[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"temporomandibular-disorders-tmd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:temporomandibular-disorders-tmd":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,49,76,103,132,154,190,218,250,277,303,331,353,389,418,438,457,494,519,537,563,586,610,635,661],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100591182","journaling-intervention-for-temporomandibular-disorder-tmd-and-chronic-overlapping-pain-100591182",false,"NCT06977100","Journaling Intervention for Temporomandibular Disorder (TMD) and Chronic Overlapping Pain","Examining the Feasibility and Acceptability of a Journaling Intervention in Alleviating Temporomandibular Pain","Inclusion Criteria:\n\n* participants between the ages of 18 and 80\n* pain in the temporomandibular (TMD) region (jaw and\u002For temple area)\n* duration of pain is at least 3 months\n* average pain score ≥4 on a 0-10 numerical rating scale over the past week\n* have at least one additional chronic overlapping pain condition (COPC) including fibromyalgia, irritable bowel syndrome, migraine-type headache, tension-type headache, low back pain, interstitial cystitis\u002Fpainful bladder syndrome or chronic prostatitis, myalgic encephalomyelitis\u002Fchronic fatigue syndrome, vulvodynia, and painful endometriosis.\n* able to read, understand, and write in English.\n\nExclusion Criteria:\n\n* history of TMD surgery\n* neoplasm or injury\u002Ftrauma to the TMD area\n* cancer-related pain\n* scheduled for any surgeries during the study time-frame\n* current participation in another clinical trial or psychological treatment for any pain-related condition that would interfere with study outcomes\n* pregnant or lactating\n* severe motor impairments (e.g., muscular dystrophy)\n* severe psychiatric conditions (e.g., uncontrolled mood disorders)\n* severe neurological or cognitive impairments (e.g., uncontrolled Parkinson's disease)\n* any other conditions that in the opinion of study investigators could make participation in the study unsafe\n* use of opioids within 48 hours prior to laboratory visit","ALL","18 Years","80 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether a 2-week gratitude journaling activity is feasible and acceptable for individuals with Temporomandibular Disorder (TMD) and chronic overlapping pain. The study will also look at whether this activity is helpful in reducing pain and how much it interferes with daily life.\n\nThe primary aims of this study are to:\n\n* Assess whether individuals with TMD and chronic overlapping pain are able to complete the 2-week gratitude journaling activity as planned (feasibility).\n* Evaluate how acceptable participants find the gratitude journaling activity (acceptability).\n\nThe secondary aim of this study is to:\n\n• Explore whether the gratitude journaling activity reduces pain and its impact on daily life, compared to a general wellness journaling activity.\n\nParticipants will:\n\n* Attend two in-person visits to complete questionnaires and take part in tests that measure how sensitive they are to pressure and heat.\n* Complete a 2-week journaling activity at home, writing in their journal on three days of their choice per week.",[28],"Temporomandibular Disorders (TMD)",[30,31,32,33,34,35],"Temporomandibular Disorder","Gratitude Journaling","Resilience","Pain Intensity","Pain Interference","Chronic Pain","RECRUITING","2026-06-26",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":40},"2025-08-11",{"date":44,"type":22},"2026-12",{"name":46,"class":47},"University of Florida","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100633438","aerobic-physical-activity-and-orofacial-myofascial-pain-100633438","NCT07526688","Aerobic Physical Activity and Orofacial Myofascial Pain","AERODOF","Inclusion Criteria:\n\nFor all participants:\n\n* Must be of legal age (18 years or older).\n* Must be fully informed of the study constraints and have provided written informed consent.\n* Must be registered with a social security scheme.\n\nTMD-M Group (Orofacial Myofascial Pain):\n\n• Diagnosis of painful Temporomandibular Disorder (TMD) according to the DC\u002FTMD (Diagnostic Criteria for TMD) clinical standards.\n\nAthletic Group (Active Healthy Subjects):\n\n• Engagement in a minimum of 3 hours of endurance training per week. This threshold is set in accordance with evidence-based WHO recommendations for adults, stating that at least 30 minutes of regular moderate-intensity physical activity per day reduces the risk of multiple diseases.\n\nControl Group (Inactive Healthy Subjects) :\n\n* Absence of TMD.\n* Absence of regular aerobic physical activity.\n\nExclusion Criteria:\n\n* Presence of chronic pain outside of TMD (temporomandibular joint disorder)\n* Patient under legal guardianship (guardianship, conservatorship)\n* Refusal to participate\n* Uncooperative patients, who do not speak or read French fluently, are unable to understand the principle of a pain scale, and are unable to cooperate with the tests.\n* Pregnant women",true,{"count":58,"type":22},90,[25],"Orofacial myofascial pain, most commonly represented by Temporomandibular Disorders (TMD) a significant public health, affecting approximately 12% to 14% of the general population. These disorders are characterized by musculoskeletal pain in the masticatory muscles and joints, leading to reduced productivity and high socio-economic costs. Pathophysiological mechanisms are largely central in origin, similar to other chronic pain syndromes like fibromyalgia. Beyond pain, TMD severely impacts oral health-related quality of life by disrupting vital functions such as mastication and swallowing, and is frequently associated with accelerated dental structure loss due to clenching or grinding. While aerobic exercise is a recommended frontline treatment for many chronic pain conditions due to its ability to induce short-term hypoalgesia and long-term neuroplastic adaptations, it remains critically underutilized in the management of orofacial pain.\n\nThis controlled clinical study aims to compare a pain neuromodulation mechanism (Temporal Summation of Pain) among patients suffering from chronic orofacial myofascial pain, inactive healthy individuals, and healthy individuals practicing endurance sports.\n\nFurthermore, investigating Endogenous Pain Modulation (EPM) in pain-free populations allows for a better understanding of how physical activity modulates pain pathways by eliminating confounding factors associated with pre-existing painful conditions.\n\nThis knowledge will help clarify how aerobic exercise can be utilized within preventive and therapeutic strategies for the management of orofacial myofascial pain. Moreover, it will facilitate the identification of efficacy markers for therapies such as exercise rehabilitation and physical activity.",[28],[63,64,65],"Orofacial myofascial pain","TMD","Aerobic Physical Activity","NOT_YET_RECRUITING","2026-06-08",{"date":69,"type":40},"2026-06-10",{"date":71,"type":22},"2026-09-01",{"date":73,"type":22},"2028-09-01",{"name":75,"class":47},"University Hospital, Brest",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":99,"leadSponsor":101,"locationsCount":4},"100638358","ultrasound-versus-virtual-reality-on-temporomandibular-disorder-100638358","NCT07575633","Ultrasound Versus Virtual Reality on Temporomandibular Disorder","Ultrasound Versus Virtual Reality on Temporomandibular Disorder Following Surgical Tooth Extraction","Inclusion Criteria:\n\n* The subject selection will be according to the following criteria:\n\n  * Patients after tooth extraction.\n  * Patients from both genders.\n  * Patients suffering from pain and reduced mouth opening.\n  * Age ranges between 40-60 years.\n  * All patients will have informed consent.\n\nExclusion Criteria:\n\n* . Surgery that conducted on the temporomandibular joint (meniscectomy, arthroscopy, etc.).\n\n  * Patients with systemic disease as diabetes mellitus.\n  * Patients with neurological conditions.","40 Years","60 Years",{"count":86,"type":22},50,[25],"The Purpose of the study is to compare between the therapeutic efficacy of ultrasound and VR in decreasing pain and improving ROM for Patients with temporomandibular joint disorder after tooth extraction surgery.",[28],[91,92,93,94],"Temporomandibular disorder","Ultrasound","Virtual Reality","surgery","2026-05-04",{"date":97,"type":40},"2026-05-08",{"date":95,"type":22},{"date":100,"type":22},"2026-07-30",{"name":102,"class":47},"Amany Refaat Mohamed Abdel Wahid",{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":23,"phases":113,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":48},"100631980","occlusal-splint-and-exercise-therapy-for-temporomandibular-disorders-100631980","NCT07507734","Occlusal Splint and Exercise Therapy for Temporomandibular Disorders","The Effects of Occlusal Splint and Exercise in Individuals With Temporomandibular Disorders","Inclusion Criteria:\n\n* Clinical and radiological diagnosis of TMD\n* Being between 18-65 years of age\n* Presence of Temporomandibular Joint (TMJ) pain for the last 3 months.\n\nExclusion Criteria:\n\n* Intra-articular or degenerative joint disorders and subluxation requiring immediate treatment,\n* A history of TMJ or cervical region surgery in the last 3 months,\n* A history of treatment from related regions,\n* The presence of rheumatic diseases, including TMJ diseases,\n* TMJ instability or fracture,\n* The presence of perception-cognition disorder,\n* The presence of chronic pain, such as trigeminal neuralgia.","65 Years",{"count":112,"type":22},38,[25],"The goal of this clinical trial is to learn if an exercise protocol can improve temporomandibular pain, jaw function and muscle mechanical properties in individuals with Temporomandibular Disorders (TMD). This study focuses on patients who are already receiving occlusal splint therapy.\n\nThe main question it aims to answer is:\n\nHow does the addition of an exercise protocol to occlusal splint therapy affect temporomandibular pain, jaw function and muscle mechanical properties of the masticatory and neck muscles? Researchers will compare the group receiving both occlusal splint therapy and the exercise protocol to a group only occlusal splint therapy to see if the combined approach is more effective.\n\nParticipants will:\n\n* Undergo an initial assessment of the Jaw Functional Limitation Scale-20 (JLFS-20), Craniofacial Pain and Disability Inventory (CF-PDI), Graded Chronic Pain Scale Version 2.0 (GCPS-2.0), jaw range of motion, pain pressure threshold and muscle mechanical properties.\n* Receive occlusal splint therapy as a part of their treatment.\n* Perform a structured exercise protocol (only 1 group)\n* Attend follow up sessions at the 4th week to monitor changes in all initial assessment parameters.",[28],[117,118,119,120,121,122],"temporomandibular disorders","exercise therapy","occlusal splint","muscle mechanical properties","pain","jaw function","2026-03-27",{"date":125,"type":40},"2026-04-02",{"date":127,"type":40},"2025-07-10",{"date":129,"type":22},"2026-07-10",{"name":131,"class":47},"Acibadem University",{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":48},"100631376","innovative-benefits-of-a-4d-virtual-simulator-100631376","NCT07499869","INNOVATIVE BENEFITS OF A 4D VIRTUAL SIMULATOR","INNOVATIVE CONTRIBUTIONS OF A 4D VIRTUAL SIMULATOR (Modjaw®) IN THE MANAGEMENT OF TEMPOROMANDIBULAR JOINT DISORDERS","DiagDTM","Inclusion Criteria:\n\n* adults;\n* positive result on the validated questionnaire for the screening of disc displacement;\n* referral for an MRI scan of the TMJs for diagnostic confirmation\n* signed informed consent form\n* membership of a social security scheme\n\nExclusion Criteria:\n\n* Patients who do not speak or understand French;\n* Pregnant women;\n* Patients who have refused an MRI scan or for whom an MRI scan is contraindicated.\n* Vulnerable patients, minors, patients under guardianship or trusteeship, or those protected by law.",{"count":141,"type":22},20,[25],"Temporomandibular disorders (TMD) encompass all temporomandibular muscular and osteoarticular conditions.\n\nTMD affects 31% of the adult population, with chronic, debilitating pain in 10% of cases. Clinical diagnosis remains complex, and patients are underdiagnosed, whereas early management of these disorders can prevent worsening and significant public health expenditure.\n\nThe Modjaw device, which is integrated into modern digital workflows in dental surgery-particularly for the manufacture of prostheses-could enable systematic joint diagnosis through the automatic interpretation of tracings. The validity of interpreting condylar tracings obtained via axiography (compared to MRI, considered the gold standard) for diagnosing disc displacement in the TMJ has been demonstrated. The team recently demonstrated the reproducibility of Modjaw® condylar recordings from healthy patients, as well as the reliability of the recordings. However, to date, the evaluation of this device has not focused on its added potential in terms of assisting the clinician in diagnosing disc displacement.",[28],"2026-03-24",{"date":147,"type":40},"2026-03-30",{"date":149,"type":22},"2026-06-01",{"date":151,"type":22},"2028-06-01",{"name":153,"class":47},"Centre Hospitalier Universitaire de Nice",{"id":155,"slug":156,"hasResults":12,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":162,"briefSummary":163,"conditions":164,"keywords":171,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":189},"100629437","comparing-the-effectiveness-of-online-vs-face-to-face-physiotherapy-for-treating-temporomandibular-disorders-100629437","NCT07474662","Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders","Comparing the Effectiveness of Online vs. One-on-one vs. Group Physiotherapy for Treating Myogenic Temporomandibular Disorders: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with myalgia\n\nExclusion Criteria:\n\n* Children, patients with systemic rheumatic diseases (RA, SLE..), previous jaw surgery or trauma",{"count":58,"type":22},[25],"Dentists and physiotherapists have two options for treating these conditions: splint therapy and physiotherapy. Right now, the gold standard is individual physiotherapy, which contains manual therapy and active exercises too. Since not many dentists and physiotherapists are experts in this area, patients have to wait for months or even years to get their treatment. Thanks to social media, patients can find many information about their condition while they are waiting, but it's our responsibility to provide safe and effective information. In view of this situation, our aim is to find out if online or group physiotherapy is as effective as individual physiotherapy.",[28,165,166,167,168,169,170],"Orofacial Pain","Temporo-mandibular Dysfunction","Temporomandibular Joint and Muscle Disorder","TMD\u002FOrofacial Pain","Temporomandibular Disorder (TMD)","Temporomandibular Disorders (TMDs)",[170,172,173,174,175,176,177,178,179],"Physiotherapy","Manual therapy","Online","Group physiotherapy","Individual physiotherapy","Video exercises","Telemedicine","Teledentistry","2026-03-11",{"date":182,"type":40},"2026-03-16",{"date":184,"type":22},"2026-03-01",{"date":186,"type":22},"2026-07-31",{"name":188,"class":47},"Semmelweis University",2,{"id":191,"slug":192,"hasResults":12,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":23,"phases":201,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":216,"locationsCount":48},"100598729","liquid-phase-concentrated-growth-factor-versus-conventional-arthrocentesis-in-temporomandibular-disc-displacement-100598729","NCT07075276","Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement","Injection of Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Management of Temporomandibular Disc Displacement: A Randomized Controlled Clinical Trial","LPCGF in TMDs","Inclusion Criteria:\n\n* 1\\. Adults aged 18-45 years. 2. Patients scored as (ASA I).9 3. Presence of complete or nearly complete set of natural dentition with Angle class I occlusion. 4. Diagnosed with unilateral involvement of disc displacement, according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC\u002FTMD).10 5. Symptoms include one or more of the following: pain, joint sounds, and limited mandibular movement (Maximum Mouth Opening\\\u003C 40mm) 6. No prior surgical intervention for TMD. 7. Patient's willingness to participate and follow the study protocol.\n\nExclusion Criteria:\n\n* 1\\. TMJ pathology related to mechanical deformities 2. Psychiatric problems or presence of systemic diseases that may affect healing (e.g., uncontrolled diabetes, autoimmune disorders, hematologic or neurologic disorders, inflammatory or connective tissue disorders as well as rheumatological or previous infectious diseases, head and neck cancer). 3. Patient unwilling or has contraindication to MRI 4. Previous injections or surgical interventions of the TMJ. 5. Concurrent use of anticoagulants or anti-inflammatory medications within the last 30 days. 6. Pregnant or breastfeeding women. 7. History of trauma or infection in the TMJ region. 8. Allergy to local anesthetics or other components used in the study. 9. Patients diagnosed with (Disc Displacement with reduction with no pain or limited mandibular movements).","45 Years",{"count":200,"type":22},32,[25],"This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial. By comparing LPCGF therapy with conventional arthrocentesis, this research looks to provide robust evidence on the efficacy, safety, and potential role of (LPCGF) as an alternative therapeutic choice for IDD.",[28,204,205],"Internal Derangement of the Tempromandibular Joint","Anterior Disc Displacement",[91,207,208,209,210],"Concentrated growth factor","Anterior disc displacement with reduction","Anterior disc displacement without reduction","Arthrocentesis","2026-03-08",{"date":180,"type":40},{"date":214,"type":40},"2025-10-01",{"date":149,"type":22},{"name":217,"class":47},"Horus University",{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":226,"enrollmentInfo":227,"targetDuration":229,"studyType":230,"phases":4,"briefSummary":231,"conditions":232,"keywords":235,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":189},"100627198","occlusal-equilibration-vs-sham-therapies-for-tmds-post-trial-follow-up-oest-100627198","NCT07445516","Occlusal Equilibration vs. Sham Therapies for TMDs: Post-Trial Follow-up (OEST)","OEST Protocol: Physiologically Oriented Occlusal Equilibration Versus Sham Therapy for Chronic Temporomandibular Disorders (TMDs): 10 Years Post-trial Follow-up","OEST","Inclusion Criteria:\n\n* Previous occlusal equilibration for TMD pain at the University of Santiago.\n* Be diagnosed with joint and\u002For muscle TMD pain according to DC\u002FTMD.\n* Be aged 18-85 years.\n* Be completely dentate with normal or adequately restored occlusion (fixed crowns\u002Fbridges allowed).\n* Report pretreatment significant TMD pain (VAS\u002FNRS 4-9 on a 0-10 scale).\n* Have actively sought treatment and been referred to the University\u002FHospital service.\n* Have undergone ≥6 months of prior conservative therapy.\n\nExclusion Criteria:\n\n* Psychosis, major depression, substance abuse, or cognitive impairment.\n* Opioid (morphine-derivative) addiction.\n* Ongoing litigation or disability claims related to chronic pain.\n* Dental professional background.\n* Orthodontic treatment within the last 2 years.\n* Severe tooth mobility (grade 3).\n* Other pain conditions indistinguishable from or more severe than TMD pain.\n* Additionally, patients will be excluded if minimally invasive occlusal adjustment cannot achieve equilibration, defined by: 2 mm discrepancy between maximal intercuspation and centric occlusion, and\u002For 4 mm total interarch discrepancy (≥2 mm on one side) in defined premolar\u002Fmolars reference points, measured intraorally using a Boley gauge.","85 Years",{"count":228,"type":22},110,"20 Years","OBSERVATIONAL","Chronic temporomandibular disorders (TMDs) affect the masticatory muscles, the temporomandibular joints (TMJs), and associated structures. Except in cases of trauma, their etiology remains uncertain, debated, and multifactorial. Conservative therapies-including no active intervention-often alleviate symptoms; however, approximately 3% of the population develops persistent forms associated with substantial individual suffering and significant social and economic burden.\n\nAt the Unit of Occlusion and Prosthodontics of the University of Santiago de Compostela (USC), Physiologically Oriented Occlusal Equilibration (POOE) has been used for chronic painful TMDs since 1985. POOE aims to correct unilateral mastication patterns and to establish appropriate non-working side contacts in order to protect the temporomandibular joints from mechanical overload. Singh (Cochrane, 2024) emphasized that occlusal interventions should be evaluated with long-term follow-up of at least 3-5 years.\n\nThis is a single-blind study: the evaluator remains blinded to treatment allocation during outcome assessment. The aim of this observational study is to assess the long-term effectiveness of POOE treatments for chronic TMDs from 1985 to the present. Treatment effectiveness will be confirmed if the reduction in pain achieved with POOE is statistically significant and clinically meaningful (≥1.5\u002F10 on a 0-10 visual analog scale) compared with sham therapy at ≥3 years post-intervention relative to baseline. Additionally, effectiveness will be supported if the proportion of individuals meeting criteria for chronic TMD (\"affected\") is lower in the POOE-treated group than in those receiving alternative therapies.",[28,233,234],"Myalgia of Mastication Muscle","Arthralgia Syndrome",[236,237,238,239,240],"Occlusal Equilibration","Occlusal Adjustment","TemporoMandibular Disorders (TMD)","Chronic Orofacial Pain","Randomized Clinical Trial","2026-03-02",{"date":243,"type":40},"2026-03-04",{"date":245,"type":22},"2026-02-16",{"date":247,"type":22},"2026-08-30",{"name":249,"class":47},"Urbano Santana Penin",{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":230,"phases":4,"briefSummary":259,"conditions":260,"keywords":262,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":48},"100621635","virtual-planning-of-total-temporomandibular-joint-replacement-100621635","NCT07373184","Virtual Planning of Total Temporomandibular Joint Replacement","Three-dimensional Virtual Planning of Total Temporomandibular Joint Replacement Using Standardized Prosthesis.","Inclusion Criteria:\n\n* Patients with severe pathology in the temporomandibular joint.\n* Previously treated with TMJ prosthesis at the department of Oral and Maxillofacial Surgery, Skåne University Hospital, Lund, Sweden.\n* Treatments performed during year 2010 to 2025.\n\nExclusion Criteria:\n\n\\- Patients with additional surgical treatment of the TMJ after total TMJ replacement.",{"count":258,"type":22},30,"A total TMJ replacement surgery is currently planned based on the X-ray appearance of the facial X-ray. It is now possible to use either an individually designed TMJ prosthesis or a prosthesis with a standard appearance. It is a significantly higher cost for treatment with an individually manufactured prosthesis, but it also provides the opportunity for virtual planning of the positioning of the jaws and prosthesis.\n\nBy using a planning program with treatment simulation through the use of our own virtual models for standard prostheses, virtual planning of jaw and prosthesis positioning is possible even with a standardized temporomandibular joint prosthesis. In this way, the advantages of virtual planning are partly brought to the patients at a much lower price.\n\nThis project aims to virtually plan treatment for patients with standardized temporomandibular joint prosthesis. Patients eligible for this study are included retrospectively (have already been treated). Their X-rays will be used for treatment planning and for comparison with the treatment outcome of previous TMJ treatment.\n\nThe study will analyze the possibilities of the standardized prostheses to provide the same positions, temporomandibular joint replacements and movements of the jaw as an individual temporomandibular joint prosthesis has. This is done by measuring the planned positions of standardized temporomandibular joint prostheses compared to the treatment outcome shown by previous postoperative X-ray examinations.\n\nThe study aims to clarify the possibilities of a simpler and less expensive technology, standardized temporomandibular joint prostheses, to achieve the same good treatment outcome as a more costly technology. This with the same possibilities for treatment planning and use that the existing, more expensive technology, individual temporomandibular joint prostheses, has today.",[28,261],"Temporomandibular Joint Ankylosis",[263,264,265,266,267],"temporomandibular joint","temporomandibular disorder","ankylosis","joint prosthesis","total joint replacement","2026-02-04",{"date":270,"type":40},"2026-02-05",{"date":272,"type":40},"2026-02-01",{"date":274,"type":22},"2027-12-31",{"name":276,"class":47},"Lund University Hospital",{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":283,"enrollmentInfo":284,"targetDuration":4,"studyType":230,"phases":4,"briefSummary":285,"conditions":286,"keywords":289,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":48},"100621482","relationship-between-upper-cervical-mobility-and-temporomandibular-joint-range-of-motion-in-patients-with-temporomandibular-disorders-100621482","NCT07371195","Relationship Between Upper Cervical Mobility and Temporomandibular Joint Range of Motion in Patients With Temporomandibular Disorders","Inclusion Criteria:\n\n* Medically stable individuals who consent to participate in the study.\n* Age between 18 and 50 years.\n* Both male and female participants.\n* Patients diagnosed with temporomandibular joint (TMJ) dysfunction for at least three months.\n\nExclusion Criteria:\n\n* Presence of systemic diseases.\n* Body mass index (BMI) greater than 30 kg\u002Fm².\n* Pregnancy.\n* Recent physical therapy for cervical spine disorders, headaches, or temporomandibular dysfunction.\n* Cervical radiculopathy or other neurological disorders.\n* History of trauma or major psychological problems.\n* Generalized joint hypermobility.\n* Down syndrome.","50 Years",{"count":86,"type":22},"Upper cervical spine mobility plays a crucial role in temporomandibular joint (TMJ) function. This observational study investigates the relationship between upper cervical spine mobility and TMJ range of motion in patients diagnosed with temporomandibular disorders (TMD). Cervical hypomobility may restrict mandibular movement and contribute to TMJ dysfunction through shared biomechanical and neuromuscular mechanisms.",[28,287,288],"Temporomandibular Joint Dysfunction Syndrome","Cervicogenic Headache",[290,291,292,293],"Temporomandibular Joint","Temporomandibular Disorders","Upper Cervical Spine","Cervical Mobility","2026-01-19",{"date":296,"type":40},"2026-01-27",{"date":298,"type":22},"2026-02",{"date":300,"type":22},"2026-09",{"name":302,"class":47},"Deraya University",{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":309,"eligibilityCriteria":310,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":311,"targetDuration":4,"studyType":23,"phases":313,"briefSummary":314,"conditions":315,"keywords":316,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":4},"100617555","effects-of-a-biopsychosocial-approach-added-to-physiotherapy-in-temporomandibular-disorders-100617555","NCT07320144","Effects of a Biopsychosocial Approach Added to Physiotherapy in Temporomandibular Disorders","Investigation of the Effects of a Biopsychosocial Approach Added to Physiotherapy on Stress, Sleep Disturbance, and Bruxism in Individuals With Temporomandibular Disorders","TMD-BPS","Inclusion Criteria:\n\n* Diagnosed with temporomandibular disorders\n* Age between 18 and 65 years\n* Presence of stress, sleep disturbance, or bruxism symptoms\n* Ability to understand and follow study instructions\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* History of temporomandibular joint surgery\n* Presence of neurological, rheumatological, or systemic diseases affecting the musculoskeletal system\n* Current orthodontic treatment\n* Use of medications that may affect pain perception or sleep\n* Pregnancy",{"count":312,"type":22},40,[25],"Temporomandibular disorders are conditions that affect the jaw joint and surrounding muscles and may cause pain, limited jaw movement, stress, sleep problems, and teeth grinding. Physiotherapy is commonly used to manage these problems, but psychological and social factors may also influence symptoms.\n\nThe purpose of this study is to examine whether adding a biopsychosocial approach to physiotherapy improves stress levels, sleep quality, and bruxism in individuals with temporomandibular disorders. Participants will receive either physiotherapy alone or physiotherapy combined with education about pain, stress management, and sleep habits. The results of this study may help improve treatment strategies for people with temporomandibular disorders.",[28],[317,318,319,320,321],"Temporomandibular joint","Pain education","Bruxism","Sleep quality","Biopsychosocial approach","2025-12-22",{"date":324,"type":40},"2026-01-06",{"date":326,"type":22},"2026-01-15",{"date":328,"type":22},"2026-05-15",{"name":330,"class":47},"Betül Özata",{"id":332,"slug":333,"hasResults":12,"nctId":334,"briefTitle":335,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":337,"targetDuration":339,"studyType":230,"phases":4,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":48},"100576197","long-term-follow-up-of-tmj-surgery-and-evaluation-of-the-6-month-control-as-a-prognostic-marker-100576197","NCT06782165","Long-term Follow up of TMJ Surgery and Evaluation of the 6-month Control as a Prognostic Marker.","Inclusion Criteria:\n\n* Patients participating in the studies with ethical approval numbers EPN 2014\u002F764-31\u002F2 and 2014\u002F622-31\u002F1.\n* Initial diagnosis DDwR or DDwoR.\n\nExclusion Criteria:\n\n* Patient unable to verify informed consent.",{"count":338,"type":22},91,"10 Years","The goal of this clinical trial is to evaluate the long-term outcome of surgical intervention (arthroscopy or discectomy) due to the diagnoses temporomandibular joint disc displacement with or without displacement. The main questions it aims to answer are:\n\n* Does the surgical outcome recorded at the earlier 6-month follow up persist at the long-term follow up approximately 10 years postoperatively?\n* How does the radiologically determined degree of joint degeneration change with time in patients that have had joint surgery? Researchers will compare the six-month surgical outcome to the ten-year outcome to see if temporomandibular joint surgery results are stable over time.\n\nParticipants with an earlier performed joint surgery will:\n\n* Have a clinical examination approximately ten years postoperatively.\n* Have a temporomandibular joint x-ray scan performed (cone-beam computed tomography).",[28,342,343],"Temporomandibular Joint Disc Displacement, With Reduction","Temporomandibular Joint Disc Displacement, Without Reduction","2025-12-09",{"date":346,"type":40},"2025-12-17",{"date":348,"type":40},"2025-04-01",{"date":350,"type":22},"2026-05",{"name":352,"class":47},"Karolinska Institutet",{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":360,"targetDuration":4,"studyType":23,"phases":362,"briefSummary":363,"conditions":364,"keywords":366,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":380,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":48},"100587747","orofacial-pain-self-management-personality-moderation-effect-100587747","NCT06932406","Orofacial Pain Self-management: Personality Moderation Effect","Orofacial Pain Self-management: Personality Moderation Effect - Randomized Clinical Trial","Inclusion Criteria:\n\n* The patient presents TMDs diagnosed according to the CD\u002FTMD classification.\n* Age between 18 and 65.\n* Presence of pain in mandibular, temporal, facial, peri-auricular and\u002For auricular regions.\n* Presence of chronic orofacial pain. Defined by the ICD-11 as orofacial pain or headache that occurs for more than two hours a day for 50% of the days of the last three months.\n* Orofacial pain is related to TMDs according to the International Classification of Headaches.\n* Moderate pain intensity, corresponding to a weekly average of at least 30 mm on a 100 mm VAS (validated representation of moderate pain on the VAS scale = 31-54 mm)\n\nExclusion Criteria:\n\n* Concomitant rheumatic systemic pathologies.\n* History of trauma or recent surgical intervention in the head, face, neck or chest.\n* Presence of intraoral infections or odontogenic pain.\n* Headache of neuropathic origin (trigeminal neuralgia, Arnold neuralgia, etc.).\n* Being receiving therapy (except rescue pharmacological therapy) for this disorder or pain.\n* Cognitive impairment that prevents the follow-up of an educational program (determined through the MoCA questionnaire)",{"count":361,"type":22},98,[25],"The objective of this clinical trial is to study the effect of self-management on pain perception in patients with chronic orofacial pain and temporomandibular disorders (TMD) comparing it with the conventional treatment proposed by the TMD clinical practice guidelines. It also evaluates its effect on function and various psychosocial variables.\n\nAs a secondary objective, this work proposes to study the variability between patients, in terms of personality factors, as moderators of the effect of treatment on pain perception. Including in the proposed statistical models certain covariates such as perception and\u002For coping with stress, anxiety and other psychosocial variables.\n\nThis is a randomized clinical trial with two intervention groups and three measurement times (T0; pre-intervention, T1; post-5 weeks and T2; post-6 months). The experimental group will be applied a protocol based on self-management, which includes: therapeutic education, cognitive-behavioral tools, therapeutic exercise of the temporomandibular region, mind-body strategies and modifications of aspects related to lifestyle. The control group will carry out an intervention program based on the Clinical Practice Guidelines for the Management of Temporomandibular Joint Disorders. Therefore, using a set of tools based on therapeutic education, cognitive-behavioral tools for bruxism and other parafunctional habits, temporomandibular region exercises and manual therapy.",[239,169,28,365],"Temporomandibular Dysfunction (TMD)",[91,367,368,369,370,371,372,373,374,375,376,377,378,379],"Orofacial pain","Self-management","self-efficacy","therapeutic exercise","therapeutic education","cognitive behavioral","mind-body techniques","Lifestyle modification training","manual therapy","personality","psychosocial","biopsychosocial","physiotherapy","2025-12-01",{"date":382,"type":40},"2025-12-08",{"date":384,"type":40},"2025-11-28",{"date":386,"type":22},"2026-05-24",{"name":388,"class":47},"Fundación Universidad Católica de Valencia San Vicente Mártir",{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":396,"targetDuration":4,"studyType":23,"phases":398,"briefSummary":399,"conditions":400,"keywords":403,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":48},"100609219","treatment-of-temporomandibular-joint-disorders-with-a-stabilizing-occlusal-splint-in-somatosensory-tinnitus-100609219","NCT07211711","Treatment of Temporomandibular Joint Disorders With a Stabilizing Occlusal Splint in Somatosensory Tinnitus","Treatment of Temporomandibular Joint Disorders With a Stabilizing Occlusal Splint in Somatosensory Tinnitus: a Randomized Double-blind Placebo-controlled Clinical Trial","Inclusion Criteria:\n\n* Patients over 18 years old;\n* Sufferers of somatosensory tinnitus and TMD for more than 6 months;\n* Dentition in good health, with at least minimal occlusion up to the second premolars on both sides;\n* Availability for at least 4 months of follow-up;\n* Able to speak and read the Portuguese language.\n\nExclusion Criteria:\n\nPregnant patients; Treatment for TMD in the last 3 months; Treatment for tinnitus in the last 3 months; Use of total or partial removable prostheses Presence of orofacial pain disorders not related to TMD; Medical contraindication to treatment; Reluctance to accept any designated treatment; Unable or unwilling to give informed consent; Language barrier or delay in neuropsychomotor development.",{"count":397,"type":22},63,[25],"This clinical trial aims to investigate whether treatment of temporomandibular joint disorder with a stabilizing occlusal splint is justified to alleviate somatosensory tinnitus. The main questions we aim to answer are:\n\n* Determine if treatment of temporomandibular disorder with a stabilizing occlusal splint improves somatosensory tinnitus.\n* Identify which patient-related, tinnitus-related, and temporomandibular disorder-related factors contribute to the therapeutic effect.",[401,402,28],"Tinnitus","TMJ",[404,117,64,263,402,405,119,406,407,408],"tinnitus","bite splint","splint","stabilizing splint","somatosensory tinnitus","2025-09-30",{"date":411,"type":40},"2025-10-08",{"date":413,"type":40},"2023-08-10",{"date":415,"type":22},"2026-06-30",{"name":417,"class":47},"University of Sao Paulo General Hospital",{"id":419,"slug":420,"hasResults":12,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":424,"eligibilityCriteria":425,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":426,"targetDuration":4,"studyType":23,"phases":428,"briefSummary":429,"conditions":430,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":435,"leadSponsor":437,"locationsCount":48},"100576199","tmj-arthroscopic-lysis-and-lavage-compared-to-operative-arthroscopy-in-disc-displacement-with-reduction-100576199","NCT06782191","TMJ Arthroscopic Lysis and Lavage Compared to Operative Arthroscopy in Disc Displacement With Reduction.","Temporomandibular Joint Arthroscopic Lysis and Lavage Compared to Operative Arthroscopy in Disc Displacement With Reduction: a Randomised, Double-blind, Controlled Trial","ALLOAA","Inclusion Criteria:\n\n* Uni- or bilateral DDwR verified with clinical and magnetic resonance imaging (MRI) findings\n* TMJ pain ≥ 3 (NRS) and\u002For TMJ disability ≥ 3 (NRS)\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Prior open TMJ surgery\n* Patient diagnosed with rheumatologic joint disease\n* ASA (American Society of Anaesthesiologists) \\> 3\n* Patient unable to verify informed consent",{"count":427,"type":22},96,[25],"The goal of this clinical trial is to compare the intervention arthroscopic lysis and lavage to the intervention operative arthroscopy in treating disabling and painful temporomandibular joint disc displacement with reduction. The main questions it aims to answer are:\n\n* Which surgical method that best improves mouth opening capacity, TMJ pain, and TMJ disability?\n* If any pre- or peri-operative variable\u002F-s could be identified as a predictor for surgical outcome? Researchers will compare arthroscopic lysis and lavage to operative arthroscopy to see if operative arthroscopy works better to treat temporomandibular joint disc displacement.\n\nParticipants will:\n\n* Have one of the two interventions under general anesthesia, not knowing which intervention.\n* Visit an external clinic for regular checkups at 1, 3, 6, 12, and 24 months after surgery.\n* Answer three different quality of life surveys at the checkups.",[342,28],"2025-06-27",{"date":433,"type":40},"2025-06-29",{"date":348,"type":40},{"date":436,"type":22},"2031-02",{"name":352,"class":47},{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":444,"eligibilityCriteria":445,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":446,"targetDuration":4,"studyType":23,"phases":448,"briefSummary":449,"conditions":450,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":452,"startDateStruct":453,"completionDateStruct":454,"leadSponsor":456,"locationsCount":48},"100576198","tmj-arthroscopy-compared-to-arthrocentesis-in-disc-displacement-without-reduction-100576198","NCT06782178","TMJ Arthroscopy Compared to Arthrocentesis in Disc Displacement Without Reduction","Temporomandibular Joint Arthroscopic Lysis and Lavage Compared to Arthrocentesis in Disc Displacement Without Reduction: a Randomised, Double-blind, Controlled Trial","ACALL","Inclusion Criteria:\n\n* Uni- or bilateral DDwoR affecting the patients mouth opening capacity to a range of ≤ 35 mm, verified with clinical and magnetic resonance imaging (MRI) findings.\n* TMJ pain ≥ 3 (NRS)\n* TMJ disability ≥ 3 (NRS)\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Prior open TMJ surgery\n* Patient diagnosed with rheumatologic joint disease.\n* ASA (American Society of Anaesthesiologists) \\> 3\n* Patient unable to verify informed consent.",{"count":447,"type":22},100,[25],"The goal of this clinical trial is to compare the intervention arthroscopic lysis and lavage to the intervention arthrocentesis in treating disabling and painful temporomandibular joint disc displacement without reduction. The main questions it aims to answer are:\n\n* Which surgical method that best improves mouth opening capacity, TMJ pain, and TMJ disability?\n* If any pre- or peri-operative variable\u002F-s could be identified as a predictor for surgical outcome? Researchers will compare arthroscopic lysis and lavage to arthrocentesis to see if arthroscopic lysis and lavage works better to treat temporomandibular joint disc displacement.\n\nParticipants will:\n\n* Have one of the two interventions under general anesthesia, not knowing which intervention.\n* Visit an external clinic for regular checkups at 1, 3, 6, 12, and 24 months after surgery.\n* Answer three different quality of life surveys at the checkups.",[451,343,28],"Temporomandibular Joint Disc Displacement",{"date":433,"type":40},{"date":348,"type":40},{"date":455,"type":22},"2030-02",{"name":352,"class":47},{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":464,"targetDuration":4,"studyType":23,"phases":466,"briefSummary":468,"conditions":469,"keywords":475,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":486,"startDateStruct":488,"completionDateStruct":490,"leadSponsor":492,"locationsCount":48},"100594388","phase-3-art-based-pain-assessment-tool-in-patients-with-temporomandibular-joint-disorders-100594388","NCT07018791","Art-Based Pain Assessment Tool in Patients With Temporomandibular Joint Disorders","Assessment of the Impact of Art-Based Pain Assessment Tool on Pain Communication, Joint Function, and Anxiety in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosed with Temporomandibular Disorders (TMD) requiring conservative management only and classified as Wilkes' stage I or II\n* Able to understand and sign the informed consent form\n\nExclusion Criteria:\n\n* Patients requiring surgical intervention for TMD\n* Presence of severe mental illness, such as psychotic disorders or bipolar affective disorders\n* Regular use of narcotic (opioid) pain medications",{"count":465,"type":22},70,[467],"PHASE3","Title of Study:\n\nAssessment of the Impact of Art-Based Pain Assessment Tool on Pain Communication, Joint Function, and Anxiety in Patients with Temporomandibular Disorders (TMD): A Randomized Controlled Trial\n\nLocation:\n\nKing Abdulaziz University Dental Hospital (KAUFD), Jeddah, Saudi Arabia What Is This Study About?\n\nThis study examines how an art-based tool can help improve communication and understanding of pain among patients with jaw joint disorders (TMD). It compares two groups:\n\n* Standard care: Routine diagnostic and therapeutic procedures\n* Intervention: Standard care plus a guided art-based tool using paintings to express and discuss the TMD experiences What Is the Art-Based Tool?\n\nThis novel method, called the Artistic Pain Exploration (APE), uses paintings to help patients describe their pain that relates to TMD and its effect on their quality of life:\n\n1. Participants will be shown three paintings (e.g., The Scream by Edvard Munch)\n2. Participants will choose the one that best resonates with them\n3. A guided discussion follows, exploring how the image relates to their physical and emotional pain as well as the effect of pain on their daily activities\n\nResearch Questions:\n\n1. Does using the APE method help participants better communicate and understand their pain?\n2. Does it improve jaw function and reduce anxiety more than standard assessment? Who Can Participate?\n\nParticipants may be eligible if they:\n\n* Are 18 years or older\n* Have early-stage TMD (not needing surgery)\n* Can give informed consent\n\nParticipants cannot participate if they:\n\n* Require jaw surgery\n* Have severe mental illness (e.g., psychosis or bipolar disorder)\n* Take narcotic pain medications regularly What Will Happen During the Study?\n* Participants are randomly assigned to one of the two groups.\n* Each participant will complete a standardized questionnaire before and after two weeks to assess the level of anxiety.\n* All participants will be screened for depression via a standardized questionnaire before the first visit.\n* All will undergo a clinical exam to assess the TMJ pain and function and receive appropriate medications and lifestyle instructions.\n* Some participants (intervention group) will also discuss their pain using the artwork.\n* All participants will be seen for a follow up in 2 weeks to assess the TMJ function and pain.\n\nPotential Risks and Discomforts\n\nParticipants may experience:\n\n* Emotional discomfort while discussing pain\n* Mild anxiety during interviews or questionnaires If needed, a psychiatrist on the research team will provide support or referrals.\n\nPotential Benefits\n\n* A better understanding of pain\n* Improved communication with care provider\n* Possible improvement in pain and jaw function\n\nCosts There are no costs to participate. All treatments are provided free of charge.\n\nCompensation \u002F Treatment for Injury\n\n* If participants experience harm from this study, necessary medical care will be provided by the research team.\n* No financial compensation will be provided by King Abdulaziz University.\n\nConfidentiality Participants' identity and medical records will remain confidential. Only approved researchers and auditors will have access to data, in accordance with applicable laws. Any results published will not include participants' name or identifying details.",[28,470,471,472,473,474],"Wilkes 1 and 2","TMJ Pain","TMJ - Oral &Amp;Maxillofacial Surgery","Art Therapy","TMD Art Pain Study",[476,477,478,479,480,481,482,483,484],"Temporomandibular joint disorders","Artistic Pain Exploration (APE)","Visual Pain Expression","Art-Based Assessment","Multisensory Pain Assessment","Randomized Controlled Trial","Pain Communication","Patient-Reported Outcomes","TMJ Function","2025-06-11",{"date":487,"type":40},"2025-06-15",{"date":489,"type":40},"2025-04-25",{"date":491,"type":22},"2025-10-30",{"name":493,"class":47},"King Abdulaziz University",{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":501,"targetDuration":4,"studyType":23,"phases":502,"briefSummary":503,"conditions":504,"keywords":506,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":517,"locationsCount":48},"100594695","behavioral-interventions-for-controlling-oral-behaviors-100594695","NCT07022795","Behavioral Interventions for Controlling Oral Behaviors","Effectiveness of an Ecological Momentary Assessment Intervention to Reduce Masticatory Muscle Activity in Individuals at Risk for Temporomandibular Disorders","Individuals reporting a score greater than or equal to 25 on the oral behavior checklist (OBC). The OBC is a self-report questionnaire used to assess the frequency of various daytime and sleep-related oral behaviors, such as teeth clenching, grinding, and jaw tension.\n\nIt helps identify habits that may contribute to temporomandibular disorders (TMD) and orofacial pain.",{"count":200,"type":22},[25],"Ecological momentary assessment (EMA) interventions via mobile devices can be implemented to monitor an individual's negative health behaviors in real-time, increase awareness, and assist patients in overting those behaviors. In recent years, EMA interventions have been used to improve patients' awareness of specific oral behaviors, such as tooth clenching or awake bruxism, which can produce excessive forces on the muscles of mastication and lead to or exacerbate symptoms of temporomandibular disorders (TMD). Yet, whether EMA interventions are effective in reducing oral behaviors and masticatory muscle activity in the short- and long-term, or whether they are more effective than patient education remains unclear.\n\nIn this randomized clinical trial, we aim to test the effects of a 1-week EMA intervention combined with structured information on masticatory muscle activity and determine whether a combined approach including an EMA intervention and structured information is more effective in reducing masticatory muscle activity than structured information alone.\n\nOur study will have a significant impact on orofacial pain clinical research as it will provide clinically relevant measures which could inform multimodal approaches for the management of painful TMD.",[28,319,505],"Masseter",[507,117,508,509,510,511],"awake bruxism","masseter","oral behaviors","surface electromyography","tooth clenching","2025-06-07",{"date":487,"type":40},{"date":515,"type":40},"2025-04-15",{"date":44,"type":22},{"name":518,"class":47},"University of Toronto",{"id":520,"slug":521,"hasResults":12,"nctId":522,"briefTitle":523,"officialTitle":523,"acronym":524,"eligibilityCriteria":525,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":230,"phases":4,"briefSummary":523,"conditions":527,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":532,"completionDateStruct":533,"leadSponsor":535,"locationsCount":189},"100591075","association-between-temporomandibular-disorders-and-sleep-disorders-100591075","NCT06975709","ASSOCIATION BETWEEN TEMPOROMANDIBULAR DISORDERS AND SLEEP DISORDERS","Gnathology TMD","Inclusion Criteria:\n\n* Age \\>18 years\n* Famale and Male\n* Signature of the privacy information form\n* Signature of the informed consent form of the protocol\n* Subjects capable of understanding and wanting\n* Subjects suffering from a sleep disorder (Insomnia,Hypersomnia,Restless legs syndrome,REM sleep behavior disorder,Narcolepsy,Obstructive sleep apnea syndrome (OSAS),Primary snoring, REM parasomnias,Nocturnal epilepsy)\n\nExclusion Criteria:\n\n* Physical trauma to the head and neck area\n* Painful oral pathologies (e.g. pulpitis, tooth fractures, tooth abscesses, tooth decay, canker sores and mucosal wounds)\n* Recent dental treatments that may cause pain (e.g. tooth extraction, tooth root canal)\n* Use of oral contraceptives\n* Subjects not capable of understanding and wanting\n* Patients suffering from neurological pathologies that may interfere with the completion of the questionnaires (ES dementia) or psychiatric pathologies or drug use as per DSM-5 criteria (including schizophrenia, bipolar, major depression, substance abuse, personality disorders).",{"count":447,"type":22},[28,528],"Sleep","2025-05-13",{"date":531,"type":40},"2025-05-16",{"date":348,"type":40},{"date":534,"type":22},"2026-04-01",{"name":536,"class":47},"IRCCS San Raffaele",{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":544,"enrollmentInfo":545,"targetDuration":4,"studyType":23,"phases":546,"briefSummary":547,"conditions":548,"keywords":551,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":555,"startDateStruct":557,"completionDateStruct":559,"leadSponsor":561,"locationsCount":48},"100564336","effectiveness-of-the-fascial-distortion-model-in-temporomandibular-disorders-a-randomized-sham-controlled-trial-100564336","NCT06627855","Effectiveness of the Fascial Distortion Model in Temporomandibular Disorders: A Randomized Sham-controlled Trial","Investigation of the Effectiveness of Manual Therapy Based on Fascial Distortion Model in Individuals With Temporomandibular Disorder: A Randomized Sham-controlled Trial","Inclusion Criteria:\n\n* Having temporomandibular joint complaints and being diagnosed with temporomandibular disorder according to the Diagnostic Criteria for Temporomandibular Disorders Axis I\n* Understand and be willing to answer assessment questions\n* A temporomandibular joint complaint for the last three months\n* Pain in the jaw, face or neck\n\nExclusion Criteria:\n\n* Has a systemic disease (neurological, rheumatologic, oncologic, etc.) that may affect the temporomandibular joint, cervical spine and\u002For assessment\n* Any history of trauma that may have affected the cranio-cervico-facial region\n* Having undergone any surgical intervention in the cranio-cervico-facial region within the last six months\n* Receiving surgical treatment, medical treatment, splint therapy or physiotherapy for temporomandibular disorder in the last month\n* Radiotherapy in the head and neck region\n* Pregnancy or breastfeeding\n* Exercise therapy for craniocervical posture for the last month","64 Years",{"count":258,"type":22},[25],"The aim of the study was to investigate the effectiveness of Manual Therapy Based on the Fascial Distortion Model in individuals with temporomandibular disorders compared to sham control. Individuals diagnosed with temporomandibular disorder will be randomly assigned to groups as Group 1 (Manual Therapy Based on Fascial Distortion Model) and Group 2 (Sham Control). Head posture, cervical and temporomandibular joint range of motion, cervical muscle performance, pain intensity, pressure pain thresholds, temporomandibular disorder severity, disability, dysfunction, health-related quality of life, kinesiophobia, and central sensitization will be assessed.",[28,549,550],"Manual Therapy","Fascial Distortion",[375,552,117,553],"fascial distortion model","head posture","2025-03-11",{"date":556,"type":40},"2025-03-12",{"date":558,"type":40},"2024-10-03",{"date":560,"type":22},"2025-12",{"name":562,"class":47},"Karabuk University",{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":569,"eligibilityCriteria":570,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":571,"targetDuration":4,"studyType":230,"phases":4,"briefSummary":572,"conditions":573,"keywords":574,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":584,"locationsCount":4},"100579379","prevalence-of-temporomandibular-joint-disorders-in-wind-musicians-100579379","NCT06823531","Prevalence of Temporomandibular Joint Disorders in Wind Musicians","Prevalence of Temporomandibular Joint Disorders in Wind Musicians and Their Relationship with Instrument Type","TMD-WIND","Inclusion Criteria:\n\n* Wind musicians (professional or student).\n* Any age (if under 18, parental\u002Flegal guardian consent is required).\n* Signed informed consent.\n\nExclusion Criteria:\n\n* History of maxillofacial surgery.\n* Presence of neurological disorders affecting mandibular function.\n* Recent treatment for TMD.\n* Severe bruxism diagnosis.",{"count":86,"type":22},"This study aims to analyze the prevalence of temporomandibular joint disorders (TMD) in wind musicians, differentiating the impact by instrument type (woodwind vs. brass) and identifying potential risk factors (embouchure, posture, practice time). A cross-sectional observational design will be used, including professional and student musicians from orchestras and conservatories.",[28],[575,64,367,576,319,577,578],"Temporomandibular disorders","Embouchure Disorders","Mandibular Mobility","Jaw diseases","2025-03-09",{"date":554,"type":40},{"date":582,"type":22},"2025-03-15",{"date":515,"type":22},{"name":585,"class":47},"University of Oviedo",{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":4,"eligibilityCriteria":592,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":593,"enrollmentInfo":594,"targetDuration":4,"studyType":23,"phases":595,"briefSummary":596,"conditions":597,"keywords":598,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":602,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":607,"locationsCount":48},"100562377","the-effect-of-manual-physical-therapy-and-exercise-in-addition-to-routine-dental-care-in-individuals-with-temporomandibular-disorders-100562377","NCT06602375","The Effect of Manual Physical Therapy and Exercise in Addition to Routine Dental Care in Individuals With Temporomandibular Disorders","The Effect of Manual Physical Therapy and Exercise in Addition to Routine Dental Care in Individuals With Temporomandibular Disorders: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Active-Duty Service Members\n* Complaint of TMD symptoms\n* Must be able to be followed for twelve weeks after consent\n* TMD Screener score ≥ 3 45\n\nExclusion Criteria:\n\n* Actively in a Trainee status\n* Utilized oral device in past 6 months\n* Facial injection therapy in the prior 6 months\n* Facial surgery in the preceding 6 months\n* Serious spinal pathology (acute fracture, active cancer, instability)\n* Diagnosed neurological or rheumatological disease\n* Currently under litigation related to temporomandibular or cervical spine pain(s)\n* Currently undergoing Medical Evaluation Board (MEB)\n* Retiring or separating from the military within a year","55 Years",{"count":21,"type":22},[25],"The goal of this randomized clinical trial among US military active-duty service-members with temporomandibular disorders (TMD) is to determine whether standard care plus 6-weeks of tailored, individualized physical therapy (PT) treatment provides greater benefit than standard care alone in patient-reported outcomes, and maximal mouth opening.\n\nThe aims of the study are to compare outcomes in individuals with TMD that receive standard care treatment versus standard care plus PT interventions at 0-, 6-, and 12-weeks. The investigators anticipate that subjects in the standard care plus PT group will exhibit improved patient-reported outcomes, and maximal mouth opening compared to those who received standard care alone.\n\nAdditionally, the investigators will compare the amount and type of healthcare utilization between the two groups (Standard Care and Standard Care + PT) in the 12-month period following enrollment in the study.\n\nAll participants will be managed by their primary dental provider and receive care as deemed appropriate by their provider. All participants will complete patient-reported outcome measures and have their jaw motion measured. Those randomized to the standard care plus PT group will also receive a tailored PT evaluation followed by an individualized plan of care two times per week for up to six weeks.",[28],[291,599,549,600],"Physical Therapy","Exercise","2025-02-03",{"date":603,"type":40},"2025-02-05",{"date":605,"type":40},"2024-09-16",{"date":415,"type":22},{"name":608,"class":609},"Brooke Army Medical Center","FED",{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":615,"acronym":4,"eligibilityCriteria":616,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":617,"targetDuration":4,"studyType":23,"phases":618,"briefSummary":619,"conditions":620,"keywords":621,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":631,"leadSponsor":633,"locationsCount":4},"100576132","digital-occlusal-analysis-and-enamel-wear-assessment-in-temporomandibular-disorder-patients-treated-with-fully-digital-versus-conventional-stabilization-splints-100576132","NCT06781320","Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital Versus Conventional Stabilization Splints","Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital Versus Conventional Stabilization Splints: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. 18-40 years old\n2. complete dentition\n3. intact tooth\n4. no occlusal disorder\n5. stable jaw relation\n6. No ongoing dental therapy, such as orthodontic or prosthodontics treatment.\n\nExclusion Criteria:\n\n1. pregnant\u002Flactating women\n2. temporomandibular joint lesions found on clinical palpation or medical imaging examination\n3. dentoalveolar pathology or ongoing treatment related to TMD\n4. jaw opening less than 3 fingers\n5. patients with occlusal dysfunctions\n6. Patients with severe or moderate periodontitis.\n7. Unable to undergo examination or treatment due to the presence of a psychological or mental disorder.\n8. Severe jaw functional limitations.\n9. Removable dentures or partially dentate patients\n10. Trauma of recent date towards face, head or neck",{"count":141,"type":22},[25],"This randomized controlled research aimed to analyse the occlusion and assist the enamel wear before and after using of the stabilization splints produced by the conventional methods with the fully digitally fabricated stabilization splints.\n\nResearch question: Will the fully digital stabilization splint offer significantly better occlusal equilibration and enamel wear compared to the conventional stabilization splint? the primary outcome will be Digital occlusal analysis, and secondary outcome will be enamel wear assessment",[64,28],[622,623,624,625],"temporomandibular disorder, TMD,","Digital occlusal analysis","enamel wear assessment","stabilization splints","2025-01-15",{"date":628,"type":40},"2025-01-17",{"date":630,"type":22},"2025-01-26",{"date":632,"type":22},"2026-07-17",{"name":634,"class":47},"Minia University",{"id":636,"slug":637,"hasResults":12,"nctId":638,"briefTitle":639,"officialTitle":640,"acronym":4,"eligibilityCriteria":641,"healthyVolunteers":56,"sex":642,"minAge":18,"maxAge":198,"enrollmentInfo":643,"targetDuration":645,"studyType":230,"phases":4,"briefSummary":646,"conditions":647,"keywords":649,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":652,"lastUpdatePostDateStruct":653,"startDateStruct":655,"completionDateStruct":657,"leadSponsor":659,"locationsCount":48},"100574561","temporomandibular-joint-function-oral-habits-and-pain-complaints-of-pregnant-women-100574561","NCT06760884","Temporomandibular Joint Function, Oral Habits and Pain Complaints of Pregnant Women","Determination of Temporomandibular Joint Function, Oral Habits and Pain Complaints of Pregnant Women: a Cross-Sectional Case-Control Study","Inclusion Criteria (Pregnancy women):\n\n* Being between the ages of 18-45,\n* At least primary school graduate,\n* Able to speak and understand Turkish,\n* Women diagnosed with pregnancy by USG,\n* Singleton pregnancy,\n* Agreeing to participate in the study voluntarily.\n\nExclusion Criteria (Pregnancy women):\n\n* Those with any systemic disease concerning the musculoskeletal system,\n* Women with any type of disability,\n* Having communication problems,\n* Multiple pregnancy,\n* Refusing to participate in the study.\n\nInclusion Criteria (Non-Pregnancy women):\n\n* Being between the ages of 18-45,\n* At least primary school graduate,\n* Able to speak and understand Turkish,\n* Agreeing to participate in the study voluntarily.\n\nExclusion Criteria (Non-Pregnancy women):\n\n* Those with any systemic disease concerning the musculoskeletal system,\n* Women with any type of disability,\n* Having communication problems,\n* Refusing to participate in the study.","FEMALE",{"count":644,"type":22},224,"1 Day","The aim of this study is to examine the temporomandibular joint functions, oral habits and pain complaints of pregnant women. .",[28,648],"Pregnancy",[117,650,651,121],"pregnancy","oral habits","2025-01-06",{"date":654,"type":40},"2025-01-07",{"date":656,"type":40},"2024-12-02",{"date":658,"type":22},"2025-06-30",{"name":660,"class":47},"Karadeniz Technical University",{"id":662,"slug":663,"hasResults":12,"nctId":664,"briefTitle":665,"officialTitle":666,"acronym":4,"eligibilityCriteria":667,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":668,"enrollmentInfo":669,"targetDuration":4,"studyType":23,"phases":671,"briefSummary":672,"conditions":673,"keywords":674,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":679,"lastUpdatePostDateStruct":680,"startDateStruct":682,"completionDateStruct":684,"leadSponsor":686,"locationsCount":48},"100572853","acupuncture-for-painful-temporomandibular-disorder-100572853","NCT06738667","Acupuncture for Painful Temporomandibular Disorder","Study on Imaging Characteristics and Predictive Radiology of Brain Network Regulation by Acupuncture in Patients with Painful Temporomandibular Disorders","Inclusion Criteria:\n\n1. Having a history of pain-related TMD for at least three months;\n2. Aged between 18 and 70 years;\n3. Voluntary participation in the trial with signed informed consent.\n\nExclusion Criteria:\n\n1. Having received occlusal splint, injection therapy, acupuncture, biofeedback, transcutaneous nerve stimulation, or TMD-specific medication (e.g., corticosteroids, benzodiazepines, sedative hypnotics, muscle relaxants, opioids, antidepressants, or anticonvulsants) for managing facial pain within one month before the screening period;\n2. Having suffered from pain of dental origin, trauma, sinus pathology, neuropathic origin, inflammatory systemic diseases and cancer;\n3. Having a history of rheumatoid arthritis;\n4. Presence of mental illness or substance abuse;\n5. Pregnant, lactating, or planning to become pregnant;\n6. Participants with common contra-indications for MRI such as claustrophobia or metal implants.","70 Years",{"count":670,"type":22},48,[25],"Temporomandibular disorder (TMD) is a common musculoskeletal pain condition affecting the jaw, and acupuncture is often used for treatment, though its neurological mechanisms are unclear. This study investigates the neural mechanisms of acupuncture in TMD using functional MRI (fMRI), structural MRI (sMRI), and diffusion tensor imaging (DTI), alongside machine learning to predict treatment outcomes. This study aims to enhance understanding of acupuncture's effects on TMD and improve personalized treatment approaches.",[28],[575,675,676,677,678],"Acupuncture","Magnetic resonance imaging","Randomized controlled trial","Protocol","2024-12-13",{"date":681,"type":40},"2024-12-18",{"date":683,"type":22},"2025-06-01",{"date":685,"type":22},"2026-12-31",{"name":687,"class":47},"Beijing Hospital of Traditional Chinese Medicine"]