[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"symptomatic-irreversible-pulpitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:symptomatic-irreversible-pulpitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,48,82,105,141,164,188,208],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100053257","phase-4-preoperative-dexamethasone-injection-to-improve-local-anesthesia-success-in-endodontic-treatment-100053257",false,"NCT07699315","Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic Treatment","Preoperative Intraligamentary Injection of Dexamethasone Can Improve the Anesthetic Success Rate of 2% Lidocaine During the Endodontic Management of Mandibular Molars With Symptomatic Irreversible Pulpitis","DILAS","Inclusion Criteria:\n\n1. Patients with pain VAS \\>\u002F= 6\n2. Carious exposed mandibular molar with symptomatic irreversible pulpitis\n3. Patients between ages 18-60 years\n4. American Society of Anesthesiologists class I or II medical histories -\n\nExclusion Criteria:\n\n1\\. Patients with contraindications to local anesthesia solution or dexamethasone 2.Pregnant or breast-feeding females 4.Tooth having fused\u002Fextra roots, full coverage crowns, or poor periodontal status 5. Patients taking drugs which could affect the pain perception\n\n\\-","ALL","18 Years","60 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study aims to determine whether giving a single dose of 4mg dexamethasone before root canal treatment can reduce the amount of pain patients experience during the procedure . Patients diagnosed with symptomatic Irreversible Pulpitis requiring endodontic treatment will be enrolled. Participants will receive either dexamethasone or placebo before treatment , and pain during the procedure will be measured using a Visual Analogue Scale (VAS) .\n\nThe findings may help improve pain management strategies during root canal treatment .",[28],"Symptomatic Irreversible Pulpitis",[28,30,31,32,33,34,35],"Dexamethasone","Root canal Treatment","Intraoperative pain","Endodontics","local anesthesia","Inferior Alveolar Nerve Block","NOT_YET_RECRUITING","2026-07-09",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":22},"2026-07",{"date":44,"type":22},"2026-12",{"name":46,"class":47},"Watim Medical & Dental College","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100613303","this-clinical-trial-aims-to-compare-the-effectiveness-of-two-intra-pulpal-cryotherapy-techniques-endo-ice-and-ice-sticks-in-decreasing-intra-operative-pain-and-enhancing-the-success-of-local-anesthesia-during-pulpectomy-of-mandibular-molars-with-symptomatic-irreversible-pulpitis-100613303","NCT07264829","This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis.","Comparative Analysis of Intra-pulpal Cryotherapy Methods During Pulpectomy in Molars With Symptomatic Irreversible Pulpitis: A Randomized Control Trial","Inclusion Criteria:\n\n1. Individuals (Male and Female) aged 18 to 40 years.\n2. Healthy individuals with no significant present and past medical findings.\n3. Mandibular molars.\n4. Symptomatic irreversible pulpitis (moderate to severe pain according to VAS 4-10).\n5. Periapical index (PAI) Score: 1-3 on periapical radiograph.\n6. DAS-R: 4-14( mild to moderate anxiety)\n\nExclusion Criteria:\n\n1. Immature teeth with open apices.\n2. Calcified pulp chamber and canals.\n3. Periodontally compromised teeth.\n4. Individuals who had taken steroids, analgesics, or antibiotics within the last 48 hours.","40 Years",{"count":57,"type":22},90,[59],"NA","The goal of this clinical trail is to compare the analgesic effect of endo-ice and ice-sticks in reducing intra-operative pain during pulpectomy in molars with Symptomatic Irreversible Pulpitis. Principal Investigator will perform the procedure and outcome assessor will interview the participants as well as fill the pre-operative questionnaire. The patient will be instructed beforehand on how to score their pre-operative, intra-operative and post-operative intensity of pain according to Visual Analogue Scale.The Anxiety level of patient will also be recorded according to the Corah's Dental Anxiety Scale questionnaire and their level of anxiety before and after the intervention will be recorded by the outcome assessor.\n\nThe principal investigator will perform all endodontic procedures, with the outcome assessor blinded to the cryotherapy method. Prior to administering IANB, a topical anesthetic gel will be applied. A 27-gauge needle will deliver 1.8 ml of 2% lidocaine with 1:100,000 epinephrine at a rate of 1 ml\u002Fmin. After a 5-minute wait, anesthesia effectiveness will be confirmed through electric pulp testing (EPT) on a neighboring tooth, with two consecutive negative responses confirming success. Once adequate anesthesia is confirmed, an access opening will be made under rubber dam isolation for the procedure.\n\n1. CONTROL GROUP: After access opening and complete de-roofing of the pulp chamber, pulpectomy of the inflamed pulp will be performed under the given effective IANB with no additional intervention to control intra-operative pain.\n2. ENDO-ICE GROUP: After access opening, pulp will be exposed and de-roofing will be performed. Endo-ice with the help of cotton pellet will be applied inside the pulp chamber for 2min (8 consecutive applications, 15sec each) and pulpectomy of the inflammed pulp will be performed immediately.\n3. ICE-STICKS GROUP: Following the access opening and complete de-roofing of pulp chamber, four ice sticks will be placed inside the pulp chamber for 2 minutes (30 seconds each, using tweezer). Subsequently, pulpectomy of the inflamed pulp will be performed immediately.\n\nPatients will be asked to rate their level of pain to the outcome assessor at four specific intervals during the trial, i.e., pre-operative (before local anesthesia), pre-operative (after local anesthesia), during pulpectomy and immediately after pulp extirpation and it will be recorded in a proforma by the blinded outcome assessor.\n\nPain and Anxiety Scores will be compared to asses either cryotherapy or which method of cryotherapy found to be effective in reducing intra-operative pain.",[62,63,28,64],"Root Canal Treatment","Intra-operative Pain","Cryotherapy Effect",[66,67,68,69,70,71,28],"Cryotherapy","Endodontic treatment","Intra-operative pain","Pulpectomy","Endo-ice","Ice-sticks","2026-03-11",{"date":74,"type":40},"2026-03-13",{"date":76,"type":22},"2026-04-15",{"date":78,"type":22},"2026-10-30",{"name":80,"class":47},"Dow University of Health Sciences",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":81},"100624526","postoperative-pain-after-root-canal-obturation-using-bioceramic-and-calcium-hydroxide-sealers-100624526","NCT07410780","Postoperative Pain After Root Canal Obturation Using Bioceramic and Calcium Hydroxide Sealers","Assessment of Postoperative Pain in Patients Obturated With Bioceramic and Calcium Hydroxide Sealers: A Randomized Clinical Trial","BCvsCaOH","Inclusion Criteria:\n\n* Patients aged 18-40 years\n* Single-rooted permanent teeth\n* Teeth diagnosed with symptomatic irreversible pulpitis\n* Normal periapical condition on radiographic examination or periodontal ligament (PDL) space widening\n* Restorable teeth\n\nExclusion Criteria:\n\n* Patients with systemic conditions that could alter the course of treatment\n* Teeth with immature root development\n* Teeth with necrotic pulp\n* Teeth exhibiting root resorption\n* Teeth with calcified root canals",{"count":91,"type":22},50,[59],"This study is designed to find out how different root canal sealers affect pain after root canal treatment. We are comparing two types of dental sealers: bioceramic sealer and calcium hydroxide sealer.\n\nParticipants who need root canal treatment will receive one of these sealers as part of their standard dental care. After the procedure, they will be asked to report any pain they experience for a few days.\n\nThe information from this study will help dentists choose sealers that may reduce post-treatment pain and improve patient comfort after root canal therapy.",[28],"RECRUITING","2026-02-13",{"date":98,"type":40},"2026-02-17",{"date":100,"type":40},"2026-01-01",{"date":102,"type":22},"2026-12-01",{"name":104,"class":47},"HITEC-Institute of Medical Sciences",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":81},"100615241","postoperative-pain-after-pulpotomy-in-children-using-calcium-silicate-cements-with-and-without-laser-therapy-100615241","NCT07290049","Postoperative Pain After Pulpotomy in Children Using Calcium Silicate Cements With and Without Laser Therapy","Evaluation of Postoperative Pain After Pulpotomy Using Calcium Silicate Cements in Permanent Molars With and Without Laser Biomodulation: A Randomized Clinical Trial","Inclusion Criteria:\n\nPatients between 9 and 14 years of age. Must have a two-rooted mandibular molar tooth (lower back tooth). The tooth must be diagnosed with symptomatic irreversible pulpitis (a painful, inflamed nerve).\n\nThe tooth must be considered restorable (can be fixed with a filling or crown). Patient and\u002For guardian must be able to understand and sign the informed consent form.\n\nThe tooth must be periodontally healthy, with no mobility, and not painful to tapping or pressing.\n\nExclusion Criteria:\n\nTeeth with immature root tips. Teeth that are not restorable (severely damaged or decayed). Bleeding from the tooth's nerve that cannot be controlled within 10 minutes during the procedure.\n\nPatients with significant medical conditions that could complicate dental treatment.\n\nTeeth with a dead (necrotic) nerve. Inability or unwillingness to provide informed consent. Individuals from vulnerable groups (as defined by the ethics committee).","9 Years","14 Years",{"count":115,"type":22},46,[59],"This study is for children and young adults who have a severe toothache in a permanent back molar, caused by an inflamed nerve (a condition called irreversible pulpitis). Usually, the treatment for this is a root canal, which removes the entire nerve. However, a different treatment called \"vital pulp therapy\" or \"pulpotomy\" may be an option. This simpler procedure removes only the infected part of the nerve, leaving the healthy part alive, and then seals the tooth with a special material.\n\nThe goal of our research is to see if we can make this pulpotomy procedure even more comfortable for patients afterward. We are testing two approaches:\n\nUsing a modern dental filling material called EndoCem to seal the tooth.\n\nUsing the same EndoCem material, but first applying a gentle laser to the healthy nerve tissue. This laser treatment, known as \"biomodulation,\" is thought to help calm the tissue and improve healing.\n\nPatients who join the study will be randomly assigned to one of these two treatment groups. The main thing we will measure is the level of pain after the procedure, which patients will record on a simple pain scale. We want to find out if using the laser in addition to the filling material leads to less pain and a better experience after the treatment.\n\nThis study will help dentists understand if combining this new sealing material with laser therapy can be a more effective and comfortable way to save a tooth with a severe toothache.",[28,119],"Symptomatic Irreversible Pulpitis (SIP)",[121,122,123,124,125,126,127,128,129,130,131],"Vital Pulp Therapy","Pulpotomy","Irreversible Pulpitis","Postoperative Pain","Calcium Silicate Cement","Bioceramic","Laser Biomodulation","Er,Cr:YSGG Laser","EndoCem","Biodentine","Randomized Controlled Trial","2025-12-04",{"date":134,"type":40},"2025-12-17",{"date":136,"type":40},"2025-04-24",{"date":138,"type":22},"2026-01-25",{"name":140,"class":47},"University of Fujairah",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":147,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":151,"conditions":152,"keywords":153,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":81},"100565288","the-effect-of-xp-endo-finisher-activation-of-bioceramic-sealer-on-postoperative-pain-in-mandibular-first-molar-with-symptomatic-irreversible-pulpitis-100565288","NCT06640231","The Effect of XP-Endo Finisher Activation of Bioceramic Sealer on Postoperative Pain in Mandibular First Molar With Symptomatic Irreversible Pulpitis","Inclusion Criteria:\n\n* Age ranges from 18 to 40 years old.\n* No sex predilection.\n* Patients seeking root canal treatment.\n* Systematically healthy patient (ASA I, II).\n* Patient who can understand numerical rate scale and sign an informed consent.\n* Mandibular first molar teeth with:\n\n  * Preoperative sharp (moderate or severe) pain.\n  * Vital response of pulp tissue to cold pulp tester (ethyl chloride spray).\n  * Normal periapical radiographic appearance.\n\nExclusion Criteria:\n\n* Patients with American association of anesthesiologists (ASA) classification other than ASA T\\& II.\n* Patients who have already ingested preoperative medication, such as analgesics, non-steroidal or steroidal anti-inflammatory drugs, within 12 hours of the start of treatment.\n* Patients with NSAIDs allergy.\n* Patients having two or more adjacent teeth needing root canal therapy.\n* Pregnant patients.\n* Patients with bleeding disorder.\n* Patients with long term corticosteroid use\n* Teeth having;\n\n  * Necrotic pulp.\n  * History or presence of swelling or fistulous tract.\n  * Acute \u002F chronic periapical abscess.\n  * Mobility more than grade 1.\n  * Pocket depth more than 5mm.\n  * No possible restorability.\n  * Previous root canal treatment.\n  * Periapical radiolucency.\n  * External or internal resorption.\n  * Vertical root fracture.\n* TMJ problems, bruxism, clenching or traumatic occlusion.\n* Inability to understand and perform the given instructions.",true,{"count":149,"type":22},30,[59],"The aim of endodontic obturation is to make a complete sealing along the length of the root canal system to ensuring the peri radicular tissue healing and sustained health. Disadvantages of gutta-percha-based root filling materials is lack of adhesiveness to canal wall dentin. So, a sealer or cement has to be used with gutta-percha to achieve a fluid-tight seal and fill the space between the canal wall dentin and the obturating material.\n\nDrawbacks of resin-based sealer are difficult preparation technique of deep root canal cavity which also limit dentin bonding, difficult to be removed from the canal in retreatment cases and its shrinkage during setting.\n\nBio-ceramic root canal sealers become popular in recent years because of their unique chemical and physical properties. These sealers are consisting of biocompatible materials that resemble the of tooth structure natural composition so bio-ceramic sealers are an ideal choice for root canal treatment. Bio-ceramic sealers are better than traditional sealers due to their multiple physical properties for example excellent sealing ability, dimensional stability, and low solubility. These properties ensure that the sealers achieve a tight seal, inhibiting bacterial leakage and decreasing the risk of reinfection. Diaroot Bioaggregate (DiaDent), a white nanoparticle-sized ceramic cement composed of calcium silicate, calcium hydroxide and hydroxyapatite and considered a modified version of MTA, with the advantage of being aluminium-free in composition, a fact that contributes to its greater biocompatibility with periradicular tissue.Root canal sealers activation may improve their penetration into dentinal tubules and improve sealability and antimicrobial effects.\n\nRecently, a non-tapered nickel-titanium rotary instrument (XP-endo Finisher; FKG, La Chaux-de-Fonds, Switzerland) has been designed to increase the efficiency in root canal wall cleaning specifically with limited impact on dentine throughout the literature, XP efficacy in decreasing microorganisms, dissolving organic tissue from artificial cavities in combination with NaOCl and penetrating into the isthmus has been analyzed.\n\nThe aim of this study to evaluate the effect of XP-Endo Finisher activation of Bioceramic sealer on postoperative pain in mandibular first molar with symptomatic irreversible pulpitis.\n\nThis study consists of 30 patients divided into 2 group each group having 15 patients.\n\nIntervention:\n\nBioceramic sealer activation with XP Endo Finisher.\n\nControl group:\n\nBioceramic sealer without activation.",[28],[154],"Postoperative pain","2025-06-25",{"date":157,"type":40},"2025-06-29",{"date":159,"type":40},"2024-11-01",{"date":161,"type":22},"2026-04-01",{"name":163,"class":47},"Future University in Egypt",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":81},"100580818","to-compare-the-effect-of-two-instrumentation-techniques-on-the-incidence-of-post-endodontic-pain-in-patients-undergoing-root-canal-treatment-in-teeth-with-irreversible-pulpitis-100580818","NCT06842251","To COMPARE the EFFECT of TWO INSTRUMENTATION TECHNIQUES on the INCIDENCE of POST-ENDODONTIC PAIN in PATIENTS UNDERGOING ROOT CANAL TREATMENT in TEETH with IRREVERSIBLE PULPITIS","A COMPARISON of EFFECT of TWO INSTRUMENTATION TECHNIQUES on the INCIDENCE of POST-ENDODONTIC PAIN in PATIENTS UNDERGOING ROOT CANAL TREATMENT","Inclusion Criteria:1.Patients of both genders having age 18-70 years, no history of analgesics within the past 1 week ,subjects with no periapical radiolucency, teeth having completely formed tooth apex ,permanent posterior teeth with symptomatic\u002Fasymptomatic irreversible pulpitis, subjects who provided the consent for study participation\n\n\\-\n\nExclusion Criteria: Subjects with a history of trauma, previous root canal treatment, associated systemic diseases ,pregnant females, subjects on analgesics or antibiotics, complaints of tenderness and pain within the past 5 days, extreme root curvature, calcified canals ,external or internal resorption.\n\n\\-","70 Years",{"count":173,"type":22},70,[59],"The aim of this study is to compare the post endodontic pain in patients presenting with irreversible pulpitis and undergoing root canal treatment with two techniques. One is rotary crown down technique and other is manual step back technique. Patients visiting OPD will be selected after fulfilment of inclusion criteria and randomly divided into two groups. In Group A rotary instrument with Crown Down approach is used and in Group B manual instrumentation with Step Back technique is used. Post endodontic pain will be graded using VAS scale at 4,12,24 and 48 hours.",[123,28,177],"Asymptomatic Irreversible Pulpitis",[28,177],"2025-02-18",{"date":181,"type":40},"2025-02-24",{"date":183,"type":22},"2025-05-01",{"date":185,"type":22},"2025-11-01",{"name":187,"class":47},"Urooj Fatima",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":23,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":204,"leadSponsor":206,"locationsCount":81},"100556495","regenerative-endodontic-therapy-in-cases-of-irreversible-pulpitis-100556495","NCT06525844","Regenerative Endodontic Therapy in Cases of Irreversible Pulpitis","Clinical and Radiographic Outcomes With the Use of I-PRF in Mature Permanent Teeth With Symptomatic Irreversible Pulpitis : A Randomized Control Trial","Inclusion Criteria:\n\n* Patients from both genders with an age range of 18-35 years old.\n* Permanent teeth with mature roots with a diagnosis of irreversible pulpitis, with absorption damage to the apex, and the diameter of the apical hole is greater than 1 mm.\n* A restorable tooth.\n* There is no need to leave space for the final post\u002Fcore restoration.\n* Anterior teeth and premolars with single canal.\n* A cooperative and compliant patient.\n* Patients not allergic to the drugs and antibiotics which needed to complete treatment.\n* No periodontal disease or root cracking.\n\nExclusion Criteria:\n\n* Patients with other serious organ diseases, such as cardiopulmonary, kidney and other major diseases.\n* Pregnant women or lactating or expecting within a year.\n* Patients with apical cysts.\n* Patients with poor cooperation and those who quit the study halfway.\n* Patients with periodontitis.\n* Patients with dental dysplasia or other oral genetic disorders.\n* Patients with dental phobia.\n* Patients with mental disorders.","35 Years",{"count":21,"type":22},[59],"Root canal therapy (RCT) is a classical and effective treatment that is currently utilised in dental practice, offering high success rates for pulp and periapical diseases; however, teeth after RCT are susceptible to altered pulp defence and sensory function, even fractures, as a consequence of pulp loss. Furthermore, several studies have highlighted that the actual failure rate of standard root canal treatments performed in general practice is significantly higher than expected . Moreover, these treatments are lengthy and costly and are often subject to retreatment .Inherent in this procedure(rct) is loss of dental hard tissue and subsequent weakening of the treated tooth,making them more prone to fracture. Therefore, less invasive alternative strategies could be used to treat pulpitis, even when irreversible.\n\nMurray et al. proposed the term \"Regenerative endodontic treatment (RET)\" in 2007, based on a tissue engineering concept (stem cells, biomimetic scaffolds, and bioactive growth factors). The 2016 American Association of Endodontists (AAE) guidelines formally defined RET as a collection of \"biologically based procedures designed to replace damaged tooth structures, including dentine and root structures, as well as cells of the pulp-dentine complex\"",[28],"2024-08-01",{"date":202,"type":40},"2024-08-05",{"date":200,"type":40},{"date":205,"type":22},"2025-10-01",{"name":207,"class":47},"Shaheed Zulfiqar Ali Bhutto Medical University",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":147,"sex":17,"minAge":214,"maxAge":19,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":217,"briefSummary":218,"conditions":219,"keywords":220,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":81},"100551264","effect-of-apical-patency-and-local-corticosteroid-on-pain-and-neuropeptides-release-in-patients-with-symptomatic-irreversible-pulpitis-a-randomized-clinical-trial-100551264","NCT06457828","Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Symptomatic acute irreversible pulpitis in molar teeth.\n* Normal periapical condition including periapical radiography with minimal widening of periodontal ligament.\n* Normal probing depth.\n* No medical condition.\n* No contraindication for administration of corticosteroids and local anesthesia.\n\nExclusion Criteria:\n\n* Facial or oral paresthesia.\n* Pregnancy \\& breastfeeding.\n* Unrestorable tooth.\n* Marginal periodontal disease.\n* Presence of a crown on the tooth involved.\n* Over instrumentation during root canal treatment.\n* Long-term use of corticosteroids.\n* False-positive cases of sensibility test with necrosis discovered after gaining access to the tooth.\n* Cases requiring intrapulpal injection to promote anesthesia.","21 Years",{"count":216,"type":22},40,[59],"The goal of this randomized clinical trial is to learn the effect of using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis in molar teeth. The main question it aims to answer is:\n\n• How effective are using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis? Participants will be asked to fill a visual analogue scale to record their pain, after receiving a root canal treatment while using local corticosteroids or not as well as maintaining apical patency or not.\n\nResearchers will compare the use of corticosteroids and maintaining apical patency in reducing post-operative pain.",[124,28],[221,124,222],"Pulpitis","VAS","2024-06-08",{"date":225,"type":40},"2024-06-13",{"date":227,"type":40},"2021-02-01",{"date":229,"type":22},"2024-09",{"name":231,"class":47},"Suez Canal University"]