[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"telomere-length-mean-leukocyte\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:telomere-length-mean-leukocyte":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100572405","does-recombinant-fsh-rfsh-ig-gonal-f-as-compared-to-human-menopausal-gonadotrophin-hmg-affect-telomere-length-of-cumulus-cells-during-antral-follicle-growth-and-impact-blastocyst-status-100572405",false,"NCT06732843","Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?","rFSH and hMG","Inclusion Criteria:\n\n1. Maternal age 18 - 38 years\n2. Patients requested PGT-A\n3. BMI 18- 30kg\u002Fm2\n4. Expected normoresponders\n5. Fresh autologous ejaculate (≥5 mill\u002Fml)\n6. Sperm abstinence: 2-3 days\n7. Normal female\u002Fmale karyotype\n8. Regular menstrual cycle length: 25-32 days\n9. AFC of 5-10 in each ovary at the beginning of the stimulation\n10. Trigger: dual trigger: 2.500 IU urinary hCG + 0.3 mg Decapeptyl. (13)\n11. A wash-out period between 1 to 3 months; an inter-cycle variation of 10% in AFC, measured by the same physician, is accepted.\n12. Couple agrees to perform two stimulations before continuing with embryo transfer\n\nExclusion Criteria:\n\n* 1\\. Uterine abnormalities as diagnosed by ultrasound 2. Any hormonal or oral contraceptive pretreatment of 3 months preceding the treatment 3. Endometriosis according to American Fertility Society (AFS) ≥3 4. ≥ 2 miscarriages 5. Bologna criteria poor responders (14)",true,"FEMALE","18 Years","38 Years",{"count":21,"type":22},10,"ESTIMATED","60 Months","OBSERVATIONAL","Gonal-F® (follitropin alfa) is a recombinant FSH without LH activity, while Menopur® contains both LH and hCG. The MEGASET trial compared Menopur® and Gonal-F® in GnRH antagonist cycles with SET, showing similar efficacy. A subsequent study (MEGASET-HR) in high responders found ongoing pregnancy rates of 35.5% for Menopur® and 30.7% for Gonal-F®, with a lower early pregnancy loss for Menopur® (14.5% vs 25.5%).\n\nTelomere length (TL) in oocyte cumulus cells (CC) correlates with oocyte quality and embryo outcomes. This study aims to assess whether stimulation type (hMG vs. Gonal-F) affects TL in CC and subsequent blastocyst development. A randomized, open-label, cross-over study in normo-responders will analyze telomere length, embryo quality, and hormonal markers.",[27,28,29],"OVARIAN STIMULATION","Telomere Length","Telomere Length, Mean Leukocyte",[31,32,33,34,35,36,37,38,39,40],"recombinant human follicle-stimulating hormone (rFSH)","uman-menopausal-gonadotropin (hMG","ocyte quality","embryo quality","blastocyst development","Menopur","GonalF","GnRH antagonist cycles","trophectoderm","cumulus cells","RECRUITING","2025-07-24",{"date":44,"type":45},"2025-07-25","ACTUAL",{"date":47,"type":45},"2025-07-23",{"date":49,"type":22},"2027-07-31",{"name":51,"class":52},"ART Fertility Clinics LLC","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":4},"100589593","mitigating-heat-stress-among-rickshaw-drivers-in-bangladesh-100589593","NCT06956430","Mitigating Heat Stress Among Rickshaw Drivers in Bangladesh","How Does Heat Stress Affect Telomere Length? A Pilot Randomized Controlled Trial in Urban Bangladesh","Inclusion Criteria:\n\n* Reports driving a manual rickshaw at least five days per week for at least 8 hours per day for the past 12 months\n\nExclusion Criteria:\n\n* Reports driving a battery-powered rickshaw in the past 12 months\n* Has hypertension, as measured by our study staff\n* Has diabetes, as measured by our staff\n* Reports diagnosis with cardiovascular disease \u002F chronic cardiac condition\n* Reports diagnosis with respiratory disease \u002F chronic respiratory condition","MALE","40 Years",{"count":64,"type":22},300,"INTERVENTIONAL",[67],"NA","The goal of the experimental study is to understand the impact of heat stress on core temperature and telomere length. Investigators will recruit rickshaw drivers who use manual power to push their rickshaws and randomly assign half of them to receive battery-powered rickshaws to use for four months. Investigators will assess how this change impacts their core body temperature while they work, the length of their telomeres (caps on the end of DNA that are associated with aging), and kidney function.",[70,29,71],"Core Temperature","Kidney Function Issue",[73,74,75,76,77,78,79],"heat stress","heat strain","rickshaw","heart rate","heart rate variability","sleep quality","Bangladesh","NOT_YET_RECRUITING","2025-05-15",{"date":83,"type":45},"2025-05-21",{"date":85,"type":22},"2025-06-01",{"date":87,"type":22},"2025-12-31",{"name":89,"class":52},"University of California, Berkeley"]