[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"symptomatic-apical-periodontitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:symptomatic-apical-periodontitis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":4},"100637854","postoperative-pain-and-substance-p-levels-after-bioceramic-vs-calcium-hydroxide-intracanal-medicaments-in-symptomatic-apical-periodontitis-100637854",false,"NCT07585721","Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis","Clinical Evaluation of the Postoperative Pain and Substance P Levels Following the Use of Bioceramic Verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular Molars With Symptomatic Apical Periodontitis","(BCvsCaOH)","Inclusion Criteria:\n\n* \\- Patients aged 18-45 years with no sex predilection\n* Medically free Patients with no systemic conditions that can affect post operative pain response.\n* Patients should not be taking any pain medications 24 hours before intervention\n* Positive patients' acceptance for participating in the study\n* Patient able to sign informed consent\n* Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis\n* Permanent molars without any anatomical variations or severe curvatures\n\nExclusion Criteria:\n\n* \\- Medically compromised patients\n* Patients who have received antibiotic therapy within the last 2 weeks.\n* Pregnant or lactating women.\n* Patients with known allergy to any of the irrigants used.\n* Patients with swelling or acute peri-apical abscess or fistulous tract.\n* Teeth that have:\n* Wide or open apex .\n* Vital pulp tissue .\n* Periodontally affected with grade 2or 3 mobility.\n* Non restorable teeth .\n* Abnormal anatomy and calcified canals .\n* Pervious root canal treatment.\n* severe curved canal\n* Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy",true,"ALL","18 Years","45 Years",{"count":22,"type":23},28,"ESTIMATED","INTERVENTIONAL",[26],"NA","Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis",[29],"Symptomatic Apical Periodontitis",[31,32,33,34,35,36,37,38,39,40,29],"Postoperative Pain","Substance P","Calcium Hydroxide","Bioceramic intra-canal medication","BIO-C TEMP","Mandibular Molars","Intra canal medication","Endodontics","Root Canal Treatment","inflammatory mediators","NOT_YET_RECRUITING","2026-05-10",{"date":44,"type":45},"2026-05-14","ACTUAL",{"date":47,"type":23},"2026-06-01",{"date":49,"type":23},"2027-02-01",{"name":51,"class":52},"Future University in Egypt","OTHER",{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":24,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100614608","phase-4-comparison-of-the-pain-levels-of-single-dose-premedication-with-piroxicam-and-prednisolone-on-post-endodontic-pain-in-single-visit-root-canal-treatment-of-premolars-100614608","NCT07281807","Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars","Inclusion Criteria:\n\n* Healthy patient ranging between 18-40 years\n* Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs.\n* Teeth having mature apex confirmed by periapical radiographs.\n\nExclusion Criteria:\n\n* History of systemic disorders including HIV, Hepatitis\n\n  * Pregnancy (As per Medical record\u002F Verbally)\n  * Patient using medication such as analgesics or anti-inflammatory drugs\n  * Patient allergic to lignocaine, piroxicam and prednisolone\n  * Tooth not suitable for restoration\n  * Periodontal probing depth ≥ 4mm\n  * Retreatment cases\n  * Patients having calcified canals assessed by radiographic findings","40 Years",{"count":61,"type":23},60,[63],"PHASE4","To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.",[66,29],"Irreversible Pulpitis With Apical Periodontitis","2025-12-02",{"date":69,"type":45},"2025-12-15",{"date":71,"type":23},"2026-01-01",{"date":73,"type":23},"2027-01-31",{"name":75,"class":52},"RANA AHMAD"]