[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thoracic-paravertebral-block\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thoracic-paravertebral-block":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,72,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100621204","costotransverse-foramen-block-versus-thoracic-paravertebral-block-in-thoracotomy-for-lung-cancer-100621204",false,"NCT07367581","Costotransverse Foramen Block Versus Thoracic Paravertebral Block in Thoracotomy for Lung Cancer","Costotransverse Foramen Block Versus Thoracic Paravertebral Block in Thoracotomy for Lung Cancer: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years and ≤ 65 years old.\n* American Society of Anesthesiologists (ASA) physical status II-III.\n* Body mass index 18-35 kg\u002Fm2.\n* Patients scheduled for thoracotomies for lung cancer.\n\nExclusion Criteria:\n\n* Patient refusal.\n* History of sensitivity to local anesthetics.\n* History of psychological disorders.\n* Contraindication to regional anesthesia, e.g., local sepsis, pre-existing peripheral neuropathies, and coagulopathy.\n* Severe respiratory, cardiac, hepatic, or renal disease.\n* Morbid obesity.\n* Uncooperative patients.\n* Patients on chronic pain therapy.","ALL","18 Years","65 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to compare the costotransverse foramen block (CTFB) with thoracic paravertebral block (TPVB) in patients undergoing thoracotomy for lung cancer.",[27,28,29,30],"Costotransverse Foramen Block","Thoracic Paravertebral Block","Thoracotomy","Lung Cancer","RECRUITING","2026-01-24",{"date":34,"type":35},"2026-01-27","ACTUAL",{"date":32,"type":35},{"date":38,"type":21},"2026-06-01",{"name":40,"class":41},"National Cancer Institute, Egypt","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100528839","phase-4-liposomal-and-standard-bupivacaine-in-thoracic-paravertebral-block-for-post-thoracoscopic-pain-100528839","NCT06165991","Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain","The Effect of Bupivacaine Liposome Combined With Bupivacaine Hydrochloride on Thoracic Paravertebral Nerve Block for Postoperative Pain After Thoracoscopic Lung Surgery","Inclusion Criteria:\n\n* 1\\) Age ≥18 years old;\n\n  2\\) Patients undergoing unilateral initial thoracoscopic lobectomy under general anesthesia (TV or robot-assisted);\n\n  3\\) American Society of Anesthesiologists (ASA) Grade I - III;\n\n  4\\) Voluntarily participate in the study and sign the informed consent.\n\nExclusion Criteria:\n\n* 1\\) Pregnant or lactating women;\n\n  2\\) Pulmonary wedge-shaped resection;\n\n  3\\) ≥2 thoracic drainage tubes;\n\n  4\\) Abnormal liver function: ALT and\u002For AST\\>2×ULN, or\n\nTBIL≥1.5×ULN;\n\n5\\) Renal function impairment (serum creatinine \\>176μmol\u002FL), or received dialysis treatment within 28 days before surgery;\n\n6\\) Participate in another research trial involving an investigational drug within 6 months;\n\n7\\) A history of drug or alcohol abuse;\n\n8\\) Long-term use of opioids (more than 3 months or more than 5 mg daily morphine equivalent per day for 1 month);\n\n9\\) History of allergy to local anesthetics or one of the investigational drugs;\n\n10\\) Uncontrolled mental or neurological symptoms.",{"count":51,"type":21},496,[53],"PHASE4","I. Research purpose\n\n1.1 Main Objective: To investigate the efficacy and safety of bupivacaine liposome thoracic paravertebral nerve block for postoperative analgesia after thoracoscopic lobectomy\n\n1.2 Exploratory Objective: To investigate the noninferiority of bupivacaine liposomes in thoracic paravertebral nerve block with standard bupivacaine",[28,56,57],"Postoperative Analgesia","Thoracoscopic Lobectomy",[59,60,61,62],"liposomal bupivacaine(LB)","Thoracic paravertebral nerve block","Postoperative analgesia","thoracoscopic lobectomy","2026-01-07",{"date":65,"type":35},"2026-01-09",{"date":67,"type":35},"2024-06-01",{"date":69,"type":21},"2026-01-31",{"name":71,"class":41},"Yongtao Sun",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":92,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":42},"100599458","non-opioid-anesthesia-based-on-thoracic-paravertebral-block-during-laparoscopic-sleeve-gastrectomy-100599458","NCT07084753","Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","Comparison of Opioid-based Anesthesia, Opioid-free Anesthesia Based on Intravenous Drugs and Opioid-free Anesthesia With Thoracic Paravertebral Block, in Patients Undergoing Laparoscopic Gastric Bypass Surgery for Obesity","Inclusion Criteria:\n\n-. patients with a prior history of treatment by a multidisciplinary obesity team scheduled for laparoscopic sleeve gastrectomy (LSG)\n\n* body mass index of 30 kg\u002Fm² or greater\n* patients classified as ASA status 2-3.\n\nExclusion Criteria:\n\n* allergies to the intended medications\n* patient refusal\n* uncontrolled psychiatric disorders\n* intracranial pathology\n* cerebrovascular damage\n* any factors impairing effective communication\n\nAdditional Exclusion Criteria:\n\n1. For patients receiving thoracic paravertebral block (TPVB):\n\n   \\- the presence of infection at the puncture site\n2. For the OFA group:\n\n   * 2nd or 3rd-degree atrioventricular block\n   * bradycardia with a heart rate below 50 beats per minute\n   * coronary artery disease,\n   * cardiomyopathy.","70 Years",{"count":81,"type":21},36,[24],"Regional anesthesia is a technique in which a local anesthetic is injected near a nerve or spinal cord to block sensation, motor stimulation, and pain. In this study, an ultrasound-guided paravertebral block will be used, with careful consideration of all positive and negative factors and possible complications. A thoracic paravertebral block is performed by inserting a needle into the intercostal spaces on the back, approximately 4 cm lateral to the spine. Many studies support excellent pain control with this technique, during and after surgery in thoracic and abdominal surgery. Investigators aim to achieve faster patient mobility after surgery, rapid recovery of bowel function, reduced nausea and vomiting, and maximum pain control. The use of opioids, which can additionally cause respiratory suppression and drowsiness, is avoided.\n\nAt any time in case of need to switch from laparoscopic to open surgery, equally adequate anesthesia and postoperative analgesia are ensured without the need to change the approach to the same. In this study, the basic scientific assumption (hypothesis) of the researchers is that non-opioid anesthesia with thoracic paravertebral block provides adequate pain control during and long-term after the surgical procedure, without the side effects of opioid anesthesia.\n\nThe main goal of the study is to determine which type of anesthesia results in the best pain control and most significantly reduces complications of anesthesia and surgery in overweight patients who are scheduled for laparoscopic longitudinal gastrectomy and partial\u002Ftotal gastrectomy.",[85,86,87,88,89,56,90,28,91],"Obese Patients","Bariatric Surgical Pain","Bariatric Surgery (Sleeve Gastrectomy )","Non-Opioid Pain Management","PONV","Postoperative Pain","Opioid Free Anesthesia",[93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,88,89,61,109,110,111],"thoracic paravertebral block","obese patients","bariatric surgery","sleeve gastrectomy","postoperative pain management","anesthesia recovery period","non-opioid anesthesia","recovery after bariatric surgery","TPVB","OFA based on thoracic paravertebral block","Visceral pain, Postoperative","Opioid based anesthesia","Opioid free anesthesia","OBA","OFA","Recovery Period, Anesthesia","Postoperative pain","Bariatric Surgery, Pain","Opioid free anesthesia, dexmedetomidine, ketamine, lidocaine","NOT_YET_RECRUITING","2025-07-17",{"date":115,"type":35},"2025-07-24",{"date":117,"type":21},"2025-07-30",{"date":119,"type":21},"2025-10",{"name":121,"class":41},"IVO JURISIC",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":139,"leadSponsor":141,"locationsCount":42},"100580785","the-impact-of-ultrasound-guided-superficial-and-deep-paravertebral-nerve-blocks-at-the-superior-costotransverse-ligament-on-hemodynamics-during-the-induction-phase-of-thoracoscopic-lung-lobectomy-a-multicenter-double-blind-randomized-controlled-trial-100580785","NCT06841822","The Impact of Ultrasound-Guided Superficial and Deep Paravertebral Nerve Blocks at the Superior Costotransverse Ligament on Hemodynamics During the Induction Phase of Thoracoscopic Lung Lobectomy: A Multicenter, Double-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients scheduled for elective two-port video-assisted thoracoscopic lobectomy\n* Age: ≥18 years\n* ASA classification: I-III\n* BMI: 18-30 kg\u002Fm²\n\nExclusion Criteria:\n\n* Severe hypertension (SBP ≥180 mmHg or DBP ≥110 mmHg)\n* MAP \\\u003C70 mmHg before anesthesia induction\n* Emergency surgery\n* Severe cardiovascular disease, including history of cerebral or thoracic\u002Fabdominal aortic aneurysm\n* Congestive heart failure (New York Heart Association class III or IV)\n* Untreated or unstable ischemic heart disease\n* Severe aortic or mitral valve disease\n* Pregnancy or lactation\n* Coagulation disorders\n* Bacteremia, sepsis, or infection at the puncture site\n* Allergy to study-related drugs\n* Severe liver and kidney dysfunction\n* Neurological disorders, spinal disease (deformity or trauma), history of spinal surgery, or abnormal skin sensation in the thoracic or back region\n* Existing or anticipated difficult airway management\n* Other conditions deemed unsuitable for inclusion by the investigators Forty patients who required CT (3D) imaging technology to observe drug diffusion after the implementation of the two methods were included as follows: patients who were scheduled to undergo double-hole thoracoscopic lobectomy, aged ≥18 years, ASA grade I to III, BMI 18 to 30kg\u002Fm2, and required preoperative CT localization. Exclusion criteria In addition to the above conditions, patients with a history of anaphylaxis induced by contrast agents should be excluded.",{"count":129,"type":21},168,[24],"This study aims to determine whether performing a paravertebral nerve block at the superficial surface of the superior costotransverse ligament (SCTL) (without needle penetration of the SCTL) is more effective in maintaining hemodynamic stability during the induction phase of thoracoscopic lung lobectomy compared to the deep surface of the SCTL (with needle penetration of the SCTL).\n\nThis is a multicenter, double-blind, randomized controlled trial enrolling a total of 168 participants across five hospitals. To investigate the effects of different nerve block methods on hemodynamics during induction, participants will be allocated to either the deep plane SCTL block group (T group) or the superficial plane SCTL block group (S group) using a stratified randomization scheme. The stratification accounts for a 40% proportion of hypertensive patients within each treatment group at each center.\n\nThirty minutes before surgery, patients will receive either an ultrasound-guided deep SCTL block (needle penetrating the SCTL) or a superficial SCTL block (needle not penetrating the SCTL) in the pre-anesthesia room. The target vertebral levels for the block are T4 and T6, and 20 mL of 0.375% ropivacaine hydrochloride solution will be injected slowly at each site. Researchers will document whether subpleural compression is observed on ultrasound imaging and monitor for complications such as hemothorax, pneumothorax, local hematoma, local anesthetic toxicity, epidural anesthesia, or total spinal anesthesia during the procedure.\n\nAnother investigator, blinded to the group allocation, will evaluate patients after the nerve block procedure, recording any occurrences of hemothorax, pneumothorax, local hematoma, local anesthetic toxicity, epidural block, or total spinal anesthesia. Cold sensitivity tests using the temperature method will be conducted at the midaxillary line within the corresponding blocked regions at 5, 10, 20, and 30 minutes post-block, and the sensory blockade level will be recorded.\n\nThirty minutes after the block, anesthesia induction will be performed using target-controlled infusion (TCI) of propofol and remifentanil, along with rocuronium (0.6 mg\u002Fkg). Heart rate (HR), mean arterial pressure (MAP), stroke volume (SV), cardiac index (CI), and stroke volume index (SVI) will be measured every minute from induction until 5 minutes after intubation. Hypotension is defined as a MAP decrease of 20% or an absolute MAP \\\u003C 65 mmHg, while severe hypotension is defined as a MAP decrease of 30% or an absolute MAP \\\u003C 55 mmHg. Hemodynamic stability will be maintained using vasoactive medications as needed.\n\nThe study will record intraoperative consumption of propofol and remifentanil, anesthesia duration, intraoperative intravenous fluid volume, urine output, blood loss, and extubation time. Postoperative assessments will include resting and movement-evoked (coughing) VAS scores at 4 and 24 hours, opioid consumption within 24 hours (oxycodone usage, first demand time, number of effective and actual demands), and additional analgesic requirements. The QOR-15 score at 24 hours and puncture-related complications within 72 hours postoperatively will be documented, along with a patient satisfaction survey at 72 hours.\n\nFor the imaging study evaluating drug diffusion following each block method using CT (3D) imaging, 40 patients will be recruited at Nanjing First Hospital. Patients requiring preoperative CT-guided localization and puncture will receive an ultrasound-guided deep SCTL block (T group) or superficial SCTL block (S group) 30 minutes before the procedure, with 10 patients in each group. The block sites will be at the surgical side T4 and T6 levels, using 20 mL of a nerve block solution containing 0.375% ropivacaine mixed with 2 mL of iohexol (total 20 mL).\n\nFollowing the nerve block, patients will be placed in the supine position, and after 30 minutes, a blinded investigator will assess sensory loss using cold stimulation at the anterior chest wall (midclavicular line), lateral chest wall (posterior axillary line), and posterior chest wall (paravertebral region). Subsequently, patients will undergo routine CT-guided lesion localization and 3D imaging technology will be used to evaluate drug diffusion patterns for the two block techniques.\n\nAny adverse events occurring during the trial will be managed according to the study protocol and recorded accordingly.",[28,133,134],"Anesthesia Induction","Hypotension on Induction","2025-05-21",{"date":137,"type":35},"2025-05-25",{"date":137,"type":21},{"date":140,"type":21},"2026-06-30",{"name":142,"class":41},"Nanjing First Hospital, Nanjing Medical University"]