[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"temperament\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:temperament":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,55,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100623790","gutlink4kids-intervention-100623790",false,"NCT07401212","GUTLINK4KIDS Intervention","The Impact of Chronic Consumption of Prebiotics on Cognitive and Affective Outcomes, Gut Microbiome Diversity and Composition in 3-5 Year Olds: a Double-blind Placebo-controlled, Parallel-groups Randomised Controlled Trial","GUTLINK4KIDS","Inclusion Criteria:\n\n* Parents (18 years and over) of generally healthy children aged 3-5-years-old (36-71 months) with lower dietary fibre intake than the recommended daily amount (10.4g\u002Fday in 18-47-month-olds and less than 12.6g\u002Fday in 48-60-month-olds).\n\nExclusion Criteria:\n\n* Children with a significant acute or chronic co-existing illness (including inflammatory bowel disease, functional gastrointestinal disorders, coeliac disease etc, neurodevelopmental, immunological, psychiatric, or metabolic disorders.\n* Children who have taken any pre\u002Fprobiotic supplements or antibiotic treatment within the 4 weeks prior to enrolment.\n* Children with food allergies and intolerances",true,"ALL","3 Years","5 Years",{"count":22,"type":23},106,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to investigate the chronic effects of prebiotic consumption on cognitive, behavioural and gut microbiome outcomes in children aged 3-5 years.",[29,30,31,32],"Temperament","Sleep","Cognition","Emotion Regulation",[34,35,36,37,38,39,40,41],"prebiotics","emotion regulation","gut microbiome diversity","children","relative abundance","sleep","internalising symptoms","externalising symptoms","RECRUITING","2026-04-27",{"date":45,"type":46},"2026-04-28","ACTUAL",{"date":48,"type":46},"2026-03-02",{"date":50,"type":23},"2027-02-01",{"name":52,"class":53},"University of Reading","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100604206","esketamine-nasal-spray-in-real-world-settings-in-treatment-resistant-depression-100604206","NCT07146503","Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression","ESKPSY: Esketamine in Real-World Settings: Clinical Outcomes, Predictors of Response, Life Functioning and Biological Pathways","ESKPSY","Inclusion criteria were: (a) age 18-74, (b) DSM-5 diagnosis of a major depressive episode (MDE), (c) failure to respond to at least 2 prior antidepressant treatments (ADTs), and (d) current treatment with an SSRI or SNRI for which esketamine nasal spray was deemed appropriate.","18 Years","74 Years",{"count":66,"type":23},100,"OBSERVATIONAL","This observational study investigates the use of Esketamine Intranasal Spray in patients with Treatment-Resistant Depression in Real-World Settings. The study aims to evaluate the clinical outcomes, including efficacy and safety, of esketamine treatment. It also explores predictors of treatment response, focusing on biological pathways such as genetics, neuroimaging, and psychophysical measures. Additionally, the study examines how esketamine impacts patients' life functioning, including social and occupational aspects. The goal is to better understand who benefits most from esketamine and how it affects daily life, to improve personalized care for patients with difficult-to-treat depression.",[70,71,72,73,74,31,29,75],"Depression and Quality of Life","Treatment Resistant Depression (TRD)","Anhedonia","Apathy","Anxiety","Psychiatric Comorbidities","2026-03-25",{"date":78,"type":46},"2026-03-31",{"date":80,"type":46},"2022-11-01",{"date":82,"type":23},"2030-08",{"name":84,"class":53},"Riccardo Guglielmo",5,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":17,"sex":93,"minAge":63,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":97,"conditions":98,"keywords":104,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":54},"100433065","mother-infant-cohort-study-in-malaysia-and-china-100433065","NCT04919265","Mother-Infant Cohort Study in Malaysia and China","Breastmilk, Infant Gut Microbiome and the Impact on Infant Health: a Prospective Mother-Infant Cohort Study in Malaysia and China","Inclusion Criteria:\n\n* Pregnant women aged between 18 and 45 years old\n* Pregnant women who attend the antenatal check-up at the selected clinics\u002Fhospitals\n* Pregnant women with the gestational age of less than 12 weeks\n* Pregnant women who plan to attend post-natal check-ups for at least one year at the same clinic\u002Fhospital\n\nExclusion Criteria:\n\n* Pregnant women who are diagnosed with immune deficiency\n* Pregnant women who have a multiple pregnancy and preterm delivery (\\\u003C37 weeks)\n* Pregnant women who plan to move out of the study area in the next one year\n* Pregnant women with fetal\u002Fnewborn with congenital abnormalities","FEMALE","45 Years",{"count":96,"type":23},200,"This mother-infant cohort study aims to determine the geographic differences in the microbial profiles in breast milk from mothers living in Malaysia and China that are potentially important determinants of infant development. It also aims to determine the impact of gut microbiome on infant health (temperament, gastrointestinal symptoms, eczema symptoms, and asthma symptoms).",[99,100,29,101,102,103],"Gut Microbiota","Gastrointestinal Symptoms","Eczema","Asthma","Breast Milk Collection",[105,106,107],"Gut microbiota","Mother-infant cohort study","Breastmilk","2024-12-09",{"date":110,"type":46},"2024-12-13",{"date":112,"type":46},"2022-06-03",{"date":114,"type":23},"2026-12",{"name":116,"class":53},"Universiti Putra Malaysia"]