[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thumb-osteoarthritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thumb-osteoarthritis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,75,108,131,154,187,221,249,270],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100636735","surgery-for-thumb-base-osteoarthritis-joint-replacement-vs-trapeziectomy-100636735",false,"NCT07569549","Surgery for Thumb Base Osteoarthritis: Joint Replacement vs. Trapeziectomy","BASTION - BASe of Thumb Osteoarthritis Management Non-inferiority Trial: Surgical Treatment of First Carpometacarpal Joint Osteoarthritis: A Comparison Between Joint Replacement and Trapeziectomy","BASTION","Inclusion Criteria:\n\n* Age 40-80 years at inclusion\n* CMC-joint osteoarthritis grade 1-3 (Eaton-Littler classification)\n* Rest pain or pain reducing hand function with indication for surgery\n* Insufficient relief from non-operative treatment for ≥3 months (orthosis, OTC analgesics, cortisone injection)\n* Eligible for both prosthesis and trapezectomy per including surgeon\n* Non-smoker or complete smoking cessation ≥6 weeks prior to surgery\n\nExclusion Criteria:\n\n* Previous surgery to thumb base or STT-joint\n* Ongoing chronic pain condition\n* Dementia or cognitive impairment\n* Trapezium height \\\u003C7 mm on plain radiograph\n* Active smoker\n* Osteoarthritis grade 4 (Eaton-Littler)","ALL","40 Years","80 Years",{"count":21,"type":22},84,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if the surgical method with total joint arthroplasty, (TOUCH joint prosthesis), is as good as or better than the traditional surgical method, trapezectomy, to treat thumb base joint osteoarthritis.\n\nThe main questions it aims to answer are:\n\nDoes surgery with total joint arthroplasty provide better power grip and pinch grip strength compared to traditional surgery?\n\nWhat is the long-term risk of complications for both methods?\n\nWhich method is more cost-effective for the healthcare system?\n\nResearchers will compare total joint arthroplasty (TOUCH) to trapezectomy (a procedure where a bone in the thumb base is removed) to see which method provides the best results for the patient.\n\nParticipants will:\n\nBe randomized to undergo either an operation with total joint arthroplasty or a trapezectomy.\n\nUndergo an initial evaluation and a health economic cost analysis after one year.\n\nAttend follow-up checkups at 2, 5, and 10 years post-surgery to evaluate long-term function and the durability of the prosthesis.",[28,29,30,31],"Thumb Osteoarthritis","Thumb Carpometacarpal Joint Osteoarthritis","Carpometacarpal (CMC) Joint Arthritis","Basal Thumb Osteoartrithis",[33,34,35,36,37,38,39,28,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61],"Thumb base arthroplasty","CMC joint","prosthesis","hand surgery","First Carpometacarpal Joint","Trapeziometacarpal Joint","Rhizarthrosis","Dual Mobility Prosthesis","Total Joint Replacement","Total Joint Arthroplasty","Ligament Reconstruction","Surgical Reconstruction","Randomized Controlled Trial (RCT)","Prospective Studies","Comparative Study","Prospective Study","Cost-Effectiveness Analysis","Cost-Benefit Analysis","Health Economics","Patient Reported Outcome Measures (PROMs)","Quality of Life (QoL)","Health-Related Quality of Life (HRQoL)","Return to Work","Grip Strength","Pinch Strength","QuickDASH","EQ-5D","Michigan Hand Outcomes Questionnaire (MHQ","Trapeziectomy","RECRUITING","2026-06-22",{"date":65,"type":66},"2026-06-25","ACTUAL",{"date":68,"type":22},"2026-07-01",{"date":70,"type":22},"2038-03",{"name":72,"class":73},"Uppsala University","OTHER",2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100636501","high-energy-laser-in-the-conservative-treatment-of-rhizarthrosis-100636501","NCT07566507","High-Energy Laser in the Conservative Treatment of Rhizarthrosis","High Intensity Laser Therapy (HL) vs Exercise in Thumb Osteoarthritis","HLEX-TO","Inclusion Criteria:\n\n* arthrosis of the trapezoid-metacarpal with stage 1 or 2 of the Eaton-Littler radiographic classification and pain (recent radiograph within 6 months previously);\n* clinical picture that has been occurring for at least 6 months;\n* pain scored with VAS scale at least 4\u002F10.\n\nExclusion Criteria:\n\n* rheumatoid arthritis or outcomes of trauma in the affected area, contra-indications to treatment with laser therapy (neoplasia, pregnancy, thrombocytopenia, epilepsy, uncompensated heart disease or arrhythmia, pacemaker, local infections),\n* corticosteroid infiltration or physical therapy in the previous 4 weeks.","18 Years",{"count":85,"type":22},42,[25],"Osteoarthritis (OA) is a degenerative joint disease that can affect the hands and is particularly debilitating when it involves the trapeziometacarpal joint (rhizarthrosis). It causes pain, deformity, limited movement and strength, joint instability, resulting in significant limitations in daily activities.Many conservative treatments, such as medications, therapeutic exercises, physical therapy, and orthoses, are effective for managing hand OA. For patients who do not respond to conservative treatments, surgical intervention will be necessary.",[28,89,90,91],"Hand Injuries","Laser","Exercise",[93,94,95,96,97],"hand","rehabilitation","conservative","lasertherapy","exercise","2026-05-13",{"date":100,"type":66},"2026-05-15",{"date":102,"type":66},"2025-11-01",{"date":104,"type":22},"2028-12-01",{"name":106,"class":73},"Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari",1,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":107},"100426127","variable-immobilization-protocol-for-arthroplasty-of-the-carpometacarpal-joint-of-the-thumb-100426127","NCT04828954","Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb","Inclusion Criteria:\n\n* Age \\>= 40 years old\n* Patients undergoing arthroplasty of the first CMC joint including:\n\n  1. Trapeziectomy with LRTI\n  2. Simple Trapeziectomy\n  3. Suspensionplasty (suture vs. APL)\n\nExclusion Criteria:\n\n* Patients \\\u003C 40 years of age\n* Patients who have undergone prior surgical procedures on the thumb base\n* Patients with history of prior procedure at the base of thumb, or those with plan for concomitant carpal tunnel release or thumb metacarpophalangeal (MCP) arthrodesis, will be excluded. Concomitant carpal tunnel surgery may skew outcome surveys, and an arthrodesis procedure will warrant a longer length of immobilization following procedure.\n* Those undergoing implant arthroplasty\n* Patients with a diagnosis of inflammatory arthritis\n* Patients with diagnosis of hypermobility syndrome",{"count":115,"type":22},90,[25],"Thumb carpometacarpal (CMC) osteoarthritis (OA) is common, seen frequently in middle-aged and elderly women. While a variety of surgical treatments have been described with none superior to any other, there is no consensus on the optimal duration of postoperative immobilization. Immobilization following surgery is critical for wound healing, pain control, and aid with activities of daily living in the early recovery period, though the duration of this must be weighed against the negative impacts of immobilization, such as stiffness, contracture, and delay in return to full function. The information gained in this study may allow hand surgeons to use an evidence-based postoperative rehabilitation protocol. Thus, our goal is to compare varying durations of postoperative immobilization after thumb CMC arthroplasty in a randomized trial design.\n\nSubjects will be randomized to treatment with non-removable thumb spica plaster postoperative splint immobilization for 2 weeks or non-removable thumb spica plaster splint transitioned to cast for a total of 6 weeks immobilization following base of thumb arthroplasty. Patient-reported outcome measures (PROs) and objective metrics will be tracked in the follow-up period.",[28],[120,121,122],"Thumb carpometacarpal joint osteoarthritis","Rehabilitation","Hand therapy","2026-05-11",{"date":98,"type":66},{"date":126,"type":66},"2021-04-19",{"date":128,"type":22},"2027-08-04",{"name":130,"class":73},"University of Chicago",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":138,"sex":17,"minAge":83,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100635449","trapeziometacarpal-joint-arthroplasty-versus-trapeziectomy-for-thumb-carpometacarpal-osteoarthritis-100635449","NCT07552831","Trapeziometacarpal Joint Arthroplasty Versus Trapeziectomy for Thumb Carpometacarpal Osteoarthritis","T3","Inclusion Criteria:\n\n* Pain at the base of the thumb affecting activities of daily living and insufficient response to at least 3 months of non-operative treatment (orthosis, non-steroidal anti-inflammatory drugs, and\u002For corticosteroid injections).\n* Radiographic thumb carpometacarpal osteoarthritis, Eaton grade 2-3.\n* For Eaton grade 2, age ≥50 years.\n* Age 18-69 years.\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Symptomatic osteoarthritis of adjacent joints (e.g., scaphotrapeziotrapezoid joint, STT-joint).\n* Need for concurrent surgery in the metacarpophalangeal joint (e.g. arthrodesis or capsulodesis).\n* Post-traumatic thumb carpometacarpal osteoarthritis.\n* Previous surgery for thumb carpometacarpal osteoarthritis in the contralateral hand.\n* Inflammatory arthritis (e.g., rheumatoid arthritis or systemic lupus erythematosus).\n* Osteoporosis\u002Fosteopenia of such severity that secure cup placement in the trapezium is not possible (for arthroplasty).\n* Ongoing systemic corticosteroid treatment.\n* Other hand surgical condition in the same hand that could confound outcomes (e.g., carpal tunnel syndrome or de Quervain tenosynovitis).\n* Cognitive impairment preventing reliable participation.\n* Ongoing, or suspected ongoing, alcohol or drug misuse.\n* Insufficient Swedish language proficiency to complete the questionnaires.",true,{"count":140,"type":22},64,[25],"Thumb carpometacarpal osteoarthritis is common and may cause severe pain and functional limitation. Trapeziectomy is widely used, whereas prosthetic arthroplasty may offer faster early recovery. However, detailed information on early postoperative and long-term radiological outcomes remains limited.\n\nThis is a single-centre, blinded randomised controlled trial at Sahlgrenska University Hospital, Gothenburg, Sweden. Adults aged 18-69 years with symptomatic thumb carpometacarpal osteoarthritis (Eaton grade 2-3) refractory to at least 3 months of non-operative treatment will be randomised 1:1 to trapeziometacarpal prosthetic arthroplasty or trapeziectomy. The primary outcome is day-by-day pain (registration on a numeric rating scale NRS, 0-10). Secondary outcomes include day-by-day analgesic consumption for 90 days, orthosis use after cast removal, patient-reported function (HQ-8, QuickDASH, and Nelson score) at 30, 45, 60, 75 and 90 days, assessor-measured range of motion and strength at 45 and 90 days, and long-term clinical follow-up at 6 months and 1, 2, 5 and 10 years. Cone beam computed tomography will be obtained in the arthroplasty group at 1 week postoperatively as reference and at 6 months and 1, 2, 5 and 10 years to assess implant position, migration and loosening. The target sample size is 64 participants (32 per group), providing 95% power to detect a 1-point between-group difference on the pain scale. Analyses will follow the intention-to-treat principle.",[28],"NOT_YET_RECRUITING","2026-04-30",{"date":147,"type":66},"2026-05-01",{"date":149,"type":22},"2026-09-01",{"date":151,"type":22},"2038-12-31",{"name":153,"class":73},"Sahlgrenska University Hospital",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":166,"conditions":167,"keywords":168,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":4},"100630717","phase-2-thumb-base-osteoarthritis-ultrasound-guided-platelet-rich-plasma-versus-placebo-injection-100630717","NCT07491302","Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection","Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (Thumbs-up Study)","Thumbs-up","Inclusion Criteria:\n\n* Age 18 or older\n* Patients with an Eaton-littler score of I, II or III\n* Patients with uni- or bilateral CMC-I osteoarthritis\n* Non-responders to conservative therapy i.e., hand therapy and immobilisation after 3 months\n\nExclusion Criteria:\n\n* Aged below 18\n* Patients with an Eaton-littler score of IV (STT arthrosis)\n* Surgical interventions of the CMC-I joint\n* A known articular systemic disease (e.g. rheumatoid arthritis) or additional hand osteoarthritis\u002F tenosynovitis or metabolic disease like diabetes mellitus\n* Patients with an infectious arthritis of CMC-I joint\n* A known psychiatric condition\n* Neuropathic chronic pain syndrome\n* Intra articular injection 6 months prior to inclusion\n* Smoking\n* Active use of statins",{"count":163,"type":22},88,[165],"PHASE2","The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections improve pain and function in adults with thumb base osteoarthritis (CMC-I OA).\n\nThe main questions it aims to answer are:\n\nDoes a PRP injection reduce pain compared to a placebo (saline) injection? Does PRP improve hand function, strength, and thumb mobility? What adverse events occur following PRP treatment?\n\nResearchers will compare PRP injections to a placebo injection (saline solution) to determine whether PRP is an effective treatment for CMC-I osteoarthritis.\n\nParticipants will:\n\nReceive a single ultrasound-guided injection of PRP or placebo (saline) in the CMC-I joint.\n\nAttend follow-up visits at 3, 6, 9, and 12 months for clinical assessments. Complete questionnaires on pain (VAS) and hand function (MHQ-DLV) at multiple time points.\n\nUndergo physical examinations (grip strength, pinch strength, thumb motion). Undergo ultrasound evaluations to assess joint characteristics.",[28],[169,170,171,172,173,174,175,176,177],"platelet-rich plasma","CMC-I joint","carpometacarpal joint osteoarthritis","Thumb base osteoarthritis","PRP injection","Placebo-controlled trial","Orthobiologics","Regenerative medicine","Ultrasound-guided injection","2026-04-03",{"date":180,"type":66},"2026-04-09",{"date":182,"type":22},"2026-04",{"date":184,"type":22},"2027-06",{"name":186,"class":73},"Goed Medisch Centrum",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":195,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":199,"phases":4,"briefSummary":200,"conditions":201,"keywords":205,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":107},"100628233","icf-based-biopsychosocial-assessment-with-ai-assisted-profile-prediction-trapeziometacarpal-osteoarthritis-model-100628233","NCT07458971","ICF-Based Biopsychosocial Assessment With AI-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model","ICF-Based Biopsychosocial Assessment With Artificial Intelligence-Assisted Profile Prediction: Trapeziometacarpal Osteoarthritis Model","ICF","Inclusion Criteria:\n\n* Diagnosis of trapeziometacarpal osteoarthritis (TMC OA) confirmed by an orthopedic surgeon and\u002For hand surgeon\n* TMC OA-related symptoms persisting for more than 3 months\n* Aged between 25 and 74 years\n* Literate in Turkish\n* Adequate cognitive function (Mini-Mental State Examination score of 25 or above)\n* No other chronic systemic disease (e.g., rheumatoid arthritis, chronic diabetes, cardiovascular disease, chronic hepatitis)\n* Voluntary participation with signed informed consent\n\nExclusion Criteria:\n\n* Unwillingness to participate\n* Presence of a different orthopedic condition or prior surgery involving the thumb on the unilateral upper extremity\n* Uncontrolled systemic diseases (chronic obstructive pulmonary disease, congestive heart failure, endocrine system disease, history of stroke)\n* Diagnosis of any major psychopathology and currently receiving psychiatric or psychological treatment\n* Pregnancy","25 Years","74 Years",{"count":198,"type":22},93,"OBSERVATIONAL","Trapeziometacarpal osteoarthritis (TMC OA) is a common condition affecting the base of the thumb that causes pain, weakness, and difficulty with daily hand use. Current clinical assessment often focuses on physical findings alone, without considering psychological and social factors that also influence patient outcomes.\n\nThis study has three objectives organized as interrelated work packages:\n\nOBJECTIVE 1 (Clinical Assessment): To comprehensively assess individuals with TMC OA using the International Classification of Functioning, Disability and Health (ICF) framework. This includes evaluating pain, joint mobility, grip strength, daily activity limitations, social participation, psychological factors (anxiety, depression, fear of movement, pain beliefs), and environmental factors (family support, ergonomic adaptations).\n\nOBJECTIVE 2 (AI Knowledge Evaluation): To compare the medical knowledge performance of four large language models (Claude, ChatGPT, Gemini, LLaMA) in answering clinical questions about TMC OA, using criteria such as accuracy, reproducibility, comprehensiveness, clinical relevance, and readability.\n\nOBJECTIVE 3 (AI-Based Prediction): To analyze whether the best-performing large language model can predict multidimensional ICF-based patient profiles using only a limited set of core clinical parameters.",[202,28,203,204],"Trapeziometacarpal Osteoarthritis","Carpometacarpal Osteoarthritis","Thumb Basal Joint Osteoarthritis",[193,206,207,208,38,209,210,211],"Biopsychosocial Assessment","Large Language Model","Artificial Intelligence","Prediction Model","Clinical Decision Support","Pain-Activity Patterns","2026-03-04",{"date":214,"type":66},"2026-03-09",{"date":216,"type":22},"2026-02",{"date":218,"type":22},"2027-07",{"name":220,"class":73},"Hacettepe University",{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":228,"targetDuration":4,"studyType":23,"phases":230,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":107},"100515544","phase-3-nsaid-injection-versus-corticosteroid-injection-for-basilar-thumb-arthritis-100515544","NCT05992883","NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis","NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis: A Randomized, Controlled Trial","Inclusion Criteria:\n\n* Adults \\>40 years of age\n* Pain at the thumb base brought on by direct pressure (grind test) and with movement\n* Pain resistant to previous conservative management (including over the counter medications (ibuprofen\u002Facetaminophen), icing, splinting\u002Fbraces, or topical analgesics)\n* Radiological observation indicative of arthritis based on the Eaton-Littler classification system (stages 1 through 4)\n* Patient understands the protocol and signed the informed consent\n* Patient is covered by health insurance\n\nExclusion Criteria:\n\n* • Known allergy to either of the treatment products\n* Patient's analgesic treatment regimen or other modalities of managing symptoms\u002Fpain associated with their hand pathology was modified within four weeks before trial inclusion\n* Symptomatic Scaphoid-trapezial arthritis present\n* Localized or systemic infection\n* Previous thumb surgery on study thumb\n* Previous thumb injury on study thumb\n* Patient with inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis)\n* Severe and\u002For uncontrolled hypertension\n* De Quervain tendinopathy present\n* History of injection to the trapeziometacarpal joint on study thumb within the previous 6 weeks\n* Uncontrolled diabetes\n* Pregnant or lactating females. Female participants of childbearing potential must have a negative pregnancy test before the injection. Women without childbearing potential (ie., surgically sterile with hysterectomy and\u002For bilateral oophorectomy and\u002For bilateral salpingectomy OR ≥ 12 months of amenorrhea and at least 50 years of age) are eligible to participate without completing a pregnancy test.\n* Immunodeficient patients\n* Patients that are currently using nicotine products, or who have quit in the last 12 months\n* Patients under guardianship, curatorship, or are otherwise not self-sufficient\n* Patients participating in another clinical research trial which interferes with this study protocol or outcomes\n* Patients unable to follow the protocol in the investigators' judgement.",{"count":229,"type":22},240,[231],"PHASE3","The Researchers are trying to compare two different types of intraarticular injections (injection in the joint) for treating the symptoms of moderate to advanced basilar thumb arthritis. One injection is ketorolac (an NSAID) and the other is triamcinolone (a corticosteroid).",[28],[235,236,237,238,239],"Injection","Steroid","NSAID","Thumb Arthritis","CMC Arthritis","2026-02-19",{"date":242,"type":66},"2026-02-23",{"date":244,"type":66},"2023-07-28",{"date":246,"type":22},"2026-12-31",{"name":248,"class":73},"Mayo Clinic",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":256,"targetDuration":4,"studyType":23,"phases":258,"briefSummary":259,"conditions":260,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":107},"100287089","turmeric-for-patients-with-basal-joint-arthritis-100287089","NCT03017118","Turmeric for Patients With Basal Joint Arthritis","A Randomized Controlled Trial Using Turmeric for Patients With Basal Joint Arthritis","Inclusion Criteria:\n\n* 40 years of age or older\n* English fluency and literacy\n* Seeking care for basal joint pain\n* Tender over basal joint\n* Positive distraction rotation test (rotation of the thumb metacarpal base while applying axial traction)\n* Radiographic evidence of Eaton stage 1 and 2 only\n\nExclusion Criteria:\n\n* Secondary gains (litigations or worker compensation) procedures that may interfere with patients' motivation for treatment\n* Inability or unwillingness to participate in a trial study\n* Rheumatoid Arthritis or other inflammatory disorder diagnoses\n* Post-traumatic osteoarthritis\n* Patients on Coumadin\u002FSteroids\u002FNSAIDs\u002FTylenol\n* Diabetes Mellitus\n* Pregnant or lactating women\n* Basal joint arthritis of Eaton stage 3\n* Patients seeking other treatment for their basal joint arthritis (splint, corticosteroid injection, surgery)",{"count":257,"type":22},60,[25],"The aim of this study is to assess whether the use of a commercially available nutraceutical, turmeric, is an effective option to manage pain and stiffness in patients with basal joint arthritis. To conduct a pilot Randomized Controlled Trial evaluating the impact of turmeric on basal joint arthritis.",[28],"2025-11-19",{"date":263,"type":66},"2025-11-24",{"date":265,"type":66},"2017-08-09",{"date":267,"type":22},"2028-01",{"name":269,"class":73},"Massachusetts General Hospital",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":138,"sex":17,"minAge":278,"maxAge":4,"enrollmentInfo":279,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":288,"leadSponsor":290,"locationsCount":292},"100449017","efficacy-of-trapeziectomy-versus-sham-surgery-in-the-treatment-of-osteoarthritis-at-the-base-of-the-thumb-100449017","NCT05127005","Efficacy of Trapeziectomy Versus Sham Surgery in the Treatment of Osteoarthritis at the Base of the Thumb","A Multi-center, Investigator-blinded, Randomized, Parallel Group, Superiority Study to Compare the Efficacy of Trapeziectomy Versus Sham Surgery in the Treatment of Osteoarthritis at the Base of the Thumb","FINTASY","Inclusion Criteria:\n\n1. Primary thumb basal joint (CMC1) osteoarthritis (Eaton Glickel grade 2 or higher) confirmed by standard x-rays and with symptoms limiting activities of daily living\n2. Indication for surgical treatment of thumb basal joint (CMC1) osteoarthritis after insufficient benefit from non-operative treatment, including use of a thumb orthosis and pain medication (NSAIDs or paracetamol, implemented for at least three months.\n3. Thumb pain in use of at least 4 on a 0 to10 numerical rating scale (NRS, 10=worst pain)\n4. Age \\> 45 years\n5. ASA-classification I-II (American Society for Anesthesiologist's Physical Status Classification System)\n6. Ability to speak, understand and read in the language of the clinical site\n7. Provision of informed consent from the participant\n\nExclusion Criteria:\n\n1. Patients' main complaint is due to some other problem than primary thumb basal joint (CMC1) osteoarthritis or patient will undergo any other surgery in conjunction with trapeziectomy\n2. Neurologic condition affecting the function or symptoms of the upper extremity\n3. \\\u003C6 months from other surgical procedure of the upper extremities\n4. Rheumatoid arthritis or other inflammatory joint disease\n5. Bilateral thumb basal joint (CMC1) osteoarthritis in which patient requests treatment for both sides\n6. Previous operation due tothumb basal joint (CMC1) osteoarthritis for either side\n7. \\>45 degrees of hyperextension in the thumb MP joint in resting position (zig zag deformity)\n8. Patient is unable to continue his\u002Fher current job due to thumb pain","45 Years",{"count":280,"type":22},132,[25],"A multi-center randomized placebo-controlled clinical trial which determines the efficacy of trapeziectomy in patients with persistent painful osteoarthritis at the base of the thumb. The primary outcome is patient reported evaluation of pain and function of the wrist and hand at 6 months after the randomization to treatment group.",[28],"2022-01-20",{"date":286,"type":66},"2022-01-21",{"date":284,"type":66},{"date":289,"type":22},"2029-12",{"name":291,"class":73},"Tampere University Hospital",4]