[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"systolic-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:systolic-hypertension":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100601380","dose-response-effects-of-inspiratory-muscle-strength-training-on-blood-pressure-and-vascular-function-100601380",false,"NCT07109739","Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function","Inclusion Criteria:\n\n* Age ≥18 years\n* Resting SBP ≥120 mmHg as measured during screening 1 \\& 2\n* Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis.\n* No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)\n* Language: English-speaking, with ability to comprehend study materials and instructions.\n* Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit.\n* Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year).\n\nExclusion Criteria:\n\n* Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum).\n* Recent abdominal surgery or presence of an abdominal hernia.\n* Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea.\n* Ruptured eardrum or any other condition of the ear.\n* Markedly elevated left ventricular end-diastolic volume and pressure.\n* Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition).\n* Female-Specific: Pregnant or planning to become pregnant during the study period.\n* Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).","ALL","18 Years",{"count":18,"type":19},144,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.",[25,26],"Systolic Hypertension","Brachial Artery Flow-mediated Dilation","RECRUITING","2025-11-24",{"date":30,"type":31},"2025-11-25","ACTUAL",{"date":33,"type":31},"2025-10-24",{"date":35,"type":19},"2027-03-31",{"name":37,"class":38},"University of Minnesota","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":16,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":39},"100420515","effect-of-labetalol-atenolol-and-nifedipine-on-maternal-hemodynamics-measured-by-icg-in-early-pregnancy-100420515","NCT04755764","Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy","The Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by Impedance Cardiography in Early Pregnancy","Inclusion Criteria:\n\n* Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital\n* English speaking\n* 18-45 years old.\n* Willing to provide informed consent\n* Gestational age prior to 15 weeks gestation\n\nExclusion Criteria:\n\n* Non-English speaking patients, patients\n* \\\u003C18 years old or \\>45 years old\n* Not willing or able to provide consent\n* Gestational age \\>15 weeks",true,"FEMALE","45 Years",{"count":51,"type":19},60,"OBSERVATIONAL","The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy. Patients will be given medication based on their hemodynamics and asked to return for a repeat measurement.",[25,55,56,57,58],"Pregnancy Related","Diastolic Hypertension","Cardiac Output, Low","Cardiac Output, High","2025-05-09",{"date":61,"type":31},"2025-05-13",{"date":63,"type":31},"2021-03-03",{"date":65,"type":19},"2025-12",{"name":67,"class":38},"Marshall University"]