[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"symptom-cluster\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:symptom-cluster":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100617211","acupressure-for-cough-in-lung-cancer-survivors-100617211",false,"NCT07315672","Acupressure for Cough in Lung Cancer Survivors","Acupressure for Cough in Lung Cancer Survivors: A Randomized Controlled Trial","Inclusion Criteria:\n\n* be at least 18 years of age;\n* have a diagnosis of LC at any stage and of any pathological type;\n* have a cough symptom rating ≥3 on a 0 to 10 numeric rating scale within 7 days preceding enrollment;\n* can perform acupressure independently in daily activities;\n* be able to read Chinese and communicate in Cantonese or Mandarin;\n* be able to provide informed consent.\n\nExclusion Criteria:\n\n* have unstable chronic diseases other than LC;\n* have received acupressure or acupuncture within the three months preceding study enrollment;\n* have serious illnesses or other conditions that prevent the participants from following the intervention protocols;\n* have a life expectancy of less than 3 months;\n* Be currently participating in other research programs that may affect the outcomes under investigation.","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this randomized controlled trial is to examine the effect of an acupressure intervention in alleviating cough and reducing co-occurring symptoms (dyspnea, cough, and fatigue) in patients with lung cancer.\n\nThe hypotheses are:\n\n1. Acupressure can alleviate cough in lung cancer survivors;\n2. Acupressure can reduce a cough-related symptom cluster (dyspnea-cough-fatigue) experienced by lung cancer survivors;\n3. Acupressure can reduce the symptom burden and improve the health-related quality of life and functional capacity of lung cancer survivors experiencing cough.\n\nParticipants will:\n\nReceive acupressure for 8 weeks or receive an education booklet; Keep a diary of their acupressure practice and symptoms; Be assessed at baseline (T0), early intervention (T1), post-intervention (T2), and 8 weeks after the intervention period (T3).",[26,27,28,29],"Lung Cancer (Diagnosis)","Acupressure","Coughing","Symptom Cluster",[27,31,32,33,29,34,35,36],"Cough","Lung Cancer","Dyspnea","Symptom Burden","Fatigue","Quality of Life","RECRUITING","2026-05-20",{"date":40,"type":41},"2026-05-22","ACTUAL",{"date":43,"type":41},"2026-03-09",{"date":45,"type":20},"2027-02",{"name":47,"class":48},"The University of Hong Kong","OTHER",2,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100614569","mindfulness-oriented-respiratory-distress-symptom-intervention-for-lung-cancer-100614569","NCT07281300","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Lung Cancer","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Patients With Lung Cancer: A Feasibility Randomized Controlled Trial","Inclusion Criteria:\n\n* HK patients who can understand Cantonese, aged 18 years or older;\n* A confirmed diagnosis of an intrathoracic malignancy, including small cell lung cancer, non-small cell lung cancer, or mesothelioma; at any stage of cancer treatment or palliative care;\n* Self-reported impact on daily life from at least two of the three symptoms, where one symptom is breathlessness;\n* Stability of COPD, if present;\n* WHO Performance Status of 0-2;\n* fMRI can be conducted;\n* Expected lifespan of more than six months.\n\nExclusion Criteria:\n\n* Cognitive impairments, severe psychotic symptoms, or other medical conditions that might hinder participation;\n* Participating in mindfulness or other psychological support interventions or symptom management interventions.",true,{"count":59,"type":20},64,[23],"Lung cancer is the leading cause of cancer mortality, posing a critical public health challenge in both Hong Kong and global populations. Patients with lung cancer frequently experience a distressing symptom cluster characterized by breathlessness-driven respiratory distress, accompanied by persistent cough and fatigue, which collectively impose a substantial disease burden. While our research team leader previously developed and validated a multi-component Respiratory Distress Symptom Intervention (RDSI) in England, demonstrating clinical efficacy for lung cancer management, its impact on psychological distress (anxiety and depression) proved limited. This limitation may reflect insufficient integration of psychological components, a crucial consideration given the well-established bidirectional relationship between respiratory symptoms and psychological distress. Emerging evidence indicates that mindfulness interventions provide dual therapeutic benefits by improving patient adherence and effectively addressing both physical symptoms, such as breathlessness and fatigue, as well as psychological distress, including anxiety and depression. Meanwhile, current evaluation methodologies have mainly focused on behavioral data collection, such as self-reported questionnaires, to reflect the effect before and after the intervention. Neuroimaging data can help understand the brain mechanisms underlying breathlessness and elucidate the effectiveness of interventions, thereby improving intervention strategies.",[29,63,28,64,65,66],"Breathlessness","Fatigue Symptom","Lung Cancer Patients","Brain Activity","2026-04-14",{"date":69,"type":41},"2026-04-17",{"date":71,"type":41},"2025-08-12",{"date":73,"type":20},"2027-07-30",{"name":75,"class":48},"The Hong Kong Polytechnic University",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":76},"100581211","home-based-transcutaneous-auricular-vagus-nerve-stimulation-tavns-for-ibs-pain-100581211","NCT06847360","Home-based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for IBS Pain","Home-Based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Pain and Symptom Management Among Young Adults With Irritable Bowel Syndrome (IBS)","IBS-taVNS","Inclusion Criteria:\n\n* 18 - 29 years of age;\n* Men and women;\n* Diagnosis of IBS from a healthcare provider with current report of pain (volunteers asked to bring provider-verification of IBS diagnosis based on Rome IV criteria to initial study appointment);\n* Experiencing moderate pain (≥3 out of 10 on numeric rating scale \\[NRS\\]) at least 4 days of the week and lasting previous three months;\n* Daily access to a computer connected to the internet; and\n* Able to read and speak English.\n\nExclusion Criteria:\n\n* Other chronic pain condition;\n* Celiac disease or inflammatory bowel disease;\n* Diabetes mellitus;\n* severe psychiatric condition requiring inpatient treatment in previous 6 months;\n* Pregnancy or lactation;\n* Regular use of opioids or other illicit substances;\n* use of probiotics or antibiotics within 2 weeks from enrollment; and\n* any other conditions\u002Fcontraindications that prohibit the application of taVNS including but not limited to any current or past history of cardiovascular disorders, recent ear trauma, and metal implants above the level of the neck.","29 Years",{"count":19,"type":20},[23],"The goal of this clinical trial is to learn the feasibility and safety of using home-based taVNS in young adults with IBS to manage their IBS-related pain and symptoms. It will also learn about participants' experience in using the home-based taVNS intervention. The main questions it aims to answer are:\n\n* Is it feasible to use a home-based taVNS intervention for pain and symptom management among YAs with IBS?\n* Is it safe and reported satisfactory to use a home-based taVNS intervention for pain and symptom management among YAs with IBS? Researchers will compare Active to Sham taVNS (a look-alike intervention that contains minimal stimulation) to see if Active taVNS works on managing IBS-related pain and symptoms.\n\nParticipants will:\n\n* Take Active or Sham taVNS intervention for a 6-week treatment (twice daily, 30 minutes per session)\n* Visit the research lab at the initial setup and the end of the 6-week treatment for checkups and tests\n* Keep a diary of their symptoms and the number of times they use the taVNS.",[90,91,29],"Pain, Chronic","Irritable Bowel Syndrome","2026-04-09",{"date":94,"type":41},"2026-04-13",{"date":96,"type":41},"2026-01-19",{"date":98,"type":20},"2028-01",{"name":100,"class":48},"Yale University"]