[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tbi-traumatic-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tbi-traumatic-brain-injury":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,34,0,25,[9,44,72,95,130,149,177,201,218,245,266,279,300,329,357,375,403,422,445,487,514,559,582,615,639],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100053878","phase-1-nanopulse-laser-therapy-100053878",false,"NCT07520383","Nanopulse Laser Therapy","Biomarker Responsiveness of Nanopulse Laser Therapy in Treatment of Traumatic Brain Injury","Inclusion Criteria:\n\n* Adults aged 18 years or older at the time of enrollment\n* Confirmed diagnosis of moderate to severe TBI (clinical assessment and radiographic evidence)\n* Admission to the neurosurgical or neurocritical care service with anticipated need for intracranial monitoring (e.g., microdialysis, ICP probe)\n* Able to initiate treatment within 48 hours of admission\n* Informed consent obtained from patient or legally authorized representative\n\nExclusion Criteria:\n\n* Patients younger than 18 years of age\n* Known or suspected pregnancy (verified via urine pregnancy test for females of childbearing age)\n* Incarcerated individuals or prisoners\n* Patients with pre-existing implanted cranial devices (e.g., deep brain stimulators) that may interfere with NPLT\n* Patients with severe scalp injury or open wounds at intended treatment site\n* Known allergy or hypersensitivity to adhesives or device components","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","The purpose of this study is to evaluate the safety and effectiveness of a novel noninvasive therapy, Nanopulse Laser Therapy (NPLT), to improve recovery following traumatic brain injury (TBI).",[27],"TBI (Traumatic Brain Injury)",[27,29,30],"Near-Infrared Laser Therapy","Neurometabolic Biomarkers","NOT_YET_RECRUITING","2026-07-10",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":21},"2026-08",{"date":39,"type":21},"2027-05",{"name":41,"class":42},"The University of Texas Medical Branch, Galveston","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100553034","cerebral-autoregulation-brain-perfusion-and-neurocognitive-outcomes-after-traumatic-brain-injury-100553034","NCT06480838","Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury","CAPCOG-TBI","Inclusion Criteria:\n\n* Documented\u002FVerified TBI (ACRM Criteria) (eg, motor vehicle (MV) occupant, MV pedestrian\u002Fcyclist, fall, other non-intentional, violence\u002Fassault)\n* A documented moderate to severe TBI defined as: Glasgow Coma Scale (GCS) \\\u003C 13, or loss of consciousness (LOC) \\> 30 minutes, or posttraumatic amnesia (PTA) \\> 24 hours or intracranial neuroimaging abnormalities\n* Between the age 18 - 80 year-old\n* ≤ 1 week postinjury\n* Acute brain CT for clinical care\n* Admitted to the hospital for TBI\n* Visual acuity\u002Fhearing adequate for testing\n* Fluent in English or Spanish\n* Patient or LAR ability to provide informed consent\n\nExclusion Criteria:\n\n* Age greater or less than the range 18-80 years\n* Significant polytrauma that would interfere with follow-up and outcome assessment\n* Major debilitating baseline mental health disorders (e.g., schizophrenia, bipolar disorder, severe depression with active suicidal thoughts at the time of evaluation) that would interfere with follow-up and the validity of outcome assessment.\n* Major debilitating neurological disease (e.g., stroke, CVA, dementia, tumor) impairing baseline awareness, cognition, or validity of follow-up and outcome assessment.\n* Significant history of pre-existing conditions that would interfere with follow-up and outcome assessment (e.g., active substance abuse, alcoholism, HIV\u002FAIDs, end-stage cancers, learning disabilities, developmental disorders)\n* Patients on psychiatric hold\n* Prisoners or patients in custody\n* Pregnancy in female subjects\n* Low likelihood of follow-up (e.g., participants or family indicating low interest, residence in another state or country, homeless or lack of reliable contacts)\n* Current participant in an interventional trial (e.g., drug, device, behavioral)\n* Penetrating TBI\n* Spinal cord injury with ASIA score of C or worse\n* Contraindications to MRI","80 Years",{"count":53,"type":21},130,"OBSERVATIONAL","Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\\\u003C 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.",[57,58,59,27,60],"Traumatic Brain Injury With Loss of Consciousness","Brain Injury Traumatic Severe","Brain Injury Traumatic Moderate","TBI","RECRUITING","2026-06-30",{"date":64,"type":35},"2026-07-02",{"date":66,"type":35},"2023-09-01",{"date":68,"type":21},"2029-05-31",{"name":70,"class":42},"University of Texas Southwestern Medical Center",3,{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":43},"100644267","fibrinogen-to-albumin-ratio-as-a-predictor-of-acute-respiratory-distress-syndrome-in-traumatic-brain-injury-100644267","NCT07664358","Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Traumatic Brain Injury","Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Patients With Traumatic Brain Injury: The Prospective, Observational, Multi-center FARDS Study","FARDS","Inclusion Criteria:\n\n* Patients ≥ 18 years admitted to the ICU with traumatic Brain Injury\n* Admission to the ICU within 24 hours of injury.\n* Patients will be expected to remain under hospital care for follow-up\n* Availability of fibrinogen and albumin measurements within the first 24 hours of ICU admission.\n* Informed consent will be obtained from a legally authorized representative.\n\nExclusion Criteria:\n\n* Preexisting advanced chronic liver disease, nephrotic syndrome, or protein-losing enteropathy.\n* Pre-existing ARDS on admission.\n* Recipient of albumin, fibrinogen concentrate, or cryoprecipitate before admission sampling.\n* Use of anticoagulant or fibrinolytic therapy before admission.\n* Active malignancy or severe systemic infection at admission.\n* Direct sever lung injury\n* Pregnancy\n* Refusal of consent",{"count":81,"type":21},350,"this study aims to assess the ability of fibrinogen-to-albumin ratio to predict the development of Acute respiratory distress syndrome in traumatic brain injury patients.",[84,85,27],"Fibrinogen Albumin Ratio","ARDS","2026-06-17",{"date":88,"type":35},"2026-06-24",{"date":90,"type":21},"2026-07-01",{"date":92,"type":21},"2026-12-30",{"name":94,"class":42},"Tanta University",{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":105,"conditions":106,"keywords":114,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":43},"100630260","fnirs-for-disorders-of-consciousness-100630260","NCT07485361","fNIRS for Disorders of Consciousness","Functional Near-infrared Spectroscopy in Disorders of Consciousness: Protocol Testing and Pilot in Neuro-ICU Setting","Inclusion Criteria:\n\nHealthy Control Participants:\n\n* Age 18 years or older\n* Proficient in English language\n* Intact cognition\n* Montreal Cognitive Assessment (MoCA) score \\> 26\n\nDoC Patients:\n\n* Age 18 years or older\n* Proficient in English language\n* Surrogate decision maker available\n* Admission to the intensive care unit within 28 days\n* Documented Glasgow Coma Scale (GCS) score\n* Auditory Function subscale score ≥1 on the Coma Recovery Scale-Revised (CRS-R)\n\nExclusion Criteria:\n\nHealthy Control Participants:\n\n* Known baseline hearing impairment without available hearing aids\n* Neurological or psychiatric history\n\nDoC Patients:\n\n* Known baseline hearing impairment without available hearing aids\n* Inability to obtain informed consent\n* Extensive bilateral frontal injury on available imaging (CT\u002FMRI)\n* Patients who have undergone craniectomy surgery\n* IV sedation in the past 24 hours\n* Absent auditory startle response (\\\u003C1 from Auditory Function subscale score of CRS-R)",true,{"count":104,"type":21},55,"The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care unit (Neuro-ICU). DoC include conditions such as coma and minimally conscious state that occur after severe brain injury. These conditions make it difficult to assess a person's level of awareness because many clinical tests rely on observable behaviors such as speaking or moving, which are commonly impaired after brain injury.\n\nThe main questions the study aims to answer are:\n\n* Can fNIRS detect changes in brain activity in healthy adults when they receive sensory stimulation or perform mental tasks?\n* Can the same fNIRS protocol be used in patients with disorders of consciousness in the Neuro-ICU to measure brain responses and determine whether the method is feasible in this clinical setting?\n\nThe investigators will first study healthy adult volunteers to establish baseline brain responses and determine which tasks produce the most reliable signals. The protocol will then be applied to patients with disorders of consciousness admitted to the Neuro-ICU.\n\nParticipants will take part in a single research session lasting about 30 to 45 minutes while wearing the lightweight fNIRS headband that measures brain oxygen levels using near-infrared light. During the session, participants will:\n\n* Wear a non-invasive fNIRS headband placed on the forehead\n* Receive gentle sensory stimulation (for example, compression devices on the legs or hands)\n* Listen to sounds or spoken sentences\n* Perform guided mental tasks such as imagining walking through their home or imagining moving a limb\n\nThe study does not test a treatment and will not change medical care. The goal is to determine whether fNIRS can safely and reliably measure brain activity at the bedside and provide preliminary information that may help guide future research on improving the assessment of consciousness after brain injury.",[107,108,109,110,111,112,113],"Disorders of Consciousness Due to Severe Brain Injury","Disorders of Consciousness","Coma","Minimally Conscious State","Unresponsive Wakefulness Syndrome","Brain Injury","TBI Traumatic Brain Injury",[115,116,117,118,119,120],"Functional Near-Infrared Spectroscopy","Neurocritical Care","Functional Neuroimaging","Neuro Intensive Care Unit","Neurovascular Coupling","Consciousness Assessment","2026-06-04",{"date":123,"type":35},"2026-06-08",{"date":125,"type":35},"2026-05-01",{"date":127,"type":21},"2026-12",{"name":129,"class":42},"University of California, Los Angeles",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":144,"completionDateStruct":145,"leadSponsor":147,"locationsCount":43},"100641090","phase-1-feasibility-of-support-tbi-100641090","NCT07625098","Feasibility of SUPPORT-TBI","From Isolation to Connection: A Dyadic Approach to Enhancing Health After TBI","Inclusion Criteria:\n\n* Age 18 or older\n* Live in a community setting (not an institutional setting)\n* Sustained a traumatic brain injury more than 6 months prior to enrollment\n* Report mild-moderate TBI-related disability (score of 5 or greater) on the Glasgow Outcome Scale - Extended\n* Report low social support (score of less than 50 on the MOS Social Support Survey)\n\nExclusion Criteria:\n\n* Insufficient English language fluency\n* Active substance use disorder (meets diagnostic criteria on the PRIME-MD MINI alcohol or non-alcoholic substances modules)\n* Active, untreated psychotic disorder (meets diagnostic criteria on the PRIME-MD MINI psychotic disorders module)\n* Severe memory impairment (score of less than 21 on the Montreal Cognitive Assessment)",{"count":138,"type":21},60,[24],"Many people who have had a traumatic brain injury (TBI) struggle to stay connected with others. They often lose friendships, become isolated, and have strained family relationships. This lack of social support is linked to worse physical and mental health, lower quality of life, and even a shorter lifespan. The investigators developed a program where a person with TBI and one close supporter work together with a therapist over 12 weekly sessions. They learn skills in communication, setting shared goals, supporting each other emotionally, and problem-solving, with occasional guidance from a peer mentor who has been through a similar experience. This study will determine whether the program is practical to deliver. We are conducting a pilot study with 30 pairs of participants to test whether sessions run smoothly, whether people show up and stay engaged, and whether participants find the program worthwhile. Based on what they learn, the investigators will refine this program before testing it on a larger scale. If successful, this could lead to a practical, low-risk intervention that improves the lives of people with TBI and the family members and friends who support them.",[113],"2026-06-01",{"date":121,"type":35},{"date":142,"type":21},{"date":146,"type":21},"2028-03-31",{"name":148,"class":42},"Washington University School of Medicine",{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":158,"conditions":159,"keywords":164,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":173,"leadSponsor":175,"locationsCount":4},"100612884","neuro-inflammation-in-extremity-trauma-risk-verification-in-elbow-trauma-the-nerve-study-100612884","NCT07259382","Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Study","Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Pilot Cohort Study","NERVE","Inclusion Criteria:\n\n* Adults 18 years or older with an acute elbow fracture and\u002For dislocation less than a week old\n* Open surgery as the chosen treatment\n\nExclusion Criteria:\n\n* Patient with a history of ipsilateral upper limb trauma or pathology, neurological disorder.\n* Patient unable to answer questionnaires.\n* Patient unavailable for a one-year follow-up, for example from another country.\n* Patient with vascular injury or open fracture\n* Patient with an active inflammatory disease (ex: rheumatoid arthritis)\n* Patient using anti-inflammatory drugs or immunosuppressants at the time of the injury.\n* Patient with another acute ipsilateral injury to the upper limb\n* Polytrauma patients with other injuries than the elbow fracture and concomitant central or peripheral neurological injury.",{"count":138,"type":21},"The primary goal of this proposal is to improve the understanding of the mechanisms causing persistent pain and disability in elbow fracture patients and their associated functional limitations. The specific objectives are as follows for elbow fractures:\n\n1\\) To describe NI mechanisms using biomarkers; 2) To identify factors related to increased NI biomarkers level; 3) To describe the associations between NI and outcomes; 4) To use these findings to refine a larger fully powered prognostic cohort study Hypotheses\n\n1. Level of neuro-inflammation (NI) biomarkers\\* will be significantly higher in patients presenting with both elbow fracture and CNS injury or PNI.\n2. Consumption of opioid in mg of morphine equivalent will be higher in patients with a higher level of NI biomarkers.\n3. Function, assessed by validated joint and limb specific functional questionnaires and QoL will be worse in patients with a higher level of NI biomarkers.\n4. Chronic pain at 3 months will be higher (McGill Pain questionnaire V2, Neuropathic pain questionnaire, NPRS) in patients with a higher level of NI biomarkers.\n5. Duration of tourniquet use and nerve dissection will be correlated to elbow fracture outcome with a higher level of NI biomarkers.\n\n   * Target biomarkers based on preliminary study will include, but not be limited to: TNFa, IL6, Substance P, IL-1B, TREM-2, IL-16, CCL22, VEGF-a, BMPs (table 1).",[160,161,162,113,163],"Elbow Dislocation","Elbow Fractures","Inflammation Biomarkers","Nerve Injury",[165,166,167,168,60],"Biomarkers","Elbow fracture","elbow dislocation","Nerve injury","2026-04-27",{"date":171,"type":35},"2026-04-28",{"date":142,"type":21},{"date":174,"type":21},"2030-12-31",{"name":176,"class":42},"Université de Montréal",{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":102,"sex":17,"minAge":184,"maxAge":18,"enrollmentInfo":185,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":187,"conditions":188,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":43},"100531096","individual-cerebral-hemodynamic-oxygenation-relationships-ichor-1-100531096","NCT06195345","Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)","ICHOR 1","Inclusion Criteria:\n\n* Individuals who are able to tolerate an MRI.\n* Are patients scheduled for a clinically indicated MRI.\n* Between birth and up to 18 years.\n\nExclusion Criteria:\n\n* Presence of an MRI-incompatible device or implant (e.g. pacemakers, stents)\n* Unable to tolerate the enclosed spaces and loud noises for the duration of time in scanner required to obtain an MRI.\n* Preterm infants less than 25 weeks\n* Any patient who is clinically too unstable to extend their MRI by up-to 7.5 minutes.","1 Minute",{"count":186,"type":21},1000,"This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study.",[189,27,60,190,191],"HIE","Hemodynamic Instability","Hypoxic-Ischemic Encephalopathy","2026-04-24",{"date":194,"type":35},"2026-04-29",{"date":196,"type":35},"2018-11-01",{"date":198,"type":21},"2035-11-01",{"name":200,"class":42},"Children's Hospital Los Angeles",{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":208,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":43},"100635231","phase-1-engage-tbi-feasibility-study-100635231","NCT07549997","ENGAGE-TBI Feasibility Study","Inclusion Criteria:\n\n* at least 18 years old\n* experienced a TBI \\> 6 months prior to enrollment, confirmed by a physician as documented in their medical record\n* live in the St. Louis area\n* report problems with social participation (retention of \\\u003C 80% of pre-TBI social activities as measured by Activity Card Sort)\n\nExclusion Criteria:\n\n* insufficient English language fluency to participate in the group intervention\n* have active substance use disorder (PRIME-MD MINI)\n* have an untreated psychotic disorder (PRIME-MD MINI)\n* have severe memory impairment that would limit their ability to recall strategies with support (Montreal Cognitive Assessment, \\\u003C 21)",{"count":20,"type":21},[24],"This study will first evaluate the feasibility of delivering the ENGAGE-TBI intervention in a community setting with adults with TBI.",[27],"2026-04-23",{"date":171,"type":35},{"date":214,"type":21},"2026-07",{"date":216,"type":21},"2028-04",{"name":148,"class":42},{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":226,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":229,"briefSummary":231,"conditions":232,"keywords":233,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":244},"100617483","phase-3-efficacy-of-early-continuous-infusion-of-hss-on-the-neurological-outcome-at-6-months-in-tbi-patients-100617483","NCT07319208","Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.","Efficacy of Early Continuous Infusion of Hypertonic Saline Solution on the Neurological Outcome at 6 Months in Traumatic Brain Injured Patients. A Single-blinded, Multicenter, Randomized, Controlled Clinical Trial With Blinded Evaluation of the Primary Outcome.","COSMOS-TBI","Inclusion Criteria:\n\n* Patient admitted to intensive care unit\n* Traumatic brain injury with Glasgow Coma Scale ≤ 12\n* Intracranial pressure (ICP) monitoring based on the attending physician's clinical judgment, in accordance with guidelines or clinical\u002Fradiological signs considered at risk of intracranial hypertension\n* Inclusion during the first 12 hours after Intracranial pressure monitoring placement\n* Informed and signed consent\n* National health insurance\n\nExclusion Criteria:\n\n* Glasgow Coma Scale (score = 3) and persistent abnormal pupillaryreactivity despite urgent therapy\n* Associated cervical spinal cord injury\n* Imminent death and do-not-resuscitate orders\n* Coma secondary to cardiac arrest\n* Pregnancy (serum or urine test performed in routine care)\n* Severe Cardiac insufficiency\n* Severe chronic renal insufficiency\n* Severe hepatic insufficiency: patient presenting with oedemato-ascitic decompensation of liver cirrhosis or patient with Child-Pugh class C cirrhosis\n* High risk of follow-up difficulties after ICU discharge\n* Patients under court protection\n* Patient who does not speak French","75 Years",{"count":228,"type":21},760,[230],"PHASE3","The purpose of this study is to demonstrate the efficacy of early continuous intravenous infusion of hypertonic saline solution (HSS) to improve survival and independence in daily life activities (at 6 months) of patients with traumatic brain injury at high risk of intracranial hypertension.",[113],[234,235,236],"Traumatic brain injury","Saline Solution","Hypertonic",{"date":194,"type":35},{"date":239,"type":35},"2026-04-21",{"date":241,"type":21},"2029-06-01",{"name":243,"class":42},"Nantes University Hospital",23,{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":253,"conditions":254,"keywords":255,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":43},"100626016","long-lasting-effect-of-hyperbaric-oxygen-therapy-on-cognitive-function-in-traumatic-brain-injury-patients-100626016","NCT07430150","Long Lasting Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Traumatic Brain Injury Patients","Inclusion Criteria:\n\n1. Diagnosed with traumatic brain injury\n2. Age 18 years or older at treatment\n3. Completed a 60 session hyperbaric treatment course at the Sagol Center for Hyperbaric Medicine and Research, Shamir Medical Center (Assaf Harofeh), and performed a neurocognitive evaluation by the computerized test Neurotrax.\n4. Willing and able to sign an informed consent. -\n\nExclusion Criteria:\n\n1. An inability to perform a neurocognitive computerized test.\n2. Any head trauma, neurodegenerative diseases or CVA after hyperbaric treatment completion.\n3. Diagnosis of a psychiatric disorder including: major depression, schizophrenia, bipolar disorder\n4. Active malignancy\n5. Chronic use of medications that may compromise cognitive function",{"count":252,"type":21},100,"To evaluate the cognitive functions of patients who suffered brain injury due to traumatic head injury and were previously treated in a hyperbaric chamber between one and four years after the end of treatment.",[27],[256],"Hyperbaric Therapy","2026-04-16",{"date":239,"type":35},{"date":260,"type":35},"2021-12-28",{"date":262,"type":21},"2030-01",{"name":264,"class":265},"Assaf-Harofeh Medical Center","OTHER_GOV",{"id":267,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":269,"briefSummary":25,"conditions":270,"keywords":271,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":278,"locationsCount":43},"100632953",{"count":20,"type":21},[24],[27],[27,29,30],"2026-04-02",{"date":274,"type":35},"2026-04-09",{"date":276,"type":21},"2026-05",{"date":39,"type":21},{"name":41,"class":42},{"id":280,"slug":281,"hasResults":12,"nctId":282,"briefTitle":283,"officialTitle":283,"acronym":284,"eligibilityCriteria":285,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":22,"phases":287,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":43},"100464448","early-phase-1-stimulating-after-recovery-from-traumatic-brain-injury-100464448","NCT05327829","Stimulating After Recovery From Traumatic Brain Injury","SMART","Inclusion Criteria:\n\n* Adults 18 years and older\n* Diagnosis of a mild to moderate TBI (GCS \\> 8 on admission)\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process\n\nHealthy participants:\n\n* Adults 18 years and older\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process\n\nExclusion Criteria:\n\n* Open wound on scalp\n* Severe TBI diagnosis or GCS of less than 8 on admission\n* Non-English speaking\n* Incarcerated\n* Implanted defibrillator or pacemaker\n* Visual impairment that hinders ability to complete computerized assessments\n\nHealthy subject exclusion criteria:\n\n* Less than 18 years of age\n* Open wound on scalp\n* TBI diagnosis\n* Non-English speaking\n* Incarcerated\n* Implanted defibrillator or pacemaker\n* Visual impairment that hinders ability to complete computerized assessments",{"count":20,"type":21},[288],"EARLY_PHASE1","This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and decision-making.",[27],"2026-04-01",{"date":293,"type":35},"2026-04-07",{"date":295,"type":35},"2025-03-31",{"date":297,"type":21},"2028-01-15",{"name":299,"class":42},"University of Minnesota",{"id":301,"slug":302,"hasResults":12,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":307,"enrollmentInfo":308,"targetDuration":4,"studyType":22,"phases":310,"briefSummary":312,"conditions":313,"keywords":315,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":43},"100580575","cognitive-rehabilitation-for-refugees-with-traumatic-brain-injury-and-cognitive-impairment-100580575","NCT06839079","Cognitive Rehabilitation for Refugees With Traumatic Brain Injury and Cognitive Impairment","Feasibility RCT of an Adapted Cognitive Rehabilitation Program for Refugees and Asylum Seekers With TBI and Cognitive Impairment","Inclusion Criteria:\n\n1. Identify as an asylum seeker, refugee or have been granted asylum or other form of humanitarian relief.\n2. Mild or moderate TBI sustained after the age of 18\n3. Age 18-65\n4. Subjective cognitive impairment\n5. English or Spanish language proficiency\n6. Ability to provide verbal informed consent\n7. Ability and willingness to answer questionnaires and participation in the Intervention\n\nExclusion Criteria:\n\n1. Participation in cognitive rehabilitation treatment current or in past 3 months\n2. Severe TBI or TBI only sustained under the age of 18\n3. Diagnosis of bipolar, psychosis, active substance use, self-reported current active suicidal ideation or plan (Potential participants can be screened again after 30 days in the case of suicidal ideation)","65 Years",{"count":309,"type":21},50,[311],"NA","Researchers at Massachusetts General Hospital are looking to see if a program created to help improve thinking and memory can work for refugees with traumatic brain injury (TBI). They're checking if this program is practical and if people find it helpful.\n\nThe study will have two groups. Participants will complete a first questionnaire and then be assigned to a group by chance. One group will participate in the program immediately and then answer the second questionnaire (approximately 3 months after the first questionnaire they did). Then they will wait and then answer the third and final questionnaire approximately 6 months after the first one.\n\nThe second group will wait and answer the second questionnaire approximately 3 months after the first one. Then they will receive the program and answer the third and final questionnaire (approximately 6 months after the first one they did.)",[27,314],"Cognitive Symptoms",[316,317,318,319],"Traumatic Brain Injury","Cognition","Refugees","Asylum Seekers","2026-03-08",{"date":322,"type":35},"2026-03-11",{"date":324,"type":35},"2025-10-15",{"date":326,"type":21},"2027-12",{"name":328,"class":42},"Massachusetts General Hospital",{"id":330,"slug":331,"hasResults":12,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":22,"phases":338,"briefSummary":339,"conditions":340,"keywords":343,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":43},"100609251","adaptation-of-the-stair-nt-for-first-responders-100609251","NCT07212140","Adaptation of the STAIR-NT for First Responders","Adaptation of the STAIR-NT Intervention to Respond to Psychological Health Conditions for First Responders With a History of Traumatic Brain Injury","Inclusion Criteria:\n\n* 18 years or older\n* be a first responder within the state of Minnesota\n* have a history of a TBI\n* screen for PTSD.\n\nExclusion Criteria:\n\n* Does not meet inclusion criteria.",{"count":337,"type":21},80,[311],"This study is a randomized controlled pilot examining the implementation of an adapted intervention, Skills Training in Affective and Interpersonal Regulation-Narrative Therapy (STAIR-NT), among a first responder population with a history of TBI and PTSD.",[341,342],"PTSD - Post Traumatic Stress Disorder","TBI-Traumatic Brain Injury",[344,60,345,346,347],"PTSD","First responders","STAIR-NT","GMT","2026-03-03",{"date":350,"type":35},"2026-03-05",{"date":352,"type":21},"2026-06",{"date":354,"type":21},"2027-06",{"name":356,"class":42},"Florida State University",{"id":358,"slug":359,"hasResults":12,"nctId":360,"briefTitle":361,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":12,"sex":17,"minAge":364,"maxAge":365,"enrollmentInfo":366,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":367,"conditions":368,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":369,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":373,"locationsCount":43},"100517944","brain-development-in-young-children-following-mild-traumatic-brain-injury---pilot-study-100517944","NCT06024122","Brain Development in Young Children Following Mild Traumatic Brain Injury - Pilot Study","KAOUENN","Inclusion Criteria:\n\n* Patient group with mild traumatic brain injury (mTBI) :\n\n  1. Children aged between 36 months (3 years) and 71 months and 31 days (5 years; before their 6th birthday)\n  2. Presentation to the emergency department within 48 hours post-injury\n  3. Documented, unintentional traumatic event (e.g. blow, fall, etc.) resulting in non-penetrating head injury\n  4. Diagnosis of mTBI (World Health Organization (WHO) paediatric diagnostic criteria)\n* Control group with orthopaedic injury:\n\n  1. Children aged between 36 months (3 years) and 71 months and 31 days (5 years; before their 6th birthday)\n  2. Presentation to the emergency department within 48 hours post-injury\n  3. Documented, unintentional traumatic event (e.g. blow, fall, etc.) resulting in trauma to an upper or lower limb\n  4. Diagnosis of simple fracture, sprain, contusion or unspecified trauma to a limb (mild).\n\nExclusion Criteria:\n\n* Diagnosis of previous TBI (any severity, any age)\n* Intentional injury,\n* Administration of sedative drugs that can alter brain function\n* Complications following injury\n* MRI contraindication,\n* Parent non-fluent in French,\n* Prematurity,\n* Diagnosis of a severe neurological, developmental, or psychiatric disorder\n* Children in foster care at the time of recruitment","36 Months","71 Months",{"count":138,"type":21},"Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties. However, our knowledge of the exact consequences of injuries on young children's brains and behavior is limited. These consequences may be different in children under 6, as their brains are fragile and undergoing significant developmental changes.\n\nThe aim of this study is to determine the extent to which a concussion sustained before the age of 6 years is associated with changes in young children's brain structure, function and behaviours, using a brain imaging.\n\nIn this study, the results of a group of 30 children with a concussion will be compared to those of 30 children of the same age with an orthopaedic injury to the upper or lower limbs.",[27],{"date":350,"type":35},{"date":371,"type":35},"2024-07-03",{"date":127,"type":21},{"name":374,"class":265},"Institut National de la Santé Et de la Recherche Médicale, France",{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":12,"sex":17,"minAge":381,"maxAge":4,"enrollmentInfo":382,"targetDuration":4,"studyType":22,"phases":383,"briefSummary":384,"conditions":385,"keywords":387,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":43},"100626912","efficacy-and-safety-of-6degrees-mymove-interactive-virtual-reality-compared-to-passive-virtual-reality-in-subacute-stroke-and-traumatic-brain-injury-rehabilitation-a-randomized-controlled-trial-100626912","NCT07441798","Efficacy and Safety of 6Degrees MyMove Interactive Virtual Reality Compared to Passive Virtual Reality in Subacute Stroke and Traumatic Brain Injury Rehabilitation: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Time since neurological event: At least 2 weeks post-stroke or post-head injury.\n2. Motor impairment: Upper extremities: Presence of hemiparesis without complete paralysis. Participants receiving rehabilitation focused on functional transfer to the contralateral hand using compensatory or adaptive motor learning strategies will also be eligible. Lower extremities: Presence of partial voluntary movement sufficient to allow participation in rehabilitation training.\n3. Cognitive ability: Sufficient cognitive capacity to understand instructions and engage with VR-based training, as determined by the principal investigator and\u002For treating physician.\n4. Medical stability: Medically stable condition allowing participation in the training.\n5. Informed consent: Ability to provide written informed consent personally or via a legal guardian.\n6. Final eligibility will be determined by the principal investigator\u002F treating physician.\n\nExclusion Criteria:\n\n1. Severe cognitive or language impairment: Cognitive deficits or language comprehension impairments that prevent safe and meaningful participation.\n2. Neurological deficits interfering with VR: Severe hemispatial neglect or visual field deficits that interfere with VR use. Moderate neglect may be permitted at the investigator's discretion.\n3. Medical contraindications:\n\n   * Uncontrolled epilepsy\n   * Severe vestibular or vertigo disorders","40 Years",{"count":138,"type":21},[311],"Stroke and traumatic brain injury frequently result in persistent upper and lower limb motor impairment. While conventional rehabilitation improves outcomes, patient adherence and training intensity remain limiting factors. Immersive virtual reality (VR)-based therapy may enhance neuroplasticity by delivering high-intensity, task-oriented motor practice with enriched sensory feedback.\n\nThis randomized controlled trial evaluates the efficacy and safety of the 6Degrees MyMove interactive VR system compared to passive VR exposure in individuals undergoing subacute inpatient rehabilitation after stroke or traumatic brain injury. Sixty participants will be randomized 1:1 to receive either interactive VR-based motor training or passive VR viewing, in addition to standard rehabilitation care, three times weekly for eight weeks.\n\nThe primary objective is to determine whether interactive VR leads to greater improvement in motor function compared to passive VR. Secondary outcomes include dexterity, gait speed, functional independence, psychological status, adherence, usability, and safety.",[113,386],"CVA (Cerebrovascular Accident)",[388,389,390,391,392,393],"Virtual Reality Therapy","Upper Limb Rehabilitation","Stroke Rehabilitation","Fugl-Meyer Assessment","Neurorehabilitation","Wearable Motion Sensors","2026-02-24",{"date":396,"type":35},"2026-03-02",{"date":398,"type":21},"2026-03-18",{"date":400,"type":21},"2028-12-31",{"name":402,"class":42},"Reuth Rehabilitation Hospital",{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":407,"acronym":4,"eligibilityCriteria":408,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":409,"targetDuration":4,"studyType":22,"phases":411,"briefSummary":412,"conditions":413,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":43},"100455025","depth-electrode-detection-of-cortical-spreading-depolarization-after-traumatic-brain-injury-100455025","NCT05205174","Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury","Inclusion Criteria:\n\n* Patient recommended to undergo EVD placement for the monitoring and possible treatment of Intracranial pressure (ICP) after TBI\n\nExclusion Criteria:\n\n* Contaminated scalp lacerations\n* Known systemic infection\n* Non-English speaking\n* Fixed, uncorrectable coagulopathy",{"count":410,"type":21},15,[311],"Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.",[27],"2026-02-19",{"date":416,"type":35},"2026-02-23",{"date":418,"type":35},"2025-04-03",{"date":420,"type":21},"2030-12-03",{"name":299,"class":42},{"id":423,"slug":424,"hasResults":12,"nctId":425,"briefTitle":426,"officialTitle":427,"acronym":428,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":22,"phases":432,"briefSummary":433,"conditions":434,"keywords":435,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":444,"locationsCount":43},"100552024","transcutaneous-auricular-neurostimulation-for-icu-patients-with-traumatic-brain-injury-100552024","NCT06467708","Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury","Delivering Transcutaneous Auricular Neurostimulation (tAN) to ICU Patients With Traumatic Brain Injury (tAN-TBI)","tAN-TBI","Inclusion Criteria:\n\n1. Post-resuscitation GCS score 12 or below and acute trauma-related intradural blood on head CT scan after TB\n2. Age 18 years or older (pediatric trauma patients are not routinely transported to Parkland)\n3. Consent from legally authorized representative\n\nExclusion Criteria:\n\n1. Hemodynamic instability\n2. Expected imminent mortality because of overwhelming neurological and\u002For systemic injury\n3. Unclear neurological status because of paralytic medications or intoxication with ethanol or other drugs\n4. Presence of other electrical stimulation devices (pacemaker, cochlear prosthesis, neurostimulator, etc.)\n5. Abnormal ear anatomy or ear infection\n6. Participant is pregnant or lactating\n7. Any other significant medical or psychosocial problems that, in the opinion of the investigator, would potentially cause harm to the participant, impact their ability to participate, or influence the results of the trial",{"count":431,"type":21},42,[311],"The overarching goal of this pilot study is to assess the feasibility and safety of transcutaneous auricular neurostimulation (tan) in ICU patients with TBi and to determine the effect of tan on serum markers of inflammation. exploratory analyses will examine effects on such physiological parameters as blood pressure, heart rate, and intracranial pressure (iCP), as well as measures of neurological function.",[27],[436],"Transcutaneous auricular neurostimulation (tAN)","2026-02-16",{"date":439,"type":35},"2026-02-18",{"date":441,"type":35},"2025-02-11",{"date":443,"type":21},"2027-02-11",{"name":70,"class":42},{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":451,"eligibilityCriteria":452,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":453,"enrollmentInfo":454,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":456,"conditions":457,"keywords":464,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":71},"100624514","augmented-renal-clearance-in-neurocritical-care-100624514","NCT07410624","Augmented Renal Clearance in Neurocritical Care","Augmented Renal Clearance in Neurocritical Care Population: A Prospective Multicenter Study","Neuro-ARC","Inclusion Criteria:\n\n1. Age 18-85 years\n2. Admitted to ICU at one of the participating sites\n3. Diagnosis: SAH, TBI, ICH, meningitis, SE or ischemic stroke\n4. Provision of informed consent\n5. Foley catheter in place at time of consent (to facilitate urine collection)\n\nExclusion Criteria:\n\n1. Incarceration\n2. Anticipated ICU length of stay is \\\u003C 72 hours (insufficient time for monitoring)","85 Years",{"count":455,"type":21},512,"Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion dollars. Seizures and infections are common complications following acute neurological illnesses and contribute significantly to poor outcomes if not promptly treated with appropriately dosed anti-seizure medications and antibiotics, respectively. Limited research suggested that many of those patients present with a phenomenon called augmented renal clearance (ARC) or, in other words, enhanced kidney function. ARC may have a significant influence on how medications are removed from the body potentially resulting in insufficient doses and treatment failure. Therefore, patients with ARC require higher medication doses; however, ARC is largely undetected using kidney assessment methods currently used in practice. In addition, it is not clear how medications should be dosed in those with ARC. The majority of ARC research has not focused on patients with life-threatening neurological illnesses. Thus, clinicians are likely under-dosing vital medications in those patients, and completely unaware. There is an immediate need to address the gap in knowledge. Therefore, this research aims to characterize the phenomenon of ARC in patients with life-threatening neurological illnesses through identifying the frequency, duration, contributing factors and clinical impact of ARC. Adult patients admitted to the neurosciences intensive care unit for life-threatening neurological illnesses will be enrolled in the study. Urine and blood samples wil be collected from participants to determine the presence of ARC and identify its contributing factors. In addition, blood samples will be collected from participants treated with select antibiotics and anti-seizure medications to determine their concentration and propose dose adjustment in those with ARC. This research is expected to improve the care of patients with life-threatening neurological illnesses through efficient identification and monitoring of patients exhibiting ARC facilitating timely medication dosage optimization. Furthermore, recommendations of optimal doses of commonly used medications in patients with ARC would improve the likelihood of treatment success with potential to improve patients' health and wellbeing.",[27,458,459,460,461,462,463],"Status Epilepticus","Bacterial Meningitis","Augmented Renal Clearance (ARC)","Subarachnoid Hemorrhage, Aneurysmal","Ischemic Stroke","Intracerebral Hemorrhage",[465,466,467,468,469,470,471,472,473,474,60,475,476,477,478],"traumatic brain injury","seizures","status epilepticus","bacterial meningitis","brain infections","neuro-ICU","augmented renal clearance (ARC)","augmented kidney function","creatinine clearance","neurological injury","ARC","subarachnoid hemorrhage","ischemic stroke","antimicrobials","2026-02-15",{"date":439,"type":35},{"date":482,"type":35},"2021-10-01",{"date":484,"type":21},"2026-09-30",{"name":486,"class":42},"University of Alberta",{"id":488,"slug":489,"hasResults":12,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":493,"eligibilityCriteria":494,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":495,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":497,"conditions":498,"keywords":500,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":512,"locationsCount":43},"100621660","emergency-department-implementation-of-the-i-stat-alinity-traumatic-brain-injury-whole-blood-test-100621660","NCT07373509","Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test","Effectiveness of the Traumatic Brain Injury Whole Blood Test on Improving Assessment and Triage for Patients With GCS 13-15 Presenting to Emergency Departments","EDI","Inclusion Criteria:\n\n1. Aged 18 or older\n2. Presenting to an enrolling ED with ED Arrival GCS of 13-15 following reported head blunt impact within 24 hours of injury\n3. Meets Department of Defense (DoD) definition of mTBI:\n\nA traumatically induced physiological disruption of brain function as a result of an external force that is indicated by new onset or worsening of at least one of the following clinical signs immediately following the event:\n\n1. Any alteration of mental status (e.g., feeling dazed, disoriented, or confused)\n2. Any period of loss of or a decreased level of consciousness, observed or self-report (loss of consciousness 30 minutes or less, an alteration of consciousness up to 24 hours)\n3. Any loss of memory for events immediately before or after the injury (post-traumatic amnesia up to 1-day post-injury)\n\nExclusion Criteria:\n\n1. Treating emergency department provider does not think a head CT scan is needed\n2. Inability to obtain results for iSTAT Alinity TBI test within 24 hours of injury\n3. Treating emergency department attending physician is not willing to participate\n4. Pre-existing neurologic condition\n5. Contraindication or inability to complete blood draw\n6. Significant polytrauma that, in the opinion of the principal investigators, could impact peripheral GFAP levels or require a full body scan\n7. History of penetrating TBI\n8. History of neurosurgical intervention for previous TBI\n9. Penetrating TBI for current injury\n10. Any history of brain surgery\n11. Any history of brain tumor\n12. Patients on psychiatric hold",{"count":496,"type":21},340,"The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential outcomes with clinical implications. The main questions it aims to answer are:\n\n1. Determine the number of patients with non-elevated (i.e., below clinical cutoff) whole blood iSTAT Alinity tests who also receive CT scans.\n2. What are the obstacles for using the i-STAT Alinity for its FDA-indicated use",[27,499],"Implementation Research",[501,316,502,503,504],"Concussion","CT scan","Blood Biomarker","i-STAT Alinity TBI Test","2026-02-04",{"date":507,"type":35},"2026-02-09",{"date":509,"type":35},"2026-01-13",{"date":511,"type":21},"2030-04",{"name":513,"class":42},"Shawn Eagle",{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":518,"acronym":519,"eligibilityCriteria":520,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":521,"enrollmentInfo":522,"targetDuration":4,"studyType":22,"phases":523,"briefSummary":524,"conditions":525,"keywords":537,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":43},"100409377","cognitive-remediation-in-forensic-mental-health-care-100409377","NCT04610697","Cognitive Remediation in Forensic Mental Health Care","CRFMHC","Inclusion Criteria:\n\ni1. Age 18 - 55; i2. Ability to read and speak in fluent English; i3. Current status as inpatient on the Forensic Treatment Unit.\n\nExclusion Criteria:\n\ne1. Intellectual disability; e2. TBI with loss of consciousness followed by known severe neurological sequelae requiring hospitalisation and rehabilitation.","55 Years",{"count":20,"type":21},[311],"Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.\n\nOne empirically-validated method to train executive functions is cognitive remediation, which consists of cognitive exercises combined with coaching.\n\nThis trial investigates whether cognitive remediation can improve cognitive, functional, and clinical outcomes in forensic inpatients.",[526,527,27,528,529,530,531,532,533,534,535,536],"Psychotic Disorders","ADHD","Aggression","Substance Use Disorders","Violence","Cognitive Dysfunction","Anxiety","Depression","Schizophrenia","Offenders","Antisocial",[538,539,540,541,542,543,544,545,546,547,548,317,549],"Cognitive Remediation","Cognitive Training","Cognitive Enhancement","Cognitive Rehabilitation","Neuropsychological Rehabilitation","Executive Function","Forensic Mental Health","Forensic Psychology","Forensic Neuropsychology","Forensic Neuroscience","Forensic Rehabilitation","Executive Functioning","2025-12-04",{"date":552,"type":35},"2025-12-12",{"date":554,"type":35},"2020-02-10",{"date":556,"type":21},"2026-02-10",{"name":558,"class":42},"The Royal Ottawa Mental Health Centre",{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":4,"eligibilityCriteria":565,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":226,"enrollmentInfo":566,"targetDuration":4,"studyType":22,"phases":568,"briefSummary":570,"conditions":571,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":43},"100609425","phase-2-veterans-cognitive-function-mental-health-and-quality-of-life-after-hyperbaric-oxygen-therapy-100609425","NCT07214415","Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy","Evaluating the Effects of Hyperbaric Oxygen Therapy on Cognitive Function, Mental Health, and Quality of Life in Veterans","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Veteran status\n3. Clinically diagnosed with a mTBI, PTSD, Anxiety, or Depression disorder by meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and by a qualified and trained professional.\n4. The subject is willing and able to read, understand, and sign an informed consent. Additionally, the subject has clear consciousness and the ability to express self-feelings independently.\n5. Exposed to at least one trauma-focused therapy or evidence-based psychotherapeutic treatment, such as prolonged exposure therapy, EMDR, or CBT, to name a few.\n6. Completed cognitive and psychological measurements.\n7. Clinical diagnoses cause significant impairment in social or occupational functioning or some other functional capacity.\n8. Sexually active female participants of childbearing potential and sexually active male participants with female partners of childbearing potential must agree to use an acceptable method of contraception for the duration of the study and for 30 days following the final HBOT session.\n9. Stability on any current psychoactive medications (antidepressants, anti-anxiety medications, antipsychotics, stimulants, and mood stabilizers).\n\nExclusion Criteria:\n\n1. Untreated pneumothorax\n2. History of spontaneous pneumothorax\n3. Severe sinus infection\n4. Upper respiratory infection\n5. Asymptomatic pulmonary lesions on chest x-ray\n6. Uncontrollable high fever (greater than 39C)\n7. History of chest or ear surgery\n8. Congenital spherocytosis\n9. Any anemia or blood disorder\n10. Any convulsive disorder\n11. History of optic neuritis or sudden blindness\n12. Middle ear infection\n13. Diabetes mellitus (insulin therapy)\n14. The subject is pregnant or lactating\n15. Nicotine use\u002Fsubstance use\u002Faddiction\n16. Acute Hypoglycemia\n17. Diagnosed Chronic Obstructive Pulmonary Disease (COPD) and Emphysema\n18. Presenting with symptoms of cough, congestion, vomiting, diarrhea, or open wounds.\n19. Active malignancy\n20. Current manic, delusional, or psychotic episodes\n21. Serious\u002Fcurrent suicidal ideations\n22. Severe or unstable physical disorders or major cognitive deficits\n23. Inability to attend scheduled clinic visits or comply with study protocols.\n24. Treated with HBOT for any reason prior to study enrollment.\n25. Non-English speakers\n26. History of retinal repair, including laser photocoagulation or retinal detachment surgery.\n27. History of middle ear surgery, including tympanoplasty, mastoidectomy, or pressure equalization tube placement.\n28. Age greater than 75 years.\n29. Use of any of the following medications during the study period: Anti-metabolites (e.g., methotrexate, azathioprine); Chemotherapuetic agents (e.g., cyclophosphamide, cisplatin); Mafenide acetate e.g., Sulfamylon); Disulfiram (e.g, Antabuse); Peripheral vasodilators known to interact with oxygen exposure (e.g., nitroglycerin); and Antibacterial drugs with known HBOT interaction risks.",{"count":567,"type":21},54,[569],"PHASE2","The purpose of this study is to evaluate how hyperbaric oxygen therapy (HBOT) may affect cognitive functioning, post-traumatic stress disorder (PTSD), depression, anxiety, and overall quality of life in veterans.\n\n1. Does Hyperbaric Oxygen Therapy improve cognitive functioning, psychological well-being, and quality of life among veterans, as measured by pre-and post-treatment scores?\n2. To what extent does Hyperbaric Oxygen Therapy improve cognitive functioning, psychological well-being, and qualify of life among veterans, after controlling for demographic characteristics.",[113,341,572],"Post Concussive Syndrome","2025-10-06",{"date":575,"type":35},"2025-10-09",{"date":577,"type":35},"2025-10-01",{"date":579,"type":21},"2026-09-15",{"name":581,"class":42},"Summit Hyperbarics and Wellness",{"id":583,"slug":584,"hasResults":12,"nctId":585,"briefTitle":586,"officialTitle":587,"acronym":4,"eligibilityCriteria":588,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":589,"targetDuration":4,"studyType":22,"phases":591,"briefSummary":592,"conditions":593,"keywords":597,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":612,"locationsCount":43},"100609083","augmented-reality-bci-longitudinal-study-for-persons-with-als-stroke-tbi-and-sci-utilizing-cognixion--apple-vision-pro-100609083","NCT07209943","Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro","Cognixion Pass Through Study","Inclusion criteria:\n\n* Must have a designated on-site support individual who can be trained on the Cognixion system\n* Fluent in understanding English\n* 18 years or older\n* Must have one of ALS, spinal cord injury or chronic brain injury and need an assistive communication device\n* Must be able to engage in volitional eye opening and sustain eye opening independently for at least 30 minutes.\n* Must have a way to communicate apart from using the Cognixion device such as vocalizations, head nod, eye blinks, eyebrow raises, etc. At a minimum, reliable, independent way of communicating \"Yes\" and \"No\"\n\nExclusion criteria:\n\n* Disruption in English comprehension, either due to lack of fluent proficiency or due to a developmental\u002Facquired language disorder (e.g. aphasia)\n* Severely hearing impaired or deaf\n* Sensitivity to flashing lights\n* Claustrophobia related to the Apple Vision Pro with comfort adapter\n* History of epilepsy and\u002For seizures\n* Vision disorders restricting the visual field such as glaucoma, diplopia (double vision), nystagmus (involuntary eye movements)\n* History of vertigo or other vestibular disorders\n* Scalp that is prone to irritation, inflammation, injury, or infectious process",{"count":590,"type":21},10,[311],"The goal of this study is refine the usability of a BCI capable communication platform.\n\nThe study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI) or spinal cord injury (SCI) that have assistive communication and computer control needs. Each subject will receive an integrated Cognixion + Apple Vision Pro device that includes an augmented reality brain computer interface and associated communication software. The study duration is 3-4 months for each participant.\n\nThe key questions that will be addressed in this study are:\n\n1. Identify the ability of individuals with target indications to use the integrated Cognixion-Apple Vision Pro system to communicate effectively.\n2. Identify the ability of such individuals to learn to use BCI, ET-BCI and other modalities, and to measure their progress over time.\n3. Identify the effectiveness of the different forms of input supported by the combined Cognixion-Apple Vision Pro system (BCI, eye-tracking) in allowing such individuals to communicate and have agency.\n4. Identify how input such as BCI can be optimized to suit the needs of individuals (e.g., specific frequencies that work best for an individual, SNR with different frequencies, number of targets, length of recording for each frequency) and improve overall usability.\n5. Identify the extent to which personalization through a large language model (LLM) affects communication.\n6. Identify the appropriate capabilities to enable through an agentic communication interface.\n\nKey measures include:\n\nITR - information transfer rate SUS - system usability scale",[594,113,595,596],"ALS (Amyotrophic Lateral Sclerosis)","SCI - Spinal Cord Injury","Stroke",[598,599,600,601,602,603,604,465],"usability study","augmented reality","brain computer interface","als","generative AI","agentic","spinal cord injury","2025-09-29",{"date":607,"type":35},"2025-10-07",{"date":609,"type":21},"2025-10-16",{"date":611,"type":21},"2026-05-31",{"name":613,"class":614},"Cognixion","INDUSTRY",{"id":616,"slug":617,"hasResults":12,"nctId":618,"briefTitle":619,"officialTitle":620,"acronym":621,"eligibilityCriteria":622,"healthyVolunteers":102,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":623,"targetDuration":4,"studyType":22,"phases":625,"briefSummary":626,"conditions":627,"keywords":628,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":631,"lastUpdatePostDateStruct":632,"startDateStruct":634,"completionDateStruct":636,"leadSponsor":638,"locationsCount":43},"100600877","evaluation-of-decision-making-fatigue-after-traumatic-brain-injury-100600877","NCT07103200","Evaluation of Decision-Making Fatigue After Traumatic Brain Injury","Evaluation of Decision-Making Fatigue After Traumatic Brain Injury (EDIFY)","EDIFY","Inclusion Criteria for TBI Participants:\n\n* Adults 18 years and older\n* Diagnosis of a mild to moderate TBI (GCS \\> 8 on admission)\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process\n\nInclusion Criteria for Healthy Participants:\n\n* Adults 18 years and older\n* Able to perform a computerized assessment\n* Willing to attend all scheduled appointments\n* Able to undergo the informed consent process",{"count":624,"type":21},40,[311],"This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.",[27],[629,630],"Mild TBI","Decision-Making Fatigue","2025-08-01",{"date":633,"type":35},"2025-08-05",{"date":635,"type":35},"2025-07-01",{"date":637,"type":21},"2029-07-15",{"name":299,"class":42},{"id":640,"slug":641,"hasResults":12,"nctId":642,"briefTitle":643,"officialTitle":644,"acronym":645,"eligibilityCriteria":646,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":647,"targetDuration":4,"studyType":22,"phases":648,"briefSummary":649,"conditions":650,"keywords":653,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":662,"leadSponsor":664,"locationsCount":43},"100596176","placing-external-ventricular-drains-using-assistive-augmented-reality-or-image-based-localization-100596176","NCT07042048","Placing External Ventricular Drains Using Assistive Augmented Reality or Image-Based Localization","Placing External Ventricular Drains Using Assistive Augmented Reality or Image-Based Localization: A Randomized Controlled Clinical Trial (PEARL)","PEARL","Inclusion Criteria:\n\n* adult patient at time of screening\n* diagnosis of spontaneous ICH with IVH with severe TBI\n* Meet one or more of the following clinical or radiographic criteria:\n\nTissue swelling on imaging Dysmorphic ventricles on imaging Midline shift \\>2mm on imaging Mass effect on imaging Evans Index \\\u003C0.3 on imaging Glasgow Coma Scale 3-8\n\n* admitted to Cooper University Health\n* requires an EVD\n\nExclusion Criteria:\n\n* Other concomitant intracranial pathology (e.g., tumor, tumor-related edema\u002Fhemorrhage, congenital condition, etc.)\n* Concurrent participation in another research protocol for investigation of an experimental therapy\n* Known or suspected inability to adhere to study protocol or protocol requirements, as per the discretion of the investigator",{"count":309,"type":21},[311],"The goal of this clinical trial is to assess if EVD placement using augmented reality is non inferior to image-guidance systems for assistance in adult patients needing an EVD for spontaneous ICH with IVH or severe TBI. The main question it aims to answer is:\n\nCan EVDs be placed successfully with at least equal safety and efficacy using augmented reality devices in comparison to using standard image-guidance techniques?",[651,652,113],"ICH - Intracerebral Hemorrhage","IVH- Intraventricular Hemorrhage",[654,655,60,656,657],"EVD","Augmented Reality","ICH","Image Guidance","2025-06-25",{"date":660,"type":35},"2025-06-27",{"date":635,"type":21},{"date":663,"type":21},"2026-03-31",{"name":665,"class":42},"The Cooper Health System"]