[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"temporomandibular-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:temporomandibular-disorder":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,38,62,88,116,136,158,186,217,246,275,296,321,350,374,400,429,456,482,501,527],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100644165","an-investigation-of-cranio-cervico-mandibular-factors-predicting-the-severity-of-temporomandibular-disorders-100644165",false,"NCT07666360","An Investigation of Cranio-Cervico-Mandibular Factors Predicting the Severity of Temporomandibular Disorders","Inclusion Criteria:\n\n* Fonseca Anamnestic Index score \\> 15\n* aged 18 years and older\n\nExclusion Criteria:\n\n* Received medical, orthodontic, or physiotherapy treatment targeting the temporomandibular joint and\u002For cervical region within the past six months\n* used analgesic, anti-inflammatory, or muscle relaxant medications\n* history of cervical spine or cranio-cervical surgery or major trauma\n* a history of facial or TMJ trauma, TMJ subluxation or dislocation\n* partial or complete dental prostheses\n* had missing teeth\n* neurological, rheumatological, or systemic inflammatory diseases","ALL","18 Years","55 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","This cross-sectional study will examine the relationship between mandibular dysfunction, cervical joint position sense, craniovertebral angle, neck pain, and temporomandibular dysfunction (TMD) severity. TMD severity, mandibular function, cervical proprioception, craniovertebral angle, and neck pain history will be assessed using standardized clinical tools and questionnaires. The study will evaluate the associations between these variables and determine the factors that may predict TMD severity.",[24],"Temporomandibular Disorder","RECRUITING","2026-06-18",{"date":28,"type":29},"2026-06-24","ACTUAL",{"date":31,"type":29},"2026-06-19",{"date":33,"type":20},"2026-07-10",{"name":35,"class":36},"sevilay seda bas","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":48,"conditions":49,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":4},"100644428","postural-assessment-in-patients-with-malocclusions-100644428","NCT07664059","Postural Assessment in Patients With Malocclusions","Postural Assessment Using 3D Spine Analysis in Patients With Malocclusions","Inclusion Criteria:\n\n* Patients referred for orthodontic evaluation\n* Presence of skeletal malocclusion\n* Availability of lateral cephalometric radiograph\n* Ability to undergo three-dimensional postural assessment using the Spine 3D system\n* Patients of any age and sex\n* Provision of written informed consent by the participant or by parents\u002Flegal guardians in case of minors\n\nExclusion Criteria:\n\n* Previous orthodontic treatment\n* Previous orthopaedic treatment affecting posture\n* Presence of craniofacial syndromes or congenital anomalies\n* History of spinal surgery\n* Significant musculoskeletal disorders\n* Neurological conditions affecting posture\n* Use of medications affecting musculoskeletal function\n* Inability to undergo postural assessment\n* Lack of written informed consent",true,{"count":47,"type":20},64,"This observational cross-sectional study aims to investigate the association between skeletal malocclusions and body posture using three-dimensional postural analysis. Patients will undergo cephalometric assessment, temporomandibular disorder evaluation using the Helkimo index, and non-invasive postural evaluation using the Spine 3D system, based on rasterstereography technology. Postural parameters, including thoracic kyphosis, lumbar lordosis, trunk inclination, pelvic asymmetry, and spinal deviations, will be analysed in relation to skeletal malocclusion classes and temporomandibular disorders. The study seeks to improve the understanding of the potential interactions between the stomatognathic system and global body posture and to support a multidisciplinary diagnostic approach in orthodontic patients.",[50,24,51],"Malocclusion","Postural; Defect","NOT_YET_RECRUITING","2026-06-17",{"date":55,"type":29},"2026-06-23",{"date":57,"type":20},"2026-09-01",{"date":59,"type":20},"2028-09-30",{"name":61,"class":36},"Andrea Scribante",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":76,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":37},"100543579","k23--physical-self-regulation-vs-placebo-100543579","NCT06357702","K23- Physical Self Regulation vs Placebo","Initial Evidence for a Brief Psychological Telehealth Intervention for Patients With Chronic Masticatory Muscle Pain","Inclusion Criteria:\n\n* Have a primary or secondary chronic masticatory muscle pain diagnosis\n* Provide signed and dated electronic informed consent form\n* Willing to comply with all study procedures\n* Male or female, aged 18 or over\n* Be able to speak and write in English\n* Be seeking treatment at UKOPC\n* Have the ability to perform telehealth visits (i.e., internet access, phone, tablet, computer or other device with audio\u002Fvisual capabilities)\n\nExclusion Criteria:\n\n* Currently using anticonvulsant, steroid, antispasmodic, or opioid medication for chronic pain 2 days a week or more often\n* Have current or recent (within the last 3 months) psychotic, suicidal, homicidal, or manic symptoms. Participants with a history of such symptoms must demonstrate psychiatric stability for at least 6 months and be under the care of a medical or mental health professional for symptom management prior to being eligible for the study (must have written note from physician authorizing them to participate)\n* Patients who are currently on medication for diabetes or seizures (i.e., epilepsy) must have written clearance from their medical providers prior to participating in the study\n* History of seizures within the last 12 months\n* Pain duration less than 3 months\n* Pregnant or planning to become pregnant",{"count":70,"type":20},104,"INTERVENTIONAL",[73],"NA","This study will use a between-person design. Participants will be treatment-seeking patients with chronic masticatory muscle pain. Participants who are eligible for the study and consent to participate will be randomly assigned to receive a brief behavioral intervention for chronic orofacial pain called Physical Self-Regulation or a control intervention. Interventions will be administered via telehealth in both arms. Both interventions will consist of 2 50-minute sessions scheduled approximately two weeks apart. Participants will be contacted two weeks and three months after completing the interventions to provide additional follow-up data. Investigators hypothesize that both PSR-TH and the control intervention will demonstrate strong feasibility (i.e., recruitment of at least 1 participant per week, \\>75% retention, \\>95% interventionist fidelity, and adequate acceptability, credibility, and burden). Investigators also hypothesize that specific biopsychosocial variables will moderate PSR-TH-related changes in outcomes, and that PSR-TH-related changes in perceived control over pain, self-efficacy, coping, parafunctional habits, and relaxation will mediate treatment effects.",[24],[77,78,79],"myalgia","orofacial","telehealth","2026-06-15",{"date":53,"type":29},{"date":83,"type":29},"2024-04-04",{"date":85,"type":20},"2028-08-31",{"name":87,"class":36},"Ian Boggero, PhD",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":15,"minAge":95,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":71,"phases":98,"briefSummary":99,"conditions":100,"keywords":101,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":115},"100642417","an-open-label-study-assessing-ren-treatment-in-headache-management-in-temporomandibular-disorders-100642417","NCT07639944","An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders","An Open Label, Single-arm Multicenter Study Assessing the Safety and Efficacy of Remote Electrical Neuromodulation (Ren) in the Management of Headache, Orofacial Pain, and Other Symptoms Attributed to Temporomandibular Disorders (TMD)","Inclusion Criteria:\n\n1. Is of 12 years of age and older (inclusive; of any gender, race, or ethnicity)\n2. Meets diagnostic criteria for chronic TMD (Myalgia and\u002For Arthralgia) based on the Diagnostic Criteria for TMD (DC\u002FTMD)\n3. Has experienced TMD pain for at least 6 months\n4. Has experienced TMD pain at level ≥4 on a 0-10 scale for at least 10 days of the last 30 days\n5. Commits to not making any changes to TMD treatment regime (medication and\u002For non-medication), including not adding or removing treatment, and if on any existing treatment then maintaining the same treatment type, dosage, and frequency from 3 months prior to enrollment to study completion\n6. Naïve to REN treatment\n7. Willing and able to understand and comply with all study procedures and be available for the duration of the study\n8. Has their own smartphone or tablet device that is connected to the internet\n9. Provides a signed and dated informed consent form\n\nExclusion Criteria:\n\n1. Has any of the following medical conditions:\n\n   1.1 Uncontrolled seizures\u002Fepilepsy 1.2 Benign and malignant TMJ and masticatory muscle tumors 1.3 Presence of implanted electrical device\n2. Has experienced facial trauma or orofacial surgery within 6 weeks prior to the Screening and Baseline Visit\n3. Is undergoing current active orthodontic treatment\n4. Currently being treated with chemotherapy or radiation therapy\n5. Meets the ICHD-3 diagnostic criteria for migraine with or without aura, either chronic or non-chronic migraine\n6. Currently taking an opioid medication, whether episodically or daily, within 30 days prior to the Screening and Baseline Visit\n7. Has been treated with another investigational drug or treatment within 30 days prior to the Enrollment Visit\n8. Taking more than one prescription drug for the treatment of pain (including all types of drugs and modalities, e.g. pill, spray, injection) Note that this criterion does not refer to drug-free based treatments (including split therapy, physical therapy, acupuncture, massage therapy, biofeedback, CBT, or transcutaneous electrical nerve stimulation) for the treatment of pain, which may be used (single or multiple treatments) as long as not changed throughout the study.\n9. Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study","12 Years",{"count":97,"type":20},40,[73],"Temporomandibular disorders (TMD) encompass a group of conditions involving the masticatory muscles, temporomandibular joint (TMJ), and associated structures. TMD is the most common cause of non-odontogenic orofacial pain and is the second most commonly occurring musculoskeletal condition. Up to 70% of the general population experiences signs and\u002For symptoms of TMD, with headache presenting as one of the most common manifestations. Recent studies highlight the comorbid presence of headache and TMD, hypothesizing that a relationship likely exists between the two conditions. Headache severity has also been associated with the number of TMD symptoms such that the prevalence of headache in TMD patients. A key mechanism underlying both TMD and migraine is the deficiency in Conditioned Pain Modulation (CPM), a descending inhibitory pathway that regulates pain processing. CPM impairment has been implicated in chronic pain states, including both migraine and TMD, contributing to their frequent co-occurrence and shared pathophysiology.\n\nRemote Electrical Neuromodulation (REN) is an emerging non-pharmacological intervention that exerts its analgesic effects by activating the CPM system, which is deficient in individuals with TMD and migraine. The Nerivio REN wearable device is FDA-cleared for acute and\u002For migraine prevention, in patients 8 years of age or older. Given the evidence linking CPM dysfunction to TMD pathogenesis, REN presents a promising therapeutic approach to addressing both the underlying pain dysregulation and symptom burden in affected patients.",[24],[102,103,104],"TMD","Nerivio","Headache","2026-06-07",{"date":107,"type":29},"2026-06-10",{"date":109,"type":29},"2026-05-04",{"date":111,"type":20},"2027-01-30",{"name":113,"class":114},"Theranica","INDUSTRY",2,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":71,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":37},"100632706","evaluating-noninvasive-brain-stimulation-for-tmd-pain-a-feasibility-study-100632706","NCT07517172","Evaluating Noninvasive Brain Stimulation for TMD Pain: A Feasibility Study","Inclusion Criteria:\n\n* Age 18 to 65 years.\n* Diagnosis of temporomandibular disorder (TMD) based on the Diagnostic Criteria for Temporomandibular Disorders (DC-TMD).\n* Pain intensity of at least 4\u002F10 on the Numeric Rating Scale (NRS) over the past two weeks.\n* Chronic pain duration of at least three months, consistent with diagnosis of chronic TMD.\n* Willingness to self-administer transcutaneous auricular nerve stimulation (tAN) at home and comply with study procedures.\n* Fluency in English to ensure comprehension of study materials and assessments.\n* Access to a smartphone or computer with internet to complete electronic study surveys and check-ins with the research team.\n\nExclusion Criteria:\n\n* Neurological conditions that may interfere with study outcomes, including epilepsy, stroke, multiple sclerosis, or traumatic brain injury.\n* Use of implanted neuromodulation devices, such as vagus nerve stimulators, deep brain stimulators, or cochlear implants.\n* Unstable or severe psychiatric disorders, including active psychosis or severe depression with suicidal ideation.\n* Pregnancy or intention to become pregnant during the study period.\n* Skin conditions or other contraindications that prevent safe electrode placement on the auricular region (e.g., metal in the cymba concha that is unable or not willing to remove).\n* History of trauma (e.g., skull fracture) or periauricular surgery (e.g., temporomandibular joint replacement, acoustic neuroma removal) which would affect the location and function of the target peripheral innervation.\n* Use of both surgical and non-surgical bone conduction hearing devices.","65 Years",{"count":97,"type":20},[73],"This study is a randomized, double-blind, sham-controlled feasibility trial designed to assess the acceptability and preliminary efficacy of Transcutaneous Auricular Neurostimulation (tAN) for individuals with Temporomandibular Disorders (TMD). Approximately 40 participants will be enrolled to evaluate whether daily, home-based tAN sessions-which deliver mild electrical pulses to the auricular branch of the vagus nerve-can effectively reduce chronic orofacial pain and improve associated cognitive and psychosocial dysfunctions. The study monitors feasibility through retention and adherence rates while tracking secondary outcomes such as pain intensity, cognitive flexibility, and mood changes using validated scales and wearable smartwatch data . Ultimately, this research aims to generate the critical data necessary to inform larger clinical trials and potentially offer a non-pharmacological, non-invasive treatment option for patients refractory to traditional TMD therapies.",[24],"2026-05-28",{"date":129,"type":29},"2026-05-29",{"date":131,"type":29},"2026-05-20",{"date":133,"type":20},"2027-09-30",{"name":135,"class":36},"University of Minnesota",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":71,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":152,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":37},"100604714","r01pilot-jaw-muscle-phenotypes-100604714","NCT07153107","R01_Pilot Jaw Muscle Phenotypes","R01_PilotStudy2_Jaw Muscle Metabolic and Brain-Derived Phenotypes of Chronic TMD Pain","Inclusion Criteria:\n\n* Provide signed and dated informed consent form.\n* Willing to comply with all study procedures and be available for the duration of study participation.\n* Be 18 years or older.\n* Have a minimum set of teeth present, be it natural, implant-supported or fixed prosthodontics: all anterior teeth (incisors, canines), at least one premolar, at least one molar (first or second molar; third molars not considered).\n* TMD-Pain screener score equal to or greater than 3\n* Myalgia (masticatory muscle pain) based on clinical exam following the DC\u002FTMD protocol\n* Concurrent arthralgia (TMJ pain) and\u002For headache attributed to TMD allowed\n* Myofascial pain must meet the following criteria:\n\n  1. Onset \\>3 months, occurring \\>15 days\u002Fmonth on average in the last three months from the screening session\n  2. Minimum of 10 jaw pain episodes since onset, each episode lasting at least 30 minutes and no less than 2 hours within the day, OR unremitting\n\nExclusion Criteria:\n\n* Traumatic facial injury or surgery on the face\u002Fjaw, arms or hands;\n* Presence of pain related to dental and periodontal pathology;\n* Currently undergoing active orthodontic treatment;\n* Pregnant;\n* Has any of the following medical conditions by self-report:\n\n  1. Renal failure or dialysis,\n  2. Heart disease (examples: uncontrolled arrythmia or hypertension, cardiomyopathy) or heart failure, Non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema),\n  3. Diabetes (type I or II) that is not controlled with medication or diet,\n  4. Hyperthyroidism,\n  5. Uncontrolled seizures;\n* Used any injection therapy (e.g., tender or trigger point injections, steroid injections), acupuncture, biofeedback, or TENS for the management of facial\u002Fjaw pain within 2 weeks prior to the screening assessment; If undergoing botulinum toxin injections in the head and neck area, must be 3 months since last set of injections and refrain from this treatment until study participation has ended\n* History of major depression or other major psychiatric disorder requiring hospitalization within the last 6 months prior to the screening assessment;\n* History of treatment for drug or alcohol abuse within the last 12 months;\n* Current pain medication use (e.g., opioids, ibuprofen, acetaminophen) that cannot be stopped \\\u003C24 hours prior to each study visit;\n* Current use of medically prescribed muscle relaxants for the duration of study participation;\n* Other conditions\u002Fdiseases associated with altered pain perception: neurological or development disorders (dementia, autism spectrum disorder), neoplasm, multiple sclerosis, trigeminal neuralgia;\n* Adults lacking capacity to provide informed consent for themselves;\n* Unable to understand instructions for study procedures in English.\n* Anything that would place the individual at increased risk or preclude the individual's full compliance with study procedures or completion of the study.\"",{"count":144,"type":20},10,[73],"The proposed study will assess the effect of local heat therapy on jaw pain and jaw fatigue secondary to a teeth clenching task in chronic TMD pain cases. Researchers expect that most participants will respond to heat therapy and consequently experience reduced jaw pain and fatigue during teeth clenching. The study will assess the clinical characteristics of those participants who respond and do not respond to local heat therapy, in order to determine the common clinical characteristics for those in each response category.",[148,24],"Chronic TMD Pain",[150,151],"Jaw Pain","Local Heat Therapy",{"date":129,"type":29},{"date":154,"type":20},"2026-07-13",{"date":156,"type":20},"2027-01-12",{"name":135,"class":36},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":71,"phases":167,"briefSummary":168,"conditions":169,"keywords":174,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":37},"100638314","arthroscopic-lysis-and-lavage-with-and-without-intra-articular-injection-of-hyaluronic-acid-in-patients-with-ddwor-in-tmj-100638314","NCT07614932","Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ","Assessment of Arthroscopic Lysis and Lavage With And Without Intra-Articular Injection of Hyaluronic Acid in the Management of Patients With Disc Displacement Without Reduction: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adults above 18 years old.\n2. Diagnosis of Disc Displacement Without Reduction (DDWOR) with limited mouth : eitherunilateral or bilateral based on the DC\u002FTMD and confirmed with MRI\n3. History of unsuccessful conservative treatment such as physical therapy, occlusal splints,or medications (e.g., NSAIDs, muscle relaxants) for at least 3 months.\n4. Patients must sign the informed consent, understand the study procedures and potential risks, accept to volunteer in the study and be available to attend the follow-up visits.\n\nExclusion Criteria:\n\n1. Degenerative Temporomandibular Joint Disorders (e.g., osteoarthritis, rheumatoid arthritis).\n2. History of prior TMJ surgery (e.g., joint replacement, previous arthroscopy).\n3. Severe Systemic Conditions (e.g., cardiovascular disease, autoimmune disorders, uncontrolled diabetes).\n4. Active joint infection, acute inflammation, or presence of any condition that may increase the risk of complications from arthroscopic surgery or injections (e.g., local infection, uncontrolled bleeding disorders).\n5. Pregnancy or Breastfeeding.\n6. Patients with severe Psychological Conditions (e.g., severe depression, psychosis, myofascial pain disorder) or dental related pain will be identified at the initial assessment and referred for appropriate psychological, behavioural, or dental management prior to inclusion in the study.",{"count":166,"type":20},52,[73],"The study aims to assess the outcomes of arthroscopic lysis and lavage procedure with and without single intra-articular injection of hyaluronic acid in managing patients with anterior disc displacement without reduction.\n\nThe research question that this study will answer is:\n\nDoes arthroscopic lysis and lavage combined with hyaluronic acid provide better outcomes in terms of pain intensity and maximum mouth opening compared to arthroscopic lysis and lavage alone?",[170,171,172,24,173],"TMJ Disc Disorder","Temporomandibular Joint Disc Displacement, Without Reduction","TMD\u002FOrofacial Pain","TMJ Closed Lock",[175,176,177],"TMJ arthroscopy","TMJ arthroscopic lysis and lavage","Anterior Disc Displacement without reduction","2026-05-22",{"date":129,"type":29},{"date":181,"type":20},"2026-05",{"date":183,"type":20},"2027-01",{"name":185,"class":36},"Cairo University",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":71,"phases":197,"briefSummary":198,"conditions":199,"keywords":203,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":115},"100532601","neural-mechanisms-of-immersive-virtual-reality-in-chronic-pain-vr-tmd-eeg-100532601","NCT06214923","Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)","Neural Mechanisms of Immersive Virtual Reality in Chronic Pain","VR TMD EEG","Inclusion Criteria:\n\n* Age (18-88 years)\n* English speaker (written and spoken)\n* Temporal Mandibular Disorder (TMD) for at least 3 months\n* TMD Grade Chronic Pain Scale (GCPS) ≥ 0\n\nExclusion Criteria:\n\n* Present or past degenerative neuromuscular disease\n* Cardiovascular, neurological diseases, pulmonary abnormalities, kidney disease, liver disease, history of cancer within past 3 years\n* Cervical pain (e.g. stenosis, radiculopathy)\n* Any personal (or family first degree) history of mania, schizophrenia, or other psychoses\n* Severe psychiatric condition (e.g. schizophrenia, bipolar disorders, autism) leading to hospitalization within the last 3 years.\n* Use of Antipsychotics (e.g., Risperdal, Ability and clozaril)Lifetime alcohol\u002Fdrug dependence or alcohol\u002Fdrug abuse in past 3 months\n* Pregnancy or breast feeding\n* Color-blindness\n* Impaired or uncorrected hearing\n* Non-dominant hand\n* Any facial trauma that has occurred in the last 6 weeks\n* History of a severe facial trauma in the last 2-3 months\n* Conditions that would interfere with the VR mask placement (e.g. trauma, burn, infection)\n* Known history of severe motion sickness\n* Non-removable head cover, artificial hair, certain types of braids or dreadlocks\n* History of fainting\n* History of angioedema\n* Failed drug test (testing for opiates, cocaine, methamphetamines, and amphetamines)","88 Years",{"count":196,"type":20},78,[73],"This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.",[200,201,202,24],"Pain","Virtual Reality","Placebo",[204,205,206,207],"TMD volunteers","VR","Clinical Pain","Ecological Momentary Assessment","2026-01-22",{"date":210,"type":29},"2026-01-26",{"date":212,"type":29},"2024-04-09",{"date":214,"type":20},"2026-11-30",{"name":216,"class":36},"University of Maryland, Baltimore",{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":45,"sex":15,"minAge":16,"maxAge":224,"enrollmentInfo":225,"targetDuration":4,"studyType":71,"phases":227,"briefSummary":228,"conditions":229,"keywords":231,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":37},"100544151","an-algorithm-for-approaching-temporomandibular-disorders-with-osteopathic-manual-therapy-in-patients-with-fibromyalgia-100544151","NCT06365151","An Algorithm for Approaching Temporomandibular Disorders With Osteopathic Manual Therapy in Patients With Fibromyalgia","Effectiveness of an Algorithm for Approaching Temporomandibular Disorders With Osteopathic Manual Therapy in Patients With Fibromyalgia","Inclusion Criteria:\n\n* be diagnosed as suffering from fibromyalgia,\n* present moderate pain or dysfunction of more than 3 months' duration in the temporomandibular joint,\n* be over 18 years old,\n* understand Spanish and\u002For Catalan correctly,\n* and read and accept the informed consent form\n\nExclusion Criteria:\n\n* history of trauma or recent surgery to the head, face or neck;\n* systemic, rheumatic or central nervous system diseases;\n* diagnosis of malignant tumors or cancer in the orofacial region;\n* participate in other studies at the same time.","75 Years",{"count":226,"type":20},114,[73],"Nowadays, fibromyalgia is the rheumatic disorder with the highest levels of deterioration in quality of life. Among the comorbidities it presents, one of the most frequent is temporomandibular disorders. A randomized clinical study will be conducted to evaluate the effectiveness of an osteopathic manual therapy approach algorithm in a group of patients with fibromyalgia and temporomandibular disorders.",[230,24],"Fibromyalgia",[232,233,234,235,236],"temporomandibular joint disorders","fibromyalgia","Osteopathic medicine","chronic pain","musculoskeletal manipulations","2025-08-27",{"date":239,"type":29},"2025-09-04",{"date":241,"type":29},"2024-04-05",{"date":243,"type":20},"2026-04-05",{"name":245,"class":36},"Universitat de Lleida",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":71,"phases":255,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":37},"100602583","low-level-laser-auriculotherapy-in-the-treatment-of-myogenic-temporomandibular-disorders-and-anxiety-100602583","NCT07125404","Low-Level Laser Auriculotherapy in the Treatment of Myogenic Temporomandibular Disorders and Anxiety","Effectiveness of Low-Level Laser Auriculotherapy in the Treatment of Myogenic Temporomandibular Disorders and Anxiety: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Clinical diagnosis of unilateral or bilateral myogenic temporomandibular disorder (TMD) based on DC\u002FTMD criteria.\n* Presence of myalgia or myofascial pain in the masticatory muscles, either spontaneous or induced by clinical palpation.\n* At least one episode of local, referred, or radiating masticatory pain in the past 30 days, lasting at least one hour.\n* Score ≥ 5 on the Generalized Anxiety Disorder 7-item scale (GAD-7), indicating generalized anxiety.\n\nExclusion Criteria:\n\n* Recent musculoskeletal injury in the cervical region.\n* Skin lesions or dermatological conditions on the auricle.\n* Regular use of medications such as corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), or photosensitizing agents (e.g., tetracyclines, quinolones, sulfonamides).\n* Tattoos on or near the auricular area.\n* History of cancer or tumors within the past five years.\n* Fitzpatrick skin phototype V or VI.\n* Autoimmune diseases (e.g., lupus erythematosus, hepatic porphyria, pellagra).\n* Epilepsy.\n\nDiscontinuation Criteria\n\n\\- The participant's withdrawal or non-attendance results in the failure to complete the evaluation or treatment protocol.",{"count":254,"type":20},32,[73],"Summary:\n\nLow-level laser auriculotherapy (LLLT-AT) is a non-invasive technique that has gained attention for managing musculoskeletal pain and anxiety. Given the painful and emotional components of temporomandibular disorders (TMD), LLLT-AT may offer therapeutic benefits by stimulating auricular points associated with pain modulation and anxiety reduction. This randomized, placebo-controlled, two-arm clinical trial with blinded outcome assessors aims to evaluate the effects of LLLT-AT in individuals diagnosed with myogenic TMD (Axis I, Group I of the DC\u002FTMD classification) and anxiety. The study will be conducted at the Physical Agents Laboratory of Universidad Andrés Bello. Eligible participants will include members of the university community with myogenic TMD (Axis I, Group I of the DC\u002FTMD classification) and anxiety. Participants will be stratified by sex and randomly assigned to either an experimental group receiving LLLT-AT combined with a standardized myofascial release protocol or a control group receiving sham LLLT-AT with the same myofascial protocol. Interventions will be administered twice weekly for three weeks. Outcome measures will be collected at baseline, post-intervention, and at a four-week follow-up. Primary outcomes include pressure pain threshold (PPT), assessed by algometry, and anxiety level, measured using the GAD-7 scale. Secondary outcomes include maximum mouth opening range of motion (MMOROM) and mandibular functional limitation (MFL), assessed using the Jaw Functional Limitation Scale 8 (JFLS-8).",[24,258],"Anxiety State",[260,261,262,263,264,265],"Laser Therapy","Low-level Light Therapy","Auriculotherapy","Joint Disorders","Temporomandibular Joint Dysfunction Syndrome","Anxiety","2025-08-12",{"date":268,"type":29},"2025-08-15",{"date":270,"type":20},"2025-09-01",{"date":272,"type":20},"2026-05-01",{"name":274,"class":36},"Quiropraxia y Equilibrio",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":281,"eligibilityCriteria":282,"healthyVolunteers":45,"sex":15,"minAge":16,"maxAge":122,"enrollmentInfo":283,"targetDuration":4,"studyType":71,"phases":284,"briefSummary":285,"conditions":286,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":37},"100536500","electrical-stimulation-of-the-mandibular-nerve-for-pain-and-function-management-in-temporomandibular-disorders-100536500","NCT06265636","Electrical Stimulation of the Mandibular Nerve for Pain and Function Management in Temporomandibular Disorders","Transcutaneous Mandibular Nerve Electrical Stimulation for the Management of Pain and Function in Patients With Temporomandibular Disorders","Origenkine","Inclusion Criteria:\n\n* Patients with local myofascial pain and\u002For increased tension in the masticatory muscles.\n* Patients with myofascial pain from temporomandibular disorder (TMD) at the time, diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC\u002FTMD).\n* Absence of temporomandibular disc displacement with or without reduction.\n* Pain in the masticatory muscles associated with limited mouth opening (\\\u003C40mm).\n* Good general health (absence of chronic diseases that may affect the temporomandibular joint or masticatory muscles).\n* Written consent to participate in the study.\n\nExclusion Criteria:\n\n* Injury to the face or head during the research participation.\n* Undergone surgical procedures performed in the craniocervical region and degenerative neurological diseases.\n* Sudden illness of the patient that prevented participation in the study.\n* Will to end participation in the study.\n* Less than 2 weeks of evolution.\n* Inability to understand instructions or sign the informed consent.\n* Minor patients.\n* Regular medication, such as muscle relaxants, anticonvulsants, antidepressants, or anxiolytics\n* Facial paralysis.\n* Presenting a disease or infectious\u002Finflammatory process of dental origin.",{"count":97,"type":20},[73],"Temporomandibular disorders (TMD) encompass dysfunction and pain of the masticatory muscles and temporomandibular joint (TMJ). Pain in the TMJ, restricted jaw movement, and joint sounds are common conditions in this disorder. This can impact patients' ability to perform daily activities such as eating, speaking, laughing, or yawning, significantly affecting their quality of life.\n\nThe TMJ and masticatory muscles are innervated by the auriculotemporal branch and the mandibular nerve (V3), a branch of the trigeminal nerve. An estimated 60% to 70% of the population shows signs of TMD, of which up to 12% report intense symptoms requiring treatment.\n\nPercutaneous electrical nerve stimulation (PENS) could be a clinically relevant therapy in TMD patients applied through minimally invasive physiotherapy. To our knowledge, there are no trials evaluating the non-surgical clinical efficacy of PENS on the mandibular nerve.\n\nThe project's objective is to assess the effectiveness of PENS on the mandibular nerve in this type of condition.",[24],"2025-07-31",{"date":289,"type":29},"2025-08-05",{"date":291,"type":29},"2024-02-17",{"date":293,"type":20},"2027-05-01",{"name":295,"class":36},"OrigenKinesis fisioterapia",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":45,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":320},"100539049","validation-and-evaluation-of-the-mastication-function-in-adults-the-functional-six-minute-mastication-test-f-6mmt-100539049","NCT06298786","Validation and Evaluation of the Mastication Function in Adults: The Functional Six-minute Mastication Test (F-6MMT).","F-6MMT","Inclusion Criteria:\n\n* Women and men of legal age\n* With or without TMDs symptoms and\n* With or without self-reported jaw fatigue when eating\n\nExclusion Criteria:\n\n* Subjects treated with any type of treatment requiring infiltration of the mandibular region\n* Participants undergoing dental interventions in the last 3 months\n* Individuals missing two or more teeth in the same quadrant.\n* Inability to understand or speak catalan, spanish or english.",{"count":304,"type":20},514,"Temporomandibular Disorders (TMD) encompass various conditions that affect the temporomandibular joint and associated tissues, often causing or being associated with other symptoms such as jaw pain, myofascial pain, neck pain, and headaches. TMDs are classified according to the DC\u002FTMD instrument in which the joint and pain axes are evaluated. However, there is no evaluation of mandibular function, and TMDs can result in a decrease in jaw strength and resistance. This leads to an increase in the chewing fatigue. Reliable and time-effective diagnostic methods for evaluating masticatory function are crucial in the clinical setting because of the high prevalence of TMD. Chewing efficiency is essential for food preparation and nutrient absorption, and muscle fatigue is a common problem affecting chewing ability. Despite this, there is a lack of validated tests to evaluate chewing fatigue in patients with TMD, which makes its consideration unnoticed in clinical practice.\n\nThe modified six-minute functional chewing test (F-6MMT) was proposed as a tool to evaluate chewing ability and fatigue in patients with TMD. This test is an adaptation of a previously designed test in which subjects with mitochondrial pathology were evaluated; however, the subjects were not instructed to perform functional chewing during the test. In this version, modifications are added so that the test is as functional as possible, allowing chewing to be evaluated in a standardized way, and cut-off points established between healthy subjects and subjects with TMD in terms of chewing capacity in general and fatigue in particular. This study will follow standardized reporting guidelines and recruit participants from diverse clinical settings.",[307,308,24,309,310],"Mastication Disorder","Fatigue","Orofacial Pain","Chewing Problem","2025-05-12",{"date":313,"type":29},"2025-05-15",{"date":315,"type":20},"2025-09",{"date":317,"type":20},"2026-04",{"name":319,"class":36},"Fundació Universitària del Bages",3,{"id":322,"slug":323,"hasResults":11,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":328,"minAge":16,"maxAge":329,"enrollmentInfo":330,"targetDuration":4,"studyType":71,"phases":332,"briefSummary":333,"conditions":334,"keywords":336,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":37},"100457131","how-is-aerobic-exercise-compared-to-localized-pain-relief-exercises-in-patients-with-jaw-pain-and-neck-pain-100457131","NCT05232604","How is Aerobic Exercise Compared to Localized Pain Relief Exercises in Patients With Jaw Pain and Neck Pain?","How is Aerobic Exercise Compared to Localized Pain Relief Exercises in Patients With Jaw Pain and Neck Pain? Pilot Study","Inclusion Criteria:\n\n* Be between 18-60 years of age\n* Be diagnosed with idiopathic chronic neck pain as described the IASP and\u002For presence of temporomandibular disorders identified by DC\u002FTMD screening\n* Have pain in the neck or jaw area for at least 3 months (chronic pain)\n* Have pain not attributable to recent acute trauma, previous infection, or to an active inflammatory cause in the last month\n* Have a moderate or severe baseline pain score of 30mm or greater using a 100mm VAS\n\nExclusion Criteria:\n\n* Present red flags for serious pathologies related to neck pain or jaw pain\n* Report comorbidity functional chronic pain disorders (e.g., fibromyalgia)\n* Have been diagnosed with psychiatric disorders (e.g., depression, schizophrenia)\n* Have received therapy within 3 months prior to entry into the study","FEMALE","60 Years",{"count":331,"type":20},42,[73],"Musculoskeletal (MSK) disorders are some of the most burdensome health issues in the world and the leading causes of years living with a disability. Between them, jaw pain and neck have been very prevalent among the general population. Subjects with chronic neck and jaw pain present with persistent pain, allodynia, and hyperalgesia, sometimes extending to regions distant from the neck, head, or face, as well as cognitive and motor dysfunction. In addition, both conditions are commonly related to pain in other anatomical regions, and they also might also exhibit a greater risk for pain-associated somatic symptom burden.\n\nThe treatment for patients with neck and jaw could involve different techniques in the rehabilitation area. Between them, therapeutic exercise is a cornerstone of MSK disease rehabilitation. Although mechanisms of action for exercise in subjects with pain are not yet understood, therapeutic exercise is widely applied in a variety of painful MSK conditions, such as low back pain, shoulder pain, knee pain, osteoarthritis, and disorders of the cervical and craniofacial regions such as temporomandibular disorders, headaches, and neck pain. Besides its effects on function and health, therapeutic exercise is known to have some pain-relieving effects and specific motor control exercises targeted to the neck can enhance the neural control of the cervical spine in patients with neck involvement such as patients with jaw and neck pain.\n\nPrevious studies have demonstrated that treatment directed to the neck may be beneficial in decreasing pain intensity in the masticatory muscles, increasing pain-free mouth opening, and decreasing pain in the head and neck regions in people with jaw pain. In addition, neck motor control exercises have been successful to manage chronic neck pain and cervicogenic headache. Subjects with neck pain and associated disorders receiving neck motor control exercises had a reduction of pain and improved quality of life. Another option that has been explored to relieve MSK pain is aerobic exercise. Aerobic exercise has been used to stimulate the release of pain-relieving peptides in healthy human beings; however, little is known about the analgesic effect of exercise in people suffering from actual musculoskeletal pain. Previous literature found positive results in favor of aerobic exercise for pain relief. However, none of them included patients with jaw and neck-related disorders. Therefore, the aim of the present pilot randomized controlled trial (RCT) is to test the effectiveness of local craniocervical motor control exercises when compared with aerobic exercise on pain-disability related outcomes such as pain intensity, pain pressure thresholds (PPTs), jaw and neck disabilities and to restore normal muscular performance and fatigability of the cervical muscles in people with jaw and neck pain. Also, an important objective for performing this pilot study is to test the feasibility of these protocols and gather data that will be the basis for applying to external funding.\n\nThis study will be a randomized controlled trial, blinded, two-armed parallel group. It will include women between 18-60 years of age; diagnosed with temporomandibular disorders (i.e., jaw pain) classified by the new Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD); or diagnosed with idiopathic chronic neck pain associated or not with TMD. Because this is an exploratory (pilot) study it will include at least 21 subjects per treatment group. The primary outcome will be pain intensity evaluated by the Visual Analogue Scale (VAS), and the secondary outcomes will be Neck Disability Index; Jaw Function; Pressure Pain Threshold; Psychological functioning; Global Rating Scale; and Muscular performance and fatigability of the cervical muscles. The patients will be randomized into two groups: local craniocervical motor control exercises and aerobic exercise. The local craniocervical motor control exercises program will be focused on training the deep and superficial flexors and extensors neck muscles. The treatment will consist of a 12-week progressive training program with a total duration of 30-45 min per session. Individuals assigned to the aerobic exercise will receive cycling exercise, with a total duration of 60 minutes. Both groups will be evaluated before the treatment starts (baseline); after two and six weeks from the beginning of treatment (1st and 2nd partial evaluation); at the end of the treatment (final evaluation - 12 weeks); and after three and six months of the end of the treatment (1st and 2nd follow-up).",[24,335],"Neck Pain",[337,338,339,340],"Temporomandibular disorder","Neck pain","Exercise therapy","Motor control exercise","2025-05-08",{"date":343,"type":29},"2025-05-13",{"date":345,"type":29},"2021-10-07",{"date":347,"type":20},"2026-07-31",{"name":349,"class":36},"Hochschule Osnabruck",{"id":351,"slug":352,"hasResults":11,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":11,"sex":328,"minAge":16,"maxAge":357,"enrollmentInfo":358,"targetDuration":4,"studyType":71,"phases":360,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":37},"100588456","phase-3-botulinumtoxin-a-as-a-treatment-for-myalgia-and-myofacial-pain-in-patient-with-temporomandibulardisorders-100588456","NCT06941636","Botulinumtoxin A as a Treatment for Myalgia and Myofacial Pain in Patient With Temporomandibulardisorders","Botulinumtoxin A as a Treatment for Myalgia and Myofacial Pain in Patient With Temporomandibulardisorders - a Quality Study Associated to a New Treatment Routine","Inclusion Criteria:\n\n* Has given a written consent\n* Diagnose of myalgia, myofacial pain or myofascial pain with referred pain according\n* Average pain due to NRS ≥ 3 for more than three months\n* Palpationpain in masseter or temporalis.\n* Eventual treatment for orofacial pain \\> three months ago.\n* Adequate contraceptives and a negative pregnancy test.\n\nPatients will still be included even if they have one or more co-diagnoses\n\n* Discdisplacement with or without reduction\n* Degenerative joint disease\n* Arthralgia\n\nExclusion Criteria:\n\n* Treatment with BTX during the last 12 months\n* Treatment for orofacial pain within the last 3 months.\n* Systemic inflammatory diseases (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis)\n* Widespread pain e.g., fibromyalgia\n* Neuropathic pain\n* Neurologic disease (myasthenia gravis)\n* Pain of dental origin\n* Use of muscle relaxants, or aminoglycoside antibiotics\n* Pregnancy or nursing\n* Hypersensitivity to BTX\n* Neuropsychiatric conditions.\n* Difficulties understanding the Swedish language","50 Years",{"count":359,"type":20},90,[361],"PHASE3","Both patients and remitters ask for treatment with Botulinumtoxin A (BTX) with the hope that it will be an effective aid for pain, but little is known regarding if the effect is dose dependent.\n\nThe aim of this project is to investigate if injections with BTX in the masseter- and temporal muscle is an efficient treatment in patient with myogenous temporomandibular disorders (TMD) and if the effect of BTX is dose dependent.",[24],"2025-04-22",{"date":366,"type":29},"2025-04-24",{"date":368,"type":20},"2025-05-01",{"date":370,"type":20},"2026-12-01",{"name":372,"class":373},"Region Stockholm","OTHER_GOV",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":381,"enrollmentInfo":382,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":384,"conditions":385,"keywords":387,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":115},"100530442","cognitive-exercise-therapy-approach-biopsychosocial-questionnaire-bety-bq-in-patient-with-temporomandibular-disorders-100530442","NCT06186830","Cognitive Exercise Therapy Approach Biopsychosocial Questionnaire (BETY-BQ) in Patient with Temporomandibular Disorders","Validity, Reliability and Responsiveness of the Cognitive Exercise Therapy Approach Biopsychosocial Questionnaire in Individuals with Temporomandibular Disorder","Inclusion Criteria:\n\n* Having received a diagnosis of temporomandibular disorder\n\nExclusion Criteria:\n\n* Experiencing difficulty in cooperating to fill out the questionnaires\n* Being unwilling to participate in the study","64 Years",{"count":383,"type":20},150,"The aim of this study is to investigate the validity, reliability, and responsiveness of the Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire (BETY-BQ) in individuals with temporomandibular disorder. The following are alternative hypotheses of the study:\n\n* BETY-BQ has significant convergence with the Patient Health Questionnaire-9 measuring depression.\n* BETY-BQ has significant convergence with the Patient Health Questionnaire-15 measuring physical symptoms.\n* BETY-BQ has significant convergence with the Generalized Anxiety Disorder-7 measuring anxiety.\n* BETY-BQ has significant convergence with the Short Form-36 measuring quality of life.\n* BETY-BQ has significant convergence with the Craniomandibular Pain and Disability Inventory measuring disability.\n* BETY-BQ has significant convergence with the Mandibular Function Impairment Questionnaire measuring function.\n* BETY-BQ has significant stability.\n* BETY-BQ has significant internal consistency.",[24,386,264],"Temporomandibular Joint Disorders",[388,389,390],"validity","reliability","responsiveness","2025-03-11",{"date":393,"type":29},"2025-03-13",{"date":395,"type":29},"2023-12-17",{"date":397,"type":20},"2025-08",{"name":399,"class":36},"Hacettepe University",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":329,"enrollmentInfo":407,"targetDuration":4,"studyType":71,"phases":409,"briefSummary":410,"conditions":411,"keywords":412,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":37},"100439797","tele-rehabilitation-in-patients-with-temporomandibular-dysfunction-100439797","NCT05006963","Tele-Rehabilitation in Patients With Temporomandibular Dysfunction","Tele-Rehabilitation in Patients With Temporomandibular Dysfunction: Randomized, Controlled and Blind","1. Age between 18 and 60 years;\n2. presence of pain in the facial region in the last 6 months;\n3. diagnosis of myalgia, arthralgia, headache attributed to temporomandibular disfunction and\u002For subluxation temporomandibular joint.",{"count":408,"type":20},50,[73],"Temporomandibular disorder or TMD is characterized by a set of symptoms such as: pain, decreased range of motion and joint noise. It's origin is multifactorial, which may be related to biological aspects, environmental and psychosocial. The multimodal approach has been widely used in physiotherapy for the treatment of TMDs. Physiotherapy has been walking together with technology so that telerehabilitation can be a reality, contributing so that quality care reaches the patient, in the impossibility office-to-face service. The objective of this study is to verify the effect of telerehabilitation on pain outcomes, range of motion, functionality and biopsychosocial aspects in individuals with temporomandibular disorders. Will be a randomized, controlled and blinded clinical trial was carried out. The study will be divided into two moments: evaluation and intervention. Evaluations will be carried out using the Diagnostic Criteria for Temporomandibular Disorders: Clinical Protocol and Assessment Instruments (DC\u002FTMD), the Fonseca Anamnesis Index (IAF), the Numerical Pain Scale (END) and the Functional Limitation Questionnaire (MFIQ). Individuals will be randomized into 2 groups: Group A (in person) Group B (telerehabilitation). Both groups will receive treatment physical therapy for 12 weeks. After collecting the data, they will be tabulated and analyzed using a 5% significance level.",[24,386,264],[232,413,414,415,416,79,417,418,419],"clinical protocols","physiotherapy","remote consultation","telemedicine","telerehabilitation","teletherapy","telepractice","2025-02-27",{"date":422,"type":29},"2025-03-04",{"date":424,"type":29},"2021-09-30",{"date":426,"type":20},"2027-03-30",{"name":428,"class":36},"University of Nove de Julho",{"id":430,"slug":431,"hasResults":11,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":11,"sex":328,"minAge":16,"maxAge":436,"enrollmentInfo":437,"targetDuration":4,"studyType":71,"phases":439,"briefSummary":440,"conditions":441,"keywords":443,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":447,"lastUpdatePostDateStruct":448,"startDateStruct":450,"completionDateStruct":452,"leadSponsor":454,"locationsCount":37},"100554538","temporomandibular-disorder-in-use-of-levonorgestrel-intrauterine-system-100554538","NCT06500390","Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System","Is the Incidence of Temporomandibular Disorder Increased in the Use of Levonorgestrel Intrauterine System","Inclusion Criteria:\n\n* Being a woman\n* Having used an intrauterine device for at least 3 months\n* Being between the ages of 18-50\n* Being in American Society of Anesthesiologists-1 and American Society of Anesthesiologists-2 systemic status\n\nExclusion Criteria:\n\n* Patients with craniofacial syndrome\n* Patients with a history of head and neck trauma\n* Isolated muscle tenderness or previous surgery on TMJ\n* Patients with rheumatological disorders\n* Patients with an additional gynecological disease other than endometriosis\n* Lack of cooperation with the patient.","45 Years",{"count":438,"type":20},100,[73],"The goal of this clinical trial is to investigate the possible role of levonorgestrel intrauterine system use(LIU) in the pathogenesis of temporomandibular joint disorder (TMD). In this clinical trial, levonorgestrel intrauterine system patients (n=30) aged 25-50 and control group patients (n=30) with the same demographics and age range are used. The main questions it aims to answer are:\n\nTo compare the frequency of temporomandibular dysfunction in women using the levonorgestrel intrauterine system with the control group of the same demographic and age range.\n\nThe levonorgestrel intrauterine system use group consisted of 50 women who had previously a mirena implanted by a gynecologist at least 3 months ago due to menstrual bleeding and pelvic pain.\n\nThe control group included 50 randomised healthy women who had regular menstrual cycles and were not taking any medication.",[442,386,24],"Levonorgestrel Adverse Reaction",[444,445,446,337],"Mirena","Levonorgestrel","Intrauterine system","2024-11-21",{"date":449,"type":29},"2024-11-25",{"date":451,"type":29},"2024-01-15",{"date":453,"type":20},"2024-12-15",{"name":455,"class":36},"Marmara University",{"id":457,"slug":458,"hasResults":11,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":463,"enrollmentInfo":464,"targetDuration":4,"studyType":71,"phases":466,"briefSummary":467,"conditions":468,"keywords":469,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":37},"100554721","efficacy-of-therapeutic-exercise-and-pain-neurophysiology-education-in-temporomandibular-disorders-100554721","NCT06502769","Efficacy of Therapeutic Exercise and Pain Neurophysiology Education in Temporomandibular Disorders","Efficacy of Therapeutic Exercise and Pain Neurophysiology Education in Temporomandibular Disorders: a Single-blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Over 18 years of age\n* Limitation of mouth opening and\u002For jaw pain lasting more than 6 months\n* Being able to understand the objective and carry out the study procedures\n* Sign the informed consent.\n\nExclusion Criteria:\n\n* Suffer from any underlying disease\n* Pain due to tumors or infections, metastases, osteoporosis, inflammatory arthritis or fractures\n* Be receiving any other treatment for TMD or consuming some type of substance that alters muscle tone.\n* Patients with myopathies, diseases of the Peripheral Nervous System, mental disorders diagnosed by a doctor\n* Inability to collaborate\n* Any other situation in which the evaluation could be altered.","80 Years",{"count":465,"type":20},36,[73],"The aim of this study is to compare the effects in pain of two different treatments in pacients with temporomandibular disorders (TMD). One group will receive isolated therapeutic exercise (TE) and the other will receive TE combined with pain neurophysiology education (PNE). The hypothesis of this study is that the PNE+TE group will obtain superior therapeutic results than an isolated TE program.",[24],[470,471,472],"therapeutic exercise","pain neurophysiology","temporomandibular disorder","2024-07-09",{"date":475,"type":29},"2024-07-16",{"date":477,"type":20},"2024-09-01",{"date":479,"type":20},"2026-09-30",{"name":481,"class":36},"University of Alcala",{"id":483,"slug":484,"hasResults":11,"nctId":485,"briefTitle":486,"officialTitle":487,"acronym":4,"eligibilityCriteria":488,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":224,"enrollmentInfo":489,"targetDuration":4,"studyType":71,"phases":490,"briefSummary":491,"conditions":492,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":496,"completionDateStruct":498,"leadSponsor":500,"locationsCount":37},"100452142","intraoral-versus-extraoral-manual-therapy-in-subjects-with-temporomandibular-disorders-100452142","NCT05167656","Intraoral Versus Extraoral Manual Therapy in Subjects With Temporomandibular Disorders","Intraoral Versus Extraoral Manual Therapy in Subjects With Temporomandibular Disorders. A Randomized Controlled Trial","Inclusion Criteria:\n\n* Unilateral temporomandibular pain for more than one month.\n* Older than eighteen.\n* No previous treatment to temporomandibular pain in the last 3 months.\n* Diagnosed based on the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD).\n\nExclusion Criteria:\n\n* Patients with cervical or cranial trauma or whiplash.\n* Diagnosed with systemic disease, like rheumatoid arthritis or fibromyalgia.\n* Diagnosed of any vascular or metabolic disease.\n* Previous cervical or temporomandibular surgery.\n* Dental, medicine or any physical therapy treatment in the last 3 months before the beginning of the interventions.",{"count":359,"type":20},[73],"The aim of this randomized controlled trial is to evaluate the effects of intraoral manual therapy versus extraoral manual therapy and compare them with a control group, in the management of patients with temporomandibular disorders regarding pain, strength, quality of life, disability and anxiety.",[24],"2024-05-13",{"date":495,"type":29},"2024-05-14",{"date":497,"type":29},"2022-04-12",{"date":499,"type":20},"2026-11",{"name":481,"class":36},{"id":502,"slug":503,"hasResults":11,"nctId":504,"briefTitle":505,"officialTitle":506,"acronym":4,"eligibilityCriteria":507,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":357,"enrollmentInfo":508,"targetDuration":4,"studyType":71,"phases":510,"briefSummary":511,"conditions":512,"keywords":514,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":521,"completionDateStruct":523,"leadSponsor":525,"locationsCount":37},"100525562","forward-head-posture-correction-impact-on-temporomandibular-dysfunction-100525562","NCT06123351","Forward Head Posture Correction Impact on Temporomandibular Dysfunction","Forward Head Posture Correction Impact on Temporomandibular Dysfunction: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The participant experiencing one or more of TMD signs or symptoms and has been diagnosed with TMD beside having forward head posture with craniocervical (CVA) angle \\\u003C 50.\n* The study will be limited to the patients in the dental clinic of the university of Sharjah.\n* Participants experiencing mild to moderate myogenic TMD with symptoms of orofacial pain and limited range of jaw opening.\n\nExclusion Criteria:\n\n* Previous head, neck or TMJ traumas.\n* History of temporomandibular joint surgery.",{"count":509,"type":20},63,[73],"The goal of this clinical trial is to test the effect of nerd neck correction on damaged jaw in people who suffers from jaw problems and nerd neck. The main question it aims to answer:\n\n* whether there are different effects of traditional nerd neck correction exercises, device correction method and dental splints on jaw features of pain and function.\n\nParticipants will:\n\n* participants will be given the consent to sign first.\n* participants will be assessed to check jaw pain and function.\n* participants will be divided randomly into 3 groups.\n* Each group will be given the treatment sessions for 6 weeks.\n* participants will come back after 6 weeks for one last assessment.\n\nResearchers will compare traditional, new and dental treatment groups to see if there is improvement in jaw characteristics.",[24,513],"Forward Head Posture",[515,516,200,517],"Traction","Exercise","Temporomandibular dysfunction","2024-03-14",{"date":520,"type":29},"2024-03-15",{"date":522,"type":20},"2025-10",{"date":524,"type":20},"2027-12",{"name":526,"class":36},"Shima Abdollah Mohammad Zadeh",{"id":528,"slug":529,"hasResults":11,"nctId":530,"briefTitle":531,"officialTitle":532,"acronym":4,"eligibilityCriteria":533,"healthyVolunteers":11,"sex":15,"minAge":534,"maxAge":329,"enrollmentInfo":535,"targetDuration":4,"studyType":71,"phases":537,"briefSummary":538,"conditions":539,"keywords":540,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":37},"100127843","the-new-serial-treatment-of-temporomandibular-disorders-100127843","NCT00932594","The New Serial Treatment of Temporomandibular Disorders","Create the New Serial Treatment of Temporomandibular Disorders","Inclusion Criteria:\n\n* Limited Month Opening\n* Abnormal of the Month Opening Type\n* Paint During the Month Open or Close\n* Condylar Position Paint\n* Clicking of the Temporomandibular Joint\n* Enlargement of the Upper Temporomandibular Joint Gap\n* Dislocation of the Temporomandibular Disc\n* Bone of the Temporomandibular Joint Changement\n* Patient in the Age of 16-60\n* Voluntary Patient\n\nExclusion Criteria:\n\n* Dysimmunity Disease\n* Dysfunction of Heart Liver and Kidney Disease\n* Patient can not do the Guide Line\n* Life-threatening Patient\n* Serious Limited Mouth Opening\n* Epilepsy\n* Tetanus\n* Pregnancy or Women in the Pregnancy Period\n* Supportive Temporomandibular Disease","16 Years",{"count":536,"type":20},4,[73],"The purpose of this study is to look at temporomandibular joint (TMJ) pressure as a guideline to analyze the different treatments for temporomandibular disorder (TMD), and judge the feasibility of the adjust TMJ pressure treatment and to reach a conclusion on the different treatments for different types of TMD, and determine the new serial treatment of temporomandibular disorders.",[24],[541,542,543,544,545],"Create the New Serial Treatment of TMD","Promote the Classification of Biodynamics in the TMD","Evaluate the Effect of Adjusting TMJ Treatment","Establish the New Standard of the TMJ Treatment","Invent New Device to Measure Pressure without Trauma","2015-05-19",{"date":548,"type":20},"2015-05-20",{"date":550,"type":4},"2006-01",{"date":552,"type":20},"2026-12",{"name":554,"class":36},"Sun Yat-sen University"]