[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"targeted-temperature-management\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:targeted-temperature-management":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,80,108,130,157],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100641106","targeted-temperature-management-on-delayed-neurocognitive-recovery-in-older-patients-after-major-cancer-surgery-100641106",false,"NCT07655687","Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery","Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery: a Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Age ≥ 65 years.\n2. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.\n\nExclusion Criteria:\n\n1. Preoperative fever (tympanic temperature ≥ 38℃).\n2. Known or suspected preoperative infection.\n3. Previous schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or preexisting delirium.\n4. Inability to communicate due to coma, severe dementia, or hearing or speech impairment.\n5. Critically ill patients, defined as NYHA functional class \\> III or LVEF \\\u003C 30%, Child-Pugh class C, preoperative dialysis dependence, ASA physical status \\> IV, or expected survival \\\u003C 24 hours.\n6. Surgery for breast cancer, intracranial tumors, or rare cancers.\n7. Planned to undergo therapeutic hypothermia.\n8. Body mass index \\> 30 kg\u002Fm² (to facilitate temperature management).\n9. Previous enrollment in this study.\n10. Other conditions deemed unsuitable for study participation.",true,"ALL","65 Years",{"count":20,"type":21},1512,"ESTIMATED","INTERVENTIONAL",[24],"NA","With aging population, more older patients will receive major surgery for cancer. Older patients are at increased risk of postoperative neurocognitive complications including delayed neurocognitive recovery (dNCR), which is associated with prolonged hospital stay, raised complications, and impaired quality of life. Intraoperative hypothermia occurs in 57.1%-78.6% of patients undergoing major cancer surgery, especially in the elderly. Studies show that intraoperative hypothermia suppresses immune function, interferes with anesthetic metabolism, and delays anesthesia emergence. All these may be correlated with the occurrence of early postoperative dNCR. This study aims to verify whether intraoperative targeted temperature management (target core temperature: 36.8°C) compared with conventional temperature management (core temperature: 35.5°C) can reduce the incidence of dNCR in older patients undergoing major cancer surgery.",[27,28,29,30,31],"Elderly Patients","Cancer Surgery","Hypothermia, Accidental","Targeted Temperature Management","Delayed Neurocognitive Recovery",[33,34,35,36,37],"elderly patient","major cancer surgery","intraoperativ hypothermia","targeted temperature management","delayed neurocognitive recovery","NOT_YET_RECRUITING","2026-06-18",{"date":41,"type":42},"2026-06-23","ACTUAL",{"date":44,"type":21},"2026-06",{"date":46,"type":21},"2028-11",{"name":48,"class":49},"Peking University First Hospital","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100535786","effects-of-intraoperative-targeted-temperature-management-on-incidence-of-postoperative-delirium-and-long-term-survival-100535786","NCT06256354","Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival","Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival in Older Patients Having Major Cancer Surgery: A Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Age ≥65 years.\n2. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.\n\nExclusion Criteria:\n\n1. Preoperative fever (tympanic temperature ≥38℃).\n2. Known or suspected preoperative infection.\n3. Previous history of schizophrenia, epilepsy, Parkinson disease, myasthenia gravis, or delirium.\n4. Unable to communicate due to severe dementia, language barrier, or coma.\n5. Critically ill (Left ventricular ejection fraction \\\u003C30%, Child-Pugh grades C, requirement of renal replacement therapy, American Society of Anesthesiologists physical status\\>IV, or expected survival \\\u003C24 hours).\n6. Scheduled surgery for breast cancer, intracranial tumors, or rare cancers.\n7. Planned to undergo therapeutic hypothermia.\n8. Body mass index \\>30 kg\u002Fm2 (to facilitate thermal management).\n9. Have participated in this study previously.\n10. Any other conditions that are considered unsuitable for study participation.",{"count":59,"type":21},3992,[24],"Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor. Studies suggest that intraoperative hypothermia is an important risk factor of postoperative delirium, which is associated with worse early and long-term outcomes. Furthermore, perioperative hypothermia increases stress responses and provokes immune suppression, which might promote cancer recurrence and metastasis. In a recent trial, targeted temperature management reduced intraoperative hypothermia and emergence delirium. There was also a trend of reduced postoperative delirium, although not statistically significant. This trial is designed to test the hypothesis that intraoperative targeted temperature management may reduce postoperative delirium and improves progression-free survival in older patients recovering from major cancer surgery.",[28,63,30,64,65],"Intraoperative Hypothermia","Postoperative Delirium","Long-term Survivors",[67,68,69,70,71],"Cancer surgery","Intraoperative hypothermia","Targeted temperature management","Postoperative delirium","Long-term survival","RECRUITING",{"date":41,"type":42},{"date":75,"type":42},"2024-05-29",{"date":77,"type":21},"2032-06",{"name":48,"class":49},36,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100616161","targeted-temperature-management-via-bladder-monitoring-in-ich-100616161","NCT07302009","Targeted Temperature Management Via Bladder Monitoring in ICH","Safety and Efficacy of Bladder Temperature Monitoring-Guided Targeted Temperature Management in Patients With Severe : A Multicenter Randomized Controlled Trial","BTTM-ICH","Inclusion Criteria:\n\n1. Neurocritical care patients: Study subjects are patients with first-time spontaneous intracerebral hemorrhage.\n2. Age ≥ 18 years and ≤ 85 years.\n3. Glasgow Coma Scale (GCS) score ≤ 8 at ICU admission.\n4. For supratentorial ICH: Hematoma volume \\\u003C 60 mL. For subarachnoid hemorrhage (SAH): Modified Fisher grade ≥ 2, and the aneurysm has been treated with endovascular intervention.\n5. Pre-morbid modified Rankin Scale (mRS) score of 0 or 1.\n6. Signed informed consent provided by a legally authorized representative.\n\nExclusion Criteria:\n\n1. Fever (≥38.0°C) that lasted over 1 hour or occurred more than once prior to enrollment.\n2. Pre-existing neurological, psychiatric, or other comorbidities that may compromise the assessment of neurological or functional outcomes.\n3. Underlying conditions with a life expectancy of less than 6 months, estimated prior to onset.\n4. Severe injury indicative of poor prognosis: brain death, receiving palliative care only, or irreversible brain injury.\n5. Pregnancy.\n6. Unilateral or bilateral pupillary dilation.\n7. Currently participating in other investigational\u002Finterventional clinical trials (involving medical devices or drugs).\n8. Subjects deemed ineligible for enrollment by the investigator.","18 Years","85 Years",{"count":91,"type":21},318,[24],"The goal of this clinical trial is to learn whether a bladder temperature monitoring-guided targeted temperature management (TTM) strategy improves functional recovery in patients with severe intracerebral hemorrhage, compared to conventional temperature monitoring. It will also assess the safety of this monitoring approach. The main questions it aims to answer are:\n\n* Does continuous bladder temperature monitoring-guided TTM improve the likelihood of a favorable functional outcome (modified Rankin Scale score 0-2) at 180 days after onset?\n* What medical problems (such as infections, shivering, deep vein thrombosis, or sepsis) do participants experience while under the TTM strategy? Researchers will compare the intervention group (using continuous bladder temperature monitoring) with the control group (using conventional intermittent temperature monitoring with a mercury thermometer at the armpit) to see if the bladder temperature-guided TTM strategy leads to better outcomes.\n\nParticipants will:\n\n* Be randomly assigned to one of the two temperature monitoring strategies\n* Receive standard medical and surgical care for severe intracerebral hemorrhage",[95,30],"Intracerebral Hemorrhage",[95,30,97],"Bladder Temperature Monitoring","2026-06-07",{"date":100,"type":42},"2026-06-10",{"date":102,"type":42},"2026-03-15",{"date":104,"type":21},"2027-12-30",{"name":106,"class":49},"Yanyan Gong",1,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":16,"sex":17,"minAge":88,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":120,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":127,"locationsCount":107},"100620743","feasibility-study-for-vcool-intranasal-cooling-system-in-healthy-volunteers-100620743","NCT07361588","Feasibility Study for VCool™ Intranasal Cooling System in Healthy Volunteers","Inclusion Criteria:\n\n1. Male or female ages 18 to 55.\n2. An Institutional Review Board (IRB) approved informed consent is signed and dated prior to any study-related activities.\n3. Baseline core body temperature between 36.8℃ and 37.5℃.\n4. Have the ability to understand the requirements of the study and are willing to comply with all study procedures.\n5. In the opinion of the Investigator, are able to participate in the study.\n\nExclusion Criteria:\n\n1. History of cardiovascular, respiratory, or metabolic disorder\n2. Any contraindication to undergoing Magnetic Resonance Imaging (MRI)\n3. Pregnant\n4. Severe peripheral vascular disease\n5. History of Raynaud's disease\n6. Currently experiencing a respiratory infection\n7. Chronic rhinosinusitis\n8. History of sickle cell disease\n9. History of cold agglutinin disease\n10. History of cryoglobulinemia\n11. Known deviated septum or nasal deformity\n12. History of nosebleeds or a nosebleed within past 24 hours\n13. Use of antipyretics or other medications affecting body temperature within the past 24 hours.","55 Years",{"count":116,"type":21},10,[24],"The objective of this study is to evaluate the performance and safety of the VCool Intranasal Cooling System in healthy adult volunteers. The study is designed to gather preliminary data regarding air flow rates and time required to reduce core body temperature to 35.5℃ and maintain the temperature between 35℃ and 36℃ for one hour after cooling.",[30],[36],"2026-01-21",{"date":123,"type":42},"2026-01-23",{"date":125,"type":21},"2026-01",{"date":44,"type":21},{"name":128,"class":129},"NeuroIntact Inc.","INDUSTRY",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":17,"minAge":137,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":146,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":107},"100611332","serious-game-for-improving-targeted-temperature-management-knowledge-and-situational-awareness-in-critical-care-nurses-100611332","NCT07239206","Serious Game for Improving Targeted Temperature Management Knowledge and Situational Awareness in Critical Care Nurses","Effectiveness of Serious Game on Facilitating Targeted Temperature Management Knowledge and Situational Awareness Among Critical Care Nurses","Inclusion Criteria:\n\n* Registered nurses currently working in adult intensive care units (medical, surgical, or mixed ICUs).\n* Able to read and understand Chinese.\n* Willing to participate and provide informed consent.\n* Available to complete pre-test, post-test, and follow-up assessments.\n\nExclusion Criteria:\n\n* Nurses working in pediatric or neonatal ICUs.\n* Nurses holding administrative or supervisory positions (non-clinical).\n* Nurses currently participating in other TTM-related educational or research programs.\n* Individuals unable to complete the intervention or evaluation schedule.","20 Years",{"count":139,"type":21},120,[24],"This randomized controlled trial aims to evaluate the effectiveness of a serious game in improving targeted temperature management (TTM) knowledge and situational awareness among critical care nurses. A total of 120 nurses from adult intensive care units will be randomly assigned to either a control group receiving traditional lecture-based teaching or an experimental group receiving lecture-based teaching combined with a digital serious game. Outcomes will be measured using a TTM knowledge test, a situational awareness scale, and a system usability scale. The findings will provide evidence for the use of serious games as an innovative educational strategy to enhance post-resuscitation care quality and patient safety.",[30,143,144,145],"Nursing Education","Serious Game","Cardiac Arrest",[69,147],"Serious game","2026-01-20",{"date":150,"type":42},"2026-01-22",{"date":152,"type":42},"2026-01-19",{"date":154,"type":21},"2026-12-31",{"name":156,"class":49},"National Taiwan University Clinical Trial Center",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":165,"phases":4,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":107},"100560281","resting-energy-expenditure-and-substrate-consumption-in-cardiac-arrest-patients-under-target-temperature-management-100560281","NCT06575101","Resting Energy Expenditure and Substrate Consumption in Cardiac Arrest Patients Under Target Temperature Management","Inclusion Criteria:\n\n* Be admitted to the emergency department of Beijing Chao-yang Hospital, Capital Medical University;\n* Successfully resuscitated, and are unconscious after restoration of spontaneous circulation (ROSC);\n* Be admitted to the intensive care unit (ICU) for advanced life support such as endotracheal intubation after restoration of spontaneous circulation (ROSC);\n* Accepted target temperature management (TTM) therapy after restoration of spontaneous circulation (ROSC);\n\nExclusion Criteria:\n\n* Age \\> 18 years old；\n* Incomplete clinical data and loss of follow-up;\n* Traumatic brain injury or cerebrovascular accident revealed by computed tomography (CT)；\n* Severe metabolic abnormalities are known: cachexia, thyroid dysfunction, and cancer；\n* Indirect calorimetry measurement is not possible such as sustained oxygen concentration \\> 70%；\n* There were no signs of resuscitation at the time of admission；",{"count":164,"type":21},40,"OBSERVATIONAL","This study is a single-center, prospective, observational study. According to the sample size formula, an estimated 40 cases should be collected, all of whom are from the emergency intensive care unit. After successful cardiopulmonary resuscitation, the enrolled patients will be transferred to the emergency intensive care unit for further standardized target temperature management (TTM). They will be divided into 33 ° C hypothermia group and 36 ° C hypothermia group according to the patient's core body temperature. The baseline data of the patients will be collected at the beginning. After admission to the hospital, they were fasted within 24 hours to reach the target temperature, and then 20kcal\u002Fkg\u002Fd parenteral nutrition will be given. At selected time points (T0: the initial time point before TTM; T1: the core temperature was reduced to 33 ° C or 36 ° C; T2-T4: 33 ° C or 36 ° C was maintained for 24h, 48h, 72h; T5: the end of rewarming; Tend: the last REE measurement before discharge or death) , various observation indicators will be collected, including resting energy expenditure (REE), glucose oxidation rate, fat oxidation rate, protein oxidation rate, and metabolism of three major nutrients Proportion. Neurological outcomes were followed up 28 days after onset according to the Cerebral Performance Categories (CPC) score.",[30,145,168,169],"Resting Energy Expenditure","Nutrition","2024-09-04",{"date":172,"type":42},"2024-09-19",{"date":174,"type":42},"2024-06-01",{"date":176,"type":21},"2025-12-31",{"name":178,"class":49},"Tang Ziren"]