[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thermoregulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thermoregulation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,76,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100054261","ai-guided-predictions-of-blood-pressure-dysregulation-using-perfusion-index-as-a-novel-biomarker-in-persons-with-spinal-cord-injury-100054261",false,"NCT07699094","AI-Guided Predictions of Blood Pressure Dysregulation Using Perfusion Index as a Novel Biomarker in Persons With Spinal Cord Injury","Inclusion Criteria:\n\n* You have had a spinal cord injury (SCI: C4-T12) for more than one year and the SCI was graded as ASIA Impairment Scale (AIS) A or B (unable to voluntarily move your legs)\n* You can also be a gender and age-matched (±5 years) able-bodied (AB) control subject (similar gender and age to a subject with SCI).\n* Subjects with SCI and AB controls must be between 18 and 75 years of age.\n* If you are going to participate, you must avoid caffeine and alcohol, maintain normal salt and water intake, and avoid strenuous exercise for 24 hours prior to the study visit.\n\nExclusion Criteria:\n\n* You have cardiovascular, kidney, or untreated thyroid disease\n* You have a traumatic brain injury (TBI)\n* You have diabetes mellitus\n* You have an acute illness or infection\n* You are dehydrated\n* You smoke\n* You are pregnant\n* You have broken, inflamed, or otherwise fragile skin\n* Your Body Mass Index (BMI) is more than 30 kg\u002Fm2",true,"ALL","18 Years","75 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to determine if perfusion index (PI) can reliably predict changes in systolic blood pressure (SBP) in persons with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI can be 18-75 years of age, male or female, neurological level of injury C4-T12, ASIA Impairment Scale (AIS: A or B: motor complete) or gender and healthy age-matched able-bodied (AB) controls.\n\nThe main question this study aims to answer is: can PI reliably predict change in SBP during a cool temperature challenge? We hypothesize that PI can be used as a biomarker of SBP in persons with SCI.\n\nResearchers will compare the relationship of 1) changes in PI and SBP and 2) relationship of changes in other vital signs to SBP, during the cool temperature challenge. The researchers aim to determine if PI can be used as a biomarker of SBP in persons with SCI during a cool temperature challenge (experimental group\u002Farm). Able-bodied controls (control group\u002Farm) will receive the same intervention (cool challenge) as the experimental group.\n\nDuring the study, participants will be asked to wear only shorts and a T-shirt so that their skin can be exposed to the warm and cool temperatures of the 2 rooms.\n\nWe will put put on non-invasive sensors (taped or attached on the surface of your body) to measure PI, BP, and other vital signs. We will record these measurements while you are seated in a wheelchair for 10 minutes in a warm room and up to 90 minutes in a cool room.",[27,28,29,30],"Spinal Cord Injuries (SCI)","Blood Pressure","Thermoregulation","Perfusion Index","RECRUITING","2026-07-07",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":21},"2026-07-01",{"date":39,"type":21},"2028-06-30",{"name":41,"class":42},"James J. Peters Veterans Affairs Medical Center","FED",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":43},"100627794","effect-of-thermoregulation-bundle-applied-at-birth-on-neonatal-physiological-parameters-and-breastfeeding-100627794","NCT07453264","Effect of Thermoregulation Bundle Applied at Birth on Neonatal Physiological Parameters and Breastfeeding","Effect of Thermoregulation Bundle Applied at Birth on Neonatal Physiological Parameters and Breastfeeding: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The baby is born vaginally\n* It is a singleton pregnancy,\n* The baby is born at term (gestational age 38-42 weeks),\n* The baby's Apgar score is ≥ 7 at 1 minute,\n* The baby's birth weight is between 2500-4000 grams,\n* The baby is exclusively breastfed,\n* The baby has no problems preventing breastfeeding,\n* The mother has no problems preventing breastfeeding,\n* There are no maternal or fetal complications.\n\nExclusion Criteria:\n\n* The baby being preterm\u002Fpostterm,\n* Starting formula feeding,\n* The baby having special care needs (intensive care, etc.),\n* The baby having intrauterine growth restriction (IUGR), genetic disease, etc.","2 Hours",{"count":53,"type":21},140,[24],"Maintaining neonatal body temperature (thermoregulation), particularly during the first hour after birth, is critical for survival and successful adaptation to the extrauterine environment. Implementation of a thermoregulation bundle is expected to facilitate faster stabilization of physiological parameters and to positively influence the initiation of breastfeeding as well as overall breastfeeding success. The effects of a thermoregulation bundle applied at birth on neonatal physiological parameters-including body temperature, respiratory rate, heart rate, and oxygen saturation-and on breastfeeding outcomes will be evaluated.",[29,57,58],"Neonatal Hypothermia","Neonatal Adaptation",[60,61,62,63,64,65],"thermoregulation bundle","term newborn","neonatal hypothermia","skin-to-skin contact","delivery room care","physiological parameters","2026-05-03",{"date":68,"type":35},"2026-05-05",{"date":70,"type":35},"2025-11-01",{"date":72,"type":21},"2026-08-30",{"name":74,"class":75},"Istanbul University - Cerrahpasa","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100585811","physiological-responses-to-heat-stress-during-high-risk-events-100585811","NCT06907225","Physiological Responses to Heat Stress During High-risk Events","Inclusion Criteria:\n\n* Individuals (to include cis- and transgender males and females and nonbinary) 18 years of age or greater\n* Current military service (active, Reserve, or National Guard)\n* Currently participating in training\n\nExclusion Criteria:\n\n* Females who are pregnant\n* Any individual currently on a physical profile that restricts running or foot marching\n* History of obstructive disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis.\n* Scheduled MRI within 2 weeks after core temp pill ingestion\n* Known allergies to skin adhesive\n* Blood donation in the past 8 weeks",{"count":83,"type":21},150,"OBSERVATIONAL","Exertional heat stroke (EHS) affects \\~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported. EHS is the most severe form of exertional heat illness (EHI) and can result in substantial, long-lasting organ damage, and even death in severe cases. Based on current knowledge and training needs, it is impossible to prevent every EHS - which shifts the focus from exclusively prevention to a combination of prevention, treatment, and enhancing recovery as much as possible. While many risk factors have been identified and there are adequate treatments available, biomarkers associated with heat stroke risk, recovery, and return-to-duty (RTD) remain largely unclear. The purpose of the proposed study is to enhance knowledge surrounding biomarkers of EHS and long-term health consequences that result from EHS. The investigators will recruit research volunteers for a field study in order to collect pre-, post-, and follow-up measures from a high-risk EHS event (i.e. ruck marches, timed runs) this will allow us to have a basis for comparison between Soldiers who collapse with EHS (from previously collected data) and those that complete high-risk events, but do not collapse. This will allow for comparison between the groups to identify EHS-specific biomarkers that could aid in recovery and RTD decisions for Soldiers.",[29],[29,88],"Heat illness","2026-04-28",{"date":68,"type":35},{"date":92,"type":35},"2025-05-31",{"date":94,"type":21},"2026-09",{"name":96,"class":42},"United States Army Research Institute of Environmental Medicine",2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":15,"sex":105,"minAge":17,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100602875","the-effects-of-caffeine-on-exercise-physiology-and-time-trial-performance-in-a-hot-environment-100602875","NCT07129200","The Effects of Caffeine on Exercise Physiology and Time-trial Performance in a Hot Environment","The Effects of Caffeine Supplementation on Exercise Physiology and Time-trial Performance in a Hot Environment","Inclusion Criteria:\n\n* Healthy trained runners\n\nExclusion Criteria:\n\n\\-","MALE","45 Years",{"count":108,"type":21},15,[24],"Maintaining a stable core temperature is vital for physiological function; yet, exercise in heat can be problematic, and there is risk of exertional heat-related illness (Flouris \\& Schlader, 2015; Leyk et al., 2019; Périard et al., 2021; Tyler et al., 2016; Veltmeijer et al., 2015). While aerobic fitness improves heat tolerance (Alhadad et al., 2019), strategies like acclimation and pre-cooling also mitigate heat stress (Casadio et al., 2016; Lorenzo et al., 2010; Ross et al., 2013; Siegel et al., 2010). Caffeine, an ergogenic aid (Del Corso et al., 2011; John et al., 2024), is known to enhance performance via adenosine antagonism and increased catecholamines in normothermic environments (Fredholm et al., 1999; Graham \\& Spriet, 1991). However, effects in heat are inconsistent (Ganio et al., 2009; Zhang et al., 2014), possibly due to caffeine reducing the ability to thermoregulate effectively. Therefore, the aim of this study is to investigate the effects of a moderate dose of caffeine (5 mg\u002Fkg) on thermoregulation during a 30-minute running time trial in 35°C heat.",[112,29],"Caffeine",[114,115,116,117],"caffeine","thermoregulation","time trial","exercise physiology","NOT_YET_RECRUITING","2025-08-12",{"date":121,"type":35},"2025-08-19",{"date":123,"type":21},"2025-08-22",{"date":125,"type":21},"2026-06-30",{"name":127,"class":75},"St. Mary's University, Twickenham"]