[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thin-endometrial-lining\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thin-endometrial-lining":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100585006","phase-1-evaluating-mechanically-engineered-stem-cell-exosomes-for-treating-endometrial-injury-a-clinical-study-100585006",false,"NCT06896747","Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study","Evaluation of the Therapeutic Effects of Mechanically Engineered Umbilical Cord-Derived Stem Cell Exosomes on Endometrial Injury: A Prospective, Non-Randomized, Parallel-Controlled Clinical Study","Inclusion Criteria:\n\n1. Females aged 20-40 years (inclusive of boundary values);\n2. Normal ovarian reserve function (criteria: AFC ≥ 7, AMH \\> 1.1 ng\u002FmL);\n3. History of transcervical resection of adhesions (TCRA);\n4. Received PRP treatment after TCRA;\n5. At least one embryo transfer (ET) cycle in which they underwent standard ovarian stimulation (fresh cycle) or standard hormone replacement therapy (FET cycle), with an endometrial thickness of \\\u003C7 mm;\n6. Planned to continue IVF\u002FICSI\u002FFET-assisted conception;\n7. Able to accept and adhere to treatment and follow-up and willing to sign an informed consent form.\n\nExclusion Criteria:\n\n1. Patients with severe systemic diseases, surgical contraindications, or cycle contraindications;\n2. Patients with reproductive tract infections, genital tuberculosis, pelvic inflammatory disease, or malignant tumors of reproductive organs;\n3. Patients with systemic diseases that cause uterine bleeding;\n4. Patients allergic to any drugs, materials, or components used in this study;\n5. Patients at high risk for hormone-dependent tumors such as breast cancer or ovarian tumors;\n6. Patients with untreated submucosal fibroids of any size (FIGO 0\u002FI\u002FII), uterine fibroids ≥5 cm (FIGO III, IV, V, VI, VII), adenomyosis, unicornuate uterus, bicornuate uterus, or endometrial polyps;\n7. Patients with hydrosalpinx ≥3 cm or hydrosalpinx of any size with significant vaginal discharge;\n8. Patients with ovarian endometriotic cysts (chocolate cysts) ≥4 cm;\n9. Patients who participated in other clinical trials within 3 months before surgery or during the study period;\n10. Patients unable to tolerate anesthesia;\n11. Patients with genetic abnormalities;\n12. Other patients deemed unsuitable for participation in this study by the investigator.","FEMALE","20 Years","40 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","The goal of this clinical trial is to evaluate if engineered mechanically umbilical cord-derived stem cell exosomes, or conventional umbilical cord -derived stem cell exosomes, can improve endometrial thickness in women with thin endometrium.\n\nThe main questions it aims to answer are:\n\nCan exosomes delivered via subendometrial injection improve endometrial thickness or clinical pregnancy rates compared to PRP (platelet-rich plasma)? Are there significant differences in endometrial thickness between the two treatment groups? Researchers will compare the intervention groups, which one group receives mechanical exosomes and the other receives conventional esosomes via subendometrial injection, to the control group, which receives PRP via the same methods, to see if exosomes provide superior therapeutic effects.\n\nParticipants will:\n\nReceive either mechanical exosomesor or conventional esosomes or PRP through subendometrial injection.\n\nBe monitored for changes in endometrial parameters.",[28,29,30],"Thin Endometrial Lining","Female Infertility","Intrauterine Adhesions","RECRUITING","2025-03-19",{"date":34,"type":35},"2025-03-26","ACTUAL",{"date":37,"type":35},"2025-02-21",{"date":39,"type":21},"2027-03-31",{"name":41,"class":42},"Tang-Du Hospital","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100550686","senescent-endometrial-cells-in-patients-with-thin-endometrial-lining-100550686","NCT06450301","Senescent Endometrial Cells in Patients with Thin Endometrial Lining","Is Thin Endometrial Lining Associated with Senescent Endometrial Cells","Inclusion Criteria:\n\n* Age 18-39\n* BMI - up to 35\n* Thin endometrium after OCP use\n* Asherman's syndrome\n* Women already undergoing endometrial biopsy for infertility testing (eg. EMMA testing)\n* Women with archived endometrial biopsy samples\n\nExclusion Criteria:\n\n* Women with systemic disease (Rheumatic disease, DM)\n* Women with coagulopathies\n* Women with active pelvic inflammatory process\n* Uterine anomalies\n* Pregnant women\n* Any hormonal contraception use or IUD",true,"18 Years","39 Years",{"count":54,"type":21},100,"OBSERVATIONAL","The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is:\n\nAre there any senescent cells present in thin endometrial lining?\n\nDuring the luteal phase of the cycle, participants will will undergo:\n\n* Gynecologic US to measure the endometrial lining thickness and pattern.\n* Endometrial biopsy with Pipelle catheter",[58,28,59],"Asherman's Syndrome","Cell Senescence","2024-11-18",{"date":62,"type":35},"2024-11-21",{"date":64,"type":35},"2024-09-11",{"date":66,"type":21},"2027-06",{"name":68,"class":42},"Trio Fertility",1]