[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thyroid-abnormalities\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thyroid-abnormalities":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100630508","a-novel-ultrasound-probe-for-thyroid-imaging-and-machine-learning-100630508",false,"NCT07488585","A Novel Ultrasound Probe for Thyroid Imaging and Machine Learning","A Novel Ultrasound Probe for Thyroid Imaging and Machine Learning: A Pilot Study","THYMAL 01","Inclusion Criteria:\n\n* Participants must be ≥ 18 years of age\n* Able and willing to sign informed consent\n* Known thyroid nodule demonstrated on a prior thyroid US and is undergoing active surveillance of the nodule with serial USs\n\nExclusion Criteria:\n\n* Unable to lay flat for 15 minutes\n* Active neck wounds, dressings, or skin conditions that would interfere with neck US (e.g., preclude transducer placement)\n* Cervical spine or back disease that would prevent neck extension and would hinder the ability to obtain accurate thyroid US images\n* Previous thyroid surgeries, radiation of face and neck\n* Known inflammatory thyroid diseases or thyroiditis (e.g., Graves, Hashimoto)","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The objective of the THYMAL 01 pilot study is to evaluate the Sound Blade Imaging System in subjects with benign thyroid nodules undergoing standard-of-care ultrasound imaging.",[27,28],"Thyroid Nodules","Thyroid Abnormalities",[30],"Thyroid Nodule","NOT_YET_RECRUITING","2026-04-03",{"date":34,"type":35},"2026-04-07","ACTUAL",{"date":37,"type":21},"2026-05-31",{"date":39,"type":21},"2027-09",{"name":41,"class":42},"Sound Blade Medical Inc.","INDUSTRY",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100566340","phase-4-levothyroxine-intervention-in-pregnant-women-with-tsh-25-miul-upper-limit-of-reference-range-and-negative-thyroid-peroxidase-antibody-100566340","NCT06653907","Levothyroxine Intervention in Pregnant Women with TSH （2.5 MIU\u002FL-upper Limit of Reference Range） and Negative Thyroid Peroxidase Antibody","Randomized Control Study of Levothyroxine Intervention in Pregnant Women with Thyroid Stimulating Hormone Between 2.5 MIU\u002FL and Upper Limit of Reference Range and Negative Thyroid Peroxidase Antibody","LIGHT","Inclusion Criteria:\n\n1. Women of childbearing age（18-45 years old）, natural pregnancy, singleton pregnancy.\n2. Measure thyroid related indexes within 8 weeks of pregnancy: TSH 2.5mIU\u002FL-ULRR, FT4 is normal and TPOAb negativity.\n3. Willing to sign an informed consent form.\n\nExclusion Criteria:\n\n1. History of recurrent miscarriage (≥3 times).\n2. Assisted reproduction (artificial insemination, in vitro fertilization and embryo transfer);\n3. Suffer from diseases that seriously affect pregnancy outcome, including hypertension, diabetes, heart disease, liver and kidney dysfunction, etc.\n4. Failure of vital organs.\n5. Except autoimmune thyroid disease，suffer from other autoimmune diseases.\n6. Thyroid diseases (including hyperthyroidism, thyroid cancer, thyroid amyloidosis and other extensive intrathyroidal diseases, current subacute thyroiditis, iodine-deficiency endemic goiter, thyroidectomy or 131I treatment, previous thyroid Ultrasound prompts diffuse thyroid disease, etc.).\n7. Use of thyroid-related drugs (lithium carbonate, thioureas, sulfonamides, sodium para-amino salicylate, potassium perchlorate, phenylbutazone, sulfate, tyrosine kinase inhibitor, etc.) during screening and affect thyroid Functional testing drugs. (Including glucocorticoids, metoclopramide, propranolol, amiodarone, sodium valproate, etc.)\n8. Secondary hypothyroidism or central hypothyroidism. (Including pituitary tumors, surgery, radiotherapy, lymphocytic hypophysitis, etc.)\n9. L-T4 allergy.\n10. Unwilling to sign an informed consent.\n11. Other clinicians judged that they are not suitable to participate in the study.","FEMALE","45 Years",{"count":54,"type":21},400,[56],"PHASE4","The goal of this clinical trial is to learn if levothyroxine (L-T4) works to treat pregnant women with TSH 2.5 mIU\u002FL-the upper limit of reference range (ULRR) of pregnancy and TPOAb-negative. It will also learn about the safety of L-T4. The main quesitons the investigator want to answer are:\n\n* Will L-T4 reduce miscarriage rates and have an impact on pregnancy complications in pregnant participants?\n* What medical issues do participants have when taking L-T4 during pregnancy? -Investigators will compare L-T4 with placebo (a substance with a similar appearance without medication) to see if L-T4 could reduce miscarriage rates\n\nParticipants should:\n\n* Take L-T4 or placebo during the whole pregnancy.\n* Visit the hospital once every 6-8 weeks during pregnancy for checkups and tests\n* Keep a diary of their pregncny complications and daily record of L-T4 or placebo intake.\n* Visit the hospital for examination 42 days postpartum for checkups and follow up by phone at 6 and 12 months postpartum.",[28,59,60],"Pregnant Woman","Pregnancy Outcomes",[62,63,64,65,66],"TSH","TPOAb","pregnant women","levothyroxine","outcome","2024-10-21",{"date":69,"type":35},"2024-10-23",{"date":71,"type":21},"2024-10-25",{"date":73,"type":21},"2027-10-31",{"name":75,"class":76},"Yang ZHANG","OTHER",1]