[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"symptomatic-irreversible-pulpitis-sip\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:symptomatic-irreversible-pulpitis-sip":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,54,82,108,132,167,195],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100644795","local-dexamethasone-administration-in-symptomatic-irreversible-pulpitis-100644795",false,"NCT07672873","Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis","Comparison of the Effects of Submucosal and Intraligamentary Dexamethasone Administration on Anesthetic Success and Pain Control in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial","SIPDEX","Inclusion Criteria:\n\n* Patients aged 18 to 65 years.\n* ASA I or ASA II systemic health status.\n* Symptomatic irreversible pulpitis in a mandibular molar tooth.\n* Positive response to pulp sensibility tests.\n* Preoperative pain score greater than 54 mm on the Heft-Parker Visual Analog Scale (HP-VAS).\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or lactation.\n* Allergy or contraindication to articaine, dexamethasone, or study-related medications.\n* Use of analgesics, anti-inflammatory drugs, or antibiotics within the previous 12 hours.\n* Presence of periapical radiolucency or diagnosis of pulpal necrosis.\n* Significant systemic disease (ASA III or higher).\n* Inability to complete pain assessment forms or follow study procedures.",true,"ALL","18 Years","65 Years",{"count":22,"type":23},84,"ESTIMATED","INTERVENTIONAL",[26],"NA","Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth. Failure to achieve profound anesthesia may result in increased intraoperative pain and patient discomfort. Corticosteroids have been suggested as adjunctive agents to improve pain control and reduce inflammatory responses; however, the influence of different local administration techniques on anesthetic success and postoperative pain remains unclear.\n\nThe aim of this randomized controlled clinical trial is to compare the effects of submucosal and intraligamentary dexamethasone administration on anesthetic success and pain control in patients with symptomatic irreversible pulpitis. A total of 84 participants requiring root canal treatment of mandibular first or second molars diagnosed with symptomatic irreversible pulpitis will be randomly allocated to one of three groups: (1) inferior alveolar nerve block (IANB) followed by submucosal saline injection (control group), (2) IANB followed by submucosal dexamethasone injection, and (3) IANB followed by intraligamentary dexamethasone injection.\n\nAll participants will receive standardized endodontic treatment under local anesthesia. The primary outcome measure is anesthetic success during access cavity preparation and pulp extirpation. Secondary outcome measures include postoperative pain intensity at 6, 12, 24, 48, and 72 hours, and postoperative analgesic consumption. The results of this study may provide evidence regarding the effectiveness of different local dexamethasone administration techniques and contribute to improved pain management strategies in endodontic practice.",[29,30],"Symptomatic Irreversible Pulpitis (SIP)","Dental Pain",[32,33,34,35,36,37,38,39,40],"Inferior alveolar nerve block","Dexamethasone","Submucosal injection","Intraligamentary injection","Symptomatic irreversible pulpitis","Endodontic treatment","Postoperative pain","Heft-Parker Visual Analog Scale","HP-VAS","RECRUITING","2026-06-26",{"date":44,"type":45},"2026-06-29","ACTUAL",{"date":47,"type":45},"2026-06-15",{"date":49,"type":23},"2026-12-18",{"name":51,"class":52},"Marmara University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":24,"phases":64,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":53},"100632721","phase-4-intraoral-cryotherapy-on-anesthetic-efficacy-in-mandibular-incisors-100632721","NCT07517367","Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisors","Evaluation of the Effect of Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisor Teeth With Irreversible Pulpitis","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Classified as ASA Physical Status I or II\n* Presence of symptomatic irreversible pulpitis in a single-rooted mandibular incisor tooth\n* Preoperative pain score ≥8 on the Numerical Rating Scale (NRS) and Wong-Baker FACES scale\n* Positive response to cold test and electric pulp testing\n* Absence of periapical pathology on preoperative periapical radiograph\n* No analgesic intake within 6 hours prior to treatment\n* Ability to understand and complete pain assessment scales\n* Willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Age below 18 years or above 60 years\n* Pregnancy\n* Known allergy to local anesthetic agents\n* Diagnosis of diabetes mellitus\n* Presence of hypothyroidism\n* Diagnosis of adrenal insufficiency\n* Presence of Raynaud disease\n* Uncontrolled diabetes (HbA1c \\>7%)\n* Presence of periapical pathology detected radiographically\n* Presence of sinus tract\n* Presence of intraoral or extraoral swelling\n* Teeth diagnosed with necrotic pulp\n* Presence of referred pain from another tooth or anatomical structure","60 Years",{"count":63,"type":23},98,[65],"PHASE4","The aim is to compare the contributions of intraoral cryotherapy and supplemental lingual infiltration anesthesia to buccal infiltration anesthesia in mandibular incisor teeth with irreversible pulpitis in terms of anesthetic efficacy, and to evaluate the effect of adding intraoral cryotherapy to buccal anesthesia on anesthetic efficacy.",[29],[69,70,71,72],"Symptomatic Irreversible Pulpitis","Mandibular Incisor","Intraoral Cryotherapy","Buccal Infiltration Anesthesia","2026-04-03",{"date":75,"type":45},"2026-04-08",{"date":77,"type":45},"2025-12-31",{"date":79,"type":23},"2026-08-30",{"name":81,"class":52},"Ondokuz Mayıs University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":18,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":24,"phases":93,"briefSummary":94,"conditions":95,"keywords":96,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":53},"100608063","regenerative-potentials-of-mature-mandibular-molars-with-symptomatic-irreversible-pulpitis-enhanced-with-different-scaffolds-100608063","NCT07196683","Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds","Regenerative Potentials of Mature Mandibular First Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds: A Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA I patients who are free from any physical or mental handicapping condition with no underlying systemic disease.\n* Age between 15-40 years.\n* Males \\& Females.\n* Patients' acceptance to participate in the trial.\n* Patients who can understand pain scale and can sign the informed consent (Appendix I).\n* Mature mandibular fist molars:\n\n  * Diagnosed clinically with symptomatic irreversible pulpitis and normal periapical tissue.\n  * Giving a positive response to pulp sensitivity testing.\n  * Having negative response to percussion.\n  * Having normal radiographic appearance of periapical tissues.\n  * Having bright red color of pulp tissue, with hemorrhage control within 10 mins, upon access cavity preparation.\n\nExclusion Criteria:\n\n* Pregnant and lactating females.\n* Patients with physical or mental handicapping conditions.\n* Patients unwilling to participate in a 12-months follow up.\n* Mandibular first molars with:\n\n  * Immature roots.\n  * Negative response to pulp sensitivity testing.\n  * Positive response to percussion.\n  * Radiographic evidence of periapical lesions, external or internal root resorption, vertical root fracture, or calcification.\n  * Intraoral swelling or fistula.\n  * Lack of pulpal bleeding, or inability to achieve hemostasis of the bleeding pulp within 10 mins, upon access cavity preparation.","15 Years","40 Years",{"count":92,"type":23},36,[26],"The current study aims to assess the influence of different scaffolds on postoperative pain and success rate of pulpotomy in mandibular mature molars with symptomatic irreversible pulpitis",[29],[97],"pulpotomy, regenerative pulpotomy, ascorbic acid-augmented PRF, tannic acid crosslinked-PRF","NOT_YET_RECRUITING","2026-03-25",{"date":101,"type":45},"2026-03-27",{"date":103,"type":23},"2026-07-01",{"date":105,"type":23},"2027-11-01",{"name":107,"class":52},"Cairo University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":90,"enrollmentInfo":115,"targetDuration":4,"studyType":24,"phases":117,"briefSummary":118,"conditions":119,"keywords":120,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":131},"100630139","short-term-comparative-assessment-of-mta-and-biodentine-in-complete-pulpotomy-for-symptomatic-irreversible-pulpitis-100630139","NCT07483788","Short Term Comparative Assessment of MTA and Biodentine in Complete Pulpotomy for Symptomatic Irreversible Pulpitis","Short Term Outcome of Complete Pulpotomy Using MTA vs Biodentine in Symptomatic Irreversible Pulpitis - A Randomized Controlled Trial","Inclusion Criteria:\n\nTeeth of generally healthy patients having following criteria will be included:\n\n1. Age between 18-40 years of both males and females\n2. Carious exposed maxillary and mandibular molars teeth\n3. Moderate to severe pain (VAS 4-10)\n4. Diagnosed with Symptomatic irreversible pulpitis on cold test and Electric pulp test (EPT)\n5. Periapical index of 1\n6. Hemostasis is achieved within 10 mins after full pulpotomy\n\nExclusion Criteria:\n\nTeeth of generally healthy patients having following criteria will be excluded:\n\n1. Any traumatic injury\n2. Non-restorable carious lesion\n3. Immature or Open apices of roots\n4. Internal or external Resorption\n5. Calcified canals",{"count":116,"type":23},60,[26],"All Patients coming to the Operative Dentistry Department (DIDC-DUHS) with complain of pain in posterior teeth will be invited to participate. The treatment will be done by one dentist. Patient's medical and dental history will be recorded, and tooth will be checked for swelling, sensitivity, cavity type, and loosening of tooth. Special tests like the cold test, electric pulp test, and an X-ray will help assess the tooth's condition. Patient will also be asked to rate pain from 1-10. Before starting the treatment, the procedure will be explained to patient in detail, and written consent will be taken. The treatment will be done in two visits by one dentist. Patient will be given an injection to make tooth pain-free so that patient does not feel any discomfort during the treatment and the area will be kept clean using a rubber sheet. The dentist will remove the hole in tooth and remove the infected soft part of tooth and stop the bleeding. Then one of the two materials will be placed inside the tooth. A temporary filling will be placed first, and patient will come the next day for the final filling. An X-ray will be taken to check the result. If patient feel pain, may take ibuprofen (400 mg) as needed, and if the pain continues, please contact the dentist. Patient will be called for follow-ups after 1 day, 1 week, 1 month, and 3 months to make sure the tooth is healing properly.",[29],[69,121],"Complete pulpotomy","2026-03-16",{"date":124,"type":45},"2026-03-19",{"date":126,"type":45},"2024-11-02",{"date":128,"type":23},"2026-07-31",{"name":130,"class":52},"Dow University of Health Sciences",2,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":18,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":24,"phases":143,"briefSummary":144,"conditions":145,"keywords":146,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":53},"100615241","postoperative-pain-after-pulpotomy-in-children-using-calcium-silicate-cements-with-and-without-laser-therapy-100615241","NCT07290049","Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy","Evaluation of Postoperative Pain After Pulpotomy Using Calcium Silicate Cements in Permanent Molars With and Without Laser Biomodulation: A Randomized Clinical Trial","Inclusion Criteria:\n\nPatients between 9 and 14 years of age. Must have a two-rooted mandibular molar tooth (lower back tooth). The tooth must be diagnosed with symptomatic irreversible pulpitis (a painful, inflamed nerve).\n\nThe tooth must be considered restorable (can be fixed with a filling or crown). Patient and\u002For guardian must be able to understand and sign the informed consent form.\n\nThe tooth must be periodontally healthy, with no mobility, and not painful to tapping or pressing.\n\nExclusion Criteria:\n\nTeeth with immature root tips. Teeth that are not restorable (severely damaged or decayed). Bleeding from the tooth's nerve that cannot be controlled within 10 minutes during the procedure.\n\nPatients with significant medical conditions that could complicate dental treatment.\n\nTeeth with a dead (necrotic) nerve. Inability or unwillingness to provide informed consent. Individuals from vulnerable groups (as defined by the ethics committee).","9 Years","14 Years",{"count":142,"type":23},46,[26],"This study is for children and young adults who have a severe toothache in a permanent back molar, caused by an inflamed nerve (a condition called irreversible pulpitis). Usually, the treatment for this is a root canal, which removes the entire nerve. However, a different treatment called \"vital pulp therapy\" or \"pulpotomy\" may be an option. This simpler procedure removes only the infected part of the nerve, leaving the healthy part alive, and then seals the tooth with a special material.\n\nThe goal of our research is to see if we can make this pulpotomy procedure even more comfortable for patients afterward. We are testing two approaches:\n\nUsing a modern dental filling material called EndoCem to seal the tooth.\n\nUsing the same EndoCem material, but first applying a gentle laser to the healthy nerve tissue. This laser treatment, known as \"biomodulation,\" is thought to help calm the tissue and improve healing.\n\nPatients who join the study will be randomly assigned to one of these two treatment groups. The main thing we will measure is the level of pain after the procedure, which patients will record on a simple pain scale. We want to find out if using the laser in addition to the filling material leads to less pain and a better experience after the treatment.\n\nThis study will help dentists understand if combining this new sealing material with laser therapy can be a more effective and comfortable way to save a tooth with a severe toothache.",[69,29],[147,148,149,150,151,152,153,154,155,156,157],"Vital Pulp Therapy","Pulpotomy","Irreversible Pulpitis","Postoperative Pain","Calcium Silicate Cement","Bioceramic","Laser Biomodulation","Er,Cr:YSGG Laser","EndoCem","Biodentine","Randomized Controlled Trial","2025-12-04",{"date":160,"type":45},"2025-12-17",{"date":162,"type":45},"2025-04-24",{"date":164,"type":23},"2026-01-25",{"name":166,"class":52},"University of Fujairah",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":174,"minAge":19,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":24,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":53},"100611355","a-randomized-controlled-trial-evaluating-whether-pre-operative-trinase-reduces-post-operative-pain-in-patients-with-symptomatic-irreversible-pulpitis-compared-to-placebo-using-vas-scores-and-analgesic-intake-over-48-hours-100611355","NCT07239505","A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.","The Role Of Trinase In Reducing Post-Operative Pain For Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy male patients (ASA I or II)\n* Aged 18 to 50 years\n* Presenting with symptomatic irreversible pulpitis in a restorable mandibular molar\n* Preoperative moderate to severe pain (VAS ≥45 mm)\n* Normal periapical tissue (no radiolucency, pocket depth ≤5 mm, mobility ≤ Grade I)\n\nExclusion Criteria:\n\nMedically compromised patients (ASA III or higher)\n\n* History of allergy or intolerance to Trinase or any of its components (trypsin, bromelain, rutin)\n* Vertical root fracture\n* External or internal root resorption\n* Periodontal pocket depth \\>5 mm\n* Tooth mobility Grade II or III\n* Presence of periapical lesion (radiolucency)\n* Female patients (to standardize pain perception and hormonal factors)","MALE","50 Years",{"count":177,"type":23},182,[26],"This study aims to determine whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment in patients with symptomatic irreversible pulpitis. A total of 182 male patients aged 18 to 50 years who present with moderate to severe tooth pain will be randomly assigned to receive either a Trinase tablet or a placebo 30 minutes before treatment. All root canal procedures will be performed in a single visit using standard endodontic techniques.\n\nPain levels will be measured on a Visual Analogue Scale (VAS) before treatment and at 6, 12, 24, and 48 hours after treatment. Patients will also record the number of pain-relief tablets they take during the first 48 hours. The goal of the study is to see whether Trinase can lower post-operative pain and reduce the need for analgesic medication compared with placebo. This information may help improve pain management for patients undergoing root canal therapy.",[29,181,182,30],"Postoperative Pain After Endodontic Treatment","Endodontic Disease",[184,157,185,150],"Visual Analogue Scale (VAS)","Trinase","2025-11-27",{"date":188,"type":45},"2025-12-01",{"date":190,"type":45},"2025-08-01",{"date":192,"type":23},"2025-12-15",{"name":194,"class":52},"Fayoum University",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":24,"phases":204,"briefSummary":205,"conditions":206,"keywords":209,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":131},"100602995","intraligamentary-vs-inferior-alveolar-nerve-block-for-pulpitis-a-randomized-clinical-trial-100602995","NCT07130760","Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial","Is Intraligamentary Injection the Anesthesia of Choice for Symptomatic Irreversible Pulpitis in Mandibular Molars? A Multicenter Randomized Comparative Trial.","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Presenting with symptomatic irreversible pulpitis in a mandibular molar\n* Vital response to cold testing\n* Ability to understand and provide informed consent\n* Available for follow-up and data collection\n\nExclusion Criteria:\n\n* Known allergy to lidocaine or epinephrine\n* Pregnancy or breastfeeding\n* Use of analgesics or anti-inflammatory drugs in the previous 6 hours\n* Non-vital or previously treated teeth\n* Significant systemic disease (ASA III or above)\n* History of psychiatric or neurological disorders affecting pain perception",{"count":203,"type":23},52,[26],"This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars. The goal is to determine which technique provides better pain control during endodontic treatment.",[29,30,207,208],"Inferior Alveolar Nerve Block Failure","Local Anesthesia",[32,210,211,36,212,213,214,215,216],"Pulpitis Mandibular molars","Emergency dental treatment","Randomized clinical trial","Endodontics","Dental pain","Local anesthesia","Intraligamentary anesthesia","2025-08-16",{"date":219,"type":45},"2025-08-19",{"date":221,"type":45},"2025-06-20",{"date":223,"type":23},"2027-07",{"name":225,"class":52},"Aula Dental Avanzada"]