[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"synkinesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:synkinesis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100615644","phase-4-botox-injections-in-non-cranial-nerve-vii-innervated-muscles-for-facial-synkinesis-100615644",false,"NCT07295288","Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis","Investigating the Efficacy of Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis Management","Inclusion Criteria:\n\n* Age \\> 18 years.\n* Current diagnosis of facial synkinesis due to facial nerve paralysis\u002Fparesis.\n* Scheduled to undergo BT injection for management of facial synkinesis.\n* Have undergone \\> 3 prior BT injection sessions at VUMC for facial synkinesis.\n* Able to read and understand English.\n* Symptoms of neck tightness, jaw tightness, or headaches.\n\nExclusion Criteria:\n\n* Cognitive impairment that would preclude the ability to provide informed consent\n* Unable to read text on a written survey or computer screen",true,"ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Facial synkinesis is a condition that occurs following facial nerve (CN7) injury, typically secondary to Bell's palsy, trauma, surgery (e.g., acoustic neuroma resection), or malignancy. Synkinesis is due to aberrant regeneration of the facial nerve, where axons regrow improperly and result in misdirected innervation of facial muscles. This results in involuntary, uncoordinated muscle movements, where activation of one muscle group triggers unintended contractions in others. Standard treatment of facial synkinesis involves botulinum toxin (BT) injections into muscles controlled by CN7 to reduce these unwanted movements. However, patients often anecdotally report that adding BT injections into non-CN7 innervated muscle groups, such as the masseter and temporalis muscles, improve their synkinesis symptoms. This study therefore aims to assess whether adding BT injections to non-CN7 innervated muscle groups, specifically the masseter and temporalis muscle, can improve treatment outcomes for people with facial synkinesis. This study will use a crossover design, where each participant will serve as their own control to compare treatment effects. In the first treatment arm, patients will receive only their standard BT injections into muscle groups controlled by CN7 - no other muscles will be treated. In the second treatment arm, will receive the same standard BT injections in CN7 muscles, plus additional injections into masseter and temporalis muscles. Patients will be randomized to a specific treatment arm at their first visit. At their second visit, they will be randomized to the other treatment arm, in standard crossover study design. Pre- and post-treatment surveys will be collected to assess the benefit of adding non-CN7 muscle groups.",[27],"Synkinesis",[29],"botulinum toxin","NOT_YET_RECRUITING","2026-04-12",{"date":33,"type":34},"2026-04-15","ACTUAL",{"date":36,"type":21},"2026-07-01",{"date":38,"type":21},"2027-06-30",{"name":40,"class":41},"Vanderbilt University Medical Center","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":16,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":79,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100290335","genetic-studies-of-strabismus-congenital-cranial-dysinnervation-disorders-ccdds-and-their-associated-anomalies-100290335","NCT03059420","Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies","Inclusion Criteria:\n\n* The Engle Lab is very interested in enrolling individuals with congenital conditions related to eye movement, cranial nerve and brainstem-based dysfunction, often broadly referred to as congenital cranial dysinnervation disorders (CCDDs).\n\nExclusion Criteria:\n\n* Individuals with cranial nerve disorders associated with known disorders, such as Saethre-Chotzen associated with established genetic mutations, or acquired conditions including trauma, stroke, tumor or spinal cord injuries.","1 Day",{"count":50,"type":21},20000,"OBSERVATIONAL","The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.",[54,55,56,57,58,59,60,61,62,63,64,65,66,67,27,68,69,70,71,72,73,74,75,76,77,78],"Congenital Fibrosis of Extraocular Muscles","Duane Retraction Syndrome","Duane Radial Ray Syndrome","Mobius Syndrome","Brown Syndrome","Marcus Gunn Syndrome","Strabismus Congenital","Horizontal Gaze Palsy","Horizontal Gaze Palsy With Progressive Scoliosis","Facial Palsy","Facial Paresis, Hereditary, Congenital","Third Nerve Palsy","Fourth Nerve Palsy","Sixth Nerve Palsy","Ocular Motility Disorders","Levator-Medial Rectus Synkinesis","Athabaskan Brainstem Dysgenesis","Tongue Paralysis","Ninth Nerve Disorder","Fifth Nerve Palsy","Seventh Nerve Palsy","Eleventh Nerve Disorder","Twelfth Nerve Disorder","Vagus Nerve Paralysis","Moebius Sequence",[80,81,82,83,84,85,86,87,88],"CFEOM (Congenital Fibrosis of Extraocular Muscles)","CCDD (Congenital Cranial Dysinnervation Disorders)","DRS (Duane Retraction Syndrome)","DRRS (Duane Radial Ray Syndrome)","Strabismus","MGJWS (Marcus Gunn Jaw Winking Syndrome)","HGP (Horizontal Gaze Palsy)","HGPPS (Horizontal Gaze Palsy with Progressive Scoliosis)","Moebius","RECRUITING","2026-02-09",{"date":92,"type":34},"2026-02-11",{"date":94,"type":34},"2004-02-01",{"date":96,"type":21},"2030-01",{"name":98,"class":41},"Boston Children's Hospital",1]