[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thyroidectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thyroidectomy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,42,60,98,129,155,184,215,244,265,287,317,346,372],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100643496","the-effect-of-esketamine-on-cough-reflex-during-tracheal-extubation-in-patients-undergoing-non-inflatable-transoral-endoscopic-thyroid-surgery-100643496",false,"NCT07641673","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Non-inflatable Transoral Endoscopic Thyroid Surgery","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Non-inflatable Transoral Endoscopic Thyroid Surgery: A Randomized Controlled Study.","Inclusion Criteria:\n\n* Patients scheduled for endotracheal intubation-free thyroid surgery under oral endoscopy\n* ASA class I-II\n* Voluntarily participate in the study and sign the informed consent form\n\nExclusion Criteria:\n\n* Body Mass Index \\> 30 kg\u002Fm²\n* Patients with unstable ischemic cardiomyopathy, pulmonary hypertension, poorly controlled or untreated hypertension (arterial hypertension, resting systolic\u002Fdiastolic blood pressure \\>180\u002F100 mmHg)\n* Hepatic or renal dysfunction\n* History of oral, maxillofacial, neck, or airway surgery, or pathological structural alterations\n* Respiratory diseases (COPD, asthma, inflammation, chronic cough)\n* Patients with elevated intracranial pressure\n* Patients undergoing repeat surgery\n* History of allergy to the investigational drug used in the study\n* Patients with psychiatric disorders or alcohol abuse (daily ethanol intake ≥40 g, or having experienced alcohol withdrawal within the past 6 months, or unable to control alcohol consumption)","ALL","18 Years","65 Years",{"count":20,"type":21},186,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study intends to implement esketamine-assisted anesthesia in patients undergoing non-inflatable transoral endoscopic thyroidectomy through a prospective randomized controlled trial, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.",[27,28],"Thyroidectomy","Coughing Reflex","NOT_YET_RECRUITING","2026-06-07",{"date":32,"type":33},"2026-06-11","ACTUAL",{"date":35,"type":21},"2026-06",{"date":37,"type":21},"2027-09",{"name":39,"class":40},"The Second Hospital of Anhui Medical University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":58,"leadSponsor":59,"locationsCount":41},"100638116","the-effect-of-esketamine-on-cough-reflex-during-tracheal-extubation-in-patients-undergoing-open-thyroid-surgery-100638116","NCT07625826","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery","The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective open thyroid surgery\n* ASA class I-II\n* Voluntarily participate in the study and sign the informed consent form\n\nExclusion Criteria:\n\n* Body Mass Index \\> 30 kg\u002Fm²\n* Patients with unstable ischemic cardiomyopathy, pulmonary hypertension, poorly controlled or untreated hypertension (arterial hypertension, resting systolic\u002Fdiastolic blood pressure \\>180\u002F100 mmHg)\n* Hepatic or renal dysfunction\n* History of oral, maxillofacial, neck, or airway surgery, or pathological structural alterations\n* Respiratory diseases (COPD, asthma, inflammation, chronic cough)\n* Patients with elevated intracranial pressure\n* Patients undergoing repeat surgery\n* History of allergy to the investigational drug used in the study\n* Patients with psychiatric disorders or alcohol abuse (daily ethanol intake ≥40 g, or having experienced alcohol withdrawal within the past 6 months, or unable to control alcohol consumption)",{"count":50,"type":21},136,[24],"This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.",[27,28],"2026-06-03",{"date":56,"type":33},"2026-06-04",{"date":35,"type":21},{"date":37,"type":21},{"name":39,"class":40},{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":67,"targetDuration":4,"studyType":22,"phases":69,"briefSummary":70,"conditions":71,"keywords":77,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":41},"100640349","niraf-guided-parathyroid-identification-during-thyroidectomy-100640349","NCT07617584","NIRAF-Guided Parathyroid Identification During Thyroidectomy","Near-Infrared Autofluorescence-Guided Parathyroid Identification During Thyroidectomy","Inclusion Criteria:\n\n* Age 18 years or older.\n* For Component A: planned thyroidectomy of any extent with an intact specimen available for ex vivo evaluation.\n* For Component B: planned total or completion thyroidectomy.\n* Ability to provide written informed consent before surgery.\n* Willingness to comply with routine postoperative laboratory testing and follow-up when feasible.\n\nExclusion Criteria:\n\n* Known pre-existing hypoparathyroidism or prior parathyroid surgery.\n* Severe chronic kidney disease or end-stage renal disease expected to substantially confound calcium and parathyroid hormone interpretation, as defined by the site investigator.\n* Pregnancy.\n* For Component B only: gross nodal disease or a surgical plan requiring extensive nodal packet dissection in the current study phase.\n* Any condition that, in the judgment of the investigator, would make participation unsafe or compromise protocol adherence.",{"count":68,"type":21},280,[24],"This is a single-site, two-component prospective study evaluating whether near-infrared autofluorescence (NIRAF) imaging can improve intraoperative identification of parathyroid glands during thyroidectomy and reduce postoperative hypocalcemia.\n\nThe investigational platform is a modified wearable stereoscopic goggle system configured for label-free NIRAF imaging. Parathyroid tissue is excited with near-infrared light at approximately 780 nm and emits autofluorescence centered near 800 nm. No injected dye or external contrast agent is used. The goggles are used only during a brief mapping interval after thyroid exposure and for ex vivo interrogation of the resected thyroid specimen.\n\nComponent A is a prospective observational run-in validation cohort of 30 adults undergoing thyroidectomy of any extent. NIRAF-positive foci on the intact thyroidectomy specimen are suture-marked and correlated with targeted pathology.\n\nComponent B is a randomized clinical study of 250 adults undergoing total or completion thyroidectomy. Participants are randomized 1:1 to standard surgery or standard surgery plus brief in vivo NIRAF mapping, ex vivo specimen interrogation, and rescue autotransplantation when indicated. The primary outcome for Component B is transient biochemical hypocalcemia on postoperative day 1, defined using albumin-corrected serum calcium.",[72,73,74,75,76,27],"Hypocalcemia","Hypoparathyroidism","Thyroid Diseases","Goiter, Nodular","Thyroid Nodule",[78,79,80,81,27,82,83,84,85,86,87,88,89],"Near-Infrared Autofluorescence","NIRAF","Parathyroid Identification","Parathyroid Preservation","Completion Thyroidectomy","Total Thyroidectomy","Postoperative Hypocalcemia","Intact Parathyroid Hormone","iPTH","Rescue Autotransplantation","Wearable Imaging","Post-thyroidectomy hypocalcemia","2026-05-29",{"date":92,"type":33},"2026-06-01",{"date":92,"type":21},{"date":95,"type":21},"2029-12-01",{"name":97,"class":40},"Ss. Cyril and Methodius University of Skopje",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":114,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100585206","the-role-of-prophylactic-central-compartment-neck-dissection-in-the-management-of-2-to-4-cm-papillary-thyroid-carcinoma-100585206","NCT06899347","The Role of Prophylactic Central Compartment Neck Dissection in the Management of 2 to 4 cm Papillary Thyroid Carcinoma","Impact of PROphylactic Central cOMpArtment Neck Dissection for 2-4 cm Papillary Thyroid Carcinoma","PRO-COMAND","Inclusion criteria:\n\n1. PTC documented by fine needle aspiration cytology (FNAC) (TIR 4 or TIR 5 according to the Italian consensus for the classification and reporting of thyroid cytology \\[16\\]);\n2. patients scheduled for thyroid lobectomy or total thyroidectomy;\n3. no pre-operative evidence of lymph node metastases (cN0) at palpation and neck ultrasound (US);\n4. no clinical evidence of distant metastasis at diagnosis;\n5. age ≥ 18 years;\n6. signing informed consent.\n\nExclusion criteria:\n\n1. histotypes other than PTC;\n2. evidence of lymph node metastases during surgery even if not previously diagnosed;\n3. presence of distant metastasis;\n4. refusal to sign informed consent.\n\nExit criteria:\n\n1. withdrawal of informed consent;\n2. post-operative radioactive iodine therapy.",{"count":107,"type":21},392,[24],"Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and is frequently associated with microscopic central neck lymph node metastases, even in the absence of preoperative clinical evidence of nodal involvement (cN0). While prophylactic central compartment neck dissection (pCCND) may improve staging accuracy and potentially reduce disease persistence or recurrence, its routine use remains controversial due to the risk of increased surgical morbidity and potential negligible impact on oncologic outcomes.\n\nThis prospective randomized study aims to evaluate the oncological and surgical outcomes of cN0 PTC patients with tumors measuring 2 to 4 cm who undergo thyroid surgery with or without pCCND. Patients will be treated according to standard clinical practice with either total thyroidectomy (TT) or thyroid lobectomy (TL), and randomized to receive pCCND (bilateral or ipsilateral, respectively) or not. Patients undergoing TT and those undergoing TL will be analyzed separately in two parallel cohorts.\n\nThe primary objective is to assess the impact of pCCND on disease persistence or recurrence during long-term follow-up. Secondary objectives include evaluation of surgical complications and the impact of pCCND on pathological staging.",[111,112,27,113],"Papillary Thyroid Carcinoma","Central Compartment Neck Dissction","Thyroid Lobectomy",[115,116,117,118,119,120],"papillary thyroid carcinoma","prophylactic central compartment neck dissection","thyroidectomy","surgical complications","outcomes","thyroid lobectomy","2026-04-28",{"date":123,"type":33},"2026-05-05",{"date":121,"type":21},{"date":126,"type":21},"2036-04",{"name":128,"class":40},"Leonardo Rossi",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":142,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":4},"100633915","comparing-medial-and-lateral-dissection-approaches-to-the-recurrent-laryngeal-nerve-during-a-thyroidectomy-100633915","NCT07532889","Comparing Medial and Lateral Dissection Approaches to the Recurrent Laryngeal Nerve During a Thyroidectomy","The Use of Continuous Nerve Monitoring to Compare Rates of Recurrent Laryngeal Nerve Injury Between Medial and Lateral Dissection Approaches to the Recurrent Laryngeal Nerve During a Thyroidectomy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* All patients undergoing a total thyroidectomy or hemithyroidectomy under the care of the participating surgeons\n\nExclusion Criteria:\n\n* Age less than 19 years old\n* Previous thyroid or parathyroid surgery, substernal goiter, preoperative vocal cord palsy (VCP)\n* Evidence of lateral or central neck lymph node metastases\n* Intentional iatrogenic transection of the RLN due to tumor invasion\n* Failure to assess real-time RLN functioning due to equipment issues with the IONM setup\n* Presurgical dissection amplitude under 100uV\n* Patient refusal to participate in the study\n* Intraoperative decision to switch to a different approach to identifying the RLN","19 Years",{"count":138,"type":21},430,[24],"The goal of this interventional study is to compare the effectiveness of two surgical approaches in identifying the recurrent laryngeal nerve (RLN) during thyroidectomy. The main questions it aims to answer are:\n\nHow does each approach affect the length of hospital stay? How does each approach affect the number of adverse events that occur during surgery? How does each approach affect vocal cord function after surgery?\n\nResearchers will compare the new medial approach to the standard lateral approach to evaluate its effectiveness.\n\nParticipants scheduled to undergo thyroidectomy surgery will be randomly assigned to one of these approaches after informed consent is obtained. Data will be collected during and after the surgery by a research assistant.",[27],[27,143,144,145],"Medial Approach to Thyroidectomy","Lateral Approach to Thyroidectomy","Continuous Nerve Monitoring","2026-04-15",{"date":148,"type":33},"2026-04-21",{"date":150,"type":21},"2026-05",{"date":152,"type":21},"2028-12",{"name":154,"class":40},"Oleksandr Butskiy",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":165,"briefSummary":167,"conditions":168,"keywords":171,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":41},"100633781","phase-4-effects-of-flurbiprofen-spray-and-ice-cream-for-pain-and-voice-outcomes-after-thyroidectomy-100633781","NCT07531147","Effects of Flurbiprofen Spray and Ice Cream for Pain and Voice Outcomes After Thyroidectomy","Comparison of the Effects of Postoperative Oral Flurbiprofen (0.25%) Spray and Ice Cream on Analgesia and Voice Quality in Patients Undergoing Thyroidectomy","Inclusion Criteria:\n\n* No history of neck surgery\n* Age between 18-85 years\n* Undergoing thyroidectomy\n* Agreeing to participate in the study\n* Operation duration between 60-120 minutes\n\nExclusion Criteria:\n\n* History of neck surgery\n* History of radiotherapy to the head and neck region\n* Pre-operative or post-operative vocal cord paralysis\n* Pre-operative phonetic disorder\n* Pre-operative laryngeal pathology\n* Being under 18 years of age\n* Refusal to participate in the study\n* Smoking\n* Flurbiprofen allergy\n* Lactose intolerance","85 Years",{"count":164,"type":21},100,[166],"PHASE4","Researchers will compare oral flurbiprofen (%0.25) spray and ice cream to a placebo (a look-alike substance that contains no drug) to see if oral flurbiprofen (%0.25) spray and ice cream works to effect post-thyroidectomy throat pain and voice quality.\n\nParticipants will:\n\n* Receive 1 puff of oral flurbiprofen (0.25%) spray or 105 ml of ice cream or 1 puff of oral spray prepared with drinking water (placebo) at 5 hours postoperatively according to randomization result\n* Undergo voice analysis using Praat voice analysis (University of Amsterdam) at 6 hours postoperatively\n* Undergo a visual analog scale for analgesia status at 6 hours postoperatively",[27,169,170],"Sore Throat","Voice Quality",[117,172,173,174,175],"sore throat","voice quality","flurbiprofen","ice cream","2026-04-11",{"date":146,"type":33},{"date":179,"type":21},"2026-04",{"date":181,"type":21},"2026-09",{"name":183,"class":40},"Izmir Katip Celebi University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":22,"phases":193,"briefSummary":194,"conditions":195,"keywords":198,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":41},"100622388","safety-and-efficacy-of-ntp-in-thyroid-surgery-pilot-study-on-morbidity-prevention-and-adjuvant-oncological-control-100622388","NCT07382973","Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control","Evaluation of Non-Thermal Plasma as an Innovative Strategy for Optimizing Post-Surgical Wound Treatment in Patients of Thyroid Surgery: An Ethical and Clinical Approach","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Diagnosis of thyroid pathology requiring total or subtotal thyroidectomy.\n* Signed Informed Consent Form (ICF).\n* Patients capable of complying with the 12-week follow-up schedule.\n\nExclusion Criteria:\n\n* History of previous neck surgery or radiation therapy in the cervical area.\n* Known history of keloid formation or hypertrophic scarring.\n* Presence of active systemic or local infection at the time of surgery.\n* Patients with implanted electronic devices (e.g., pacemakers or defibrillators) due to the use of RF-based plasma.\n* Pregnancy or breastfeeding.\n* Concurrent use of systemic corticosteroids or immunosuppressive drugs that may impair wound healing.",{"count":192,"type":21},26,[24],"The goal of this clinical trial is to evaluate the therapeutic efficacy and safety of non-thermal plasma (NTP) as an adjuvant treatment for surgical bed decontamination and accelerated tissue repair in patients undergoing total thyroidectomy. The study aims to address the following objectives:\n\n* Does the intraoperative application of NTP to the surgical bed and closed incision promote accelerated tissue regeneration compared to conventional postoperative care?\n* Does NTP treatment reduce postoperative inflammatory response, pain intensity, and the incidence of site-specific complications (such as surgical site infection or seroma)?\n* What is the safety profile of helium-based NTP in the cervical anatomical region regarding neighboring neurovascular structures?\n\nParticipants will be randomized into two arms:\n\n1. The experimental group: Receiving a standardized application of helium-based NTP (at a frequency of 13.56 MHz) to the surgical bed prior to closure and subsequently to the sutured incision.\n2. The control group: Receiving standard-of-care surgical wound management.\n\nClinical follow-up will include quantitative assessment of healing rates, pain scales (VAS), and biochemical or clinical markers of inflammation at scheduled intervals (Days 1, 7, 15, and up to 12 weeks post-surgery).",[74,196,27,197],"Wound Healing","Surgical Wound Infection",[199,200,201,196,202,203,204],"Non-Thermal Plasma","Cold Plasma","Thyroid Surgery","Postoperative Pain","Adjuvant Therapy","Surgical Bed Decontamination","RECRUITING","2026-02-05",{"date":208,"type":33},"2026-02-09",{"date":210,"type":33},"2025-08-20",{"date":212,"type":21},"2026-12-30",{"name":214,"class":40},"National Institute of Nuclear Research - Mexico",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":223,"targetDuration":4,"studyType":22,"phases":225,"briefSummary":226,"conditions":227,"keywords":229,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":243},"100597184","toetva-technique-compared-with-anterior-cervical-thyroidectomy-ac-in-terms-of-efficacy-and-safety-100597184","NCT07055191","TOETVA Technique Compared With Anterior Cervical Thyroidectomy (AC) in Terms of Efficacy and Safety","Prospective Randomized Multicenter Trial Comparing the Efficacy and Safety of the Transoral Endoscopic Thyroidectomy by Vestibular Approach (TOETVA) Versus Anterior Cervical Thyroidectomy (AC)","THYRORAL","Inclusion Criteria:\n\n* Patients with a surgical indication for lobectomy or thyroidectomy\n* Estimated thyroid volume measured by ultrasonography of less than 60 mL\n* Nodules suspected to be malignant measuring less than 4 cm\n* Patient aged between 18 and 65 years old\n* Patient who has benefited from an endocrinological evaluation, with a favorable opinion for TOETVA or AC Patient who understands and accepts the need for follow-up\n* Patient who agrees to be included in the study and who signs the informed consent form\n* Patient affiliated to a healthcare insurance plan\n\nExclusion Criteria:\n\n* Patients refusing an alternative to AC or refusing AC\n* History of cervical surgery\n* Associated parathyroid surgery\n* Identification of malignant lymph nodes\n* Presence of a severe and evolutive life threatening pathology\n* Patients with unstable psychiatric disorder, under supervision or guardianship\n* Patient who does not understand French\u002F is unable to give consent\n* Patient not affiliated to a French or European healthcare insurance\n* Patient who has already been included in a trial which has a conflict of interests with the present study\n* Pregnant or breast-feeding patient\n* Patient incarcerated",{"count":224,"type":21},616,[24],"Nearly 50,000 thyroidectomies are performed in France each year for benign and malignant pathologies. Each one affects the life of the patient and represents, for some, suffering, symbolized by the stigma of the operation. The consequences of these scars vary according to the patient, their experience and their culture. For example, cervicotomies are particularly badly accepted in Asia since they are supposed to interrupt the fertility meridian. In France, increasing attention is being paid to the global management of a person with some disease. As a disease state may be transitory, the medical team must consider the situation \"after the illness\" and plan a return to normality. In particular, alternative approaches to cervicotomy have been developed, in which the scar is in a less visible location, at the cost of a more extensive dissection. These techniques include the transaxillary approach, the bi-areolar biaxillary approach and the retroauricular approach. Such procedures, initially developed as an endoscopic approach, have become progressively robotically assisted, to help with the ergonomics of the procedure. Even though robotic assistance initially helped to spread use of these techniques, it has, over time, limited them, first because of higher cost, and second because of the high learning curve (50 to 75 cases). Finally, the transaxillary approach, which is the most commonly performed, has an inherent problem due to the decreased visibility of the noble structures on the contralateral side, leading to frequent subtotal resection.\n\nSince 2014, the Transoral Endoscopic Thyroidectomy by Vestibular Approach (TOETVA) has been developed as an alternative to these robot-assisted procedures. Because this technique offers the surgeon similar access to the anatomical structures on both sides of the trachea and makes it possible to identify the noble structures to be preserved, TOETVA is currently undergoing a more widespread use in France and worldwide and more candidates for are being offered the procedure. TOETVA reduces the need for dissection to reach the thyroid gland. Moreover, this procedure does not require any special equipment, even if robotic assistance has been used in transoral thyroidectomy.\n\nJust like the electric light was not developed from the continuous improvement of candles, entirely new approaches are sometimes necessary in surgery. The Scientific Committee of the French Association of Endocrine Surgery is convinced that TOETVA, will become more widely used in France, even if this technique is a major departure from the standard approach. However, it is technically more demanding and must, therefore, be evaluated and supervised. This will require a safety study and a comparison with the current reference procedure, the anterior cervical thyroidectomy (AC). The investigators assume, based on our initial experience, that the use of endoscopic equipment and its magnification will allow good visualization of the noble elements (recurrent nerve and parathyroid glands) and that the complication rate of TOETVA will not be higher than that of the reference approach.\n\nThe investigators propose to evaluate, through a prospective randomized study, an innovative endocrine surgical technique that has started to be used worldwide. Although this study is in line with the objectives of an evaluation of the pertinence of care by the health authorities, it would be the first assessment of this innovative surgical technique in thyroid surgery. To our knowledge, after an extensive bibliographic search, no prospective multicenter randomized trial comparing TOETVA to AC has yet been performed, even if many cohorts of patients have been reported to have benefited from this approach6.\n\nIn this trial, any change to the quality of life will be extensively evaluated. The use of validated scores to quantify pain and quality of life will provide objective information and make it possible to determine the impact of the presence or absence of a scar.",[228,27],"Lobectomy",[230,117,231,232,233],"Endocrinology","mini-invasive","TransOral Endoscopic Thyroidectomy by Vestibular Approach (TOETVA)","Anterior Cervical thyroidectomy (AC)","2026-01-15",{"date":236,"type":33},"2026-01-16",{"date":238,"type":33},"2025-11-07",{"date":240,"type":21},"2028-11",{"name":242,"class":40},"University Hospital, Lille",10,{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":22,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":4},"100614076","ligasure-vs-bipolar-diathermy-in-thyroidectomy-100614076","NCT07274891","LigaSure vs Bipolar Diathermy in Thyroidectomy","Comparative Evaluation of LigaSure Versus Bipolar Diathermy in Thyroidectomy: A Single-Center Study From Upper Egyp","Inclusion Criteria:\n\n1. Adult patients (≥18 years) undergoing partial or total thyroidectomy.\n2. Diagnosed with benign or low-risk malignant thyroid disorders.\n3. Fit for general anesthesia.\n4. Provided written informed consent to participate in the study.\n\nExclusion Criteria:\n\n1.Previous neck surgery or radiotherapy.",{"count":252,"type":21},30,[24],"Comparative Evaluation of LigaSure Versus Conventional Bipolar Diathermy in Thyroid Surgery: Operative and Postoperative Outcome.",[27],"2025-12-08",{"date":258,"type":33},"2025-12-10",{"date":260,"type":21},"2025-12-01",{"date":262,"type":21},"2027-01-01",{"name":264,"class":40},"Assiut University",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":275,"phases":4,"briefSummary":276,"conditions":277,"keywords":4,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":41},"100506028","dcnn-developed-for-detection-and-assessing-the-perfusion-of-ptg-100506028","NCT05869058","DCNN Developed for Detection and Assessing the Perfusion of PTG","Development and Improvement of a Deep Convolutional Neural Network for Detection and Assessing the Perfusion of Parathyroid Gland During Endoscopic Thyroidectomy","Inclusion Criteria:\n\n* The patients who undergo endoscopic thyroidectomy\n\nExclusion Criteria:\n\n* hyperparathyroidism\n* hypoparathyroidism\n* neck surgery history\n* cervical radiotherapy history","70 Years",{"count":274,"type":21},300,"OBSERVATIONAL","Since the anatomical location and appearance of the parathyroid gland (PTG) vary, detection of the PTG and preserving the blood supply are among the difficulties encountered during a thyroidectomy procedure. We are planning to train a deep convolutional neural network based on a larger sample of endoscopic images to develop a model to assist surgeons in detection of PTG during endoscopic thyroidectomy. Furthermore, we would like to train a DCNN to predict blood perfusion based on endoscopic images comparing to indocyanine green fluorescence angiography as reference standard, and assess the performance of DCNN in predicting postoperative hypoparathyroidism.",[27],"2025-11-25",{"date":280,"type":33},"2025-12-03",{"date":282,"type":33},"2023-06-13",{"date":284,"type":21},"2026-10",{"name":286,"class":40},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":293,"minAge":294,"maxAge":295,"enrollmentInfo":296,"targetDuration":4,"studyType":22,"phases":298,"briefSummary":299,"conditions":300,"keywords":305,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":41},"100596961","water-based-burpee-exercises-on-functional-capacity-in-poste-menopausal-women-after-thyroidectomy-100596961","NCT07052279","Water Based Burpee Exercises on Functional Capacity in Poste-menopausal Women After Thyroidectomy","Inclusion Criteria:\n\n* Adults aged 54 ± 4 years .\n\n  * Post-menopausal women after tyhroidectomy\n  * Body mass index (BMI) ≥ 30 kg\u002Fm².\n  * Absence of osteoarticular dysfunctions in the lower limbs.\n  * No personal history of cardiovascular disease\n  * No water trauma\n  * Non-smokers\n\nExclusion Criteria:\n\n* History of Cardiovascular disorders.\n\n  * Severe osteoarticular dysfunctions.\n  * Presence of Water panic.\n  * Participation in another clinical trial within the last 30 days.\n  * Neurologic and psychiatric disorders (spina bifida, cerebral palsy, anorexia nervosa, known autism spectrum disorders).","FEMALE","50 Years","54 Years",{"count":297,"type":21},40,[24],"Skeletal muscle mass plays an important role with both metabolism and functional capacity. It is well established that the aging process leads to a significant decline in both muscle mass and strength which is associated with frailty , an increased risk of falls and decreased physical fitness and function In this context, high-load resistance training has been shown to reduce the risk of falls and increase strength and functional capacity in middle-aged and\u002For elderly individuals.\n\nAquatic exercise is one method that has previously been shown to improve muscle strength, balance, and coordination in those of advancing age Although the evidence supports the effectiveness of both water-based burpee exercise in middle-aged and elderly individuals, has, to our knowledge, never been investigated. Thus, the objective of this study was to assess the long-term effect of water-based burpee exercises",[301,302,303,304,27],"Burpee Exercise","Water Exercises","Functional Capacity","Postmenopausal",[306,307,117],"burpee exercises","postmenopausal","2025-11-15",{"date":310,"type":33},"2025-11-19",{"date":312,"type":33},"2025-09-01",{"date":314,"type":21},"2025-11-30",{"name":316,"class":40},"Al-Zaytoonah University of Jordan",{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":323,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":325,"targetDuration":4,"studyType":275,"phases":4,"briefSummary":327,"conditions":328,"keywords":331,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":345},"100590114","thyroidectomy-for-graves-disease-or-amiodarone-induced-thyrotoxicosis-100590114","NCT06963203","Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis","Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis: Is it Still Necessary to Achieve a Preoperative Euthyroid State? - A Prospective Observational Multicenter European Study (GRATES)","GRATES","Inclusion Criteria:\n\n* Adult patients (≥ 18 years of age) undergoing surgical treatment for Graves' disease or Amiodarone-induced thyrotoxicosis (AIT) with biochemically confirmed hyperthyroidism or on specific medication for the treatment of Graves' disease or AIT.\n* Patients providing signed informed consent.\n\nExclusion Criteria:\n\n* Children and minors (\\\u003C18 years).\n* Pregnant women.\n* Patients unable or unwilling to provide informed consent due to language barriers or intellectual limitations.\n* Patients undergoing concurrent parathyroidectomy for primary or secondary hyperparathyroidism, lymph node clearance, or redo surgery.\n* Surgical procedures performed for other reasons than Graves' disease or AIT",{"count":326,"type":21},486,"The goal of this observational study is to learn about the potential differences in morbidity of thyroidectomy (removal of the thyroid gland) depending on the preoperative hormonal status. The main question it aims to answer is:\n\nDo patients undergoing thyroidectomy for thyreotoxicosis (thyroid hyperfunction) due to Graves' disease or Amiodarone induced thyreotoxicosis have comparable complication rates depending on their thyroid metabolic status prior or during the procedure.\n\nThe data from participants undergoing a thyroidectomy at one of the study sites will be prospectively registered in the EUROCRINE registry, including an add-on module for additional study specific routine data. The operation itself, the preoperative or postoperative treatments are not altered in any way.",[329,330,27],"Graves Disease","Amiodarone-Induced Thyrotoxicosis",[323,332,333,334,335],"GRATE Study","thyreotoxicosis","euthyreoidism","Thyroid storm","2025-06-28",{"date":338,"type":33},"2025-07-02",{"date":340,"type":21},"2025-07-01",{"date":342,"type":21},"2027-12",{"name":344,"class":40},"Andrea Goldmann",15,{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":353,"enrollmentInfo":354,"targetDuration":4,"studyType":22,"phases":356,"briefSummary":357,"conditions":358,"keywords":361,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":41},"100516320","effectiveness-of-intraoperative-neuromonitoring-of-external-branch-of-superior-laryngeal-nerve-in-thyroid-surgery-100516320","NCT06002984","Effectiveness of Intraoperative Neuromonitoring of External Branch of Superior Laryngeal Nerve in Thyroid Surgery","Effectiveness of Intraoperative Neuromonitoring to Identify and Preserve External Branch of Superior Laryngeal Nerve During Thyroid Surgery","Inclusion Criteria:\n\n* Patients who are scheduled to undergo thyroid surgery\n* Patients who understand and agree to take part in this study\n\nExclusion Criteria:\n\n* If the thyroid tumor is suspected to invade adjacent organs (esophagus, trachea, carotid artery, jugular vein etc.)\n* Patients who are required with lateral compartment neck dissection\n* Patients with recurrent thyroid cancer\n* Patients with palsy of recurrent laryngeal nerve or superior laryngeal nerve external branch in the past or present\n* Patients with a history of vocal cord and larynx disease\n* History of hyperthyroidism (e.g., Graves' disease)\n* Taking anticoagulants (aspirin, warfarin, etc.) before surgery\n* Disorders of coagulation\n* In the case of women, pregnant women and breastfeeding patients\n* Patients judged inappropriate by clinical trial researcher","79 Years",{"count":355,"type":21},94,[24],"The frequent occurrence of impaired function in the external branch of the superior laryngeal nerves following thyroid surgery is recognized as a prevalent complication leading to a diminished quality of life. The objective of this randomized controlled trial (RCT) is to assess the efficacy of neuromonitoring during thyroid surgery in order to safeguard the integrity of these nerves.",[359,27,360],"Laryngeal Nerve Injuries","Voice Change",[362],"External branch of the superior Laryngeal Nerve","2025-06-09",{"date":365,"type":33},"2025-06-12",{"date":367,"type":33},"2023-11-24",{"date":369,"type":21},"2026-12-31",{"name":371,"class":40},"Seoul National University Hospital",{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":376,"acronym":4,"eligibilityCriteria":377,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":378,"targetDuration":4,"studyType":275,"phases":4,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":41},"100577680","comparison-of-intr-operative-neuromonitoring-technique-in-trans-oral-endoscopic-thyroidectomy-vestibular-approach-100577680","NCT06801444","Comparison of Intr-operative Neuromonitoring Technique in Trans-oral Endoscopic Thyroidectomy Vestibular Approach","Inclusion Criteria: Benign solitary or multiple thyroid nodules, follicular lesions (the largest diameter \\\u003C6.0 cm), and early papillary thyroid carcinoma (\\\u003C1 cm in diameter, without cervical lymphadenopathy)\n\nExclusion Criteria: History of thyroid surgery, neck radiotherapy, and recurrent laryngeal nerve paralysis; intraoperative conversion to conventional thyroidectomy.",{"count":379,"type":21},304,"Transoral endoscopic thyroidectomy vestibular approach (TOETVA) has the advantage of scarless cosmesis but has limitations of recurrent laryngeal nerve (RLN) palsy. Intermittent intraoperative neuromonitoring (I-IONM) techniques have been utilized during TOETVA to identify and map RLN to prevent RLN injury. However, the insult may still occur between two neural stimulations. Continuous intraoperative neuromonitoring (C-IONM) has been used in TOETVA to persistent stimulation of RLN. but only in our hospital. This rare use may be related to technical challenges. Recently, we successfully developed a novel technique of percutaneous C-IONM using an external fixator to secure the stimulation probe to steadily monitor the real-time functional status of RLN during the TOETVA. In this retrospective study, 304 patients undergone TOETVA were enrolled and divided according to the usage of IONM techniques into percutaneous or peroral intermittent and continuous groups. Patient's age, sex, BMI, thyroid disease, operation time, EMG signal and RLN palsy rate were compared to verified the feasibility, safety, and effectiveness of different IONM techniques. We hypothesized percutaneous C-IONM has the superiority in early detection of RLN injury and reducing of RLN palsy in TOETVA.",[27],"2025-01-24",{"date":384,"type":33},"2025-01-30",{"date":386,"type":33},"2023-03-29",{"date":388,"type":21},"2025-12-11",{"name":390,"class":40},"China Medical University Hospital"]