[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"survivors-of-childhood-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:survivors-of-childhood-cancer":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,77,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100632639","feasibility-of-incorporating-a-standardized-substance-use-measure-with-linked-brief-intervention-into-routine-psychosocial-care-of-adult-childhood-cancer-survivors-100632639",false,"NCT07516301","Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors","Piloting the Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors","Inclusion Criteria:\n\n* Followed in the ACT Clinic at St. Jude Children's Research Hospital\n* Greater than or equal to 15 years of age at time of evaluation\n* Able to speak and read English\n\nExclusion Criteria:\n\n* Significant mental or cognitive impairment that would impact ability to complete surveys or participate in the brief intervention","ALL","15 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","The ASSIST Study is designed to explore whether a brief, evidence based substance use screening and counseling approach can be easily integrated into routine survivorship care at St. Jude Children's Research Hospital.\n\nDuring a regularly scheduled psychosocial visit, participants complete the World Health Organization's Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). This short questionnaire helps identify patterns of use related to tobacco, alcohol, cannabis, prescription medications, and other substances. Survivors whose results show possible risk receive a brief, supportive counseling session during the same appointment. This session uses motivational interviewing techniques to help individuals reflect on their use and consider steps to reduce potential harm.\n\nPrimary Objective:\n\n\\- Assess the feasibility and acceptability of integrating a standardized substance use screening and brief intervention protocol into routine psychosocial workflows within a survivorship clinic.\n\nSecondary Objective:\n\n\\- Evaluate the fidelity of delivering a brief substance use intervention to reduce substance use behaviors among survivors.",[26,27],"Survivors of Childhood Cancer","Substance Use",[29,30],"Adult childhood cancer survivors (ACCS)","Cancer Survivorship","RECRUITING","2026-06-25",{"date":34,"type":35},"2026-06-29","ACTUAL",{"date":37,"type":20},"2026-07",{"date":39,"type":20},"2028-10",{"name":41,"class":42},"St. Jude Children's Research Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100601942","validation-of-a-rapid-screening-tool-for-anxiety-depressive-disorders-in-children-adolescents-and-young-adults-treated-in-oncology-multicenter-study-100601942","NCT07117058","Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.","Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study. Short Title: HARMONY-Tool","HARMONY-Tool","Inclusion Criteria\n\n* Patients diagnosed with pediatric cancer before the age of 18,\n* Patient whose intensive treatment had ended at least 3 months prior to inclusion,\n* Patients considered to be in complete remission by the doctor responsible for their treatment,\n* Patient affiliated to or entitled under a social security scheme,\n* Patient having received informed information about the study OR the holder(s) of parental authority having received informed information about the study in the case of minors.\n\nExclusion Criteria\n\n* Refusal to participate expressed by the patient or minor,\n* Patients whose cancer has relapsed or progressed,\n* Pregnant women, women in labor, breast-feeding mothers,\n* Persons deprived of their liberty, hospitalized without consent, hospitalized for purposes other than those of the research,\n* Adults under legal protection (guardianship) or unable to express their consent.","7 Years","25 Years",{"count":55,"type":20},545,"OBSERVATIONAL","In France today, it is estimated that one in every 850 people aged between 20 and 45 is a childhood cancer survivor (CCS), equivalent to around 40,000 to 50,000 people. Some descriptive studies have established that the diagnosis and treatment of cancer can affect psychological health. A French study published by our team in 2015 and 2020 showed that in adulthood, 40% of CCS had anxiety symptoms, a rate significantly higher than that of the general French population (25%). However, although there are validated scales for screening children for psychological disorders (anxiety, depression, etc.), there is no rapid screening tool that can be used routinely by an oncologist during consultations. So, the study aims to develop and validate a short test, which could easily be carried out systematically during follow-up consultations after childhood cancer. It would make it possible to identify people with no psychological complications and, conversely, those in whom further investigation, based on the classic reference scales for assessing psychological disorders, would be relevant.",[59,60,61,26],"Generalized Anxiety","Introspective & Anxiety-Prone Patient","Depression, Anxiety",[63,64,65,66],"anxiety symptoms","childhood cancer","screening","psychological complication","2026-03-25",{"date":69,"type":35},"2026-03-30",{"date":71,"type":35},"2025-03-18",{"date":73,"type":20},"2027-09",{"name":75,"class":42},"Centre Hospitalier Universitaire de Saint Etienne",7,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":43},"100622489","behavioral-reinforcement-intervention-for-greater-health-trajectories-after-childhood-cancer-bright-100622489","NCT07384286","Behavioral Reinforcement Intervention for Greater Health Trajectories After Childhood Cancer (BRIGHT)","BRIGHT","Inclusion Criteria:\n\n* Participant in NOPHO-CARE Sweden\n* Performing \\\u003C150 min moderate-vigorous physical activity per week and\u002For body mass index 28-35.\n\nExclusion Criteria:\n\n* Pre-existing diagnosis of heart failure or coronary artery disease\n* Uncontrolled hypertension, defined as \\>180\u002F100 mmHg\n* Other medical reasons that the intervention or outcome assessments are considered unsafe (as decided by a study physician)\n* Inability to perform the intervention or outcome assessments due to lack of mobile device (computer, tablet or telephone) with internet access or language barriers.","18 Years",{"count":86,"type":20},900,[23],"Survivors of childhood cancer have a substantially increased risk of long-term health problems in adulthood, including cardiovascular disease, metabolic disorders, psychological morbidity, and impaired health-related quality of life (HRQoL). These risks are partly related to cancer treatment exposures but are also strongly influenced by modifiable lifestyle factors such as physical activity, diet, body weight, and cardiometabolic risk factors. Although healthy lifestyle behaviors are known to reduce morbidity and mortality in this population, many adult childhood cancer survivors do not meet current lifestyle recommendations and rarely receive structured, tailored support to change health behaviors.\n\nThe Behavioral Reinforcement Intervention for Greater Health Trajectories (BRIGHT) study aims to evaluate whether a person-centered, remotely delivered lifestyle intervention can improve health-related quality of life and key health markers in adult survivors of childhood cancer with an unhealthy lifestyle. The intervention focuses on increasing physical activity and improving dietary habits through structured video-based coaching delivered by trained health promoters over a 26-week period.\n\nBRIGHT is conducted within NOPHO-CARE Sweden, a national population-based cohort of childhood cancer survivors, and uses a register-based randomized controlled design with two randomization steps. First, eligible participants are randomized to be offered the intervention or not, enabling evaluation of the population-level effect of offering the intervention through long-term register-based follow-up. Second, participants who consent to active participation are randomized to immediate or delayed start of the intervention, allowing controlled assessment of short-term intervention effects.\n\nThe primary research question is whether the BRIGHT lifestyle intervention leads to a clinically meaningful improvement in health-related quality of life, measured by the PROPr utility index derived from PROMIS-29, compared with a control period. Secondary questions address whether the intervention improves physical activity, cardiorespiratory fitness, muscle strength, diet quality, body weight, blood pressure, and cardiometabolic and biological markers, including epigenetic age acceleration. The study also examines feasibility, adherence, and scalability of delivering a person-centered lifestyle intervention within a national survivorship follow-up structure.\n\nIn addition, BRIGHT investigates whether offering the intervention to the full eligible population leads to long-term reductions in cardiovascular disease, metabolic disease, psychiatric morbidity, and mortality, using national health registers. By combining individual-level efficacy and population-level effectiveness within a single study framework, BRIGHT aims to generate robust evidence to inform future preventive care and long-term follow-up strategies for adult survivors of childhood cancer.",[26],[91,92],"Lifestyle","Survivors of childhood cancer","NOT_YET_RECRUITING","2026-01-28",{"date":96,"type":35},"2026-02-03",{"date":98,"type":20},"2026-05",{"date":100,"type":20},"2030-12",{"name":102,"class":103},"Vastra Gotaland Region","OTHER_GOV",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":43},"100438790","impact-of-chemotherapy-on-urinary-biomarkers-and-non-invasive-urodynamics-in-children-100438790","NCT04993859","Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children","Inclusion Criteria:\n\n* Children aged 5-13 years old\n* A history of cancer\n* Treatment with a chemotherapy regimen including VCR and\u002For DOX\n* Completion of chemotherapy at least one year prior to study enrollment and survey completion.\n\nExclusion Criteria:\n\n* Patients with a:\n* Primary pelvic tumor\n* Pelvic irradiation\n* Pre-existing bladder\u002Fbowel dysfunction\n* Spinal defects\n* Neurologic disorder\n* Neuro-oncologic tumor or brain metastasis\n* Cyclophosphamide or ifosfamide therapy","5 Years","13 Years",{"count":113,"type":20},152,"The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.",[26,116],"Bladder Dysfunction","2025-10-13",{"date":119,"type":35},"2025-10-15",{"date":121,"type":35},"2021-06-02",{"date":123,"type":20},"2026-07-09",{"name":125,"class":42},"University of Colorado, Denver"]