[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"susceptibility-genetic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:susceptibility-genetic":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100535791","association-of-gene-polymorphism-with-susceptibility-to-t2dm-and-the-therapeutic-responses-to-exenatide-in-chinese-patients-with-t2dm-100535791",false,"NCT06256419","Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM","Department of Pharmacy, the Affiliated Hospital of Xuzhou Medical University","Inclusion Criteria:\n\n1. a diagnosis of T2DM\n2. a body mass index (BMI) of 20-35 kg\u002Fm2\n3. an HbA1c of 7.0%-12%, an age of 25-70 years\n4. required data available at baseline and 6 months after GLP-1RA therapy.\n\nExclusion Criteria:\n\n1. Patients with serious diseases such as acute myocardial infarction, cerebral vascular accident, trauma, kidney or liver diseases, severe gastrointestinal dysfunction, and history of pancreatitis\n2. patients receiving GLP-1 analogues, weight loss drugs, glucocorticoids, drugs affecting gastrointestinal peristalsis in the past 3 months\n3. those with missing data at the time points of baseline, 3 months, and 6 months after GLP-1 RA therapy.","ALL","25 Years","70 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a retrospective cohort study of patients with T2DM who were treated with exenatide twice daily as a part of their diabetes care for at least 12 months. The objective of this study is to investigate the influence of T2DM susceptibility gene polymorphisms (NOS1AP, KCNQ1, TCF7L2, WSF1, GLP-1R, etc.) on the efficacy of GLP-1 RA (exenatide, liraglutide, etc.), to identify the variables that can predict the efficacy of GLP-1 RA, and to evaluate the weight of these variables on the efficacy.",[27,28],"Type 2 Diabetes Mellitus","Susceptibility, Genetic",[27,30,31,32,33],"GLP-1 RA","gene polymorphism","susceptibility gene","variation","RECRUITING","2025-09-17",{"date":37,"type":38},"2025-09-18","ACTUAL",{"date":40,"type":38},"2024-01-01",{"date":42,"type":21},"2028-01-31",{"name":44,"class":45},"The Affiliated Hospital of Xuzhou Medical University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":14,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":68,"locationsCount":46},"100537410","effect-of-mutations-in-t2dm-susceptibility-genes-on-the-expression-of-susceptibility-genes-in-patients-with-t2dm-and-controls-100537410","NCT06277466","Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls","Inclusion Criteria:\n\n1. no drug therapy; 25 to 70 years old; Hemoglobin A1c (HbA1c) 7%-12%; BMI 20-35 kg\u002Fm2; Stable body weight (≤10% change within 3 months)（For newly diagnosed patients with T2DM）.\n2. 25 to 60 years old; BMI 19-26 kg\u002Fm2; in good health, with no abnormalities of motor system, digestive system, respiratory system, urogenital system, blood system, circulatory system, nervous\u002Fmental system, endocrine system, etc（For healthy subjects）.\n3. 20-80 years old; surgical resection of part or all of the pancreas; pancreatic lesions confirmed by enhanced CT or magnetic resonance (MR) examination or confirmed by intraoperative and postoperative pathology（For the patients in general surgical）.\n\nExclusion Criteria:\n\n1. had taken antidiabetic drugs;\n2. had a history of pancreatic surgery;\n3. Complicated with severe organ lesions;\n4. Long-term use of drugs that affect pancreatic function.",true,{"count":20,"type":21},[24],"In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression.\n\nParticipants (T2DM patients and controls) were recruited to identify genotypes and detect the levels of T2DM susceptibility genes expression in the fresh peripheral plasma. The normal pancreatic tissues or adjacent tissues of pancreatic cancer were also collected to identify the expression differences of T2DM susceptibility genes under different genotypes.",[27,58,59,28],"Gene Polymorphisms","Genetic Mutations",[61,31,32,62],"T2DM","genetic mutations","2024-02-25",{"date":65,"type":38},"2024-02-28",{"date":40,"type":38},{"date":42,"type":21},{"name":44,"class":45}]