[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"swallowing-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:swallowing-disorders":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,80,109,133,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100630826","effect-of-visual-biofeedback-assisted-oropharyngeal-exercises-in-post-stroke-dysphagia-100630826",false,"NCT07492719","Effect of Visual Biofeedback-Assisted Oropharyngeal Exercises in Post-Stroke Dysphagia","Effectiveness of Visual Biofeedback-Assisted Oropharyngeal Exercises Combined With Neuromuscular Electrical Stimulation in Patients With Post-Stroke Dysphagia: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Clinical diagnosis of dysphagia, defined by at least one of the following: presence of cough or throat clearing during the 90 mL water swallow test, reduced laryngeal elevation on clinical examination, or at least one symptom related to dysphagia\n* Ability to initiate reflex swallowing\n* History of cerebrovascular event within the previous 6 months\n* Stable vital signs\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment (Mini-Mental State Examination \\[MMSE\\] score \\\u003C 20), dementia, or severe communication difficulties due to aphasia\n* Contraindications to electrical stimulation, including the presence of an\n* implantable cardioverter-defibrillator (ICD), impaired skin integrity or open wounds at the electrode placement site, or active epilepsy\n* History of cervical surgery or presence of respiratory distress\n* Diagnosis of malignancy","ALL","18 Years",{"count":19,"type":20},34,"ESTIMATED","INTERVENTIONAL",[23],"NA","Post-stroke dysphagia is a common complication that negatively affects nutritional status, quality of life, and morbidity. Conventional swallowing rehabilitation, including oropharyngeal exercises and neuromuscular electrical stimulation (NMES), is widely used to improve swallowing function. This randomized controlled clinical study aims to investigate the effectiveness of visual biofeedback-assisted oropharyngeal exercises combined with NMES in patients with post-stroke dysphagia. Participants will be randomly assigned to either a visual biofeedback-assisted exercise group or a conventional exercise group, with both groups receiving NMES. Treatment will be administered five days per week for four weeks. Changes in swallowing function, suprahyoid muscle activity assessed by surface electromyography, and muscle stiffness evaluated by shear wave elastography will be analyzed to determine the effectiveness of the intervention.",[26,27,28,29],"Dysphagia After Stroke","Stroke","Dysphagia","Swallowing Disorders",[31,32,33,34,35,36,37],"Post-Stroke Dysphagia","Swallowing Rehabilitation","Oropharyngeal Exercises","Neuromuscular Electrical Stimulation (NMES)","Visual Biofeedback","Surface Electromyography (sEMG)","Shear Wave Elastography","RECRUITING","2026-03-19",{"date":41,"type":42},"2026-03-25","ACTUAL",{"date":44,"type":42},"2026-02-16",{"date":46,"type":20},"2028-01",{"name":48,"class":49},"Gazi University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100598825","muscle-wasting-and-dysphagia-in-critically-ill-patients-signal-100598825","NCT07076524","MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)","The Relationship Between Oral and Suprahyoid Muscle Wasting and Dysphagia in Critically Ill Patients","SIGNAL","Inclusion Criteria:\n\n* Adults \\>18 years\n* Receiving mechanical ventilation via endotracheal tube and\u002For tracheostomy. Expected to receive ventilation for at least 72 hours.\n* Expected to survive admission and spend more than 7 days in the intensive care unit.\n\nControl participants\n\n* Adults \\>18 years\n* Receiving ward-based care.\n* Expected to survive hospital admission. Present with a primary medical diagnosis of acute medical or surgical illness, not requiring critical care admission.\n\nExclusion Criteria:\n\nApplies to both critically ill and control participants.\n\n* Pregnancy\n* Patients with a diagnosis of a primary neuromuscular pathology (e.g., motor neurone disease), central nervous system disease (e.g., stroke, Guillain barre), traumatic brain injury, connective tissue disease (e.g., scleroderma), head and neck cancer, previous surgery or radiotherapy to the head and neck.",{"count":60,"type":20},160,"OBSERVATIONAL","The goal of this study is to find out how muscle wasting in the mouth and throat affects swallowing (dysphagia) in adults who are critically ill and being treated in intensive care units.\n\nThe main aims of this research study are to understand: how much and how quickly the oral and suprahyoid muscles waste in critically ill participants, and whether muscle wasting causes problems with swallowing. The investigators will compare critically ill participants with non-critically ill participants to determine if muscle wasting is linked to swallowing problems.\n\nIn this study, participants will have the size and strength of their mouth and throat muscles measured at four different times during their critical care admission and hospital stay. Tests will also be performed to check how well and how safely participants can swallow. Tongue strength will be measured, and participants will answer questions about their experience with swallowing and eating using patient-reported outcome measures.\n\nThis study may help identify better ways to diagnose and treat swallowing problems in people who are critically ill, to support safe eating and drinking and promote faster recovery.",[64,28,65,29],"Critical Illness","Muscle Wasting in Critically Ill",[67,68,69,70],"dysphagia","critical illness","swallowing disorders","muscle wasting","2025-11-17",{"date":73,"type":42},"2025-11-18",{"date":75,"type":42},"2025-08-01",{"date":77,"type":20},"2028-01-31",{"name":79,"class":49},"Barts & The London NHS Trust",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":50},"100596745","the-effect-of-swallowing-exercise-and-maneuver-program-for-older-adults-with-dysphagia-in-nursing-home-100596745","NCT07049471","The Effect of Swallowing Exercise and Maneuver Program For Older Adults With Dysphagia in Nursing Home","Inclusion Criteria:\n\n* aged 60 years or older\n* experiencing swallowing difficulties as assessed by the Eating Assessment Tool-10 (EAT-10)\n* having no history of neurological disease\n* possessing adequate communication abilities\n* and being capable of performing daily activities either independently or with partial assistance\n\nExclusion Criteria:\n\n* individuals with dermatological conditions in the anterior neck region, hypertension, orofacial pain such as trigeminal neuropathy or toothache, as well as those with significant malocclusion or facial asymmetry","60 Years",{"count":88,"type":20},72,[23],"This clinical trial aimed to evaluate the effectiveness of a structured swallowing exercise and maneuver program for older adults with dysphagia living in a nursing home. Dysphagia, or difficulty in swallowing, is common in elderly populations and may lead to malnutrition, dehydration, and aspiration pneumonia.\n\nIn this study, 72 participants aged 60 years and older were randomly assigned to either an intervention group or a control group. The intervention group received a combined swallowing exercise and maneuver program-including Masako Maneuver, Chin Tuck Against Resistance, Supraglottic Swallow, and Super-Supraglottic Swallow-performed three times daily before meals over a six-week period. The control group received standard care, including upright sitting posture during meals.\n\nSwallowing ability was measured using the EAT-10 questionnaire. The intervention group showed significant improvement in swallowing scores, while no meaningful changes were observed in the control group. This study suggests that nurse-led swallowing exercises can be a safe, simple, and effective strategy to improve swallowing function and quality of life in older adults living in long-term care settings.",[92,29,93,94],"Oropharyngeal Dysphagia","Frailty-related Dysphagia","Nursing Homes",[92,96,97,98],"older adult","nursing home","swallowing","NOT_YET_RECRUITING","2025-06-25",{"date":102,"type":42},"2025-07-03",{"date":104,"type":20},"2025-07-10",{"date":106,"type":20},"2025-08-31",{"name":108,"class":49},"Indonesia University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":115,"sex":16,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":50},"100594602","tongue-pressure-in-middle-aged-and-elderly-individuals-with-chronic-cervical-pain-100594602","NCT07021586","Tongue Pressure in Middle-Aged and Elderly Individuals With Chronic Cervical Pain","1\\. Inclusion Criteria (chronic cervical pain group):\n\n1. Aged between 50-65 year olds\n2. Chronic neck pain (caused by specific neck movements or prolonged neck posture)\n3. Cervical pain duration: at least 3 months within the past year\n4. Cervical pain intensity: during activity or rest, as measured by the Numeric Pain Rating Scale, must have an average score of at least 3 over the past two weeks\n5. No anti-inflammatory or painkillers can be used within 48 hours prior to the test\n\n2\\. Inclusion Criteria (healthy group):\n\n1. Matching gender, age, and body mass index with those in the chronic cervical pain group\n2. No cervical pain has occurred within the past 6 months\n\n3\\. Exclusion Criteria:\n\n1. Neurological diseases that may affect tongue pressure readings, such as stroke or Parkinson's disease\n2. Head or neck surgery in the past year\n3. Severe head or neck injuries (e.g., whiplash from a car accident) in the past year\n4. Diagnosed with cervical radiculopathy or myelopathy with symptoms in the form of numbness or tingling, or fail relative clinical tests (spurling's\u002F cervical distraction\u002F cervical rotation test\u002F upper limb tension test-1\u002F Hoffman sign)\n5. History of head or neck deformities or cancer\n6. History of head or neck radiation therapy\n7. Diagnosed with dysphagia\n8. Experience pain or restricted movement in the temporomandibular joint (TMJ) during chewing in the last 6 months\n9. Require anticonvulsants or antidepressant medications\n10. Cognitive impairments preventing understanding of the test order or communication",true,"50 Years","65 Years",{"count":119,"type":20},40,"The goal of the cross-sectional study is to explore the impact of neck pain on tongue pressure in the middle-aged and elderly population and analyze the effects of different cranio-cervical positioning on tongue pressure performance.\n\nThe main questions it aims to answer are:\n\n1. Do middle-aged and elderly individuals with chronic cervical pain exhibit reduced maximal tongue pressure compared to those without cervical pain?\n2. What are the effects of different cranio-cervical positioning on tongue pressure performance?\n\nParticipants will complete all the assessments on the day of testing.",[122,123,29],"Cervical Pain, Posterior","Swallowing Difficulties","2025-06-13",{"date":126,"type":42},"2025-06-15",{"date":128,"type":42},"2025-02-20",{"date":130,"type":20},"2025-06-30",{"name":132,"class":49},"National Yang Ming Chiao Tung University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":115,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":21,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":154},"100517220","modelling-of-pharyngeal-laryngeal-effectiveness-100517220","NCT06014710","Modelling of Pharyngeal Laryngeal Effectiveness","Modelling of Pharyngeal Laryngeal Effectiveness to Assess Swallowing Disorders","Eph-L","Inclusion criteria for patients with swallowing disorders :\n\n* Indication to perform a swallowing test (suspected or proven swallowing disorder or presence of a complication)\n* Able to follow up by phone for 6 months or have a caregiver who can answer for them\n* Affiliated subject or beneficiary of the social security system\n* Consent to participate obtained in writing and signed by the subject or, if applicable, the next of kin\u002Fsupport person\n\nInclusion criteria for healthy volunteers :\n\n* No swallowing disorder or discomfort (DHI score\\\u003C8)\n* Affiliated subject or beneficiary of the social security system\n* Signed Consent to Participate\n\nNon-inclusion criteria for patients with swallowing disorders :\n\n* Skin lesion(s) at the neck\n* Tracheotomy or tracheostomy (laryngectomy)\n* Nasogastric probe\n* Iodine allergy\n* Asthma\n* Refusal or any pathology incompatible with passing one of the two reference exams or the sensors used\n* Any serious pathology (severe health or behavioral disorders) where, according to the investigator, this could expose participants to additional risks\n* Legal protection (guardianship, curators, safeguarding of justice)\n* Pregnant and lactating women\n\nNon-inclusion criteria for healthy volunteers :\n\n* Medical history may result in chronic (history of oral-rhino-laryngeal cancer or neurological disease) or temporary (upper respiratory tract infections) swallowing impairment\n* Presence of swallowing disorder or discomfort (Deglutition Handicap Index score superior or equal to 8)\n* Skin lesion(s) at the neck\n* Tracheotomy or tracheostomy (laryngectomy)\n* Nasogastric probe\n* Iodine allergy\n* Asthma\n* Refusal or any pathology incompatible with passing one of the two reference exams or the sensors used\n* Any serious pathology (severe health or behavioral disorders) where, according to the investigator, this could expose participants to additional risks\n* Legal protection (guardianship, curators, safeguarding of justice)\n* Pregnant and lactating women",{"count":142,"type":20},520,[23],"The purpose of this study is to collect the signals of pharyngeal laryngeal activity through five non-invasive sensors (microphone, accelerometer, surface electromyography (EMG), nasal cannula and oximeter) in order to identify indicators of functional efficiency of swallowing, protection of the lower airways and phonation.\n\n440 patients (subjects with swallowing disorders), spread over 4 centers and 80 healthy subjects spread over 2 centers will be recruited for the study in an interventional research study involving the prospective, multicentric and longitudinal.\n\nPharyngolaryngeal effectiveness will be measured from 6 indicators identified by examinations or reference tests grouped into 3 functions:\n\n* swallowing: pharyngeal transport capacity (Yale Residue) and Penetration Aspiration Scale (PAS) rated by videofluoroscopy of swallowing (VFS) or flexible endoscopic evaluation of swallowing (FEES);\n* airway protection: cough trigger (citric acid test) and cough power (peak expiratory flow);\n* phonation: vocal efficiency (maximum phonation time) and velar efficiency (nasal scores).\n\nThe signals obtained from the 5 sensors will be annotated. Stochastic modelling based on hidden Markov models will be used initially and followed by the implementation of deep neural networks to model indicators. For the complication's prediction algorithm, deep neural networks will also be used to evaluate signal-based methods.\n\nThe expected benefits are to obtain automated recognition of pharyngeal-laryngeal effectiveness to diagnose swallowing disorders using objective and quantifiable indicators, non-invasive devices, to assess the severity of these disorders and to identify the risk of complications.",[29],"2025-06-10",{"date":124,"type":42},{"date":149,"type":42},"2023-04-14",{"date":151,"type":20},"2026-12",{"name":153,"class":49},"University Hospital, Toulouse",4,{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":50},"100545829","radiation-related-dysphagia-development-prediction-using-a-two-step-ultrasonographic-model-r-2d-2-100545829","NCT06387004","Radiation-Related Dysphagia Development Prediction Using a Two-Step Ultrasonographic Model (R-2D-2)","Evaluation of the Prognostic Value of Aerodigestive Tract Ultrasound in the Occurrence of Radiotherapy-related Swallowing Disorders in Head and Neck Cancer Patients","R-2D-2","Inclusion Criteria:\n\n* Patients admitted to Hôpital Forcilles for head and neck cancer radiotherapy;\n* Ultrasound operator available ;\n* Patient at least 18 years old at the time of inclusion;\n* Membership of a social security scheme or beneficiary of such a scheme ;\n* Oral, free, informed and express patient consent.\n\nExclusion Criteria:\n\n* Patients with neurological disorders;\n* Patients with DR before the start of radiotherapy;\n* Patient's refusal to participate in the study ;\n* Person subject to a safeguard of justice measure ;\n* Patient under guardianship;\n* Patient with limited care.",{"count":164,"type":20},112,"Radiotherapy for head and neck cancers (H\\&NC) heightens the risk of swallowing disorders (SD), impacting nutrition, quality of life, and overall health, leading to increased hospitalization and mortality. Dietary plans hinge on patients' nutritional status, swallowing ability, and prognosis. Early interventions are crucial, emphasizing the need for precise assessments guiding prognosis, specifying structures for intervention, and facilitating targeted rehabilitation.\n\nClinical examinations lack precision, while existing complementary methods like videofluoroscopy or Fiberoptic Endoscopic Evaluation of Swallowing are invasive, irradiating, resource-intensive, and challenging to access, with uncertain prognostic values.\n\nUltrasound imaging emerges as a non-invasive alternative, offering morphological and dynamic evaluation of swallowing-related structures. It enables qualitative and quantitative analyses, improving precision in targeting structures for rehabilitation. Researchers propose an ultrasound predictive model to anticipate SD risk during H\\&NC radiotherapy, assessing its reliability and accuracy.\n\nOver eighteen months, 124 outpatients beginning H\\&NC radiotherapy at Forcilles's Hospital will undergo weekly clinical and water-swallow tests by a speech language therapist, with videofluoroscopy when SD is suspected. Ultrasound evaluations pre-treatment and at seven and fourteen days will be conducted by blinded ultrasonographers. Cox models will test ultrasound measurement thresholds for SD prediction, estimating sensitivity, specificity, and prediction values. A global ultrasound predictive model will be developed via logistic multivariable regression.\n\nThe study aims to establish an association between ultrasound markers and SD, improving early detection for tailored management. This non-invasive alternative to videofluoroscopy offers potential for enhancing patient outcomes in H\\&NC radiotherapy.",[29],[168,169,170,171],"Swallowing disorders","Echography","Prediction model","head and neck cancer","2025-01-17",{"date":174,"type":42},"2025-01-22",{"date":176,"type":42},"2024-01-18",{"date":178,"type":20},"2026-02-18",{"name":180,"class":49},"Hopital Forcilles"]