[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"temporomandibular-joint-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:temporomandibular-joint-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100613940","the-effect-of-prolonged-sugar-free-chewing-gum-mastication-on-self-reported-fatigue-levels-and-changes-of-static-and-dynamic-surface-electromyography-parameters-in-young-individuals-with-and-without-temporomandibular-joint-disorders-100613940",false,"NCT07273123","The Effect of Prolonged Sugar-Free Chewing Gum Mastication on Self-Reported Fatigue Levels and Changes of Static and Dynamic Surface Electromyography Parameters in Young Individuals With and Without Temporomandibular Joint Disorders.","Effect of Sugar-Free Chewing Gum Mastication on Fatigue of the Masticatory Muscles in Young Adults With and Without Temporomandibular Joint Disorders","Inclusion criteria (both groups):\n\n* Age 19-35 years\n* Chewing-gum users, even occasional\n* Good general health\n* Good oral health\n\nInclusion criteria (Healthy controls):\n\n\\- no diagnosed temporomandibular joint disorders\n\nInclusion criteria (study group)\n\n\\- diagnosed temporomandibular joint disorders\n\nExclusion criteria (both groups):\n\n* Non chewing gum users\n* History of neurological disorders\n* History of musculoskeletal diseases\n* History of facial or cervical injuries\n* Presence of cervical pain\n* Two or more missing teeth\n* Current treatment with fixed or removable orthodontic appliances\n* Active periodontal disease\n* Presence of cavitated carious lesions",true,"ALL","19 Years","35 Years",{"count":21,"type":22},30,"ESTIMATED","OBSERVATIONAL","This case-control study investigates fatigue induced by prolonged gum mastication in individuals with temporomandibular disorders (TMD). The study addresses two primary questions:\n\nHow does self-reported fatigue, measured with a visual analogue scale (VAS), change during sustained chewing? How do static and dynamic surface electromyographic (sEMG) parameters evolve over the same period? Participants with TMD will be compared with healthy controls to determine group differences in perceived fatigue and EMG responses.\n\nAll participants will undergo baseline EMG assessment, then chew sugar-free gum continuously for 3 minutes, alternating sides without rest. After each 3-minute interval, static and dynamic EMG recordings will be obtained and participants will rate their fatigue on the VAS. This cycle may be repeated up to six times (maximum 18 minutes). Participants are free to stop chewing at any time if fatigue becomes intolerable.",[26],"Temporomandibular Joint Disorder","RECRUITING","2026-04-27",{"date":30,"type":31},"2026-05-01","ACTUAL",{"date":33,"type":31},"2025-10-01",{"date":35,"type":22},"2026-07-30",{"name":37,"class":38},"University of Milan","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100600254","epropp---ehealth-for-preventing-and-reducing-orofacial-pain-in-the-population-100600254","NCT07095101","ePROPP - eHealth for Preventing and Reducing Orofacial Pain in the Population","Effect and Cost-effectiveness of Smartphone-based Behavioural Intervention on Orofacial Pain","ePROPP","Inclusion criteria\n\n* Chronic orofacial pain, duration ≥3 months with a diagnosis of Myalgia according to the brief DC\u002FTMD.\n* Patients will be included even if they have one or more additional DC\u002FTMD diagnoses\n* Regular smartphone users\n* Understanding written and spoken Swedish\n* Age ≥ 18 years\n\nExclusion criteria\n\n* Other orofacial non-TMD pain conditions\n* Cognitive impairment.","18 Years",{"count":50,"type":22},120,"INTERVENTIONAL",[53],"NA","Pain in the orofacial region has a 10% prevalence in the general population and health care providers are therefore expected to encounter these patients on a daily basis. Chronic orofacial pain often presents as jaw pain related to overload of the jaw muscles and temporomandibular joints. The aim of this study is to evaluate the effectiveness of a smartphone-based behavioural intervention (Ecological Momentary Intervention, EMI) grounded in Cognitive Behavioural Therapy (CBT), compared to standard treatment with an occlusal splint and a waiting list control group.",[26,56],"Temporomandibular Disorders (TMDs)",[56,58,59,60,61,62,63,64,65,66,67],"Myalgia","Facial Pain","Behavior therapy","Telemedicine","Digital health","Occlusal splints","Cost-effectiveness analysis","Bruxism","Mobile applications","Cognitive Behavioral Therapy","NOT_YET_RECRUITING","2025-07-31",{"date":71,"type":31},"2025-08-05",{"date":73,"type":22},"2025-08-22",{"date":75,"type":22},"2028-12-31",{"name":77,"class":38},"Malmö University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":16,"sex":17,"minAge":48,"maxAge":4,"enrollmentInfo":85,"targetDuration":87,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":39},"100583326","salivary-cortisol-as-a-biomarker-in-patients-with-temporomandibular-disorder-100583326","NCT06874868","Salivary Cortisol As a Biomarker in Patients with Temporomandibular Disorder","Assessment of Salivary Cortisol As a Biomarker in Patients with Temporomandibular Disorder","Inclusion Criteria:\n\n* Patients who attend the dental clinic of the Faculty of Medicine of University of Coimbra\n\nExclusion Criteria:\n\n* Pregnant women, minors and non-autonomous individuals",{"count":86,"type":22},50,"1 Day","t is recognized that cortisol, a hormone produced by the adrenal glands, is a marker that is elevated in patients with psychological disorders, particularly anxiety. On the other hand, Temporomandibular Disorders (TMD) are a condition with a multifactorial etiology, in which emotional disturbances play a crucial role.\n\nTherefore, the aim of this study is to evaluate whether patients with TMD have higher levels of salivary cortisol compared to the general population.\n\nInitially, an assessment will be conducted using the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD) protocol to determine whether the patient suffer of any kind of Temporomandibular Disorder. Based on the results, individuals will be classified into two groups: the study group, consisting of patients with TMD, and the control group, composed of individuals without the disorder.\n\nThose who agree to participate will be required to sign an informed consent form. Subsequently, a saliva sample will be collected for analysis.",[26],[91,92,93],"Temporomandibular disorders","TMD","Cortisol","2025-03-07",{"date":96,"type":31},"2025-03-13",{"date":98,"type":31},"2024-09-15",{"date":100,"type":22},"2025-05-30",{"name":102,"class":38},"University of Coimbra"]