[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"temporal-lobe-epilepsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:temporal-lobe-epilepsy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,78,109,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":40,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100640275","spatial-scene-recognition-memory-in-epilepsy-surgery-100640275",false,"NCT07580183","Spatial Scene Recognition Memory in Epilepsy Surgery","Investigations of Spatial Recognition Memory to Improve Cognitive Outcomes in Epilepsy Surgery","Inclusion Criteria:\n\n* Age 18 years or older\n* For Aims I and III: Diagnosis of focal epilepsy or temporal lobe lesion; patients undergoing evaluation for or having undergone epilepsy surgery\n* For Aim II: Healthy adult participants\n* Full-Scale IQ ≥ 70\n* English proficiency sufficient to understand and complete the task\n* For Aim I: Enrolled in or eligible for Emory University epilepsy surgery research registry\n* For Aim III: Undergoing clinically indicated stereoelectroencephalography (SEEG) at UC Davis Medical Center\n* Able to provide informed consent (or for Aim I retrospective component, prior consent in Emory registry)\n\nExclusion Criteria:\n\n* Full-Scale IQ \\\u003C 70\n* Inability to provide informed consent\n* For Aim III: Age \\> 55 years\n* For Aim II: History of neurological or psychiatric disorder (as applicable per study protocol)",true,"ALL","18 Years","55 Years",{"count":21,"type":22},620,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial\u002Fscene memory, recollective experience, and familiarity processing. Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures. In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions. In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition. In Aim III, intracranial EEG recordings (including local field potentials and single-unit activity) in epilepsy surgery patients at UC Davis determine the precise network dynamics underlying spatial scene familiarity and recall. The long-term goal is to improve the prediction and prevention of cognitive morbidity from epilepsy surgery by providing a more complete model of spatial recognition memory circuits.",[28,29,30,31,32,33,34,35,36,37,38,39],"Focal Epilepsy","Temporal Lobe Epilepsy","Medically Refractory Epilepsy","Memory Disorders","Epilepsy Comorbidities","Epilepsy Intractable","Epilepsy Surgery","Epilepsy, Temporal Lobe","Memory Deficits","Memory Disorder, Spatial","Memory Dysfunction","Spatial Perception",[41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64],"spatial memory","recognition memory","familiarity","recollection","neural circuits of memory","phenomenology of memory","scene memory","virtual tour","epilepsy surgery","SEEG","stereo-electroencephalography","lesion-symptom mapping","network-symptom mapping","cognitive electrophysiology","event-related potentials","intracranial EEG","iEEG","parahippocampal gyrus","perirhinal cortex","hippocampus","tetrodes","deja vu","neuropsychology","consciousness","RECRUITING","2026-05-06",{"date":68,"type":69},"2026-05-12","ACTUAL",{"date":71,"type":69},"2024-07-01",{"date":73,"type":22},"2030-06-30",{"name":75,"class":76},"University of California, Davis","OTHER",2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100551945","changes-in-attentional-control-after-a-focal-seizure-100551945","NCT06466681","Changes in Attentional Control After a Focal Seizure.","ATTENTIONEPIF","Inclusion Criteria:\n\n* Age superior to 18 and under 80\n* Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up\n* Normal global cognitive performance (standard progressive Raven matrices score \\> 5th percentile)\n* Be affiliated to the social security system\n* Have signed an informed consent\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Not able to give consent (Article 1121-8 of the CSP)\n* Vulnerable person\n* Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP)\n* Guardianship\n* Have a high probability of not respecting the protocol or of abandoning the study\n* Absence of any epileptic seizure recorded during the hospitalization\n* Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.","80 Years",{"count":87,"type":22},100,"OBSERVATIONAL","Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.",[29,91,92],"Frontal Lobe Epilepsy","Others Subtypes",[94,95,96,97,98],"Attentional control","Focal epilepsy","Event related potentials","Functionnal connectivity","high-resolution EEG","2026-04-22",{"date":101,"type":69},"2026-04-27",{"date":103,"type":69},"2024-03-04",{"date":105,"type":22},"2027-03-09",{"name":107,"class":76},"University Hospital, Lille",1,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":108},"100608510","integrating-metabolism-connectivity-and-mesoscale-imaging-at-ultra-high-field-to-decipher-mechanisms-of-resilience-and-neurodegeneration-in-neurological-diseases-and-healthy-aging-100608510","NCT07202494","Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging","MESO7","Inclusion Criteria:\n\n* Age:Female or male, aged 18 years or older.\n* Health Status: No uncontrolled general diseases, such as cancer, autoimmune diseases, liver failure, severe or untreated high blood pressure, or severe rhythm disorders. No chronic psychiatric illnesses, including severe dementia.\n* MRI Compatibility: No contraindications for MRI exams (e.g., claustrophobia, metal foreign bodies, pacemakers, severe kidney failure).\n* Social Security Coverage: Participants must have social security coverage.\n* Informed Consent: The participant must have read, understood, and signed the informed consent after being adequately informed about the study.\n* Specific Disease Criteria (For Disease Groups): Specific inclusion criteria apply to each pathology, such as MS (based on McDonald criteria), NMOSD (Wingerchuk 2015), Alzheimer's (meeting NINCDS-ADRDA criteria), etc.\n\nExclusion Criteria:\n\n* Pregnancy: Pregnant women are excluded from the study.\n* Inability to Provide Informed Consent:\n* Any participant who refuses to sign the informed consent or is unable to do so due to mental or physical conditions.\n* Refusal of MRI: Individuals who refuse to undergo brain MRI.\n* Contraindications for MRI:Participants with contraindications for MRI exams, such as claustrophobia, metal foreign bodies, pacemakers, or severe kidney failure.\n* Medical Conditions: Known allergy to Dotarem (contrast agent) for neuroinflammatory patients. Individuals with severe renal insufficiency or other conditions that prevent MRI scanning.\n\nCognitive or Psychiatric Issues:\n\nChronic psychiatric conditions, including severe dementia or cognitive dysfunction that could hinder participation.\n\nLegal or Institutional Restrictions:\n\nAdults under legal protection (e.g., under guardianship or curatorship). Individuals deprived of their liberty.\n\nOther Medical Conditions:\n\nIndividuals with neurological diseases such as ischemic accidents, brain trauma, or encephalitis.\n\nPatients on treatments that would interfere with the study, as outlined for each disease.\n\nAllergy to Contrast Agent:\n\nAllergy to Dotarem for neuroinflammatory patients (MS, NMOSD, etc.).\n\nInability to Adhere to Protocol:\n\nParticipants who are unable or unwilling to comply with the study protocol.","90 Years",{"count":118,"type":22},700,"The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging. It leverages advanced multiparametric brain and spinal cord imaging at high (3T) and ultra-high magnetic fields (7T) to assess structural, functional, metabolic, and mesoscale changes in the central nervous system (CNS). Particular emphasis is placed on sodium (23Na-MRI) and phosphorus (31P-MRI) imaging, along with layer-dependent brain connectivity analysis.\n\nThe primary objective is to evaluate the impact of neuronal energy failure, measured via sodium concentration, on functional and structural reorganization in both healthy individuals and patients with various neurological conditions. Directed brain network models will be constructed from MRI data to quantify the connectivity strength (in- and out-degree) of cortical nodes. These connectivity metrics will be correlated with sodium concentrations to assess energy failure and its role in network reorganization. Longitudinal follow-up over two years is planned for subgroups with clinically progressive diseases.\n\nSecondary objectives include decoding metabolic, microstructural, and functional signatures of successful aging at the laminar level; characterizing disease-specific patterns of cortical and spinal microstructure associated with physical and cognitive dysfunction; describing longitudinal mesoscale and metabolic changes; and generating representative normative imaging datasets for the neuroscience community.\n\nThe study plans to enroll a total of 540 patients across 9 neurological conditions:Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD), MOG Antibody Disease (MOGAD), Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), temporal and non-temporal epilepsy, and mild traumatic brain injury (mTBI),in addition to 160 age- and sex-matched healthy controls, totaling 700 participants. Imaging and clinical assessments will be performed at the CEMEREM center at Timone University Hospital, AP-HM, Marseille, France.\n\nEach participant will undergo multiparametric brain and spinal cord MRI, including DTI, BOLD, MP2RAGE, SWI, quantitative sodium and phosphorus imaging, and functional assessments including neuropsychological testing, visual and motor function tests. Disease-specific assessments such as OCT, evoked potentials, and disability scores (e.g., EDSS for MS) will also be included when appropriate.\n\nThe study is expected to improve understanding of CNS adaptation mechanisms and support the development of more accurate diagnostic and prognostic tools for neurodegenerative diseases",[121,122,123,124,125,126,29,127,128,129],"Multiple Sclerosis","Neuromyelitis Optica Spectrum Disorders","Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)","Alzheimer Disease","Parkinson Disease","Amyotrophic Lateral Sclerosis (ALS)","Epilepsy","Mild Traumatic Brain Injury","Healthy Aging","2025-09-29",{"date":132,"type":69},"2025-10-01",{"date":134,"type":69},"2025-05-19",{"date":136,"type":22},"2030-05-18",{"name":138,"class":76},"Assistance Publique Hopitaux De Marseille",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":146,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},"100486054","intensive-preoperative-speech-rehabilitation-in-drug-resistant-temporal-epilepsy-100486054","NCT05609084","Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy","REPREO","Inclusion Criteria:\n\n1. Patient 16 years of age and older,\n2. Patient whose epileptogenic area involves the temporal structures of the hemisphere specialized for language,\n3. Patient whose hemispheric specialization for language is known\n4. Patient willing to undergo resective surgery such as anterior temporal lobectomy or resection in the temporal lobe involving the hippocampus and\u002For the baso-temporal language area and whose planned surgery date is compatible with the performance of the study,\n5. Patient with a known NTB score\n6. Patient who has signed an informed consent or patient whose parents or legal guardians have signed the informed consent (or a single parent or legal guardian if applicable)\n7. Patient whose first language is French (1st language learned by the patient),\n8. Patient declaring to be familiar with the use of a computer and having access to an internet connection from home\n9. Patient affiliated or benefiting from a social security system.\n\nExclusion Criteria:\n\n1. Patient with a speech disorder that may impair intelligibility and compromise the use of the interface;\n2. Patient with an uncorrected hearing impairment,\n3. Patients with a total intelligence quotient (IQ) \\\u003C70 (assessed in the context of care, in the year preceding the surgical procedure)\n4. Patients who are pregnant, nursing, deprived of liberty, under guardianship or curatorship.","16 Years",{"count":148,"type":22},214,[25],"Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients . Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, the investigators have developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They rely on cognitive hypotheses explaining the disorders but also on models of rehabilitation-induced neural plasticity likely to improve cognitive reserve before surgery. The investigators hypothesize that preoperative cognitive language rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative language prognosis.\n\nThe primary objective is to demonstrate the protective efficacy of preoperative speech rehabilitation on language performance postoperatively.",[127,152,29],"Anomia","2024-07-17",{"date":155,"type":69},"2024-07-18",{"date":157,"type":69},"2023-03-30",{"date":159,"type":22},"2027-11-30",{"name":138,"class":76},12]