[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"syndesmotic-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:syndesmotic-injuries":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,73,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100522666","fibulink-syndesmosis-repair-system-with-early-full-weight-bearing-100522666",false,"NCT06085586","Fibulink Syndesmosis Repair System With Early Full-Weight Bearing","Evaluation of Safety and Performance Outcomes of the Fibulink Syndesmosis Repair System With Early Full-Weight Bearing","Inclusion Criteria:\n\n* ankle fracture with syndesmotic disruption as assessed with intra-operative cotton test.\n\nThis includes the following injuries:\n\n* Syndesmotic sprain (without fractures)\n* Bimalleolar equivalent ankle fractures\n* Bimalleolar ankle fractures\n* Maisonneuve fractures\n* Trimalleolar ankle fractures without the need for posterior malleolus fixation\n* Ankle fracture dislocations\n\nExclusion Criteria:\n\n* 1\\) previous ankle surgery, 2) active local infection about the ankle, 3) chronic ankle deformity secondary to trauma or congenital, 4) ligamentous laxity, 5) pathologic fractures, 6) peripheral vascular disease, 7) peripheral neuropathy, 8) diabetes neuropathy and charcot, 9) open fractures, 10) poly trauma, 11) inability to provide informed consent, 12) symptomatic ankle osteoarthritis, 12) retained hardware, 13) pregnant, 14) metabolic bone disease, 15) history of chronic steroid use, 16) mal-reduced ankle fractures",true,"ALL","22 Years",{"count":20,"type":21},56,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of the study is to evaluate the ability of the Fibulink Syndesmosis Repair System to maintain reduction of the ankle syndesmosis. Appropriate reduction of the syndesmosis is critical due the changes in tibiotalar contact pressure observed in cadaveric studies.6,7 Malreduction and instability of the distal tibiotalar joint can lead to chronic instability, increased articular damage and ultimately degenerative arthritis.7,8 Medial to lateral translation of distal tibia and fibula of 2 mm or more has been considered pathologic.9 Earlier biomechanical study demonstrated the Fibulink system is superior in maintaining displacement of less than 2 mm.4 Given the improved strength, we also look to evaluate the outcomes of initiating full weight bearing (100%) with Controlled Ankle Motion (CAM) boot at 4 weeks postoperatively. One of the big limitations for trans-osseous screw fixation is delayed weight bearing due to risk of screw breakage.1 Suture button technique allowed for early weight bearing with average of 6 weeks postoperatively using TightRope.2,10-12By initiating full weight bearing (100%) with CAM boot at 4 weeks postoperatively, this would be a significant improvement in current clinical practice.",[27,28,29,30,31,32,33],"Ankle Fractures","Bimalleolar Fractures","Syndesmotic Injuries","Bimalleolar Equivalent Fracture","Maisonneuve Fracture","Trimalleolar Fractures","Ankle Dislocation",[27,28,30,32,35,29,36],"Maisonneuve Fractures","Ankle Dislocations","RECRUITING","2026-03-17",{"date":40,"type":41},"2026-03-20","ACTUAL",{"date":43,"type":41},"2023-07-13",{"date":45,"type":21},"2026-12-31",{"name":47,"class":48},"Maimonides Medical Center","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":49},"100495312","comparing-clinical-outcomes-of-suture-button-versus-fibulink-fixation-for-acute-ankle-syndesmosis-injuries-100495312","NCT05729542","Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries","Randomized Controlled Trial Comparing Clinical Outcomes of Patients Treated Surgically With Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries","Inclusion Criteria:\n\n* Ankle fracture with associated syndesmotic injury requiring surgery\n* Age 18 years or older\n* Ability to understand the content of the patient information\u002Finformed consent form\n\nExclusion Criteria:\n\n* Any not medically managed severe systemic disease\n* Patient preference for specific implant\n* Refusal of randomization\n* Pregnant patients\n* Prisoners\n* Participation in any other pharmacologic or medicinal product study within the previous month that could influence the results of this study","18 Years",{"count":59,"type":21},140,[24],"This project consists of a randomized controlled study design. Study candidates will include all patients 18 years or older, who were evaluated at UCSD and found to have an acute ankle syndesmosis injury requiring surgery. Patients who consent to study participation will be randomized to receive one of two standard of care procedures - either a suture button or Fibulink implant. Outcome measures, including the Olerud-Molander and American Orthopaedic Foot and Ankle Society scores, pain, range of motion, time to return to work, and radiographic evaluation will be collected for each participant. Given the potential degenerative changes and poor radiographic and clinical outcomes with inadequate repair of the syndesmosis, it is imperative to evaluate existing and emerging methods of fixation for patients with acute ankle fractures with syndesmosis injuries.",[63,29,27],"Ankle Injuries","2026-02-05",{"date":66,"type":41},"2026-02-10",{"date":68,"type":41},"2021-11-18",{"date":70,"type":21},"2027-12-31",{"name":72,"class":48},"University of California, San Diego",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":49},"100473520","correlation-between-intraoperative-tourniquet-use-and-limb-ph-functional-measures-and-patient-reported-outcomes-after-ankle-fracture-surgery-100473520","NCT05445960","Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture Surgery","Inclusion Criteria:\n\n* Adult patients (18 years to 89 years) undergoing surgical ankle fracture fixation at OHSU\n\nExclusion Criteria:\n\n* sepsis\n* other significant long bone or internal injuries (including ipsilateral limb injuries).","89 Years",{"count":81,"type":21},390,[24],"This study aims to 1) characterize skeletal muscle pH during\u002Fafter tourniquet use and 2) investigate any relationship between intraoperative tourniquet use and postoperative functional measures and patient-reported outcomes.",[27,85,86,87,88,89,29,90],"Ankle Fracture - Lateral Malleolus","Ankle Fracture, Bimalleolar","Ankle Fracture, Trimalleolar","Ankle Fracture - Medial Malleolus","Maisonneuve's Fracture","Fibula Fracture","2025-03-19",{"date":93,"type":41},"2025-03-24",{"date":95,"type":41},"2021-08-17",{"date":97,"type":21},"2027-03-17",{"name":99,"class":48},"Oregon Health and Science University",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":49},"100471041","weber-b-ankle-fractures-with-associated-posterior-malleolus-fracture-100471041","NCT05413707","Weber B Ankle Fractures With Associated Posterior Malleolus Fracture","Posterior Malleolus Fractures (PMF) in Weber B Ankle Fractures - Fixation Versus no Fixation - a Randomized Controlled Trial","PMFIX","Inclusion Criteria:\n\n* Posterior malleolar (PM) fracture, of Mason \\& Molly type 2A\u002F2B, associated with Weber B lateral malleolar fracture, with or without medial malleolar fracture\n* Posterior malleoli \\>=2 mm displaced (on CT in axial, sagital or coronal plane)\n* Patients informed, written consent\n* Age 18-65 years\n* For inclusion axial CT images are examined\n\n  * Measurements are performed 5 millimeters (mm) cranial to the tibia plafond\n  * Posterior malleolus fractures involving less than 40% of the fibular notch are included.\n\nExclusion Criteria:\n\n* Non-compliant patient, i.e.: dementia, alcohol- or substance abuse\n* ASA-4 patients\n* Known congenital bone decease\n* Pathological fractures\n* Immunocompromised patients\n* Tourists or patients on a short-term work\u002Fstudy permit\n* Previous injury or condition of the ipsilateral ankle or ipsilateral lower extremity with a resulting dysfunction\n* Poor controlled diabetes\n* Patients with known arterial insufficiency\n* Open fractures\n* Severely traumatized patients (ISS\\>16)\n* Patient declines to participate in study","65 Years",{"count":110,"type":21},198,[24],"Ankle fractures constitute 9% of all fractures and have an incidence of approximately 187 per 100,000 persons per year in Norway. A posterior malleolar fragment (PMF), located on the lower backside of the tibia, is present in up to 46% of Weber B. Weber B fractures are the most common type of fractures of the fibula, located at the height of the syndesmosis. Patients with a PMF were recently shown to have significantly lower patient-reported outcome measures (PROM) than the general population. For this reason, the indication and choice of intervention for these fractures have been the object of increased interest over the recent years. It is one of the most debated areas within ankle fracture surgery. Traditionally, these PMFs have been treated with closed reduction, without direct manipulation of the PMF, anteroposterior screw fixation, or even no-fixation of the smaller fragments. A more novel posterior approach to the ankle for open reduction and internal fixation is increasingly popular and has led to fixation of smaller and medium-sized PMFs. Studies suggest fracture reduction is better with a posterior approach. However, there is no consensus as to what the best treatment is. There are no available randomized controlled studies examining PROM in patients after surgery with fixation versus no fixation for the PMF.\n\nThrough a multicenter prospective randomized controlled trial initiated from Haukeland University Hospital, patients will be recruited and randomized to receive treatment with or without fixation of the PMF. Patients will be recruited at six study hospitals from all Regional Health Trusts in Norway. Treatment today is often based on local tradition and retrospective, ambiguous literature. As there is no clear evidence supporting the choice to fixate, or not fixate, the posterior malleolus fracture. The current study can contribute new knowledge and thereby contribute to an evidence-based approach to treating these patients.\n\nMason and Molly type 2A and 2B fractures will be included in the study.",[114,27,29,115,116],"Posterior Malleolus Fractures","Patient Reported Outcome Measure","Treatment Outcome",[118,119,120,121,122,123],"Posterior malleolus fractures","Ankle factures","Weber B fractures","Syndesmotic injuries","Fixation","Randomized Controlled Trial","2024-02-27",{"date":126,"type":41},"2024-02-29",{"date":128,"type":41},"2023-03-13",{"date":130,"type":21},"2030-12-31",{"name":132,"class":48},"Haukeland University Hospital"]