[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"temporal-interference-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:temporal-interference-stimulation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,65,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100635597","tis-for-nssi-in-adolescent-depression-100635597",false,"NCT07554755","TIS for NSSI in Adolescent Depression","Efficacy and Safety of Temporal Interference Stimulation on Non-suicidal Self-injury Behaviors in Adolescents With Depression","Inclusion Criteria:\n\n1. Meet the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders 5th Edition) diagnostic criteria for major depressive disorder.\n2. Patients aged 12-22 years with at least one guardian to monitor them for 3 months\n3. HAMD-17 Total score ≥18\n4. Patients who had two or more non-suicidal self-injury behaviors meeting the 5.DSM-5 diagnostic criteria in the 2 weeks before admission (NSSI behavior of more than 5 days in the past year)\n\n6.Obtain informed consent from patients and guardians\n\n\\-\n\nExclusion Criteria:\n\n1. Substance abusers such as psychoactive drugs or alcohol.\n2. Severe physical disability and unable to complete follow-up.\n3. Comorbid other major mental illnesses that meet the DSM-5 criteria, such as bipolar disorder, schizophrenia, mental retardation, dementia, severe cognitive impairment, attention deficit hyperactivity disorder, etc.\n4. Suffering from any severe physical disease, neurological disease, traumatic brain injury, etc, that affects the structure or function of the brain in the lifetime.\n\n   Unable to read, understand and complete the assessment or to cooperate with the investigators.\n5. Any implants covering a pacemaker, metallic or magnetic objects in the body, or other conditions not suitable for TIS.\n6. Those who have received systematic psychotherapy (interpersonal relationship therapy, dynamic therapy, cognitive behavioral therapy) or TMS within 3 months before baseline.\n7. Other examination abnormalities considered to be inappropriate by investigators.\n\n   \\-","ALL","12 Years","22 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Temporal Interference Stimulation (TIS) has been successfully used to help patients with depression. However, its role in alleviating self injuries remained uncertain. This trial will compare the effectiveness of TIS to a placebo control on non-suicidal self injury (NSSI) in patients with major depressive disorder(MDD).",[27,28,29],"Temporal Interference Stimulation","Non Suicidal Self Injury","Major Depressive Disorder","RECRUITING","2026-04-23",{"date":33,"type":34},"2026-04-28","ACTUAL",{"date":36,"type":21},"2026-04-30",{"date":38,"type":21},"2027-01-31",{"name":40,"class":41},"The Second Hospital of Anhui Medical University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},"100607656","intervention-effect-of-temporal-interference-stimulation-tis-on-depressive-disorder-100607656","NCT07191392","Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder","Inclusion Criteria:\n\n* the patients were diagnosed by more than 2 psychiatrists and met the diagnostic criteria of DSM-5 for depression, and HAMD\\>17, BSS\\>6, PHQ-15\\>5.\n* the age ranged from 18 to 65 years old, and the length of education was more than 5 years.\n* the visual acuity or corrected visual acuity is normal, right-handed, can cooperate with the completion of various experimental tests.\n\nExclusion Criteria:\n\n* accompanied by severe somatic diseases, such as severe heart, liver, renal insufficiency and so on.\n* accompanied by other neurological diseases, such as stroke, epilepsy and so on. pregnant and lactating women.\n* accompanied by other mental disorders, such as drug abuse, schizophrenia, schizophrenic affective",true,"60 Years",{"count":20,"type":21},[24],"To investigate the effect of Temporal Interference Stimulation (TIS) on associative memory (AM) in patients with depressive disorder",[55,27],"Depressive Disorder","2026-03-09",{"date":58,"type":34},"2026-03-10",{"date":60,"type":34},"2025-09-01",{"date":62,"type":21},"2026-06",{"name":40,"class":41},2,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":49,"sex":16,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":42},"100606768","phase-1-safety-and-feasibility-of-temporal-interference-brain-stimulation-for-treatment-in-psychiatric-disorders-100606768","NCT07179848","Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders","Phase I Clinical Trial of a New Non-invasive Deep Brain Stimulation Technique","Inclusion Criteria:\n\n* Healthy adults from the community\n* Age between 20 and 65 years old\n* No diagnosis of severe psychiatric disorders\n* No family history of psychiatric diseases\n\nExclusion Criteria:\n\n* Age below 20 years old or above 65 years old\n* Currently prescribed any medication\n* Diagnosis of psychiatric disorders (e.g., Major Depressive Disorder, Bipolar Disorder, Schizophrenia)\n* Diagnosis of neurological disorders (e.g., Dementia, Stroke, Parkinson's disease)\n* History of substance abuse\n* Diagnosis of cancer or malignant tumors\n* Chronic kidney failure or undergoing hemodialysis\n* Pregnant or breastfeeding\n* Severe arrythmia, presence of pacemaker, or metal implants in the brain\n* Claustrophobia\n* History or family history of seizure\n* History of syncope\n* Organic brian disease, brian trauma, or history of neurosurgery\n* Received electroconvulsive therapy or repetitive transcranial magnetic stimulation within the past month\n* Skin disorders (e.g., dermatitis, psoriasis, eczema)\n* Currently participating in other clinical interventional trials\n* Presence of any metal implants or devices affected by electromagnetic fields","20 Years","65 Years",{"count":75,"type":21},80,[77],"PHASE1","The goal of this clinical trial is to validate if temporal interference brain stimulation (TIBS) is safe in healthy volunteers aged 20 to 65. The main questions it aims to answer are:\n\n* Is it safe to apply TIBS intervention to the left hippocampus in healthy participants?\n* Is it safe to apply TIBS intervention to the left insula in healthy participants?\n* Is it safe to apply TIBS intervention to the left anterior cingulate cortex in healthy participants?\n* Is it safe to apply TIBS intervention to the right inferior frontal cortex in healthy participants?\n\nParticipants will:\n\n* Be Randomly allocated to either sham-first group or treat first-group, stratified by stimulated brain region, following a crossover-controlled experimental design\n* Complete baseline cognitive evaluations and mental status assessments, and undergo a baseline MRI scan on the same day\n* Receive stimulation for 5 consecutive days, followed by a 2-days washout period, then complete the remaining 5 days of stimulation.\n* Complete post-intervention cognitive evaluations and mental status assessments, and undergo a post-intervention MRI scan on the same day",[80,27,81,82],"Health Adults","Safety and Effectiveness","Crossover Study",[84,27,85,86,87],"Hippocampus","Insula","Anterior Cingulate Cortex","Inferior Frontal Cortex","2026-02-05",{"date":90,"type":34},"2026-02-09",{"date":92,"type":34},"2025-02-26",{"date":94,"type":21},"2026-10",{"name":96,"class":97},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":64},"100584970","study-on-the-effectiveness-and-safety-of-temporal-interference-stimulation-in-treating-patients-with-severe-consciousness-disorders-100584970","NCT06896279","Study on the Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients With Severe Consciousness Disorders","Inclusion Criteria:\n\n* Severe consciousness disorder patients aged 18 to 75 years old, regardless of gender;\n* Patients with severe consciousness disorders, namely a minimally conscious state or vegetative state that lasts for 28 days or more;\n* Patients with normal body temperature, stable vital signs, spontaneous breathing, tracheotomy without the use of a metal cannula and with a small amount of sputum, and who are eligible for magnetic resonance imaging (MRI) examination;\n* Written informed consent obtained from the patient's family members in advance.\n\nExclusion Criteria:\n\n* Individuals with a previous history of significant neuropsychiatric and other major disorders such as those involving the heart, lung, liver, and kidney;\n* Those who have undergone V-P shunt or Ommaya reservoir implantation and other procedures that may influence the analysis of magnetic resonance scanning signals;\n* Patients who are scheduled for V-P shunt or Ommaya reservoir implantation in the near future;\n* Pregnant women;\n* Those who have participated in other drug or device clinical trials;\n* Patients with poorly controlled epilepsy in the recent period;\n* Those with infections at the TI stimulation site or compromised skin integrity at the electrode placement site;\n* Those currently taking medications prone to inducing epilepsy, such as quinolone drugs;\n* Those with intracranial infections, intracranial tumors, or metallic objects within the cranium;\n* Those allergic to electrode gel or adhesives;\n* Those with implanted electronic devices within the body;\n* Those with severe cardiac disorders and those equipped with cardiac pacemakers.","18 Years","75 Years",{"count":107,"type":21},20,[24],"Investigating the efficacy and safety of temporal interference stimulation for patients with disorders of consciousness.",[111,27],"Disorder of Consciousness",[111,113,27],"Randomized clinical trail","2025-12-08",{"date":116,"type":34},"2025-12-16",{"date":118,"type":34},"2025-04-21",{"date":120,"type":21},"2026-05-17",{"name":122,"class":41},"Huashan Hospital"]