[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"telomere-shortening\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:telomere-shortening":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100485229","ta-65-and-aging-associated-microvascular-dysfunction-100485229",false,"NCT05598359","TA-65 and Aging Associated Microvascular Dysfunction","Inclusion Criteria:\n\n* Healthy Adults 18 - 35 and 65+ years of age\n* Subjects with clinical diagnosis of CAD\n\nExclusion criteria will include:\n\n* 36-64 years of age without clinical diagnosis of CAD\n* Self-reported habitual vigorous exercise (\\>20 min, 3 times per week, 1 yr)\n* Major Adverse Cardiovascular Event (MACE) in the last year (heart attack, stroke)\n* Heart Failure\n* Renal Impairment\n* \\>3 Pre-existing Cardiovascular Risk Factors (healthy groups only)\n* Type 1 or type 2 diabetes\n* Uncontrolled hypertension\n* Current tobacco use or within last 6 months\n* BMI \\> 35\n* Hyperlipidemia\n* Hypercholesterolemia\n* Use of anti-coagulant drugs\n* Use of anti-platelet drugs\n* Erectile dysfunction medication in the past 6 months\n* Use of topical\u002Fnon-topical steroids in last 6 months\n* Hormone replacement therapy (Post-Menopause or Gender Reassignment)\n* History of retinopathy\n* Documented neuromuscular disorders\n* Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity)\n* Pregnancy (young female subjects)\n* Allergy to lidocaine\n* Current diagnosis of cancer with or without active anti-cancer treatment (pharmaceuticals) or treatment within last 12 months\n* Active COVID-19 or within the past 3 months",true,"ALL","18 Years","80 Years",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to test whether activation of telomerase with a dietary supplement (TA-65) improves microvascular function.",[27,28,29],"Telomere Shortening","Aging","Vascular Diseases","NOT_YET_RECRUITING","2026-04-27",{"date":33,"type":34},"2026-05-01","ACTUAL",{"date":36,"type":21},"2027-01-01",{"date":38,"type":21},"2029-12-31",{"name":40,"class":41},"Medical College of Wisconsin","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100520423","phase-1-biological-and-behavioral-outcomes-of-community-nature-walks-100520423","NCT06056375","Biological and Behavioral Outcomes of Community Nature Walks","Examining Anti-Racist Healing in Nature to Protect Telomeres of Transitional Age BIPOC for Health Equity","Inclusion critieria:\n\n* 18 years or older\n* able to commit to a 9-month Nature Intervention (6-month walks; 3-month chosen nature activity)\n* spoken languages: English, Spanish, or Tagalog\n* able-bodied as in must be able to walk.\n\nExclusion criteria:\n\n* pregnant women (and other gender identities who are pregnant)\n* prisoners\n* cognitively impaired",{"count":50,"type":21},200,[52],"PHASE1","The investigators will test the efficacy of our proposed intervention to reduce embodied stress in four racial\u002Fethnic groups (Black, Latinx, Pilipinx, and Pacific Islander) as a preventative intervention for health disparities found in these communities. The intervention is comprised of two phases. The first consists of community nature walks in a pristine redwood forest for six months. This is followed by chosen nature activities with family and\u002For friends for three months. The investigators will test the ability of these activities in nature to reduce chronic stress that underpins many health disparities using validated biological, behavioral, and sociocultural measures. The use of these measures is in alignment with the National Institute of Minority Health and Health Disparities (NIMHD) Research Framework, and will increase understanding of individual, interpersonal, community, and social level factors that lead to, and that can eliminate health disparities.",[55,27,56],"Stress, Psychological","Stress Reaction","RECRUITING","2023-09-20",{"date":60,"type":34},"2023-09-28",{"date":62,"type":34},"2023-02-01",{"date":64,"type":21},"2026-09-01",{"name":66,"class":41},"Charlotte Tate",1]