[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"suspected-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:suspected-stroke":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100575521","phase-3-early-initiated-ambulance-delivered-levetiracetam-and-headposition-in-hyper-acute-stroke-trial-100575521",false,"NCT06773364","Early Initiated Ambulance-delivered Levetiracetam and Headposition in Hyper-acute Stroke Trial","An Investigator Initiated and Conducted, Prospective, Multicentre, Randomised Outcome-blinded Study of Pre-hospital Initiated Levetiracetam and Headposition in Patients With Presumed Acute Stroke","EAST","Inclusion Criteria:\n\n* Adults (age ≥18 years);\n* Acute condition that is presumed due to acute stroke, defined on the FAST (Face, Arm, Speech, Time) screen (score ≥2 with an arm deficit);\n* Time ≤2 hours from last seen well;\n* Able to provide brief consent (if a waver of consent not approved by ethics committee).\n\nExclusion Criteria:\n\n* coma (no response to painful stimulation);\n* severe co-morbid disease (e.g. cancer, chronic airflow disease, severe dementia, severe heart failure, pre-existing disability \\[needing help with everyday activities\\]);\n* history of epilepsy or seizure at onset;\n* recent head injury;\n* hypoglycaemia (glucose \\\u003C2.8mmol\u002FL);\n* clear indications or contraindications (allergies) for levetiracetam;\n* lactating women;\n* clear indications for a particular head position or situations where either head position cannot be maintained (such as severe vomiting and inability to lie down, severe obesity with fatigue and difficulty sitting up, etc.).","ALL","18 Years",{"count":20,"type":21},2423,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","This is an investigator initiated and conducted, multicentre, ambulance-delivered, prospective, randomised, open-label, blinded outcome (PROBE) study. EAST aims to evaluate the effects of pre-hospital levetiracetam and different head positions initiated in ambulance settings on the functional outcome of participants assessed at 90 days.",[27],"Suspected Stroke",[29,30,31,32,33],"Ambulance","Acute stroke","Levetiracetam","Head position","intervention","RECRUITING","2025-05-19",{"date":37,"type":38},"2025-05-22","ACTUAL",{"date":40,"type":38},"2025-04-30",{"date":42,"type":21},"2029-12-31",{"name":44,"class":45},"Shanghai East Hospital","OTHER",2]