[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tattoo-skin-markers\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tattoo-skin-markers":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100629763","tumor-margin-skin-tattooing-before-neo-adjuvant-chemotherapy-in-patients-with-breast-cancer-100629763",false,"NCT07478900","Tumor Margin Skin Tattooing Before Neo-adjuvant Chemotherapy in Patients With Breast Cancer","Tumor Margin Skin Tattooing Before Neo-adjuvant Chemotherapy in Patients With Breast Cancer: A Prospective Cohort Study","TUMS","Inclusion Criteria:\n\nFemale patients aged 18-75 years\n\nHistologically confirmed Breast Cancer on biopsy\n\nPatients with T2 or T3 breast tumors planned for Neoadjuvant Chemotherapy\n\nPresence of a clinically palpable primary breast tumor suitable for localization\n\nPatients who are candidates for Breast-Conserving Surgery following neoadjuvant therapy\n\nAbility and willingness to provide written informed consent\n\nExclusion Criteria:\n\nKnown allergy or hypersensitivity to tattooing materials used for tumor localization\n\nEarly-stage Breast Cancer not requiring Neoadjuvant Chemotherapy\n\nDiagnosis of Inflammatory Breast Cancer\n\nT3 tumors in patients with small breast size or T4 breast cancer\n\nPatients unwilling to undergo Breast-Conserving Surgery\n\nDiffuse microcalcifications of the breast parenchyma on Mammography\n\nDuctal Carcinoma In Situ\n\nMale Breast Cancer\n\nMulticentric or multifocal breast cancers\n\nTumor location that precludes breast-conserving surgery\n\nRecurrent Breast Cancer","FEMALE","18 Years","75 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Study Description\n\nThis prospective cohort study evaluates the feasibility and effectiveness of pre-neoadjuvant tumor localization using skin tattooing, with or without radiopaque clips, in patients with biopsy-proven T2-T3 breast cancer and axillary lymph node metastasis. Eligible patients will undergo tumor localization in the supine position with the ipsilateral arm abducted to 90°. Palpable tumor margins will be marked with sterile tattoo ink, and deep or mobile tumors will receive additional localization with ultrasonography-guided radiopaque clips. Following localization, patients will receive standard neoadjuvant chemotherapy. Tumor response will be monitored clinically and radiologically. Post-therapy, the tattoo markings and\u002For clips will guide breast-conserving surgery. Primary outcomes include feasibility of breast conservation, achievement of negative margins (R0 resection), and avoidance of mastectomy, while intraoperative technical challenges will also be documented.",[28,29,30],"Breast Cancer (Locally Advanced or Metastatic)","Tattoo Skin Markers","Neoadjuvant Chemoimmunotherapy","RECRUITING","2026-03-14",{"date":34,"type":35},"2026-03-18","ACTUAL",{"date":37,"type":35},"2025-09-10",{"date":39,"type":22},"2028-02-09",{"name":41,"class":42},"All India Institute of Medical Sciences, Bhubaneswar","OTHER"]