[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"the-application-of-hyaluronic-acid-on-teeth-bone-healing-hyaluronic-acid-which-is-widely-used-in-medicine-for-joint-eye-care-wound-healing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:the-application-of-hyaluronic-acid-on-teeth-bone-healing-hyaluronic-acid-which-is-widely-used-in-medicine-for-joint-eye-care-wound-healing":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100617413","effect-of-injectable-hyaluronic-acid-hyadent-bg-ha-on-bone-healing-in-extraction-sockets-100617413",false,"NCT07318298","Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets","Inclusion Criteria:\n\nMale and female participants aged 18 to 35 years\n\nPresence of bilateral impacted mandibular third molars classified as Pell and Gregory Class II, Position B\n\nClassified as American Society of Anesthesiologists (ASA) Physical Status I\n\nAbsence of active local infection at the surgical site (e.g., no swelling, trismus, hyperthermia)\n\nAbility to maintain adequate oral hygiene\n\nAbility to understand and provide written informed consent\n\nAbility to read and understand Arabic or English\n\nWillingness to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\nHistory of systemic diseases such as diabetes mellitus, hypertension, gastric ulcer, or other significant medical conditions\n\nPresence of severe or chronic illness requiring frequent hospitalization\n\nPregnant or breastfeeding individuals\n\nHistory of cognitive or motor impairment that may interfere with study participation\n\nUse of anti-inflammatory or analgesic medications within two weeks before surgery\n\nKnown allergy or hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs)\n\nCurrent smoker\n\nUse of anticoagulant therapy\n\nAny condition that, in the investigator's judgment, may interfere with healing or study outcomes",true,"ALL","18 Years","35 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","Complications such as postoperative pain and delayed socket healing are relatively common following surgical extraction of mandibular third molars. Various biomaterials have been investigated to enhance wound healing and reduce postoperative morbidity. Hyaluronic acid (HA) has demonstrated anti-inflammatory and regenerative properties that may improve both soft and hard tissue healing.\n\nThe aim of this study is to evaluate the effect of topical hyaluronic acid on postoperative pain and alveolar socket bone healing following surgical extraction of mandibular third molars. A prospective, randomized, controlled clinical trial with a split-mouth design will be conducted. Twenty patients requiring bilateral mandibular third molar surgical extraction will be enrolled. In each patient, one extraction socket will receive hyaluronic acid combined with a collagen sponge, while the contralateral socket will receive a collagen sponge alone, according to random allocation. Postoperative pain will be assessed using a visual analogue scale, and socket healing will be evaluated radiographically and histologically.",[27],"The Application of Hyaluronic Acid on Teeth Bone Healing. Hyaluronic Acid Which is Widely Used in Medicine for Joint, Eye Care, Wound Healing",[29],"hyauronic acid, wisdom teeth extraction, bone healing","RECRUITING","2026-01-27",{"date":33,"type":34},"2026-01-28","ACTUAL",{"date":36,"type":34},"2024-08-01",{"date":38,"type":21},"2026-04-30",{"name":40,"class":41},"Jordan University of Science and Technology","OTHER"]