[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tibia-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tibia-fracture":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,70,97],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100561133","outpatient-floor-pedal-bike-utilization-100561133",false,"NCT06586190","Outpatient Floor Pedal Bike Utilization","Inclusion Criteria:\n\n* Patients \\>18 years of age\n* Operative fractures of the femur, tibia and select ankle injuries\n* Under the care of an orthopaedic surgeon\n* English or Spanish competent\n* 12 month follow up\n\nExclusion Criteria:\n\n* Type IIIB\u002FC fracture\n* Unable to provide consent\u002Fneed for an LAR\n* Major lower extremity peripheral nerve injury (ex. foot drop, sciatic nerve palsy, etc)","ALL","18 Years",{"count":18,"type":19},20,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goals of this clinical trial are: to test the feasibility of identifying patients and getting patients the floor pedal bikes, to test how well floor pedal bikes help patients with lower body injuries heal, and to test methods of patient self-reported logs for home pedal bike use.\n\nParticipants will be given a floor pedal bike at first post-operative appointment where weightbearing restrictions are lifted (weight-bearing as tolerated) along with instructions on utilization. Participants will be asked to complete patient reported outcome measure surveys at each follow-up visit.",[25,26,27],"Femur Fracture","Tibia Fracture","Ankle Injuries",[29,30,31],"floor pedal bike","lower extremity","rehabilitation","NOT_YET_RECRUITING","2026-05-21",{"date":35,"type":36},"2026-05-26","ACTUAL",{"date":38,"type":19},"2026-08",{"date":40,"type":19},"2028-12",{"name":42,"class":43},"Wake Forest University Health Sciences","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100490596","a-case-series-trumatch-graft-cage-for-segmental-long-bone-defects-100490596","NCT05668182","A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects","Early Outcomes Utilizing the TRUMATCH Graft Cage for Segmental Long Bone Defects: A Case Series","Inclusion Criteria:\n\n* Humerus, femur, or tibia segmental defects requiring surgery\n* Evaluation and treatment at UCSD\n* Ages 18 year and older\n* Abiltiy to understand the content of the patient information\u002Finformed consent form\n\nExclusion Criteria:\n\n* Any not medically managed severe systemic disease\n* Their doctor has decided that it is in the patient's best interest to receive a different method of repair\n* Their doctor has determined that the patient has a condition that would make them unsuitable for participation in the study\n* Pregnancy or women planning to conceive within the subject participation period (1 year) note: pregnancy will be self-reported and no test will be performed to test for it\n* Prisoner\n* Participation in any other pharmacologic or medicinal product study within the previous month that could influence the results of this study.",{"count":52,"type":19},5,"OBSERVATIONAL","This project consists of a prospective case design. Study candidates will include all patients ages 18 and over who were evaluated at UCSD and found to have a critical-sized humerus, femur, or tibia segmental defect that would be fixed through surgery. Patients who consent to study participation will receive the TRUMATCH Graft Cage for their long bone segmental defect repair. Data on healing rates, complication rates, re-operation rates, time to return to normal activity, and pain levels will be collected for each participation. After 3 years of data collection, we will analyze this data to provide further insight on the utility of the TRUMATCH Graft Cage. Given the significant difficulty with repairing segmental long bone defects, it is imperative to evaluate novel systems to appropriately manage these injuries.",[26,56,57,58],"Humerus Fracture","Femoral Fracture","Long Bone Segmental Defect","RECRUITING","2026-02-05",{"date":62,"type":36},"2026-02-09",{"date":64,"type":36},"2021-06-29",{"date":66,"type":19},"2026-06-29",{"name":68,"class":43},"University of California, San Diego",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":20,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":96},"100450932","limb-injuries-and-post-injury-rehabilitation-trials---tibial-shaft-fracture-100450932","NCT05151926","Limb Injuries and Post Injury Rehabilitation Trials - Tibial Shaft Fracture","Limb Injuries and Post Injury Rehabilitation Trials - Tibial Shaft Fracture (LIMPER-TSF): a Protocol for Prospective, Randomized,Multicentre Trial Comparing the Early Partial and Early Full Weightbearing After Nailed Tibial Shaft Fracture","LIMPER-TSF","Inclusion Criteria:\n\n* AO\u002FOTA 42-A\u002FB acute, noncomminuted diaphyseal fracture of the tibia treated with intramedullary nailing with or without posterior malleolus screw fixation\n* operated within 72 hours of admittance\n* age between 18-65 years\n\nExclusion Criteria:\n\n* the inability to fill out the Finnish versions of the questionnaires\n* previous arthroplasty of the knee or the ankle of the fractured limb\n* previous ipsilateral below-knee fracture requiring surgical treatment or ankle arthrodesis\n* inability to co-operate\n* not living independently (institutionalized living before fracture)\n* open fracture (Gustilo grade 2 or over)\n* pathologic or stress fracture\n* multiple fractures requiring operative treatment in polytrauma patient\n* severe medical comorbidity impairing daily activities (inability to go climb three floors without assistance and stopping)\n* Body Mass Index over 40\n* unacceptably high risk of surgery due to severe medical comorbidities\n* severe substance abuse\n* patient is retired\n* age is less than 18 or more than 65\n* patient required a fasciotomy due to acute compartment syndrome during or after index surgery\n* inability to walk before fracture or a daily need of walking aid, such as crutches","65 Years",{"count":80,"type":19},240,[22],"Aim of our study is to compare immediate full weight-bearing and partial weight-bearing for 6 weeks after a tibial shaft fracture treated with intramedullary nailing. Co-primary outcome is return to work and physical component scale in the SF-36 questionnaire.",[26],[85,86],"intramedullary nail","weight-bearing","2024-12-31",{"date":89,"type":36},"2025-01-01",{"date":91,"type":36},"2021-12-03",{"date":93,"type":19},"2027-12-31",{"name":95,"class":43},"Tampere University Hospital",3,{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":20,"phases":106,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":69},"100505291","effect-of-tobacco-heating-system-ths-on-closed-lower-limb-fracture-healing-100505291","NCT05859451","Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing","Evaluation of Tobacco Heating System (THS) Compared to Conventional Cigarette Smoking During the Closed Lower Limb (Tibia and Femur) Fracture Healing in Orthopedic Smokers' Patients","Inclusion Criteria:\n\n* Closed tibia or femur fracture (according to AO\u002FOTA: 41A2-41C3, 42A-C, 43A-C, 32A-C, 33A2-3, 33B-C) which is surgically treated within 14 days after the trauma at the BG trauma clinic Tübingen.\n\nAdditional inclusion criteria for the smoking and THS groups:\n\n* Smokers with 10-20 packyears smoking history.\n* Smoking history \\>10 years.\n* Decision not to participate in the free smoking cessation seminars.\n\nExclusion Criteria:\n\n* Legal guardian or loss of capacity to consent.\n* Refusal to participate in the study.\n* Open fractures or concomitant injuries or complications requiring surgery existing at the time of surgical indication.\n* Initial surgical treatment of the fracture has occurred ex domo.\n* No initial surgical treatment within 14 days of sustained trauma.\n* Using nicotine delivery electronic devices.\n* Pre-existing autoimmune, immunological, bone or malignant diseases.\n* Pregnant, breastfeeding and women of childbearing age with existing desire to have children.\n* History of alcohol abuse or drug abuse.\n* Taking antioxidants approval by the German Federal Institute for Drugs and Medical Devices (BfArM).\n* Taking drugs with known effect on bone metabolism (according to Institute for medical and pharmaceutical examination issues (IMPP): allosteric CaSR modulators, bisphosphonates, calcium release inhibitors, alkaline earth ions, RANKL inhibitors, calcitriol, colecalciferol).",{"count":105,"type":19},150,[22],"The goal of this clinical trial is to investigate the role of switching from cigarette smoking (CS) to tobacco heat system (THS) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic patients. Validated and standardized assays, medical state and self-reported outcomes will be evaluated in orthopedic patients' smokers or switch from CS to using THS throughout six months compare to ex-smokers (control).",[109,26],"Smoking",[111,112,113],"Bone healing","Tobacco heating system","Smoking cessation","2024-12-05",{"date":116,"type":36},"2024-12-11",{"date":118,"type":36},"2023-06-02",{"date":120,"type":19},"2026-04-17",{"name":122,"class":43},"University Hospital Tuebingen"]