[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tetraplegiatetraparesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tetraplegiatetraparesis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,54,95,119,150,182,211,232,255,289,312,333,354],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100451833","early-phase-1-spinal-cord-associative-plasticity-study-100451833",false,"NCT05163639","Spinal Cord Associative Plasticity Study","SCAP","NON-INVASIVE\n\nInclusion Criteria:\n\n(All participants)\n\n* Age between 18-80 years.\n* Must have stable prescription medication for 30 days prior to screening\n* Must be able to: abstain from alcohol, smoking and caffeine consumption on the day of each experiment; abstain from recreational drugs for the entirety of the study; commit to study requirements (i.e., 7 visits); provide informed consent.\n\n(Able-bodied participants)\n\n* No known central or peripheral neurological disease or injury.\n\n(SCI participants - including patients scheduled for intraoperative procedures)\n\n* Score of 1-4 (out of 5) on manual muscle testing of finger extension, finger flexion, or finger abduction in left or right hand.\n\nExclusion criteria:\n\n(All participants)\n\n* Personal or extensive family history of seizures;\n* Ventilator dependence or patent tracheostomy site;\n* Use of medications that significantly lower seizure threshold, such as amphetamines, neuroleptics, dalfampridine, and bupropion;\n* History of stroke, brain tumor, brain abscess, or multiple sclerosis;\n* History of moderate or severe head trauma (loss of consciousness for greater than one hour or evidence of brain contusion or hemorrhage or depressed skull fracture on prior imaging);\n* History of implanted brain\u002Fspine\u002Fnerve stimulators, aneurysm clips, ferromagnetic metallic implants in the head (except for inside mouth); cochlear implants; cardiac pacemaker\u002Fdefibrillator; intracardiac lines; currently increased intracranial pressure; or other contraindications to brain or spine stimulation;\n* Significant coronary artery or cardiac conduction disease; recent history of myocardial infarction and heart failure with an ejection fraction of less than 30% or with a New York Heart Association Functional Classification of Class III or IV;\n* Recent history (within past 6 months) of recurrent autonomic dysreflexia, defined as a syndrome of sudden rise in systolic pressure greater than 20 mm Hg or diastolic pressure greater than 10 mm Hg, without rise in heart rate, accompanied by symptoms such as headache, facial flushing, sweating, nasal congestion, and blurry vision (this will be closely monitored during all screening and testing procedures);\n* History of significant hearing problems;\n* History of bipolar disorder;\n* History of suicide attempt;\n* Active psychosis;\n* Recent history (\\>1 year) of chemical substance dependency or significant psychosocial disturbance;\n* Heavy alcohol consumption (greater than equivalent of 5oz of liquor) within previous 48 hours;\n* Open skin lesions over the face, neck, shoulders, or arms;\n* Pregnancy; and\n* Unsuitable for study participation as determined by study physician.\n\nINTRA-OPERATIVE\n\nInclusion Criteria:\n\n* Clinical indication for cervical spine surgery.\n\nExclusion criteria:\n\n(For experiments involving cortical stimulation)\n\n* Epilepsy;\n* A history of skull surgery with metal implants;\n* Cochlear implants;\n* Patients with aneurysm stents in neck or brain blood vessels;\n* Evidence of skull shrapnel; (For experiments involving spinal cord stimulation)\n* Stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)",true,"ALL","18 Years","80 Years",{"count":21,"type":22},92,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury.\n\nThe proposed study will advance understanding of SCAP, which is critical to its effective translation to human therapy. The purpose of the study is to:\n\n1. Determine whether signaling through the spinal cord to the muscles can be strengthened by electrical stimulation.\n2. Improve our understanding of the spinal cord and how it produces movement.\n3. Determine whether spinal surgery to relieve pressure on the spinal cord can improve its function.\n\nAim 1 is designed to advance mechanistic understanding of spinal cord associative plasticity (SCAP).\n\nAim 2 will determine whether SCAP increases spinal cord excitability after the period of repetitive pairing. In rats, SCAP augments muscle activation for hours after just 5 minutes of paired stimuli.\n\nWhereas Aims 1 and 2 focused on the effects of paired stimulation in the context of uninjured spinal cord, Aim 3 assesses whether paired stimulation can be effective across injured cord segments. Aim 3 will incorporate the experiments from Aim 1 and 2 but in people with SCI, either traumatic or pre-operative patients with myelopathy in non-invasive experiments, or targeting myelopathic segments in intraoperative segments.",[28,29,30],"Cervical Spinal Cord Injury","Tetraplegia\u002FTetraparesis","Cervical Myelopathy",[32,33,34,35,36,37,38,39,40],"spinal cord injury","paired brain and spinal cord stimulation","convergent stimulation","spinal cord associative plasticity","transcutaneous spinal cord stimulation","intraoperative monitoring","upper-limb muscle activation","motor cortex","cervical spinal cord","RECRUITING","2026-06-16",{"date":44,"type":45},"2026-06-18","ACTUAL",{"date":47,"type":45},"2021-09-10",{"date":49,"type":22},"2027-12-30",{"name":51,"class":52},"Columbia University","OTHER",3,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":53},"100620423","connect-one-early-feasibility-study-of-connexus-brain-computer-interface-bci-100620423","NCT07357428","Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)","Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI) to Provide Human Connection Through Communication","CONNECT-ONE","Inclusion Criteria:\n\n* Clinical diagnosis of a progressive neuromuscular disease or a neurological injury.\n* Clinical diagnosis of anarthria or severe dysarthria.\n* Wheelchair dependent with severely impaired upper limb function.\n* Has a reliable method of communication and the ability to read and understand the English language.\n* Has a study care partner (e.g. caregiver or multiple caregivers) for the duration of the study.\n* Lives within a 4-hour radius of a study site.\n\nExclusion Criteria:\n\n* Cognitive impairment or psychiatric illness that could impact the ability to comply with study requirements, as determined by the Study Investigator.\n* Co-morbidities or an ongoing chronic medical condition that would impair the ability to comply with study requirements.\n* The presence of another implanted device, like a pacemaker, deep brain stimulator, or implantable pulse generator.\n* Requires, or is expected to require regular MRI scans for on-going medical conditions.\n* In the opinion of the Study Investigator, the patient is not an appropriate candidate for the study, for reasons that could place the patient at undue risk or otherwise result in non-compliance with the study requirements.","22 Years","75 Years",{"count":65,"type":22},2,[67],"NA","The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an assistive communication device to decode imagined language correlates and speech for patients with impaired communication as a result of severe loss of voluntary motor control; and (2) to provide control of computer devices for individuals with severe loss of voluntary motor control of the upper extremity.",[70,71,72,29,28,73],"Amyotrophic Lateral Sclerosis","Neuromuscular Disease","Stroke","Dysarthria",[75,76,77,78,79,80,81,82,83,84,85],"BCI","ALS","Paradromics","speech","dysarthria","neural injury","progressive neuromuscular disease","stroke","assistive technology","communication device","brain computer interface","2026-04-09",{"date":88,"type":45},"2026-04-14",{"date":90,"type":45},"2026-03-31",{"date":92,"type":22},"2032-01",{"name":77,"class":94},"INDUSTRY",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":23,"phases":104,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":116,"locationsCount":118},"100538769","virtual-peer-coaching-in-manual-wheelchair-skills-100538769","NCT06295146","Virtual Peer Coaching in Manual Wheelchair Skills","Improving Manual Wheelchair Skills Through Remote Training","Inclusion Criteria:\n\nCoaches:\n\n* At least 18 years old\n* Non-progressive SCI\n* Able to speak and read English\n* Reside in the community\n* Independently use a manual wheelchair for at least 50% of mobility\n\nCoaches with paraplegia:\n\n\\- Able to complete all skills targeted by the intervention, except stair ascent, (WST-Q item scores 2) independently.\n\nCoaches with tetraplegia:\n\n\\- Able to complete all skills targeted by the intervention with or without assistance\n\nTrainees:\n\n* At least 18 years old\n* Non-progressive SCI\n* Able to speak and read English\n* Reside in the community\n* Independently use a manual wheelchair for 50% of mobility\n* Access to an Internet-ready device with video capabilities.\n* Access to a spotter for practicing wheelchair skills\n* Desire training for at least 5 of the 16 skills targeted by the training program\n\nExclusion Criteria:\n\n* none",{"count":103,"type":22},132,[67],"The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program. First, peer coaches will be enrolled and trained. Then, trainees will be enrolled into one of three interventions: intervention with remote feedback (Group 1), and a wait list control group (Group 2).",[107,108,109,29,110],"Wheelchair","Paraplegia","Spinal Cord Injury","Spinal Cord Injuries (SCI)","2026-04-08",{"date":88,"type":45},{"date":114,"type":45},"2024-06-25",{"date":49,"type":22},{"name":117,"class":52},"University of Pittsburgh",1,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":138,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":118},"100633072","interfacing-with-neurotechnology-to-expand-neural-throughput-intent-100633072","NCT07521930","Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)","INTENT","Inclusion Criteria:\n\n* Complete or incomplete tetraplegia (quadriplegia), tetraparesis (quadriparesis), severe ataxia, or disabling motor impairments in both upper limbs, based on neurological exam. In addition, these motor impairments may be combined with severe motor-related speech impairment (dysarthria or anarthria), as in Locked In Syndrome (LIS) and amyotrophic lateral sclerosis (ALS), including the bulbar variant of ALS.\n* Clinical diagnosis must be established for the etiology of motor impairments, including brainstem stroke\\*, traumatic spinal cord injury (SCI), or progressive and irreversible neuromuscular disease, including muscular dystrophy and motor neuron disease, including amyotrophic lateral sclerosis (ALS). \\*Brain stem stroke is defined as an acute onset of neurological deficit with clinical features of brain stem or cerebellar dysfunction lasting more than 24 hours together with computed tomography (CT) or magnetic resonance imaging (MRI) evidence of ischemic infarction or parenchymal hemorrhage.\n* Candidates with traumatic spinal cord injury must have a complete or incomplete tetraplegia or tetraparesis (ASIA Impairment Scale A, B, C) with an injury level of C6 or higher.\n* Candidates with tetraplegia or tetraparesis from traumatic SCI and other non-progressive neurological disorders must have an upper extremity motor score (UEMS, ISNCSCI) of 7 or less in each of the upper extremities. Candidate must also have less than antigravity strength (\\\u003C 3) throughout the lower limbs.\n* Candidates with progressive conditions with shortened life expectancy, such as ALS, must have less than antigravity strength (\\\u003C3) throughout the upper limbs.\n* Persistence of motor impairments at least 12 months prior to enrollment if due to a non-progressive neurological cause such as stroke or spinal cord injury\n* Meeting surgical safety criteria, including surgical clearance by the participant's primary healthcare provider, study physicians, and any necessary consultants\n* Ability to communicate reliably, such as through speech or eye movement\n* Stable psychosocial support system with caregiver capable of monitoring participant throughout the study\n* Ability and willingness to travel to study location up to five days per week for the duration of the study\n* Ability to understand and comply with study session instructions\n* Corrected visual acuity sufficient for use of computer monitor\n\nExclusion Criteria:\n\n* Psychiatric conditions or cognitive impairments that would interfere with obtaining informed consent or fully participating in study activities.\n* Individuals with active implanted devices, including devices that are incompatible with magnetic resonance imaging (MRI).\n* Contraindications to MRI or anticipated need for an MRI during the study period\n* Medical conditions contraindicating device implantation surgery (for example significant pulmonary, cardiovascular, metabolic, or renal impairments making the surgical procedure unsafe)\n* Chronic anti-coagulation and medical contraindication to temporary suspension for surgery\n* Medical conditions contraindicating chronic device implantation (e.g. osteomyelitis, chronic infection, poorly controlled diabetes, cancer, severe autoimmune disorder, epilepsy, poor wound healing)\n* Participants with dental caries and a significant risk of dental or periodontal infection\n* Chronic oral or intravenous use of steroids or immunosuppressive therapy\n* Active cancer within the past year or ongoing chemotherapy\n* Uncontrolled autonomic dysreflexia within the past 3 months\n* Hydrocephalus with or without an implanted ventricular shunt\n* Other chronic, unstable medical conditions that could interfere with subject participation.\n* Persistent suicidal ideation within the past 12 months.\n* History of substance use disorder within the past year\n* Pregnancy (confirmation through blood test)\n* Nursing an infant, planning to become pregnant, or not using adequate birth control",{"count":127,"type":22},5,[67],"The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility for more details) to control and receive feedback from assistive devices.",[29,131,132,133,110,134,135,136,137],"Amyotrophic Lateral Sclerosis (ALS)","Muscular Disorders, Atrophic","Brain Stem Stroke","Muscular Dystrophies","Muscular Atrophy, Progressive","Pontine Hemorrhage","Pontine Infarction",[139,140],"Assistive device","Brain Computer Interface","2026-04-02",{"date":143,"type":45},"2026-04-13",{"date":145,"type":22},"2026-06",{"date":147,"type":22},"2028-12",{"name":149,"class":52},"Johns Hopkins University",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":163,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":118},"100592167","early-phase-1-mep-up-conditioning-to-target-corticospinal-plasticity-100592167","NCT06989905","MEP Up-conditioning to Target Corticospinal Plasticity","Operant Conditioning of the Wrist Extensor Motor Evoked Potential to Target Corticospinal Plasticity and Upper Limb Motor Recovery After Cervical Spinal Cord Injury","uMEP2","Inclusion Criteria:\n\n* Adult (≥18 yrs old)\n* A history of injury to spinal cord at or above C6\n* \\>6 months post SCI\n* Weak wrist extension at least unilaterally\n* Expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted.\n\nExclusion Criteria:\n\n* Motoneuron injury\n* Medically unstable condition\n* Cognitive impairment\n* A history of epileptic seizures\n* Metal implants in the cranium\n* Implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)\n* Extensive use of functional electrical stimulation to the arm on a daily basis\n* Pregnancy (due to changes in posture and potential medical instability)\n* Contraindications to MRI\n* No measurable MEP elicited in the ECR\n* Unable to produce any voluntary ECR EMG activity",{"count":159,"type":22},11,[25],"Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor).\n\nInvestigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand. Also, brain and spine magnetic resonance imaging will be collected before and after the training. The imaging measurements will tell investigators about how spinal damage, brain function, and brain structure relate to motor presentation and the response to the training.",[109,29],[164,165,166,167,32,168,169,170,171,172],"Central Nervous System","Nervous System","Rehabilitation Studies","Spinal Cord","upper extremity","upper limb","motor impairment","tetraplegia","quadriplegia","2026-03-25",{"date":175,"type":45},"2026-03-30",{"date":177,"type":45},"2025-05-27",{"date":179,"type":22},"2027-03-31",{"name":181,"class":52},"Medical University of South Carolina",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":190,"targetDuration":4,"studyType":23,"phases":192,"briefSummary":193,"conditions":194,"keywords":198,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":65},"100549109","precise-robotically-implanted-brain-computer-interface-100549109","NCT06429735","Precise Robotically IMplanted Brain-Computer InterfacE","PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","PRIME","Inclusion Criteria:\n\n* Severe quadriplegia (tetraplegia) due to spinal cord injury or amyotrophic lateral sclerosis (ALS) for at least 1 year without improvement, where quadriplegia is defined as having very limited or no hand, wrist, and arm movement and all levels below\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria\n\n* Moderate to high risk for serious perioperative adverse events\n* Active implanted devices\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Use of smoking tobacco or other tobacco products\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":191,"type":22},15,[67],"The PRIME Study is a first-in-human early feasibility study to evaluate the initial clinical safety and device functionality of the Neuralink N1 Implant and R1 Robot device designs in participants with tetraparesis or tetraplegia. The N1 Implant is a skull-mounted, wireless, rechargeable implant connected to electrode threads that are implanted in the brain by the R1 Robot, a robotic electrode thread inserter.",[29,195,28,70,196,197],"Quadriplegia","Quadriplegia\u002FTetraplegia","Tetraplegic; Paralysis",[32,199,75,85,76,172,200,201],"SCI","tetraplegic","paralysis","2026-01-07",{"date":204,"type":45},"2026-01-09",{"date":206,"type":45},"2024-01-09",{"date":208,"type":22},"2031-01",{"name":210,"class":94},"Neuralink Corp",{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":23,"phases":219,"briefSummary":220,"conditions":221,"keywords":222,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":65},"100569990","targeting-cervical-epidural-spinal-cord-stimulation-for-functional-recovery-100569990","NCT06701422","Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery","Inclusion Criteria:\n\n•Clinical indication for cervical spine surgery.\n\nExclusion criteria:\n\n•Stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)",{"count":218,"type":22},36,[67],"The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial. The purpose of this study is to determine which cervical levels epidural electrical stimulation (EES) should target to recruit arm and hand muscles effectively and selectively in spinal cord injury (SCI).",[28,29,30],[32,38,40,223],"myelopathy","2025-11-20",{"date":226,"type":45},"2025-11-24",{"date":228,"type":45},"2024-12-06",{"date":230,"type":22},"2026-06-30",{"name":51,"class":52},{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":238,"targetDuration":4,"studyType":23,"phases":240,"briefSummary":241,"conditions":242,"keywords":243,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":118},"100610182","voice-an-early-feasibility-study-of-a-precise-robotically-implanted-brain-computer-interface-for-communication-restoration-100610182","NCT07224256","VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration","Inclusion Criteria:\n\nAdults with diagnosis of ALS, PLS, stroke, or Spinal Cord Injury who have severe speech impairment and impaired upper limb function.\n\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria\n\n* Moderate to high risk for serious perioperative adverse events\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":239,"type":22},6,[67],"The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate. The Neuralink N1 Implant is intended to provide the ability to communicate to individuals with severe and irreversible speech production impairment. It is indicated for adults with neurological conditions of the central speech pathways who have impaired upper limb function. The N1 Implant is a skull-mounted, wireless, rechargeable implant connected to electrode threads that are implanted in the brain by the R1 Robot, a robotic electrode thread inserter.",[29,195,28,70,196,197,72],[82,32,199,76,85,75,244,245,78,79,246],"PLS","voice","neuralink","2025-10-31",{"date":249,"type":45},"2025-11-04",{"date":251,"type":45},"2025-10-03",{"date":253,"type":22},"2031-10",{"name":210,"class":94},{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":23,"phases":264,"briefSummary":265,"conditions":266,"keywords":269,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":65},"100602719","gb-prime-an-early-feasibility-study-of-a-precise-robotically-implanted-brain-computer-interface-for-the-control-of-external-devices-100602719","NCT07127172","GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","GB-PRIME","Inclusion Criteria:\n\n* (a) A diagnosis of a spinal cord injury, brain stem stroke, or other neurological condition causing the participant to be non-ambulant and with bilateral upper limb motor impairment with no expectation of recovery that significantly or completely impairs the participant's ability to manually control a computer, smartphone or tablet with their hands.\n\nOR (b) A diagnosis of Amyotrophic Lateral Sclerosis (ALS) or other progressive neurological condition where the natural history of the disease is well understood and where there is tetraparesis and the expectation in the view of the participants treating neurologist that the disease will progress such that the participant will meet 1a within 1 year of recruitment.\n\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria:\n\n* Moderate to high risk for serious perioperative adverse events\n* Active implanted devices\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Use of smoking tobacco or other tobacco products\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":263,"type":22},7,[67],"The GB-PRIME Study is an early feasibility study designed to assess the clinical safety and functionality of the Neuralink N1 Implant and R1 Robot. This study involves participants who have tetraparesis, tetraplegia, or a diagnosis that may lead to these conditions.\n\nThe N1 Implant is a wireless, rechargeable device mounted on the skull, connected to electrode threads that are inserted into the brain by the R1 Robot, which is a robotic device specifically designed for this procedure.",[29,195,196,28,131,267,109,268,133],"Spinal Cord Injury (Quadraplegia)","Motor Neuron Disease",[85,270,271,272,273,171,172,76,32,274,275,276,277,278,279,199,201,280],"Neuralink N1 Implant","Neuralink","Robot","tetraparesis","Amyotrophic lateral sclerosis","chip","brain chip","External device control","Wireless implant","Neuroprosthetics","motor neuron disease","2025-08-11",{"date":283,"type":45},"2025-08-17",{"date":285,"type":45},"2025-07-31",{"date":287,"type":22},"2031-02",{"name":210,"class":94},{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":302,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":53},"100471801","transspinal-stimulation-with-and-without-blood-flow-restricted-exercise-via-telehealth-in-persons-with-tetraplegia-100471801","NCT05423600","Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia","SCIMS Main","Inclusion Criteria:\n\n1. A written clearance from the study medical doctor to ensure that the participant is safely able to engage in the study.\n2. Participants must have a companion that will be able to help him\u002Fher throughout the study.\n3. Greater than 1-year post SCI, neurologic level of C8 or above.\n4. American Spinal Injury Association Impairment Scale (AIS) scores of B, C, or D indicating presence of an incomplete SCI.\n5. Visible muscle contraction response to NMES wrist extensors, bilaterally.\n6. Agreement to use telehealth services for delivery of research exercise training by study staff. Possesses appropriate technology to engage in telehealth including a personal web camera, computer, microphone, speakers, and high-speed broadband internet connection, valid email address (needed to obtain VA issued video conferencing software), and telephone number used to obtain login credentials for the In-Home Video Software - Cisco Jabber Video for Telepresence Software.\n7. Response of muscle contraction of wrist extensors bilaterally to neuromuscular electrical stimulation.\n\nExclusion Criteria:\n\n1. Unhealed fracture in upper or lower extremities.\n2. Severe scoliosis, severe upper extremity contractures, or other musculoskeletal issues that would impede participation in a BES + TS intervention or valid evaluation of outcome measures.\n3. High resting blood pressure greater than 140\u002F80 mmHg.\n4. Taking anti-coagulants or anti-platelet agents, including aspirin if unable to be off this medication for medical reasons.\n5. Pregnancy (female participants). A home pregnancy test will be conducted to role out any pregnancy before the study at the McGuire VAMC. The test will be repeated every month during the course of the study.\n6. Implanted pacemakers and\u002For implanted defibrillator devices.\n7. Other exclusion criteria may include the presence of implanted electrical device, cancer, thrombosis, pacemaker, defibrillator, or seizures. Patients who are currently on or receive anti-platelet or anticoagulant medications will be excluded from the trial.\n8. Any condition that, in the judgment of the principal investigator or medical provider, precludes safe participation in the study.\n9. Other exclusion criteria at the discretion of the medical team may include:\n\n   1. Uncontrolled autonomic dysreflexia (AD), refers to episodes of AD that do not respond to medications to ensure stable blood pressure in persons with SCI\n   2. Concurrent severe neurological injuries other than SCI: MS, CP, severe TBI, and stroke.\n   3. Unresolved deep vein thrombosis.\n   4. Psychiatric or cognitive impairments that preclude adherence to the intervention.\n   5. Known cardiac pathology that precludes safe participation.\n   6. Metabolic conditions such as cardiovascular disease, uncontrolled type II diabetes mellitus, uncontrolled hypertension, and those on insulin.\n   7. Presence of pressure sores stage three or greater.\n   8. Presence of a symptomatic urinary tract infection.\n   9. Severe spasticity as assessed by the Modified Ashworth Scale.\n   10. Changing neurologic status due to conditions such as progressive posttraumatic syringomyelia.","70 Years",{"count":298,"type":22},44,[67],"The purpose of the current study is to evaluate whether a home-based, telehealth-supported intervention combining Blood Flow Restricted Exercise (BES) and Transspinal Stimulation (TS) will improve motor and functional abilities greater than BES+sham TS in persons with chronic, incomplete tetraplegia.",[29],[109],"2025-06-30",{"date":305,"type":45},"2025-07-01",{"date":307,"type":45},"2022-06-15",{"date":309,"type":22},"2026-09",{"name":311,"class":52},"Virginia Commonwealth University",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":319,"targetDuration":4,"studyType":23,"phases":321,"briefSummary":322,"conditions":323,"keywords":324,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":118},"100592374","uae-prime-a-feasibility-study-of-a-precise-robotically-implanted-brain-computer-interface-for-the-control-of-external-devices-100592374","NCT06992596","UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","UAE-PRIME","Inclusion Criteria:\n\n* (a) A diagnosis of a spinal cord injury (\\>12 months), stroke (\\>12 months), or other neurological condition causing the participant to experience bilateral upper limb motor impairment, with no expectation of recovery.\n\nOR (b) A diagnosis of Amyotrophic Lateral Sclerosis (ALS) or other progressive neurological condition where the natural history of the disease is well understood and where there is tetraparesis and the expectation, in the view of the participant's treating neurologist, that the disease will progress such that the participant will meet criteria 1a within 1 year of recruitment.\n\n* Life expectancy ≥ 12 months.\n* Ability to communicate verbally or with the use of a computer or communication aid, and working proficiency in English.\n* Presence of a stable caregiver\n\nExclusion Criteria:\n\n* Moderate to high risk for serious perioperative adverse events\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Smoking tobacco or use of other tobacco products \\> once per month within the last year.\n* Psychiatric or psychological disorder\n* Pre-existing damage to the cortical region of interest (as determined by MRI)\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":320,"type":22},10,[67],"The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot. This study involves participants who have tetraparesis, tetraplegia, or a diagnosis that may lead to these conditions.\n\nThe N1 Implant is a wireless, rechargeable device mounted on the skull, connected to electrode threads that are inserted into the brain by the R1 Robot, which is a robotic device specifically designed for this procedure.",[29,195,196,28,131,267,109,268,133],[85,270,271,272,273,171,172,76,32,274,275,276,277,278,279,199,201,280],"2025-06-03",{"date":327,"type":45},"2025-06-05",{"date":329,"type":45},"2025-05-09",{"date":331,"type":22},"2027-11",{"name":210,"class":94},{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":339,"eligibilityCriteria":340,"healthyVolunteers":11,"sex":17,"minAge":341,"maxAge":4,"enrollmentInfo":342,"targetDuration":4,"studyType":23,"phases":343,"briefSummary":344,"conditions":345,"keywords":346,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":118},"100569904","can-prime-precise-robotically-implanted-brain-computer-interface-for-the-control-of-external-devices-100569904","NCT06700304","CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","CAN-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","CAN-PRIME","Inclusion Criteria:\n\n* Severe quadriplegia (tetraplegia) due to spinal cord injury or amyotrophic lateral sclerosis (ALS) for at least 1 year without improvement, where quadriplegia is defined as having very limited or no hand, wrist, and arm movement and all levels below\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria:\n\n* Moderate to high risk for serious perioperative adverse events\n* Active implanted devices\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Use of smoking tobacco or other tobacco products\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure","19 Years",{"count":239,"type":22},[67],"The CAN-PRIME Study is to test the safety and functionality of Neuralink's N1 Implant and R1 Robot in people who have difficulty moving their arms and legs (tetraparesis or tetraplegia). The N1 Implant is a small, wireless device placed in the skull. It connects to tiny threads inserted into the brain by the R1 Robot, which is a machine designed to carefully place these threads. This study will help researchers learn how well the implant and robot work and if they are safe for use.",[29,195,196,28,131,267,109],[85,270,271,272,273,171,172,76,32,274,275,276,277,278,279,199,201],{"date":348,"type":45},"2025-05-31",{"date":350,"type":45},"2024-11-20",{"date":352,"type":22},"2030-11-30",{"name":210,"class":94},{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":361,"enrollmentInfo":362,"targetDuration":4,"studyType":363,"phases":4,"briefSummary":364,"conditions":365,"keywords":369,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":118},"100557663","nerve-transfers-plus-electrical-stimulation-to-improve-hand-function-in-cervical-spinal-cord-injury-100557663","NCT06541041","Nerve Transfers Plus Electrical Stimulation to Improve Hand Function in Cervical Spinal Cord Injury","Evaluation of Electrical Stimulation During Nerve Transfer Surgery for Cervical Spinal Cord Injury","Inclusion Criteria:\n\n1. Cervical spinal cord injury, ASIA A or ASIA B\n2. International Standards for Neurological Classification of Spinal Cord Injury neurological level of injury C6 or C7\n3. Agreed upon surgical plan includes at least 1 nerve transfer targeting finger flexion with the anterior interosseous nerve as the recipient and at least 1 nerve transfer targeting finger extension with the posterior interosseous nerve as the recipient\n4. Age 18-65 years\n5. Mentally and physically able to comply with evaluations and assessments\n6. Upper motor neuron pattern of injury in the recipient nerve with planned surgery 36 months or less from the time of injury OR lower motor neuron pattern of injury in the recipient nerve with planned surgery 9 months or less from the time of injury\n7. Muscle grade at least 4+\u002F5 on the Medical Research Council (MRC) scale in the territory of the donor nerve(s)\n8. Stable function for at least 3 months (i.e., no ongoing recovery)\n9. Non-operative rehabilitation for at least 3 months\n10. Able to read and write in English at a level necessary to complete the questionnaires\n\nExclusion Criteria:\n\n1. Contraindication to electrical stimulation, including any implanted electronic device such as a pacemaker or intrathecal drug delivery pump\n2. Active infection at the operative site or systemic infection\n3. Active malignancy\n4. Pregnancy\n5. Joint contractures or limited passive range of motion that would limit recovery of function\n6. Lack of appropriate social support and\u002For infrastructure to commit to scheduled follow-up visits\n7. Previous tendon transfer or other surgery for restoration of function following cervical spinal cord injury\n8. Planned tendon transfer surgery or other surgery for restoration of function following cervical spinal cord injury","65 Years",{"count":320,"type":22},"OBSERVATIONAL","The goal of this prospective observational study is to determine whether brief intraoperative electrical stimulation and temporary postoperative electrical stimulation improve motor and\u002For pain outcomes for patients with cervical spinal cord injury undergoing standard of care nerve transfer surgery to improve hand function.\n\nThe main hypotheses include:\n\nHypothesis #1: Brief intraoperative electrical stimulation of the donor nerves will result in improved motor outcomes (hand function) compared to standard nerve transfer surgery in patients with cervical spinal cord injuries.\n\nHypothesis #2: Placement of a temporary peripheral nerve stimulator for 60 days of postoperative electrical stimulation will result in improved pain outcomes compared to standard nerve transfer surgery in patients with cervical spinal cord injuries.\n\nResearchers will prospectively enroll patients with cervical spinal cord injury and no hand function who will undergo standard of care nerve transfer surgery combined with standard of care brief intraoperative electrical stimulation and temporary postoperative electrical stimulation. Motor and pain outcomes will be compared to a retrospective group of patients who underwent nerve transfer surgery without intraoperative or postoperative electrical stimulation.\n\nParticipants will receive standard medical care (nothing experimental) as part of this study. Participants will:\n\n* Have a preoperative assessment including physical examination, electrodiagnostic studies, functional electrical stimulation, and will complete questionnaires assessing function and quality of life\n* Agree upon a surgical plan, including the specific nerve transfers to be performed and whether to include brief intraoperative electrical stimulation and\u002For temporary postoperative electrical stimulation before being considered for enrollment in the study\n* Will undergo standard of care nerve transfer surgery, with at least one nerve transfer targeting improvement in hand function and will receive brief intraoperative electrical stimulation of the donor nerves and placement of a temporary peripheral nerve stimulator\n* Will follow-up with the surgeon 3, 6, 12, 24, and 36 months after the surgery\n* Will have a physical examination and will complete questionnaires at the postoperative visits\n* Will participate in hand therapy following the operation\n* Will be eligible for placement of a permanent peripheral nerve stimulator, depending on response to the temporary peripheral nerve stimulator.",[28,366,367,29,368],"Cervical Spinal Cord Paralysis","Tetraplegia","Tetraplegic Spinal Paralysis",[28,370,371,372,367],"Nerve Transfer","Brief Intraoperative Electrical Stimulation","Peripheral Nerve Stimulation","2025-02-16",{"date":375,"type":45},"2025-02-19",{"date":377,"type":45},"2025-02-10",{"date":379,"type":22},"2028-09",{"name":381,"class":52},"Stanford University"]