[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thoracotomy-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thoracotomy-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100618717","intertransverse-process-block-for-postoperative-analgesia-after-thoracotomy-and-lobectomy-100618717",false,"NCT07335250","Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy","Postoperative Pain Control With Intertransverse Process Block in Patients Undergoing Thoracotomy With Lobectomy","Inclusion Criteria:\n\n* Provision of written informed consent\n\nAge between 18 and 85 years\n\nASA Physical Status classification I-III\n\nElective thoracotomy with planned unilateral lobectomy\n\nAnticipated hospital stay of at least one night\n\nExpected requirement for parenteral opioid analgesia for at least 24 hours postoperatively\n\nAbility to operate an intravenous patient-controlled analgesia (PCA) device\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n\nPresence of infection or open wound at the injection site\n\nCoagulopathy\n\nHepatic or renal failure\n\nPatients undergoing reoperation\n\nPatients with missing or incomplete data\n\nPregnancy or lactation\n\nTracheal malformation or tracheostomy\n\nChronic opioid use (≥30 days within the last 3 months, ≥15 mg\u002Fday morphine equivalent)\n\nPatients exceeding the maximum safe local anesthetic dose based on weight (2.5 mg\u002Fkg, max 150 mg)\n\nPatients who refuse data privacy consent will be excluded from the study","ALL","18 Years","85 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized, triple-blind, placebo-controlled clinical trial will investigate the effectiveness of the intertransverse process block (ITPB) for postoperative analgesia in patients undergoing elective thoracotomy with unilateral lobectomy. The study will be conducted at a single tertiary center in accordance with the principles of the Declaration of Helsinki, and written informed consent will be obtained from all participants.\n\nPatients will be randomized in a 1:1 ratio to receive either ultrasound-guided ITPB with 0.5% bupivacaine or placebo (normal saline) prepared in identical syringes to ensure allocation concealment. The block will be performed by an experienced anesthesiologist immediately after surgery and before emergence from anesthesia. Both groups will receive standardized general anesthesia, multimodal perioperative analgesia, and postoperative intravenous morphine patient-controlled analgesia (PCA).\n\nThe trial aims to evaluate the analgesic efficacy and opioid-sparing effect of ITPB while maintaining safety and adherence to routine clinical practice. Outcomes will include postoperative pain scores, opioid consumption, rescue analgesia requirement, and adverse events.",[27,28,29],"Acute Postoperative Pain","Thoracotomy Surgery","Intertransverse Process Block",[29,31,27],"Thoracotomy Lobectomy","RECRUITING","2026-04-08",{"date":35,"type":36},"2026-04-09","ACTUAL",{"date":33,"type":36},{"date":39,"type":21},"2027-03-01",{"name":41,"class":42},"Konya City Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100620143","mechanical-power-in-one-lung-ventilation-100620143","NCT07353788","Mechanical Power in One-lung Ventilation","Postoperative Complications and Outcomes Related to Mechanical Power in One-lung Ventilation- A Multicentre Observational Study","POWEROL","Inclusion Criteria:\n\n1. Patients aged 18 years or older,\n2. ASA physical status I-IV\n3. All thoracic surgeries\n4. One lung ventilation period \\>1 hour\n5. Patients capable of giving written informed consent\n\nExclusion Criteria:\n\n1-Patients undergoing cardiac surgery",{"count":53,"type":21},300,"OBSERVATIONAL","Thoracic surgery usually necessitates one-lung ventilation (OLV) to provide surgical access while maintaining adequate gas exchange. However, OLV is associated with an increased risk of PPCs , a major cause of morbidity and mortality. Mechanical power, a composite parameter incorporating tidal volume, respiratory rate, driving pressure, and flow resistance, has been proposed as a key factor influencing ventilator-induced lung injury (VILI) and postoperative outcome. Understanding the association between mechanical power during OLV and PPCs could provide insights for optimizing intraoperative ventilatory strategies and reducing the burden of PPCs. As OLV inherently alters normal lung mechanics by decreasing functional residual capacity and introducing inequalities in ventilation-perfusion ratio, the complexity of managing mechanical power becomes even more pronounced. Under these altered conditions, the risk of PPC-including atelectasis, pneumonia, and respiratory failure-can be significantly elevated. Factors such as ventilatory settings, lung protection strategies, and the duration of OLV play pivotal roles in influencing mechanical power delivery and thereby impacting lung function recovery post-surgery. Current literature indicates a correlation between inappropriate mechanical ventilation strategies during OLV and increased incidence of PPCs. However, there remains a gap in understanding how precisely mechanical power, as a quantifiable measure, influences patient outcomes following OLV. Therefore, this study aims to investigate the relationship between mechanical power during OLV and the subsequent risk of PPC. By elucidating these dynamics, the findings may inform clinical practices surrounding OLV management, ultimately improving patient safety and outcomes in thoracic surgery.",[57,28],"Thoracic Anesthesia",[59,60,61],"one lung ventilation","mechanical power","postoperative pulmonary complications","NOT_YET_RECRUITING","2026-01-19",{"date":65,"type":36},"2026-01-20",{"date":67,"type":21},"2026-02-01",{"date":69,"type":21},"2026-12-01",{"name":71,"class":42},"Ankara University"]