[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tdcs\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tdcs":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,54,86,119,150,181,207,232],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100623769","brain-stimulation-combined-with-watching-hand-movements-to-improve-hand-recovery-in-chronic-stroke-100623769",false,"NCT07400939","Brain Stimulation Combined With Watching Hand Movements to Improve Hand Recovery in Chronic Stroke","Investigating The Neurophysiological Mechanisms Of Transcranial Direct Current Stimulation Combined With Action Observation Therapy On Hand Muscle Neuroplasticity in Chronic Stroke","Inclusion Criteria:\n\n* Adults aged 18 to 59 years\n* Single episode of unilateral stroke and weakness in hand muscles 6 to 24 months post-stroke\n* No excessive spasticity of the upper limb, defined as grade two or less on Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Patients diagnosed with posterior circulation infarction\n* Unable to follow commands due to poor cognitive function\n* Unilateral neglect\n* Homonymous hemianopia\n* Other existing neurological disorders that lead to poor hand function\n* Grade four or five hand muscle strength.","ALL","18 Years","59 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates the neurophysiological mechanisms underlying the combined use of transcranial direct current stimulation (tDCS) and action observation therapy (AOT) for hand motor recovery in individuals with stroke. Background: While both tDCS and AOT have shown promise individually for stroke rehabilitation, the neural mechanisms of their combined effects remain unclear. Understanding these mechanisms could optimise rehabilitation protocols and improve functional outcomes. Intervention: Participants will receive 10 sessions of anodal tDCS over the ipsilesional motor cortex combined with AOT over two weeks in a clinical setting, followed by 8 weeks of home-based AOT practice. Control groups will receive tDCS alone or AOT alone. Neurophysiological changes will be assessed using motor evoked potentials (MEPs) to evaluate corticospinal excitability. Clinical hand function will be assessed using standardised outcome measures. Measurements: Assessments will be conducted at baseline, during intervention (week 2), and after the home practice phase (week 10) to evaluate neuroplastic changes. Significance: This study will provide mechanistic insights into how neuromodulation and observational learning interact to promote motor recovery, informing evidence-based rehabilitation strategies for stroke survivors in Malaysia and globally. Study Design: Randomised controlled trial with three parallel arms, recruiting 60 participants with chronic stroke from Sabah, Malaysia.",[27,28,29,30,31,32,33,34],"Stroke","tDCS","Action Observation Therapy","Hand","Motor Evoked Potential","EMG","Neuroplasticity","Neurophysiological Assessment",[36,37,38,39,40],"stroke rehabilitation","transcranial direct current stimulation","action observation therapy","neuroplasticity","neurophysiological","RECRUITING","2026-05-07",{"date":44,"type":45},"2026-05-12","ACTUAL",{"date":47,"type":45},"2026-04-01",{"date":49,"type":21},"2028-01-20",{"name":51,"class":52},"Universiti Malaysia Sabah","OTHER",2,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":16,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100626682","influence-of-physical-exercise-on-neuroplasticity-and-sensorimotor-networks-in-older-adults-100626682","NCT07438808","Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults","EXOPLASTIC","Inclusion Criteria:\n\n* Men or women aged 20 to 35 for the younger group and 65 to 80 for the older group.\n* Healthy right-handed or left-handed subjects.\n* Subjects who have signed an informed consent form.\n* Ability to understand spoken and written French to follow study procedures.\n* Subjects affiliated with or beneficiaries of a social security system.\n\nExclusion Criteria:\n\n* History of psychaitric disorders : individuals with mental retardation or severe impairment of cognitive, behavioral, or emotional functions that prevent them from understanding the protocol and signing the informed consent form.\n* Neurological history (epilepsy, stroke, brain or spinal cord surgery, and history of neurological diseases affecting motor skills and sensitivity, such as multiple sclerosis, neurodegenerative diseases such as Parkinson's or Alzheimer's).\n* Inability to give informed consent (e.g., dementia, significant hearing impairment, insufficient language proficiency).\n* Contraindications to TMS and tDCS : uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp skin lesion, high intracranial pressure, cerebrospinal fluid shunt).\n* Presence of a cardiac pacemaker or other implanted electronic medical device.\n* Use of psychotropic drugs.\n* Individuals under legal guardianship or curatorship.\n* Pregnant and breastfeeding women.\n* Inability or recognized contraindication to physical activity.",true,"20 Years","80 Years",{"count":65,"type":21},66,[24],"The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current stimulation (tDCS), and to compare these effects with those observed in young adults.\n\nNormal aging is associated with changes in the central nervous system that can affect motor function, sensorimotor integration, and cortical inhibitory mechanisms. These alterations may reduce the brain's capacity for neuroplasticity, which is essential for motor learning and functional adaptation. Physical exercise has been proposed as a potential strategy to counteract age-related decline in neuroplasticity.\n\nIn this study, healthy young and older adults will participate in three experimental sessions. Participants will complete two experimental conditions in a randomized crossover design: (1) aerobic exercise followed by transcranial direct current stimulation (tDCS), and (2) physical inactivity followed by tDCS and a third session will assess the effects of exercise alone. Moderate aerobic exercise will consist of 20 minutes of cycling on an ergometer.\n\nCorticospinal excitability and intracortical and sensorimotor circuit function will be assessed using transcranial magnetic stimulation (TMS) before and after each intervention. Neuroplasticity will be evaluated by measuring changes in motor evoked potentials recorded from a hand muscle of the dominant side.\n\nThe primary objective is to determine whether aerobic exercise enhances tDCS-induced plasticity, and whether this enhancement differs between young and older adults. Secondary objectives include evaluating age-related differences in intracortical inhibitory and facilitatory mechanisms and sensorimotor integration processes.\n\nBy improving understanding of how exercise interacts with brain stimulation to modulate motor cortex plasticity, this study may help inform strategies aimed at preserving motor function and functional independence in aging populations.",[28,69,70],"Physical Activity + tDCS","Physical Inactivity + tDCS",[28,72,73,74,75],"Corticospinal Excitability","Transcranial Magnetic Stimulation","Physical Exercise","Aerobic Exercise","2026-02-22",{"date":78,"type":45},"2026-02-27",{"date":80,"type":21},"2026-02-04",{"date":82,"type":21},"2026-07",{"name":84,"class":52},"Universite du Littoral Cote d'Opale",1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":94,"minAge":17,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":105,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":85},"100608575","home-based-transcranial-direct-current-stimulation-tdcs-compared-to-duloxetine-non-inferiority-clinical-trial-fibrostim-100608575","NCT07203339","Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM)","Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine in the Treatment of Fibromyalgia: a Randomized Non-inferiority Clinical Trial (FIBROSTIM)","FIBROSTIM","Eligibility Criteria\n\nInclusion Criteria:\n\n* Woman aged between 18 and 75 years\n* Right-handed\n* Literate in reading and writing\n* Clinical diagnosis of fibromyalgia based on the American College of Rheumatology (ACR) 2010-2016 criteria\n* Numeric Pain Scale (NPS) score ≥ 4 on most days in the past 30 days\n* Agree no changes in medication dosage during the treatment period (except for analgesics)\n* Able to swallow tablets\n* Able to understand instructions for using tDCS at home\n\nExclusion Criteria:\n\n* Living more than 250 km from Porto Alegre\n* Pregnancy\n* Decompensated systemic diseases\n* Chronic inflammatory rheumatologic diseases\n* Untreated hypothyroidism\n* Active cancer under treatment\n* Alcohol or drug abuse in the past 6 months\n* Decompensated psychiatric disorders with suicide risk and a defined plan\n* Use of duloxetine at a dose \\> 60 mg\u002Fday\n* Metal implants in the brain\n* Implanted brain medical devices\n* Cardiac pacemaker\n* Cochlear implant\n* Neurological disorders\n* History of traumatic brain injury or neurosurgery","FEMALE","75 Years",{"count":97,"type":21},610,[24],"Fibromyalgia is characterized by widespread pain, fatigue, non-restorative sleep, and psychocognitive alterations, compromising quality of life and leading to absenteeism and early retirement. Up to 70% of patients discontinue treatment with antidepressants and anticonvulsants due to adverse effects or low efficacy, and more than 30% resort to opioid use. Given the treatment challenges and the scarcity of safe alternatives, there is growing interest in interventions such as transcranial direct current stimulation (tDCS), which has shown efficacy in improving symptoms and functionality, with low cost and few side effects. In this context, we designed a randomized, double-blind, double-dummy clinical trial to compare the non-inferiority of 28 home-based anodal tDCS (2 mA) applied over the primary motor cortex (M1) versus duloxetine 60 mg. Both treatments will be combined with physical exercise and pain education. Outcomes will be assessed through multidimensional measures of pain, functionality, global impression of improvement, and the function of the descending pain inhibitory system. Secondary outcomes include quality of life, depressive symptoms, psychophysical pain measures, and treatment adherence. An additional analysis will compare the results of sham tDCS and duloxetine placebo within the non-inferiority model. Predictors of treatment response will also be explored, including symptom severity and oscillatory patterns of cortical electrical activity, rest-activity rhythm, and autonomic function assessed by R-R interval. Furthermore, serum levels of S100-B protein, brain-derived neurotrophic factor (BDNF), and genetic variants related to neuroplasticity in the BDNF Val66Met, Catechol-O-Methyltransferase (COMT) (rs4680) (G\\>A), OPRM1, and PER2 genes will be analyzed. Inflammatory markers (TNF-α, IL-1, IL-2, IL-6, IL-10, C-reactive protein) and serum endorphins will also be assessed. A total of 610 women with fibromyalgia (aged 18 to 75 years) will be randomized into three groups (2:2:1): duloxetine + sham tDCS (n=244); active tDCS + placebo (n=244); and sham tDCS + placebo (n=122). Participants will be assessed during treatment and at 3, 6, and 12 months after completing the intervention protocol. An interim analysis will be conducted when \\~50% of participants (n ≈ 305) complete the 3-month follow-up by an independent, blinded Data Monitoring Committee (DMC). (i) The trial may be stopped if the conditional probability of demonstrating non-inferiority is \\\u003C10%, based on frequentist or Bayesian methods. (i) The trial will be stopped if serious adverse events (SAEs) in the active tDCS group increase by ≥30% compared to duloxetine (p \\\u003C 0.01, adjusted). (ii) Early stopping for efficacy will be considered if active tDCS demonstrates clear non-inferiority or superiority over duloxetine on the primary outcome. Superiority requires: (iii) a clinically relevant difference exceeding the non-inferiority margin (≥10% pain reduction); (ii) statistical significance (p \\\u003C 0.005, O'Brien-Fleming adjusted); and (iii) a ≥2-point (20%) improvement on the BPI, confirmed in the ITT analysis. This study aims to generate evidence to support the decision-making process of the National Committee for Health Technology Incorporation (CONITEC) regarding the availability of tDCS in the Brazilian Unified Health System (SUS). In addition, identifying predictors of response to tDCS and duloxetine, through the integration of genetic, neurophysiological, inflammatory, and psychosocial markers using machine learning algorithms, will allow for identifying factors that can personalize fibromyalgia treatment. This approach enhances clinical efficacy, reduces costs associated with ineffective interventions, and supports more accurate therapeutic decisions, expanding access to safe, effective, and sustainable care within the public healthcare system",[101,28,102,103,104],"Fibromyalgia (FM)","Duloxetine","BDNF","EEG",[106,107,102,108,109],"Fibromyalgia","Transcranial Direct Current Stimulation","Biomarkers","Precision Medicine","2025-12-31",{"date":112,"type":45},"2026-01-06",{"date":114,"type":45},"2025-09-30",{"date":116,"type":21},"2028-12",{"name":118,"class":52},"Hospital de Clinicas de Porto Alegre",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":126,"maxAge":17,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":136,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":85},"100611858","hd-tdcs-for-adolescent-bipolar-depression-targeting-s1-100611858","NCT07246044","HD-tDCS for Adolescent Bipolar Depression Targeting S1","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) Targeting the Primary Somatosensory Cortex for Bipolar Depression in Adolescents: A Randomized Double-Blind Controlled Trial","Inclusion Criteria:\n\n* Between 12 and 18 years of age;\n* Participants fulfill the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnostic criteria for bipolar disorder (BD). Participants are assessed by the Structured Clinical Interview for DSM-IV for Axis I Disorders (SCID-I, patients' age ≥18 years old), or the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K- SADS-PL, patients' age\\\u003C 18 years old);\n* A current moderate or severe depressive episode defined by HAMD≥17 and Young Mania Rating Scale (YMRS) \\\u003C12;\n* Participants receive a stable psychotropic medication regimen prior to randomization to the trial and are willing to remain on the stable regimen during the HD-tDCS treatment phase;\n* Participants and 1 or 2 parents (patients' age\\\u003C 18 years old) provide informed consent after the detailed description of the study.\n\nExclusion Criteria:\n\n* Prior rTMS or tDCS or electroconvulsive therapy (ECT) treatment or standard psychological therapy within 6 months prior to screening;\n* Comorbidity of other DSM-IV axis I disorders or personality disorders;\n* Judged clinically to be at serious suicidal risk;\n* Diabetes mellitus, hypertension, vascular and infectious diseases and other major medical comorbidities;\n* Unstable medical conditions, e.g., severe asthma;\n* Neurological disorders, e.g., history of head injury with loss of consciousness for ≥ five minutes, cerebrovascular diseases, brain tumors and neurodegenerative diseases;\n* Mental retardation or autism spectrum disorder;\n* Contraindications to MRI (e.g., severe claustrophobia, pacemakers, metal implants);\n* Contraindications to tDCS (e.g., metal in head, history of seizure, EEG test suggesting high risk of seizure, known brain lesion);\n* Current drug\u002Falcohol abuse or dependence;\n* Pregnant or lactating female.","12 Years",{"count":128,"type":21},100,[24],"This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy and underlying biological mechanisms of HD-tDCS targeting the primary somatosensory cortex in adolescents with bipolar depression. Participants will be randomly assigned to receive either active HD-tDCS or sham stimulation, in addition to routine clinical care. Biological data, including neuroimaging, blood biomarkers, voice and facial features, Photoplethysmography (PPG), Electroencephalography (EEG), and behavioral data, will be collected to explore potential predictors of treatment response.",[132,133,28,134,135],"Adolescent","Bipolar Depression","Primary Somatosensory Cortex","Bipolar Disorder Depression",[137,138,139,140],"primary somatosensory cortex","adolescent","bipolar depression","high-definition transcranial direct current stimulation","2025-11-17",{"date":143,"type":45},"2025-11-24",{"date":145,"type":45},"2025-09-16",{"date":147,"type":21},"2027-12-31",{"name":149,"class":52},"Jiangsu Province Nanjing Brain Hospital",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":95,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":161,"conditions":162,"keywords":165,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":180},"100598576","phase-2-efficacy-of-cerebello-spinal-direct-current-stimulation-csdcs-on-functional-mobility-in-chronic-stroke-patients-100598576","NCT07073287","Efficacy of Cerebello-spinal Direct Current Stimulation (csDCS) on Functional Mobility in Chronic Stroke Patients","Efficacy of Cerebello-spinal Direct Current Stimulation on Functional Mobility in Chronic Stroke Patients","Inclusion Criteria:\n\n* Confirmation of Stroke by digital or physical imaging or medical report\n* Gait impairment\n* Stroke with at least 6 months after ictus\n\nExclusion Criteria:\n\n* Metallic implants in spinal cord\n* Major orthopedic\u002Frheumatological disorders\n* Inability of verbal or non-verbal communication",{"count":158,"type":21},30,[160],"PHASE2","The aim of this clinical trial is to determine if cerebello-spinal direct current stimulation (csDCS) is effective in treating gait disorders in individuals with chronic stroke. Additionally, the trial seeks to evaluate the safety of this technique.\n\nThe primary objectives include:\n\nInvestigating whether cerebello-spinal direct current stimulation improves gait and functional mobility in participants with chronic stroke.\n\nAssessing any potential side effects associated with the method.\n\nResearchers will conduct a comparative analysis between cerebello-spinal direct current stimulation and a sham procedure (which mimics the stimulation without any actual effect) to assess its effectiveness in addressing gait disorders and enhancing mobility.\n\nParticipants in the trial will:\n\nUndergo cerebello-spinal direct current stimulation combined with treadmill training or a sham procedure with treadmill training daily over a two-week period.",[163,164,28],"Stroke Rehabilitation","Gait Disorders, Neurologic",[166,167,168,169,170],"spinal cord","stroke","gait","rehabilitation","direct current stimulation","2025-07-09",{"date":173,"type":45},"2025-07-18",{"date":175,"type":45},"2024-05-01",{"date":177,"type":21},"2026-08-01",{"name":179,"class":52},"Universidade Federal de Pernambuco",3,{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":205,"locationsCount":53},"100591888","tdcs-combined-with-treadmill-training-in-patients-with-multiple-sclerosis-100591888","NCT06986278","tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis","Transcranial Direct Current Stimulation Combined With Treadmill Training With Partial Body Weight Support in Patients With Multiple Sclerosis","TDCS","Inclusion Criteria:\n\n* Ability to understand and follow instructions.\n* Diagnosis of Multiple Sclerosis according to McDonald criteria.\n* Expanded Disability Status Scale (EDSS) between 1 and 6.\n* Stable condition in the last three months.\n\nExclusion Criteria:\n\n* Peripheral neurological injury of lower limbs.\n* Metal objects in the head.\n* Uncontrolled epilepsy.\n* Diagnosis of psychiatric disorder.\n* Fractures or fissures in the skull.\n* Presence of any implanted electronic device (pacemaker, baclofen pump).\n* Presence of ulcers in the harness attachment area.\n* Osteoporotic fractures in the last 2 years.\n* Height \\> 190 cm.\n* Weight \\> 120 kg.",{"count":190,"type":21},78,[24],"This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.",[28,194],"Sham tDCS",[196,168,197,198],"tdcs","multiple sclerosis","gait training","2025-05-22",{"date":201,"type":45},"2025-05-29",{"date":203,"type":21},"2025-05-26",{"date":110,"type":21},{"name":206,"class":52},"University of Castilla-La Mancha",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":63,"enrollmentInfo":213,"targetDuration":4,"studyType":22,"phases":215,"briefSummary":217,"conditions":218,"keywords":4,"overallStatus":222,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":85},"100587357","phase-4-the-study-on-the-efficacy-of-tdcs-stimulation-of-the-cerebellum-combined-with-xingnaojing-injection-in-patients-with-consciousness-disorders-after-cranial-injury-100587357","NCT06927336","The Study on the Efficacy of tDCS Stimulation of the Cerebellum Combined With XingNaoJing Injection in Patients With Consciousness Disorders After Cranial Injury","Inclusion Criteria:\n\n1. aged 18-80 years;\n2. All patients met the diagnostic criteria of DoC;\n3. more than 1 month after the initial head injury;\n4. stable consciousness for at least 2 weeks before admission (no change in CRS-R total score);\n5. no skull defect or large area of skull repair;\n6. The legal representative authorized by the patient approved the experimental protocol and signed the informed consent form.\n\nExclusion Criteria:\n\n1. supratentorial abnormalities on computed tomography (CT) or magnetic resonance imaging (MRI) involving more than one third of the middle cerebral artery territory;\n2. a life expectancy of less than 3 months or a follow-up of less than 3 months;\n3. retention of intracranial metal objects, cranial debridement, or presence of cranial defects and any clinically significant or unstable medical diseases;\n4. EEG recording with significant muscle artifacts and inhibitory bursts;\n5. nonconvulsive status epilepticus; Periodic or burst rhythms evoked by stimulation;\n6. disturbance of consciousness due to surgical injury or tumor.",{"count":214,"type":21},200,[216],"PHASE4","The purpose of this study is to investigate the effect of tDCS stimulation of cerebellum combined with Xingnaojing on patients with disturbance of consciousness after craniocerebral injury, and to clarify the relationship between the following two points: (1) to clarify whether MMN, P300, fNIRS, BAEP, SEP can be used as objective indicators to distinguish VS from MCS. (2) To clarify the changes of consciousness level and brain function in DoC patients with craniocerebral injury treated with tDCS stimulation of cerebellum combined with Xingnaojing.",[28,219,220,221],"Cerebellum","Brain Injury","Disturbance of Consciousness","NOT_YET_RECRUITING","2025-04-14",{"date":225,"type":45},"2025-04-15",{"date":227,"type":21},"2025-04-25",{"date":229,"type":21},"2026-12-30",{"name":231,"class":52},"The Second Affiliated Hospital of Kunming Medical University",{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":16,"minAge":239,"maxAge":17,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":242,"briefSummary":243,"conditions":244,"keywords":250,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":85},"100532423","optimized-and-personalized-trans-cranial-brain-stimulation-in-partial-refractory-epilepsies-100532423","NCT06212609","Optimized and Personalized Trans-cranial Brain Stimulation in Partial Refractory Epilepsies","PerEpi2","Inclusion Criteria:\n\n* Any patient, male or female aged 1 to 18, with refractory partial epilepsy considered potentially surgical according to the definition of ILAE. Drug-resistant epilepsy can be defined as the failure of adequate therapeutic trials of two antiepileptics (either monotherapy or in combination) so that the patient is free from seizures on a lasting basis.\n* Any epileptic patient with interictal epileptic spikes on his standard or High Resolution EEG and or on the Magnetoencephalography examination\n* Any epileptic patient undergoing a structural MRI\n* Any patient who has agreed to participate in the PerEpi 1 study allowing the optimization of the location of epileptic sources and the modelling of the optimization of the parameters of transcranial electrical stimulation\n* Patients who have at least 4 seizures per month\n\nExclusion Criteria:\n\n* Patient not meeting the age criteria\n* And\u002For presenting generalized epilepsy\n* And\u002For presenting diffuse interictal peaks and\u002For presenting a serious alteration of the general condition and vital functions\n* And\u002For in the event of refusal by one of the parents or the child\n* Pregnant, parturient or breastfeeding woman.\n* Contraindication to the use of mc-tDCS stimulation without seizure","1 Year",{"count":241,"type":21},20,[24],"Epilepsy is one of the most common neurological diseases, affecting between 0.5% and 1% of the general population. Therefore, new diagnostic and treatment methods are having a big impact on society. Epilepsy is also one of the most commonly diagnosed pediatric neurological disorders, with long-term implications for the quality of life of those affected and their relatives. In only two-thirds of cases, seizures can be adequately controlled with anticonvulsant drug therapy. For other patients with a drug-resistant focal epilepsy (up to around 2 million in Europe) epilepsy surgery is currently the most effective treatment. However, only 15-20% of these drug-resistant patients are eligible for epilepsy surgery. This is either because the cortical epileptogenic zone cannot be localized with sufficient precision with standard diagnostic means, or because the epileptogenic zone overlaps meaningful cortical areas, so that it cannot be surgically removed without considerable neurological deficit.",[245,28,246,247,248,249],"Transcranial Electric Stimulation","Epilepsy","Pharmacoresistant","HR EEG","Children",[251,28,246,252,248,253],"Transcranial electric stimulation","pharmacoresistant","children","2024-01-30",{"date":256,"type":45},"2024-01-31",{"date":258,"type":45},"2023-12-01",{"date":260,"type":21},"2027-01-01",{"name":262,"class":52},"Centre Hospitalier Universitaire, Amiens"]