[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thumb-basal-joint-osteoarthritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thumb-basal-joint-osteoarthritis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100628233","icf-based-biopsychosocial-assessment-with-ai-assisted-profile-prediction-trapeziometacarpal-osteoarthritis-model-100628233",false,"NCT07458971","ICF-Based Biopsychosocial Assessment With AI-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model","ICF-Based Biopsychosocial Assessment With Artificial Intelligence-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model","ICF","Inclusion Criteria:\n\n* Diagnosis of trapeziometacarpal osteoarthritis (TMC OA) confirmed by an orthopedic surgeon and\u002For hand surgeon\n* TMC OA-related symptoms persisting for more than 3 months\n* Aged between 25 and 74 years\n* Literate in Turkish\n* Adequate cognitive function (Mini-Mental State Examination score of 25 or above)\n* No other chronic systemic disease (e.g., rheumatoid arthritis, chronic diabetes, cardiovascular disease, chronic hepatitis)\n* Voluntary participation with signed informed consent\n\nExclusion Criteria:\n\n* Unwillingness to participate\n* Presence of a different orthopedic condition or prior surgery involving the thumb on the unilateral upper extremity\n* Uncontrolled systemic diseases (chronic obstructive pulmonary disease, congestive heart failure, endocrine system disease, history of stroke)\n* Diagnosis of any major psychopathology and currently receiving psychiatric or psychological treatment\n* Pregnancy","ALL","25 Years","74 Years",{"count":21,"type":22},93,"ESTIMATED","OBSERVATIONAL","Trapeziometacarpal osteoarthritis (TMC OA) is a common condition affecting the base of the thumb that causes pain, weakness, and difficulty with daily hand use. Current clinical assessment often focuses on physical findings alone, without considering psychological and social factors that also influence patient outcomes.\n\nThis study has three objectives organized as interrelated work packages:\n\nOBJECTIVE 1 (Clinical Assessment): To comprehensively assess individuals with TMC OA using the International Classification of Functioning, Disability and Health (ICF) framework. This includes evaluating pain, joint mobility, grip strength, daily activity limitations, social participation, psychological factors (anxiety, depression, fear of movement, pain beliefs), and environmental factors (family support, ergonomic adaptations).\n\nOBJECTIVE 2 (AI Knowledge Evaluation): To compare the medical knowledge performance of four large language models (Claude, ChatGPT, Gemini, LLaMA) in answering clinical questions about TMC OA, using criteria such as accuracy, reproducibility, comprehensiveness, clinical relevance, and readability.\n\nOBJECTIVE 3 (AI-Based Prediction): To analyze whether the best-performing large language model can predict multidimensional ICF-based patient profiles using only a limited set of core clinical parameters.",[26,27,28,29],"Trapeziometacarpal Osteoarthritis","Thumb Osteoarthritis","Carpometacarpal Osteoarthritis","Thumb Basal Joint Osteoarthritis",[15,31,32,33,34,35,36,37],"Biopsychosocial Assessment","Large Language Model","Artificial Intelligence","Trapeziometacarpal Joint","Prediction Model","Clinical Decision Support","Pain-Activity Patterns","NOT_YET_RECRUITING","2026-03-04",{"date":41,"type":42},"2026-03-09","ACTUAL",{"date":44,"type":22},"2026-02",{"date":46,"type":22},"2027-07",{"name":48,"class":49},"Hacettepe University","OTHER"]