[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"thyroiditis-autoimmune\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:thyroiditis-autoimmune":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100483908","thyroid-function-and-structure-in-klinefelter-syndrome-100483908",false,"NCT05581147","Thyroid Function and Structure in Klinefelter Syndrome","Thyroid Function and Structure in Klinefelter Syndrome (THINKS)","THINKS","Inclusion Criteria:\n\n* Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis;\n* Availability of thyroid function test results (TSH, fT3, and fT4) and\u002For thyroid US imaging;\n* Availability of concurrent clinical data.\n\nExclusion Criteria:\n\n* Presence of other known genetic conditions or chromosomal abnormalities;\n* Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests;\n* History of previous surgery or radiotherapy on the thyroid or pituitary glands;\n* Current or previous T therapy (for the pre-pubertal and pubertal groups).","MALE","1 Year","80 Years",{"count":21,"type":22},600,"ESTIMATED","OBSERVATIONAL","This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.",[26,27,28],"Klinefelter Syndrome","Thyroiditis, Autoimmune","Hypothyroidism",[30,28,31,32,33,34],"Klinefelter syndrome","Thyroiditis","Puberty","Prepuberty","Testosterone","RECRUITING","2025-03-25",{"date":38,"type":39},"2025-03-30","ACTUAL",{"date":41,"type":39},"2007-05-11",{"date":43,"type":22},"2026-12-01",{"name":45,"class":46},"University of Roma La Sapienza","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100483701","phase-4-effect-of-prednisone-and-aspirin-on-ivf-et-outcome-among-patients-with-thyroid-autoimmunity-100483701","NCT05578456","Effect of Prednisone and Aspirin on IVF-ET Outcome Among Patients With Thyroid Autoimmunity","Effect of Prednisone and Aspirin on Pregnancy Outcomes After Embryo Transfer Among Patients With Thyroid Autoimmunity: a Randomized Clinical Trial","Inclusion Criteria:\n\n1. TPOAb\\>34IU\u002Fml and\u002For TgAb\\>115IU\u002Fml\n2. ≥5 follicles with average diameter lager than 14 mm at trigger day\n3. ≥5 oocytes retrieved\n4. for frozen embryo transfer, at least 2 cleavage stage embryos, among which at least one morphologically good quality embryo, or at least 1 morphologically good quality embryo in blastocyst stage\n5. age: 20-38 years old\n6. Patients whose written ICF approved by the EC has been obtained, after having been duly informed of the nature of the study and voluntarily accepted to participate after being fully aware of the potential risks, benefits and any discomfort involved.\n\nmeet item 1, 5, 6, and one of item 2, 3, 4.\n\nExclusion Criteria:\n\n* hyperthyroidism\n* intrauterine adhesion\n* with endometrium thickness less than 6mm\n* uterine malformation\n* PGT\n* with other autoimmune diseases need glucocorticoid or aspirin treatment\n* gluacoma\n* gastric ulcer","FEMALE","20 Years","38 Years",{"count":59,"type":22},540,"INTERVENTIONAL",[62],"PHASE4","This trial was a 1:1 (active:placebo) randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of prednisone and aspirin for the in vitro fertilization and embryo transfer outcome among patients with thyroid autoimmunity.",[27,65],"Infertility","NOT_YET_RECRUITING","2022-10-11",{"date":69,"type":39},"2022-10-13",{"date":71,"type":22},"2022-11-01",{"date":73,"type":22},"2026-12-31",{"name":75,"class":46},"Second Affiliated Hospital, School of Medicine, Zhejiang University"]