental group receiving TIVA combined with a bilateral intermediate cervical plexus block.\n\nInvestigators hypothesized that a combination of bilateral intermediate cervical plexus block and total intravenous anesthesia (TIVA) would reduce the surgical stress response, as measured by salivary and blood biomarkers, compared to TIVA alone in patients undergoing total thyroidectomy.\n\nShould the research confirm the hypothesis, it will provide an objective scientific argument for including the block in standard anesthetic protocols for total thyroidectomy surgeries, with the ultimate goal of reducing the surgical stress response and ensuring faster patient recovery.",[26,27,28,29],"Thyroid Cancer","Thyroid and Parathyroid Surgery","Hyperthyreosis and Goiter","Surgical Stress Response",[31,32,33,34],"bilateral intermediate cervical plexus block","surgical stress response","IL-6, cortisol, alpha-amylase","saliva analysis","RECRUITING","2026-06-13",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":39},"2024-05-13",{"date":43,"type":20},"2027-08-01",{"name":45,"class":46},"University Hospital Dubrava","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":47},"100643437","timing-of-midazolam-n-children-undergoing-adenotonsillectomy-effects-on-stress-cortisol-and-recovery-100643437","NCT07622641","Timing Of Midazolam İn Children Undergoing Adenotonsillectomy: Effects On Stress, Cortisol, And Recovery","Optimization of Midazolam Administration Timing in Pediatric Adenotonsillectomy: Effects on Cortisol Response, Behavioral Stress, and Recovery Quality","Timing-Midazol","Inclusion Criteria:\n\n* Children aged 3-10 years,\n* Scheduled for elective adenoidectomy, tonsillectomy, or adenotonsillectomy,\n* American Society of Anesthesiologists (ASA) physical status I-II,\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Children younger than 3 years or older than 10 years,\n* American Society of Anesthesiologists (ASA) physical status greater than II,\n* Known allergy to apple or apple-derived products,\n* Known allergy or hypersensitivity to benzodiazepines,\n* Presence of developmental delay,\n* History of neuropsychiatric disorders,\n* Current or recent use of corticosteroids,\n* Expected or actual surgical duration longer than 90 minutes,\n* Refusal of participation by parents or legal guardians","3 Years","10 Years",{"count":59,"type":20},100,[61],"NA","This study is a prospective, randomized, controlled clinical trial designed to evaluate the optimal timing of midazolam administration in children undergoing adenotonsillectomy. The study will be conducted at the Departments of Otorhinolaryngology and Anesthesiology of Erzurum City Hospital.\n\nMidazolam is commonly used in pediatric patients to reduce anxiety and improve perioperative comfort. However, the optimal timing of its administration (before surgery or during anesthesia induction) remains unclear. This study aims to compare the effects of preoperative oral midazolam and intraoperative intravenous midazolam on stress response, behavioral outcomes, and recovery quality.\n\nParticipants will be randomly assigned to one of two groups. In Group A, children will receive oral midazolam (0.5 mg\u002Fkg) 30 minutes before surgery. In Group B, children will receive intravenous midazolam (0.05-0.1 mg\u002Fkg) during anesthesia induction.\n\nThe primary outcome of the study is the change in serum cortisol levels, which reflects the physiological stress response. Blood samples will be collected twice: once 10 minutes after anesthesia induction and once 15 minutes after surgery in the post-anesthesia care unit.\n\nIn addition to cortisol levels, the study will assess preoperative anxiety using an observational anxiety scale, postoperative pain using a behavioral pain scoring system, and parental satisfaction using a standardized questionnaire. These measures aim to provide a comprehensive evaluation of the child's perioperative experience.\n\nThe findings of this study may help determine the most effective timing of midazolam administration to reduce stress, improve recovery, and enhance overall patient and family satisfaction in pediatric surgical care.",[64,65,29,66],"Adenotonsillectomy","Preoperative Anxiety","Postoperative Pain",[68,69,64,70,65,71,66,72],"Midazolam","Pediatric Anesthesia","Premedication Timing","Cortisol Response","Recovery Quality","NOT_YET_RECRUITING","2026-06-07",{"date":76,"type":39},"2026-06-10",{"date":78,"type":20},"2026-08-01",{"date":80,"type":20},"2027-09-01",{"name":82,"class":46},"Erzurum City Hospital",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":91,"minAge":17,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":21,"phases":95,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":47},"100636883","coresys-monitoring-for-intraoperative-stress-management-in-abdominal-hysterectomy-100636883","NCT07571473","CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy","CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy: A Randomized Controlled Trial","CORESTRESS","Inclusion Criteria:\n\n* Female patients aged 18-70 years\n* Scheduled elective open abdominal hysterectomy in the morning\n* Written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Significant endocrine\u002Fmetabolic disease\n* Pacemaker or major arrhythmias\n* Contraindication to epidural anesthesia","FEMALE","70 Years",{"count":94,"type":20},30,[61],"This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy. Surgical stress involves complex hemodynamic, endocrine, and inflammatory responses that may negatively impact postoperative recovery.\n\nPatients will be randomized to either anesthesia guided by conventional clinical and hemodynamic parameters or anesthesia additionally guided by CoreSys-derived indices of consciousness, nociception, and stress activity. The primary objective is to assess whether CoreSys-guided anesthesia attenuates stress biomarkers, including interleukin-6 (IL-6), cortisol and glycemia.",[29,98,99,100],"Inflammation","Anesthesia","Perioperative Care",[102,103,104,105,106,107],"CoreSys","Surgical Stress","Total Intravenous Anesthesia","Nociception Monitoring","Anesthesia Depth","IL-6","2026-04-30",{"date":110,"type":39},"2026-05-06",{"date":112,"type":39},"2025-01-08",{"date":114,"type":20},"2026-05-30",{"name":116,"class":46},"Hospital Provincial de Rosario",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":91,"minAge":17,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":21,"phases":126,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":4},"100633046","effect-of-video-based-versus-verbal-preoperative-information-on-anxiety-and-cortisol-levels-in-elective-cesarean-section-100633046","NCT07521592","Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Cortisol Levels in Elective Cesarean Section","The Effect of Video-Based Versus Verbal Preoperative Information on Anxiety and Serum Cortisol Levels in Elective Cesarean Section: A Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Scheduled for elective cesarean delivery\n* Planned to receive spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency cesarean delivery\n* History of psychiatric disorders\n* Current use of anxiolytic or antidepressant medications\n* Endocrine disorders, particularly adrenal or thyroid disease\n* Current corticosteroid therapy\n* History of previous surgery under spinal anesthesia\n* Cognitive impairment preventing effective communication or completion of the assessment scales\n* American Society of Anesthesiologists (ASA) physical status III-V",{"count":125,"type":20},140,[61],"Preoperative anxiety is a common problem in patients undergoing elective cesarean section and may negatively affect perioperative outcomes through activation of the stress response, including increased cortisol levels. Effective preoperative information is considered a key non-pharmacological strategy to reduce anxiety; however, the optimal method of information delivery remains unclear. This prospective randomized controlled trial aims to compare the effects of video-based versus verbal preoperative information on anxiety levels and serum cortisol response in patients scheduled for elective cesarean delivery under spinal anesthesia. Anxiety will be assessed using the State-Trait Anxiety Inventory (STAI), and serum cortisol levels will be measured before and after the intervention. The findings of this study are expected to provide evidence for improving patient-centered preoperative education strategies in obstetric anesthesia.\"",[65,129,29,130],"Cesarean Section","Cortisol",[65,132,133],"Cesarean Delivery","Cortisol Biomarker","2026-04-08",{"date":136,"type":39},"2026-04-13",{"date":138,"type":20},"2026-04-02",{"date":140,"type":20},"2026-07",{"name":142,"class":46},"Elazıg Fethi Sekin Sehir Hastanesi",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":150,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":21,"phases":153,"briefSummary":154,"conditions":155,"keywords":158,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":47},"100553011","phase-4-the-effect-of-nocturnal-dexmedetomidine-on-postoperative-sleep-quality-and-fatigue-after-major-surgery-in-elderly-patients-dexsleep-study-100553011","NCT06480539","The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study","DEXSLEEP","Inclusion Criteria:\n\n* aged 60 years or older;\n* scheduled for thoracoscopic lung surgery.\n\nExclusion Criteria:\n\n* lack of informed consent or inability to give informed consent;\n* ≥ 2nd-degree atrioventricular block without pacemaker;\n* uncontrolled hypotension (blood pressure \\< 90\u002F60 mmHg);\n* known hypersensitivity to dexmedetomidine or to any of the excipients;\n* acute cerebrovascular conditions;\n* urgent, not elective surgery.","60 Years",{"count":152,"type":20},102,[23],"In the aftermath of major surgery, many patients suffer from pain, fatigue, reduced general well-being, and cognitive dysfunction. Another common concern after major surgery is sleep impairment and there is little known about its effect on postoperative morbidity, especially postoperative fatigue and muscle function.\n\nDexmedetomidine has been shown to possibly improve postoperative sleep quality in critically ill patients. However, whether the administration of dexmedetomidine translates into reduced postoperative fatigue and\u002For weakness and improved enhanced recovery after surgery by improving sleep, is currently unknown.\n\nThe DEXSLEEP study will evaluate the effect of nocturnal administration of dexmedetomidine, as compared to placebo (i.e. no dexmedetomidine), on postoperative quality of recovery, postoperative fatigue and muscle weakness.",[156,157,29],"Postoperative Fatigue","Postoperative Sleep Disturbances",[159,160,161,162,163,164,165,166],"Major surgery","Enhanced Recovery After Surgery (ERAS)","Elderly patients","Quality of recovery","Postoperative fatigue","Postoperative muscle weakness","Postoperative sleep disturbances","Dexmedetomidine","2026-04-07",{"date":134,"type":39},{"date":170,"type":39},"2024-06-06",{"date":172,"type":20},"2026-04",{"name":174,"class":46},"Ziekenhuis Oost-Limburg",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":182,"sex":16,"minAge":183,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":21,"phases":186,"briefSummary":187,"conditions":188,"keywords":200,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":4},"100628685","feasibility-of-breathwork-intervention-with-older-adults-after-knee-surgery-100628685","NCT07464860","Feasibility of Breathwork Intervention With Older Adults After Knee Surgery","A Box Breathing Intervention and the Surgical Stress Response in Older Adults Undergoing Total Knee Arthroplasty: A Randomized Controlled Feasibility Trial","Adults aged 65 years or older of any sex, gender and ethnic background who meet the following criteria will be eligible to enroll in the present study:\n\nInclusion Criteria:\n\n* scheduled for elective TKA within the next week to two months (can be second knee, but cannot be a revision of the original knee)\n* self-reported good health, including denial of debilitating illness that may affect participation in or be potentially exacerbated by deep, controlled breathing (i.e., chronic obstructive pulmonary disorder \\[COPD\\], symptomatic or advanced heart failure, complete heart block, glaucoma, epilepsy)\n* denial of conditions that alter cortisol release or that require corticosteroid therapy (i.e., Cushing's syndrome, Addison's disease, pituitary tumors, adrenal gland tumors, asthma)\n* denial of severe psychiatric or cognitive conditions that warrant the need for a durable power of attorney (DPOA)\n* able to understand written and verbal English.\n\nExclusion Criteria:\n\n* currently taking oral, injectable, intranasal, topical, or inhaled corticosteroid medications (i.e., prednisone, hydrocortisone, dexamethasone, methylprednisolone, methylprednisolone acetate, triamcinolone, betamethasone, mometasone, fluticasone, budesonide, clobetasol)\n* do not have the technology requirements to complete data collection (i.e., participant does not have a smartphone, tablet, laptop, or desktop computer; lack of reliable internet)\n\nThe following exclusion criteria may affect participants' ability to remain in the study following enrollment:\n\n• Development of complications during surgery that require prolonged hospitalization into Postoperative Day (POD) 2 (e.g., postoperative intubation and ventilation requirements, intractable pain, intractable nausea\u002Fvomiting, signs of infection or sepsis)",true,"65 Years",{"count":185,"type":20},32,[61],"Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients. Older adults (≥65 years) are particularly vulnerable to postoperative complications and their associated morbidities due to the biological aging process. Older adults comprise nearly half of surgical patients worldwide, and this number is expected to increase in the next 10-20 years as the aging population continues to grow. TKA is the most common procedure undergone by older adults, and the rate of TKA procedures is also expected to rise. Despite perioperative guidelines and protocols to prevent postoperative complications, the prevalence of postoperative complications following TKA is approximately 12%. Given these statistics, millions of older adults undergoing TKA may be at risk for postoperative complications and their associated morbidities in the coming decades. Therefore, additional interventions are needed to combat postoperative complications in this population.\n\nThe body's natural response to surgery, also known as the surgical stress response (SSR), contributes to postoperative complications through complex mechanisms involving the autonomic nervous system (ANS). Increased sympathetic nervous system (SNS) activity, or the body's fight-or-flight response, causes dysregulation in feedback systems that regulate the stress response, potentially leading to poorer outcomes. Interventions, such as breathwork, that induce the parasympathetic nervous system (PNS), or the body's rest-and-digest response, have been shown to balance the ANS, regulate stress biology, and improve outcomes. This study will examine the feasibility of adding a breathwork intervention (Box Breathing), compared to an attention control, to standard perioperative care for older adults undergoing TKA. This study will also examine the proof of concept that Box Breathing, compared to an attention control, may help regulate the SSR by assessing an objective measure of stress-related biology, diurnal cortisol rhythm, and gathering self-report information on pain, anxiety, depression, and quality of recovery following TKA.",[29,189,190,191,192,193,194,195,196,130,66,197,198,199],"Stress Physiological","Stress Physiology","Stress Psychological","Breathing Techniques","Breathing Exercises","Hypothalamic Pituitary Adrenal","Relaxation","Relaxation Therapy","Postoperative Anxiety","Postoperative Depression","Quality of Recovery (QoR-15)",[29,201,202,203,193,192,204,66,197,198,205,206],"Total Knee Arthroplasty","Hypothalamic-Pituitary-Adrenal Axis","Breathwork","Postoperative Complications","Quality of Recovery","Diurnal Cortisol Rhythm","2026-03-06",{"date":209,"type":39},"2026-03-11",{"date":211,"type":20},"2026-04-06",{"date":213,"type":20},"2026-09-30",{"name":215,"class":46},"University of Arizona",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":21,"phases":226,"briefSummary":227,"conditions":228,"keywords":233,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":47},"100622155","guided-visualization-meditation-for-reducing-surgical-stress-response-in-cardiac-surgery-patients-100622155","NCT07379944","Guided Visualization Meditation for Reducing Surgical Stress Response in Cardiac Surgery Patients","The Effect of Guided Visualization Meditation on Surgical Stress Response in Patients Undergoing Cardiac Surgery: A Nonrandomized Controlled Clinical Trial","GVM-CARDIO","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled to undergo open-heart surgery\n* ASA physical status I-II\n* First-time cardiac surgery\n* On-pump, median sternotomy technique planned\n* Mild to moderate intraoperative hypothermia protocol\n* No diagnosed psychiatric disorder\n* Not using psychotropic medications\n* No endocrine disorders affecting cortisol (e.g., Addison's disease, Cushing's syndrome)\n* Not taking corticosteroid medications\n* Glasgow Coma Score = 15 postoperatively\n* No perioperative complications that may interfere with participation\n* Able and willing to provide informed consent\n\nExclusion Criteria:\n\n* Prolonged or complicated surgery\n* Withdrawal of consent at any stage\n* Postoperative altered consciousness (GCS \\\u003C 15)\n* Perioperative administration of corticosteroids\n* Severe intraoperative complications\n* Surgery cancelled or rescheduled\n* Hearing impairment preventing participation in auditory intervention\n* Any condition clinically judged by the investigator to interfere with study participation",{"count":225,"type":20},72,[61],"This study aims to evaluate whether guided visualization meditation can reduce the surgical stress response in patients undergoing open-heart surgery. Surgical stress response includes changes in hormones, blood glucose, and anxiety levels that occur before and after major surgery. Guided visualization meditation is a non-invasive relaxation technique that uses calming audio instructions to help patients imagine peaceful scenes and reduce stress.\n\nIn this study, patients scheduled for cardiac surgery will be assigned to one of two groups: an intervention group that receives guided visualization meditation and a control group that receives standard care only. Patients in the intervention group will listen to an audio recording containing guided visualization and calming background music through headphones. Sessions will be provided twice on the day before surgery, twice on the day of surgery, and twice on the first postoperative day.\n\nTo evaluate the effects of the intervention, blood samples will be collected to measure cortisol, glucose, and insulin levels. Anxiety levels will be assessed using the State-Trait Anxiety Inventory (STAI-I and STAI-II), and pain will be measured using a visual pain scale. These measurements will be performed at three specific time points: one day before surgery, six hours after extubation, and one day post-surgery.\n\nThe goal of this research is to determine whether guided visualization meditation can help reduce stress-related physiological and psychological changes in patients undergoing cardiac surgery. If effective, this method may offer a simple, safe, and supportive strategy to improve recovery and overall patient well-being.",[229,29,230,231,232],"Cardiac Surgery","Coronary Artery Disease","Postoperative Stress","Anxiety",[234,235,236,237,238,239,240,241],"guided visualization","meditation","mind-body intervention","STAI","perioperative care","cardiac surgery patients","insulin resistance","blood glucose","2026-01-23",{"date":244,"type":39},"2026-02-02",{"date":246,"type":20},"2026-01-15",{"date":248,"type":20},"2027-03-31",{"name":250,"class":46},"University of Gaziantep",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":183,"enrollmentInfo":259,"targetDuration":4,"studyType":21,"phases":261,"briefSummary":262,"conditions":263,"keywords":267,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":285,"locationsCount":47},"100610797","effects-of-intraoperative-warming-methods-on-hematologic-inflammatory-indices-in-laparoscopic-cholecystectomy-100610797","NCT07232251","Effects of Intraoperative Warming Methods on Hematologic Inflammatory Indices in Laparoscopic Cholecystectomy","Evaluation of the Effects of Different Intraoperative Warming Techniques on Core Body Temperature and Hematologic Inflammatory Indices (SII, NLR, PLR, LMR) in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Study","WARM-CHOL","Inclusion Criteria:\n\n* Patients scheduled for elective laparoscopic cholecystectomy.\n* ASA (American Society of Anesthesiologists) physical status I-III.\n* Age between 18 and 65 years.\n* Willingness and ability to provide written informed consent.\n\nExclusion Criteria:\n\n* ASA IV-V patients.\n* Emergency surgery requirement.\n* Preoperative fever (\\>38.0 °C) or hypothermia (\\\u003C36.0 °C).\n* Operation duration \\\u003C60 minutes or \\>180 minutes.\n* Endocrine\u002Fmetabolic disorders affecting body temperature (e.g., moderate-severe thyroid dysfunction, pheochromocytoma, severe dysautonomia, malnutrition).\n* Active infection\u002Fsepsis or systemic infection within past 2 weeks.\n* Chronic immunosuppressive therapy (e.g., ≥10 mg\u002Fday prednisolone equivalent ≥2 weeks or biological agents in the past month).\n* Hematologic disorders (e.g., leukemia, aplastic anemia, myeloproliferative disorders) or abnormal blood counts (platelet \\\u003C100 ×10⁹\u002FL, leukocyte \\\u003C3 ×10⁹\u002FL).\n* Active malignancy or ongoing chemotherapy\u002Fradiotherapy in last 3 months.\n* Severe organ failure (Child-Pugh C liver, eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or dialysis, NYHA III-IV heart failure, GOLD III-IV COPD).\n* Coagulopathy or uncontrolled antithrombotic therapy.\n* Pregnancy or lactation.\n* Conversion from laparoscopic to open surgery.\n* Non-adherence to assigned warming protocol.\n* Inability to place esophageal temperature probe or unreliable temperature monitoring.\n* Intraoperative hemodynamic instability requiring prolonged vasopressor support or blood transfusion.\n* Missing or incomplete preoperative or postoperative CBC preventing calculation of inflammatory indices.\n* Withdrawal of consent or loss to follow-up.",{"count":260,"type":20},128,[61],"Perioperative hypothermia is a frequent and preventable complication that may cause adverse outcomes such as increased blood loss, impaired coagulation, and delayed recovery. Various active warming techniques are used to maintain normothermia during anesthesia; however, their comparative effects on systemic inflammatory responses remain unclear.\n\nThis randomized controlled clinical trial aims to evaluate the effects of different intraoperative warming methods on hematologic inflammatory indices - including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) - in patients undergoing elective laparoscopic cholecystectomy under general anesthesia.\n\nA total of eligible adult patients will be randomly assigned into four groups according to the intraoperative warming method applied:\n\nControl Group: No active warming applied.\n\nForced-Air Warming (FAW) Group: Warming blanket system used throughout surgery.\n\nFluid Warming (FW) Group: Intravenous fluids warmed to maintain normothermia.\n\nCombined Warming (FAW + FW) Group: Both forced-air and fluid warming applied simultaneously.\n\nCore body temperature and perioperative data will be recorded. Venous blood samples will be obtained preoperatively and 24 hours postoperatively to calculate inflammatory indices.\n\nThe primary objective is to determine whether active intraoperative warming techniques modulate postoperative inflammatory markers compared to no warming. Secondary outcomes include intraoperative temperature trends, recovery times, and the incidence of hypothermia-related complications.\n\nThe results are expected to identify the most effective warming strategy to minimize inflammation and optimize postoperative recovery in laparoscopic procedures.",[264,265,266,29],"Inflammatory Response","Perioperative Hypothermia","Laparoscopic Cholecystectomy",[268,269,270,271,272,273,274,275,276,277,278],"Intraoperative warming","Forced-air warming","Combined warming","Hypothermia prevention","Fluid warming","Hematologic inflammatory indices","Neutrophil-to-lymphocyte ratio (NLR)","Platelet-to-lymphocyte ratio (PLR)","Systemic immune-inflammation index (SII)","Laparoscopic surgery","Cholecystectomy","2025-11-17",{"date":281,"type":39},"2025-11-19",{"date":283,"type":20},"2025-12-01",{"date":138,"type":20},{"name":286,"class":46},"Ataturk University",{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":182,"sex":16,"minAge":17,"maxAge":183,"enrollmentInfo":294,"targetDuration":4,"studyType":21,"phases":295,"briefSummary":296,"conditions":297,"keywords":301,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":47},"100600652","the-effect-of-video-supported-online-preoperative-education-on-fear-anxiety-sleep-and-stress-100600652","NCT07100275","The Effect of Video-Supported Online Preoperative Education on Fear, Anxiety, Sleep, and Stress","The Effect of Video-Supported Online Preoperative Education on Fear, Anxiety, Sleep, and Stress in Patients Undergoing Laparoscopic Cholecystectomy: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Patients over the age of 18,\n* Those who can speak and write Turkish (education level primary school and above),\n* Those who have undergone laparoscopic cholecystectomy surgery for the first time,\n* Those who are not receiving psychiatric treatment or taking medication,\n* Those who do not have a chronic disease,\n* Those who are not taking cortisone-type medication,\n* Those who have a smartphone and know how to use it,\n* Patients whose anesthesia evaluation was performed 1-3 days before the surgery,\n* Patients who volunteer to participate in the study will be included in the study.\n\nExclusion Criteria:\n\n* Those whose surgery is canceled for any reason.\n* Those who want to leave the study at any stage after volunteering to participate in the study.",{"count":260,"type":20},[61],"Gallbladder stone disease is among the most common digestive system problems worldwide. The global incidence of gallstones is estimated to be 10-20%. In Europe, this rate is approximately 20%. In Turkey, the incidence of gallstones is accepted as 6% and it is estimated that an average of 4 million people have gallstones. ). Laparoscopic cholecystectomy is the most commonly used minimally invasive technique in the surgical treatment of gallbladder diseases. Although this is a technique, it also has many complications. Although drains placed after surgery are protective and therapeutic, they may cause some complications. Due to all these reasons, there are disadvantages such as lack of training and incomplete information given to the patient before surgery, and the patient not knowing what to do in physiological and psychological preparation before surgery. This training and information seems to be important in post-operative recovery and shortening the hospital period. Pre-surgical virtual training enables early detection of changes in the patient's vital signs, early intervention, and reduction of the number of home visits.",[298,299,29,300],"Patient Education","Surgical Fear and Worrying","Medical-surgical Nursing",[302,303,304,305,306,307],"Laparoscopic cholecystectomy","Preoperative education","Preoperative anxiety","Surgical fear","Sleep quality","Stress levels","2025-07-30",{"date":310,"type":39},"2025-08-03",{"date":312,"type":20},"2025-08-20",{"date":314,"type":20},"2025-12-30",{"name":316,"class":46},"Bingol University"]