[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"syncope-vasovagal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:syncope-vasovagal":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,54,78,98,124,144,172,195],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100644473","comparison-of-focal-cryoablation-vs-radiofrequency-cardioneuroablation-for-bradyarrhythmias-100644473",false,"NCT07671898","Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias","Prospective Non-Randomized Comparison of Point-by-Point Cryoablation Using Freezor™ Xtra Versus Radiofrequency Ablation Using TactiFlex™ SE of Parasympathetic Ganglia (Cardioneuroablation) in Patients With Vagally-Mediated Bradyarrhythmias","CRYO-CNA vs RF","Inclusion Criteria:\n\n* Age 18 to 60 years;\n* Symptomatic bradycardia (sinus bradycardia or bradycardia due to atrioventricular block, including transient);\n* Severe asymptomatic sinus bradycardia (heart rate less than 30 beats per minute);\n* Transient second- or third-degree atrioventricular block;\n* Persistent second-degree atrioventricular block;\n* Rhythm pauses greater than 6 seconds;\n* Recurrent syncope or presyncope with documented association with bradycardia (without trauma);\n* Positive response to atropine (heart rate increase ≥25% from baseline or \\>90 beats per minute) OR positive response to exercise (heart rate increase ≥25% from baseline or \\>90 beats per minute, OR conversion of second- or third-degree atrioventricular block to first-degree block or complete normalization of atrioventricular conduction during sinus rhythm);\n\nExclusion Criteria:\n\n* Chronic antiarrhythmic drug therapy (ongoing);\n* Presence of implanted pacemaker, cardiac resynchronization therapy device, or implantable cardioverter-defibrillator;\n* Bradyarrhythmia secondary to medications;\n* Bradyarrhythmia secondary to electrolyte imbalance (hyperkalemia);\n* Bradyarrhythmia secondary to hypothyroidism;\n* Bradyarrhythmia secondary to obstructive sleep apnea syndrome;\n* Absence of response to pharmacological denervation (no heart rate increase after atropine administration up to maximum dose of 0.2 mg\u002Fkg);\n* Clinically significant coronary artery disease;\n* Post-myocardial infarction cardiosclerosis;\n* Hemodynamically significant congenital heart disease (including surgically corrected);\n* Stable ventricular tachycardia in the setting of bradycardia;\n* History of stroke or transient ischemic attack;\n* Prior open-heart surgery;\n* Prior catheter-based coronary artery intervention or percutaneous coronary intervention;\n* Pregnancy or breastfeeding; Age less than 18 years Age greater than 60 years","ALL","18 Years","60 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Bradyarrhythmias are conditions where the heart beats too slowly, causing symptoms like dizziness, fainting, and fatigue. In some patients, these slow heart rhythms are caused by overactivity of the vagus nerve (the part of the nervous system that slows the heart down).\n\nCardioneuroablation (CNA) is a catheter-based procedure that targets and reduces the effect of these overactive nerves on the heart. It is an alternative to permanent pacemaker implantation, especially for younger patients.\n\nTraditionally, CNA is performed using radiofrequency (RF) energy to create small burns in specific areas of the heart. This study investigates whether focal cryoablation (freezing technology using the Freezor™ Xtra catheter) is as safe and effective as standard RF ablation for CNA.\n\nThis is a prospective, non-randomized study. Participants will receive either RF ablation (N=30) or cryoablation (N=30). The study will evaluate the recurrence of slow heart rhythms and fainting episodes, as well as any complications, over 12 months of follow-up.",[28,29,30,31],"Bradycardia","Syncope, Vasovagal","Sick Sinus Syndrome","Atrioventricular Block",[33,34,35,36,37,38,39,40,30,31],"Cardioneuroablation,","Cryoablation","Radiofrequency Ablation","Ganglionated Plexi","Parasympathetic Nervous System","Bradyarrhythmias","Functional Bradycardia","Vasovagal Syncope","RECRUITING","2026-06-22",{"date":44,"type":45},"2026-06-26","ACTUAL",{"date":47,"type":45},"2024-09-01",{"date":49,"type":22},"2028-12-25",{"name":51,"class":52},"Tomsk National Research Medical Center of the Russian Academy of Sciences","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":18,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":53},"100487944","postural-sway-and-counterpressure-maneuvers-for-pediatric-syncope-100487944","NCT05633693","Postural Sway and Counterpressure Maneuvers for Pediatric Syncope","Impact of Postural Sway on Cardiovascular Control in Pediatric Patients With Syncope","Inclusion Criteria:\n\nWe are looking for English speaking pediatric patients aged 6-18 years with a diagnosis of recurrent fainting (at least two episodes of fainting with loss of consciousness or near loss of consciousness in the last year) of a vasovagal origin or associated with the postural orthostatic tachycardia syndrome (POTS) (as determined by a paediatric cardiologist) to take part in this study.\n\nExclusion Criteria:\n\nThose with a diagnosis of recurrent fainting accompanied by any of the following will not be eligible to take part:\n\nKnown history of:\n\n* Suspected or confirmed cardiac arrhythmia (e.g., Wolff-Parkinson-White, Long QT)\n* Traumatic head injury\n* New presentation of a seizure disorder OR epilepsy recurrence\n* Overdose or intoxication\n* Structural heart disease\n* Cardiovascular disease including hypertension, diabetes, or renal disease\n* Hypoglycemia\n* Physical and\u002For psychological disability that impact their ability to complete the tests\n\nFemale participants of childbearing age will be excluded if they are pregnant, or think they might be. Participants who are taking any cardiovascular acting medications, including treatment for cardiovascular disease, or medications for orthostatic syncope (e.g. fludrocortisone, slow-release sodium chloride, β-blockers, midodrine) will be excluded from the study.\n\nIn order to reduce the likelihood of transmission of COVID-19, participants will only be eligible to participate in the study if they have received full immunisation against COVID-19 according to current Health Canada guidelines. Accordingly, participants will be asked to provide evidence of their vaccination status in order to take part in the study.","6 Years",{"count":63,"type":22},30,[25],"The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gluteal muscle tensing in children who faint (N=20), as well as their height, weight, muscularity, and pubertal (Tanner) stage. Autonomic cardiovascular control will be measured using a Valsalva manoeuvre (expiration against a closed airway for 20 seconds) and a supine-stand test. The primary outcomes are noninvasive measures of cardiovascular responses to the maneuvers (blood pressure, cerebral blood flow, and stroke volume (volume of blood pumped per heartbeat). Comparisons will be made across levels of sex, diagnosis, Tanner stage, muscularity, height, and degree of autonomic control.",[29,67,68],"Postural Orthostatic Tachycardia Syndrome","Orthostatic Intolerance","2026-04-22",{"date":71,"type":45},"2026-04-23",{"date":73,"type":45},"2023-04-17",{"date":75,"type":22},"2027-06",{"name":77,"class":52},"Simon Fraser University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":18,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":91,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":53},"100481957","paediatric-syncope-in-the-emergency-department-100481957","NCT05555771","Paediatric Syncope in the Emergency Department","Determining the Effectiveness of Counterpressure Maneuvers in Pediatric Patients Presenting With Syncope to the Emergency Department","DETECT-ED","Inclusion Criteria:\n\n1. Those between the ages of 6-18 years (inclusive)\n2. Presenting to the ED daily 1000-2200 with resolved transient loss of consciousness that has occurred within the last week\n3. Able to complete the survey in English\n4. Willing and able to provide consent and assent\n\nExclusion Criteria:\n\n1. Those with a known history of any of the following:\n\n   * Suspected or confirmed cardiac arrhythmia diagnosis (e.g., Wolff-Parkinson-White, long QT)\n   * Traumatic head injury\n   * New presentation of seizure disorder\n   * Epilepsy recurrence\n   * Overdose, intoxication\n   * Structural heart disease\n2. Patients with hypoglycaemia and who are psychogenic with vasovagal syncope who do not present with prodromal symptoms\n3. Previously enrolled in this study",{"count":87,"type":22},300,[25],"The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients. Participants presenting to the emergency department (ED) will first provide written informed consent. In stage I, they will be asked to complete a brief survey documenting the presentation of their syncopal episode, and any prodromal symptoms they experienced. Participants that consent to the second stage of the study will either receive usual care (control arm) or training in counter pressure maneuvers alongside usual care (intervention arm; leg crossing, bending, arm tensing). These patients will be followed for one years time, and will be asked to complete monthly surveys detailing their syncopal and presyncopal recurrence. Medical records will be accessed over the duration of the study to identify any changes in medical diagnosis.",[29,67,68],{"date":71,"type":45},{"date":93,"type":45},"2022-09-03",{"date":95,"type":22},"2027-09-30",{"name":97,"class":52},"Dr. Victoria Claydon",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":106,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":109,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":53},"100552362","cardioneuroablation-fragmented-atrial-potentials-intracardiac-echocardiography-and-computed-tomography-100552362","NCT06472102","Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography","Value of fRagmented Atrial electrOgrams, Computed Tomography and Intracardiac Echocardiography for Identification of optiMal Sites for Radio-frequency Delivery During cArdioneuroablation for Asystolic Reflex syNcope","Roman5","Inclusion Criteria:\n\n* severe, recurrent symptoms due to reflex syncope with ECG documented asystole \\>3 seconds, especially if associated with injury, or recurrent presyncope with persistent reflex bradycardia\n* history of ineffective prior non-pharmacological treatment and positive baseline atropine test (sinus rate acceleration \\> 30% and no AV block following 2 mg of intravenous atropine) -\n* informed written consent obtained\n\nExclusion Criteria:\n\n* contraindications to perform cardioneuroablation\n* contraindications to perform computed tomography with intravenous contrast injection\n* lack of informed written consent obtained","14 Years",{"count":108,"type":22},100,[25],"Cardioneuroablation (CNA) is a new method for the treatment of asystolic reflex syncope, however, optimal methods for identification of presumed sites of ganglionated plexi (GP), which are the target for CNA and are located in the epicardial fat, have not yet been established. This study will compare the accuracy of three methods used for identification of these areas: intracardiac recordings of fractionated atrial electrograms, intracardiac echocardiography and computed tomography. The study group will consist of 100 patients undergoing CNA in our institution. The procedure will be performed in a standard manner with the use of extracardiac vagal stimulation as the intraprocedural end-point. Correlation between the three methods used for localisation of optimal sites for CNA as well as their predictive value for achieving effective CNA will be computed.",[29],[113,114],"cardioneuroablation","syncope","2025-09-23",{"date":117,"type":45},"2025-09-26",{"date":119,"type":45},"2024-05-20",{"date":121,"type":22},"2025-12-31",{"name":123,"class":52},"Centre of Postgraduate Medical Education",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":137,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":138,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":53},"100549917","cardioneuroablation-for-reflex-syncope-and-exercise-capacity-100549917","NCT06440291","Cardioneuroablation for Reflex Syncope and Exercise Capacity","Effects of caRdioneurOablation on Exercise perforMance in Patients With Reflex Asystolic syNcope: The Roman 3 Study","Roman3","Inclusion Criteria:\n\n* severe, recurrent symptoms due to reflex syncope or recurrent presyncope due to slow heart rate\n* ECG documented asystole \\>3 seconds\n* ineffective prior non-pharmacological treatment\n* positive baseline atropine test (sinus rate acceleration \\> 30% and no atrio-ventricular block following 2 mg of intravenous atropine)\n* signed written informed consent\n\nExclusion Criteria:\n\n* serious comorbidities precluding general anaesthesia and cardioneuroablation\n* non-functional sinus arrest or atrio-ventricular block (negative atropine test)\n* lack of consent to participate in the study",true,{"count":108,"type":22},[25],"Cardioneuroablation (CNA) is a new promising method to treat reflex syncope which is due to vagally-induced functional sinus arrest or atrio-ventricular block (AVB). Although the procedure is effective in \\> 80% of patients, there are potential adverse effects associated with the lack of vagal protection. One of them is increased sinus rate and possible worsening of exercise capacity. However, it is not known how often this happens. Moreover, the most accurate tool to asses exercise capacity - cardiopulmonary exercise testing (CPET), has not yet been used in this group of patients. Therefore, the aim of the study is to assess one-year effects of CNA-induced total vagal denervation on cardiorespiratory fitness in patients undergoing CNA due to reflex asystolic syncope.\n\nThe study group consists of patients undergoing CNA in our institution. All patients give informed written consent to undergo CNA and to participate in the study (Ethics Committee approval # 22\u002F2024). CNA is performed according to standard protocol used in our institution. A symptom-limited cardiopulmonary exercise (CPET) is performed twice, at baseline (1-2 days before CNA) and after one year of follow-up. Standard CPET parameters are measured. Quality of life is measured using a dedicated questionnaire. Also, a control group of healthy volunteers will undergo CPET to answer the question whether subjects with reflex syncope differ in exercise capacity from healthy people.",[29],[114],{"date":117,"type":45},{"date":140,"type":45},"2023-05-02",{"date":142,"type":22},"2025-12-01",{"name":123,"class":52},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":151,"enrollmentInfo":152,"targetDuration":154,"studyType":155,"phases":4,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":171},"100528361","national-registry-of-cardioneuroablation-in-recurrent-reflex-syncope-100528361","NCT06159764","National Registry of Cardioneuroablation in Recurrent Reflex Syncope","CANVAS-R","Inclusion Criteria:\n\n* Patients aged 18 or more\n* Recurrent vasovagal syncope (≥2 episodes during the last year) with an asystolic component (≥3 second pause) recorded during a spontaneous episode. The asystole can be related to sinus arrest or paroxysmal AV block.\n* Scheduled cardioneuroablation procedure\n* Estimated residual battery life ≥ 1 year.\n* Patient affiliated to or beneficiary of national health security scheme.\n* Patient who have received an information notice and has not objected to the use of their data in the registry.\n\nExclusion Criteria:\n\n* Contraindication to anticoagulation therapy: major bleeding, risk of major bleeding, severe hepatic disease\n* Contraindication to cardiac CT: contrast medium allergies\n* Intracardiac thrombus\n* Patient detained by judicial or administrative decision.","100 Years",{"count":153,"type":22},50,"12 Months","OBSERVATIONAL","This registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in France. The aim is to evaluate success rates, compare techniques and help institutions set up their own cardioneuroablation program",[29,28,158],"Heart Arrest",[113,160,161],"vasovagal syncope","registry","2025-06-12",{"date":164,"type":45},"2025-06-17",{"date":166,"type":45},"2024-11-27",{"date":168,"type":22},"2026-01-31",{"name":170,"class":52},"University Hospital, Bordeaux",14,{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":132,"sex":17,"minAge":18,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":182,"conditions":183,"keywords":185,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":53},"100541912","impact-of-blood-phobia-on-fainting-susceptibility-100541912","NCT06336031","Impact of Blood Phobia on Fainting Susceptibility","Inclusion Criteria:\n\n* male and female\n* 18 to 50 years old\n* those without a suspected BII fear and those with a suspected fear\n* english speaking\n\nExclusion Criteria:\n\n* diagnosis of any cardiovacular or neurological disorder\n* menopausal\n* taking medication for a cardiovascular condition\n* if they are pregnant","50 Years",{"count":180,"type":22},20,[25],"The primary purpose of this study is to characterize cardiovascular autonomic function to emotional stimuli (blood-injection-injury phobia \\[needle phobia\\]) during an orthostatic (upright) challenge in individuals with and without known needle phobia. It is well established that emotional stress can produce hypotensive (low blood pressure) reactions. Interestingly, these hypotensive reactions to venipuncture (even with minimal blood drawn), insulin injections, finger sticks for blood sugar monitoring, dental care, and vaccinations can affect up to a quarter of adults and appear to be uniquely associated with blood-injection-injury phobia rather than other phobias. These hypotensive reactions can ultimately lead to a vasovagal syncope (fainting) response, and lead to increased avoidance of medical and dental procedures as a result of this phobia. Ultimately, this has severe implications on public health and places additional strain on the Canadian healthcare system. Currently, there is limited understanding surrounding the initiation of this response. Additionally, a comprehensive profile of cardiovascular autonomic function during exposure to provoking stimuli during orthostatic stress has not been captured in the literature. We will test individuals with and without blood-injection-injury phobia using our standard approach while exposing them to emotional stimuli.",[29,184],"Blood, Injection, Injury Type Phobia",[186],"tilt table","2025-05-12",{"date":189,"type":45},"2025-05-15",{"date":191,"type":45},"2024-03-30",{"date":193,"type":22},"2026-12",{"name":77,"class":52},{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":106,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":204,"briefSummary":205,"conditions":206,"keywords":207,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":214,"leadSponsor":215,"locationsCount":53},"100551288","cardioneuroablation-and-ventricular-proarrhythmia-100551288","NCT06458140","Cardioneuroablation and Ventricular Proarrhythmia","Acute electRophysiOlogical Changes of Ventricular Myocardium Following cArdioneuroablatioN for Asystolic Reflex Syncope","Roman4","Inclusion Criteria:\n\n* severe, recurrent symptoms due to reflex syncope with ECG documented asystole \\>3 seconds\n* history of ineffective prior non-pharmacological treatment\n* positive baseline atropine test (sinus rate acceleration \\> 30% and no atrio-ventricular block following 2 mg of intravenous atropine)\n* informed written consent to participate in the study\n\nExclusion Criteria:\n\n* Lack of consent to participate in the study\n* Contraindications to perform right ventricular stimulation",{"count":153,"type":22},[25],"Cardioneuroablation (CNA) is a promising tool to treat patients with asystolic reflex syncope. CNA acts through complete or near complete abolition of vagal nerve chronotropic and dromotropic effects on the heart, resulting in sinus node acceleration and improved atrio-ventricular conduction, which in turn prevents vagally-mediated reflex asystole. However, lack of parasympathetic protection may potentially be proarrhythmic, especially on the ventricular level. Whether this is a real threat is not known. Therefore, the aim of our study is to assess acute effects of CNA-induced total vagal denervation, measured by extracardiac vagal stimulation, on ECG and electrophysiological parameters as well as vulnerability to ventricular arrhythmias. The study group will consist of 50 consecutive patients undergoing CNA in our institution. Cardioneuroablation will be performed in standard manner. The following parameters will be assessed at baseline and after CNA (directly after CNA, after atropine injected after CNA and after isoproterenol bolus injected at the very end of the procedure): QTc interval, QT dispersion, right ventricular action potential duration, right ventricular effective refractory period and susceptibility to complex ventricular arrhythmias using programmed ventricular stimulation.",[29],[113,208,209],"reflex syncope","ventricular arrhythmia","2025-05-10",{"date":212,"type":45},"2025-05-14",{"date":119,"type":45},{"date":121,"type":22},{"name":123,"class":52}]