[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thyroid-and-parathyroid-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thyroid-and-parathyroid-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100642663","phase-4-the-association-between-bilateral-intermediate-cervical-plexus-block-during-total-thyroidectomy-and-surgical-stress-response-100642663",false,"NCT07600580","The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response","The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary and Serum Biomarkers of Surgical Stress Response During Total Thyroidectomy","Inclusion Criteria:\n\n* patienets of both sexes\n* 18 years of age and older\n* ASA I or ASA II\n* euthyroid status\n* signed informed consent\n\nExclusion Criteria:\n\n* patients who refuse to sign the informed consent form\n* infection at the block injection site\n* hypersensitivity or contraindications to the medications used in the study\n* hypothyroidism or hyperthyroidism at the time of surgery\n* presence of substernal goiter\n* additional surgical interventions during the procedure\n* history of previous neck surgery or radiation\n* coagulopathy\n* uncontrolled respiratory disease\n* diabetes mellitus\n* autoimmune disease\n* chronic corticosteroid therapy\n* smokers\n* pregnant women.","ALL","18 Years",{"count":19,"type":20},48,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of stress and inflammatory biomarkers in the participants' saliva and serum.\n\nThe study will be conducted on 48 subjects divided into two groups of 24: a control group receiving total intravenous anesthesia (TIVA) and an experimental group receiving TIVA combined with a bilateral intermediate cervical plexus block.\n\nInvestigators hypothesized that a combination of bilateral intermediate cervical plexus block and total intravenous anesthesia (TIVA) would reduce the surgical stress response, as measured by salivary and blood biomarkers, compared to TIVA alone in patients undergoing total thyroidectomy.\n\nShould the research confirm the hypothesis, it will provide an objective scientific argument for including the block in standard anesthetic protocols for total thyroidectomy surgeries, with the ultimate goal of reducing the surgical stress response and ensuring faster patient recovery.",[26,27,28,29],"Thyroid Cancer","Thyroid and Parathyroid Surgery","Hyperthyreosis and Goiter","Surgical Stress Response",[31,32,33,34],"bilateral intermediate cervical plexus block","surgical stress response","IL-6, cortisol, alpha-amylase","saliva analysis","RECRUITING","2026-06-13",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":39},"2024-05-13",{"date":43,"type":20},"2027-08-01",{"name":45,"class":46},"University Hospital Dubrava","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100640858","analysis-of-chlordecone-tissue-concentrations-in-patients-treated-for-thyroid-surgery-at-guadeloupe-university-hospital-100640858","NCT07611994","Analysis of Chlordecone Tissue Concentrations in Patients Treated for Thyroid Surgery at Guadeloupe University Hospital","COTICHLO","Inclusion Criteria:\n\n* adult patients hospitalized at the Guadeloupe University Hospital for surgical treatment of thyroid pathology\n* person affiliated to or beneficiaries of a social security system\n* person with free, informed, and written consent signed by the participant and the investigator\n\nExclusion Criteria:\n\n* patients subject to a judicial safeguard measure,\n* patient under 18 years old\n* patient without signed consent\n* current pregnancy at the time of inclusion",{"count":56,"type":20},69,[58],"NA","Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor. Accumulation in thyroid tissue may be modeled using several factors, including blood chlordecone levels, environmental exposure associated with place of residence, and dietary habits.",[27],[62,63,64],"chlordecone","thyroid nodes","thyroid disruptor","NOT_YET_RECRUITING","2026-05-28",{"date":68,"type":39},"2026-06-01",{"date":70,"type":20},"2026-07-01",{"date":72,"type":20},"2027-11-01",{"name":74,"class":46},"Centre Hospitalier Universitaire de la Guadeloupe",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":47},"100602525","phase-4-sore-throat-after-open-neck-elective-surgery-100602525","NCT07124650","Sore Throat After Open Neck Elective Surgery","Effect of Hydrocortisone and Lidocaine on Endotracheal Tube for Sore Throat and Hoarseness After Thyroid\u002FParathyroid Surgery With Neuromonitoring: A Randomized Controlled Trial","STONES","Inclusion Criteria:\n\n* Patients scheduled for elective open surgery on the thyroid\u002Fparathyroid glands with intraoperative neuromonitoring.\n* Age ≥18 years.\n* Willing and able to provide voluntary informed consent for participation in the study.\n\nExclusion Criteria:\n\n* Pregnancy (for women of childbearing potential).\n* Known allergy to hydrocortisone or lidocaine.\n* Refusal to participate in the study.",{"count":84,"type":20},764,[23],"This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough following thyroid or parathyroid surgery with neuromonitoring.\n\nA total of 764 adult patients undergoing elective neck surgery at Saint-Petersburg State University Hospital will be enrolled and randomly assigned to receive either a hydrocortisone-coated or lidocaine-coated endotracheal tube.\n\nOutcomes will be assessed upon awakening from anesthesia, at 24 hours, and again at 3 days postoperatively.\n\nThe findings may contribute to improving postoperative comfort and recovery for patients undergoing similar surgical procedures.",[88,27],"Postoperative Sore Throat, Cough, Hoarseness",[90,91,92,93,94],"Hydrocortisone","Lidocaine","Endotracheal tube","Neuromonitoring","Randomized controlled trial","2026-04-06",{"date":97,"type":39},"2026-04-13",{"date":99,"type":39},"2025-09-15",{"date":101,"type":20},"2027-05",{"name":103,"class":46},"Saint Petersburg State University, Russia"]