[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thyroid-nodule-benign\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thyroid-nodule-benign":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,68,91,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100596521","thyroid-artery-goitre-embolization-trial-a-pilot-study-investigating-thyroid-artery-embolisation-as-a-treatment-for-large-thyroid-nodules-100596521",false,"NCT07046546","Thyroid Artery Goitre Embolization Trial A Pilot Study Investigating Thyroid Artery Embolisation as a Treatment for Large Thyroid Nodules","Thyroid ARtery Goitre Embolization Trial: A Service Introduction and Safety Assessment","TArGET","Inclusion Criteria:\n\n* The participant may enter the study if ALL of the following apply:\n\n  * Adults over 18 years of age willing and able to give informed consent.\n  * Symptomatic or cosmetically distressing benign nodular thyroid disease with or without intrathoracic extension and with or without hyperthyroidism. Or auto-immune hyperthyroidism (Graves disease).\n  * Single nodular goitre causing local mass effect warranting treatment or multi-nodular goitre\n  * TIRADS score 1, 2 and 3 nodules (benign or mildly suspicious) as assessed by ultrasound.\n  * FNA confirmed benign disease (x2 FNA Thy2 (benign) result required for TR3 nodules, 1x FNA if nodule classified TR2 or less). FNA performed on most high grade nodule or if equal grade then largest nodule.\n  * No enlarged \u002F suspicious neck lymphadenopathy on ultrasound.\n  * Patient willing to undergo thyroid nodule embolization in preference to other viable treatment options after discussion with Consultant ENT surgeon and \u002F or Consultant Interventional Radiologist. TAE can also be performed as a bridge to surgery, Radiofrequency ablation or Radioactive iodine. Patients may also be unsuitable or unfit for other treatment options.\n  * Patient able to lay on the angiography table flat with one or two pillows, and can lay comfortably with 30 degrees or less of head elevation for a minimum of two hours.\n\nExclusion Criteria:\n\n* The participant may enter the study if ALL of the following apply:\n\n  * Adults over 18 years of age willing and able to give informed consent.\n  * Symptomatic or cosmetically distressing benign nodular thyroid disease with or without intrathoracic extension and with or without hyperthyroidism. Or auto-immune hyperthyroidism (Graves disease).\n  * Single nodular goitre causing local mass effect warranting treatment or multi-nodular goitre\n  * TIRADS score 1, 2 and 3 nodules (benign or mildly suspicious) as assessed by ultrasound.\n  * FNA confirmed benign disease (x2 FNA Thy2 (benign) result required for TR3 nodules, 1x FNA if nodule classified TR2 or less). FNA performed on most high grade nodule or if equal grade then largest nodule.\n  * No enlarged \u002F suspicious neck lymphadenopathy on ultrasound.\n  * Patient willing to undergo thyroid nodule embolization in preference to other viable treatment options after discussion with Consultant ENT surgeon and \u002F or Consultant Interventional Radiologist. TAE can also be performed as a bridge to surgery, Radiofrequency ablation or Radioactive iodine. Patients may also be unsuitable or unfit for other treatment options.\n  * Patient able to lay on the angiography table flat with one or two pillows, and can lay comfortably with 30 degrees or less of head elevation for a minimum of two hours.","ALL","18 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","Large non-cancerous thyroid nodules (lumps in the thyroid gland) can cause pressure or discomfort in the neck or cosmetic issues. The standard treatment options include radiofrequency ablation, radioactive iodine, and surgery. Not all patients are suitable however for these treatments, some lumps are too large, or the patients are not fit enough for surgery.\n\nThyroid artery embolization (TAE) is a new minimally invasive technique (smaller incisions \u002F cuts and shorter recovery time) performed under light sedation. It is used by other European Thyroid Centres, but it hasn't been used in the UK. Embolization means arteries supplying the thyroid gland are blocked by injecting small occlusive particles, like very fine grains of sand that can get stuck in small spaces, preventing blood from passing through. Blocking the thyroid arteries causes the gland to shrink. This provides symptom relief or controls an overactive gland.\n\nWe aim to undertake a TAE pilot study to explore the safety of TAE in a UK patient population. We are planning to recruit 10 eligible patients. We will also collect additional data (for example on pain, effectiveness, cost and health related quality of life) to inform a future larger trial comparing TAE to other treatment options.",[27,28,29],"Thyroid Nodule (Benign)","Graves Disease","Goitre",[31,32],"Thyroid artery embolisation","Benign thyroid nodules","RECRUITING","2025-12-23",{"date":36,"type":37},"2025-12-24","ACTUAL",{"date":39,"type":37},"2025-09-29",{"date":41,"type":21},"2027-05",{"name":43,"class":44},"Royal Berkshire NHS Foundation Trust","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":45},"100572168","ultrasound-guided-thermal-ablation-for-benign-thyroid-nodules-100572168","NCT06729762","Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules","Ultrasound-guided Thermal Ablation for the Treatment of Benign Thyroid Nodules: A Multicenter Study","Inclusion Criteria:\n\n1. confirmation of benign nodule status on two separate fine- needle aspiration or core-needle biopsy\n2. no suspicious malignant features on ultrasound examination\n3. report of cosmetic and\u002F or symptomatic problems or concern of nodules growing rapidly or malignant transformation\n4. refusal or ineligibility for surgery\n5. follow-up time ≥12 months\n\nExclusion Criteria:\n\n1. follicular neoplasm or malignancy findings on biopsy\n2. nodules with benign result on biopsy had suspicious of malignancy in US\n3. patients with contra-lateral vocal cord paralysis\n4. previous radiation to the head and neck\n5. follow- up time less than 12 months",{"count":54,"type":21},1500,"OBSERVATIONAL","To evaluate long-term outcomes of ultrasound-guided thermal ablation for benign thyroid nodules",[27],"2025-02-13",{"date":60,"type":37},"2025-02-14",{"date":62,"type":37},"2024-12-09",{"date":64,"type":21},"2030-12-31",{"name":66,"class":67},"Chinese PLA General Hospital","OTHER",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":74,"targetDuration":76,"studyType":55,"phases":4,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":45},"100576012","evaluation-of-different-diagnostic-therapeutic-strategies-in-patients-with-thyroid-pathology-100576012","NCT06779747","Evaluation of Different Diagnostic Therapeutic Strategies in Patients with Thyroid Pathology","Inclusion Criteria:\n\n* Age older than 18 years at the time of diagnosis;\n* Patients with thyroid pathology (hypothyroidism, hyperthyroidism\u002Fthyrotoxicosis, benign thyroid nodule, and thyroid carcinoma) in whom the diagnosis was made in our Center or another Center from 01\u002F01\u002F1995 until the approval of this study (retrospective phase) or from the time of approval of this study to the next 10 years (prospective phase);\n* Obtaining informed consent.\n\nExclusion Criteria:\n\n* Follow up lasting less than 3 months;\n* Incomplete or missing clinical data that may affect the correct assessment of the patient.",{"count":75,"type":21},5850,"20 Years","Observational single-center prospective and retrospective, nonpharmacological, spontaneous cohort study.",[79,80,27,81],"Hypothyroidism","Hyperthyroidism\u002FThyrotoxicosis","Thyroid Carcinoma","2025-01-13",{"date":84,"type":37},"2025-01-17",{"date":86,"type":37},"2021-12-30",{"date":88,"type":21},"2041-12-30",{"name":90,"class":67},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":45},"100548866","mwa-vs-rfa-for-the-treatment-of-moderate-sized-benign-thyroid-nodules-100548866","NCT06426563","MWA vs RFA for the Treatment of Moderate-sized Benign Thyroid Nodules","Microwave Ablation Versus Radiofrequency Ablation for the Treatment of Moderate-sized Benign Thyroid Nodules, a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adult patients \\>\u002F=18 years of age\n2. Nodule maximal diameter ≥2cm and nodule volume \\<20ml\n3. Nodule being predominantly solid (≥80% solid)\n4. Confirmed benign nature of nodules, either by : two benign fine needle biopsies, with the most recent biopsy performed within 1 year of enrollment in study or one benign fine needle biopsy and low suspicion characteristics on ultrasound\n5. Both functional and non-functional nodules are eligible.\n\nExclusion Criteria:\n\n1. Cytologically indeterminate nodules\n2. Nodules with substernal extension or posterior extension that cannot be viewed sufficiently with ultrasound\n3. current pregnancy or cardiac arrhythmias; presence of pacemaker or any medical condition that renders patient unfit for thermal ablation",{"count":99,"type":21},150,[24],"Thyroid nodule is a common condition that affects up to 60% of the population. There is an estimated 10% lifetime probability of developing a thyroid nodule. Although most thyroid nodules are benign, up to 10-15% can enlarge to cause compressive symptoms including neck pressure and discomfort, dysphagia, dyspnea, and dysphonia. The conventional treatment for these benign but problematic nodules has been thyroidectomy. Although generally a low risk operation, thyroidectomy is associated with some risk for recurrent laryngeal nerve injury, bleeding, infection, and need for thyroid hormone supplementation. Since the early 2000s, ultrasound-guided percutaneous thermal ablation has emerged as a potential alternative treatment to surgery for benign thyroid nodules. Of the myriad ablation methods, the most commonly used techniques are radiofrequency ablation (RFA) and microwave ablation (MWA). \\[1-3\\] A growing body of evidence shows that RFA is an effective treatment for benign solid thyroid nodules, toxic adenomas, and thyroid cysts resulting in overall volume reduction ranges of 40-80% at 1 year, with durable resolution of compressive and hyperthyroid symptoms. However, RFA is not without its limitations. Radiofrequency waves can be limited by the heat sink effect and tissue char leading to longer procedure times and potentially less optimal outcomes in larger, hypervascular, and\u002For more cystic nodules.\n\nMicrowave ablation (MWA) is another ablative technique that uses electromagnetic energy waves to cause tissue hyperthermia and coagulative necrosis. It generally causes higher ablation temperatures than RFA and is less subject to the heat sink effect, and therefore can facilitate more efficient ablation procedures. Current evidence comparing RFA versus MWA for thyroid ablation was limited and was either retrospective, non-randomized \\[4-9\\], under-powered, or with an unequal baseline. The results from these studies were also conflicting, suggesting suboptimal quality of evidence and bias due to non-standardized technique of ablation across studies. To date, there is no randomized controlled trial comparing the efficacy and safety of RFA versus MWA for the treatment of benign thyroid nodules. Given the higher ablation temperatures, freedom from heat sink effect, and no influence from impedance changes during ablation, MWA may achieve different treatment efficacy.",[103,104],"Thyroid Nodule \\(Benign\\)","Ablation Therapy",[106,107,108,109,110],"Ablation therapy","Thyroid nodule","benign","RFA","MWA","2024-05-23",{"date":113,"type":37},"2024-05-28",{"date":115,"type":37},"2024-04-15",{"date":117,"type":21},"2028-06-30",{"name":119,"class":67},"The University of Hong Kong",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":45},"100413631","function-integrity-of-neck-anatomy-in-thyroid-surgery-100413631","NCT04666103","Function Integrity of Neck Anatomy in Thyroid Surgery","Preserving Function Integrity of Neck Anatomy in Thyroid Surgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients diagnosed with unilateral thyroid carcinoma and contralateral benign nodule confirmed by preoperative ultrasound-guided fine-needle aspiration cytology;\n* Patients with contralateral nodules ≤ 20mm and located in the thyroid gland;\n* Patients with clinical node-negative cervical compartment at palpation and neck ultrasound.\n\nExclusion Criteria:\n\n* Previous history of neck surgery\n* Previous history of neck radiation therapy","75 Years",{"count":129,"type":21},1264,[24],"Recent trends in the management of patients with low-risk papillary thyroid carcinoma who have a nonsuspicious or cytologically benign contralateral nodule call into question the need for routine total thyroidectomy. Although the lobectomy for the unilateral thyroid cancer with contralateral benign nodules is sufficient treatment, some of the patients might suffer from the anxiety of the residual benign thyroid nodule and tend to choose total thyroidectomy, which might be overtreatment.\n\nThermal ablation has been proven to be effective in achieving nodule shrinkage and being also free from major complications. In our institution, intraoperative RFA was a proposed alternative strategy to treat the contralateral benign nodules after the thyroid lobectomy for the malignant lobe, which was found to have a better quality of life on anxiety, physiological health, social family, psychological and sensory mentions with a considerable complication rate.",[81,27,133],"Ablation; Retina","2020-12-11",{"date":136,"type":37},"2020-12-14",{"date":134,"type":37},{"date":139,"type":21},"2026-12-12",{"name":141,"class":67},"Wuhan University"]