[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tic-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tic-disorders":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,47,81,105,128,159,181,202,242],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100547491","remote-delivery-of-a-mindfulness-based-intervention-for-tics-100547491",false,"NCT06408662","Remote Delivery of a Mindfulness-based Intervention for Tics","MBIT","Inclusion Criteria:\n\n1. be ≥18 years of age;\n2. meet diagnostic criteria for a primary or co-primary diagnosis of Tourette Syndrome or a Persistent Motor or Vocal Tic Disorder on a structured clinical interview;\n3. have moderate or greater tic severity as evidenced by a YGTSS Total Tic Score of \\>14 (when motor and vocal tics are present) or \\>10 (when only motor or vocal tics are present);\n4. be medication free and\u002For on a stable dose of psychiatric medication 8 weeks prior to study participation;\n5. be not engaged in psychotherapy for non-TS conditions and\u002For be on a stable course of therapy for 6 months prior to study participation\n6. be fluent in English;\n7. have access to a smart phone and\u002For tablet.\n\nExclusion Criteria:\n\n1. a current diagnosis of substance use disorder, psychosis, mania or another condition that requires another form of care;\n2. severe current suicidal\u002Fhomicidal ideation and\u002For self-injury requiring medical intervention;\n3. concurrent psychotherapy for TS;\n4. prior extensive experience with mindfulness and\u002For meditation.","ALL","18 Years",{"count":19,"type":20},150,"ESTIMATED","INTERVENTIONAL",[23],"NA","This research study is being done to compare a mindfulness-based intervention for tics (MBIT) to psychoeducation with relaxation and supportive therapy (PRST) for individuals with Tourette's syndrome or Persistent Tic Disorders (collectively TS). It is the investigator's hope that this information cam be used to improve current treatments for individuals with TS.",[26,27,28,29,30,31,32,33],"Tourette Syndrome","Tourette's Disorder","Chronic Motor Tic Disorder","Chronic Vocal Tic Disorder","Persistent Motor Tic Disorder","Persistent Vocal Tic Disorder","Persistent Tic Disorder","Tic Disorders","RECRUITING","2026-05-07",{"date":37,"type":38},"2026-05-11","ACTUAL",{"date":40,"type":38},"2024-05-23",{"date":42,"type":20},"2028-12",{"name":44,"class":45},"Johns Hopkins University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100519962","objective-characterizatoion-of-repetitive-behaviors-100519962","NCT06050369","Objective Characterizatoion of Repetitive Behaviors","Actimetric and Electrophysiological Analyses of Repetitive Behaviors (Tics and Compulsions)","Inclusion Criteria:\n\n* To be more of 15 years old or less than 65 years old\n* To suffer from OCD and\u002For GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted)\n* To be registered to the french social security (or something equivalent)\n* To give written consent to participate to the research\n* To have contraception for women participants (or to not have any sexual activity)\n\nExclusion Criteria:\n\n* Patients with any other psychiatric disorders than those mentioned in the inclusion criteria\n* Patients with any other neurological disorder than GTS\n* Patients who are not able to take decisions for themselves\n* Pregnant women\n* Patients not allowed to get MRI due to contraindication\n* Patients not speaking french","15 Years","65 Years",{"count":57,"type":20},50,[23],"Introduction:\n\nRepetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric\u002Fneurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment.\n\nAim:\n\nIn our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions.\n\nMethod:\n\nSubjects: Both OCD and GTS patients will be recruited, 25 patients in each group.\n\nProtocol: our study protocol will involve two step: a step in laboratory, another step at patient home.\n\n* first step: both patients group will be recorded through a high density EEG and a portative EEG while doing a task of symptom provocation. Then they will get an anatomical MRI for source recontruction. Finally, the patients will have to mimic their symptom while wearing an accelerometer (a smartwatch).\n* second step: both patient groups will be recorded at home through a portative EEG while tagging their symptom through a smartwatch (also used for accelerometry). After the recording, the patients will keep the smartwatch for 2 weeks, still tagging their sympoms (compulsions or tics).",[61,33,62],"OCD","Gilles de la Tourette Syndrome",[64,65,66,67,68,69],"Electrophysiology","Electroencephalogram","EEG","Accelerometer","Biomarker","Symptom provocation","2026-02-10",{"date":72,"type":38},"2026-02-12",{"date":74,"type":38},"2023-12-28",{"date":76,"type":20},"2027-12-27",{"name":78,"class":79},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",3,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100467716","comprehensive-behavioral-intervention-for-tics-100467716","NCT05370391","Comprehensive Behavioral Intervention for Tics","Comprehensive Behavioral Intervention for Tics (CBIT) for Youth With Tics and Related Emotional Disorders","CBIT","Inclusion criteria\n\n* A current diagnosis of a Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 Tic disorder (e.g., Tourette's Disorder\u002Fsyndrome, Persistent (Chronic) Motor or Vocal Tic Disorder, or Provisional Tic Disorder) or caregiver\u002Fyouth report of clinically impairing tic symptoms\n* Ability for youth to speak\u002Fread English sufficiently\n* At least one parent\u002Fcaregiver available to sign study consent forms, remain present during assessments, and fill out study questionnaires in English.\n\nExclusion criteria\n\n* A current diagnosis of psychosis, bipolar disorder, intellectual disability, acute suicidality, alcohol\u002Fsubstance dependence, or eating disorder.\n* Youth currently receiving psychotherapy elsewhere and\u002For have previously received CBIT.\n* Currently suicidal or who have engaged in suicidal behaviors within the past 6 months will be excluded\n* Youth currently taking psychotropic medication for a co-morbid psychiatric illness will be included without a wash-out period (to not delay treatment).","5 Years","17 Years",{"count":92,"type":20},200,[23],"The purpose of this protocol is to examine treatment outcomes of youth receiving the Comprehensive Behavioral Intervention for Tics (CBIT) and better understand the predictors, moderators, mediators and\u002For mechanisms of change for this intervention.",[33],"2026-01-27",{"date":98,"type":38},"2026-01-29",{"date":100,"type":38},"2022-09-09",{"date":102,"type":20},"2027-01-31",{"name":104,"class":45},"University of Miami",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":111,"maxAge":17,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":46},"100620002","clinical-study-on-a-novel-strategy-of-individualized-non-invasive-neuromodulation-for-the-treatment-of-tic-disorders-in-children-100620002","NCT07351955","Clinical Study on a Novel Strategy of Individualized Non-Invasive Neuromodulation for the Treatment of Tic Disorders in Children","Inclusion Criteria:\n\n* 1: Children and adolescents aged 5 to 18 years\n\n  2: Meets DSM-5 diagnostic criteria for Tic Disorders (TDs) with normal EEG findings\n\n  3: No prior treatment received for TDs\n\n  4: Full-scale intelligence quotient (FIQ) ≥70 on the Wechsler Intelligence Scale for Children-Revised (WISC-R)\n\nExclusion Criteria:\n\n* 1: WISC-R Full-Scale Intelligence Quotient (FIQ) \\\u003C70\n\n  2: Presence of metal implants in the body ，Non-right-handedness\n\n  3: Head movement (HM) \\>2mm during fMRI scanning, including both translational movement (TM) and rotational movement (RM)\n\n  4: Any other neurological or psychiatric conditions, including but not limited to autism spectrum disorder (ASD), epilepsy, obsessive-compulsive disorder (OCD), etc\n\n  5: Previous head trauma ，Neurological diseases ，Major systemic illnesses","5 Months",{"count":113,"type":20},60,[23],"This study aims to establish a novel personalized closed-loop NiBS\u002FTMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations. Additionally, it seeks to elucidate the underlying neural circuit mechanisms, enhance the therapeutic efficacy of TMS in pediatric TDs, and achieve precision neuromodulation for children with TDs.",[33],[118],"Transcranial Magnetic Stimulation","2026-01-11",{"date":121,"type":38},"2026-01-20",{"date":123,"type":38},"2025-06-01",{"date":125,"type":20},"2026-05-31",{"name":127,"class":45},"Shanghai Children's Medical Center",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":134,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":21,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":46},"100463645","clinical-validation-of-dystonianet-deep-learning-platform-for-diagnosis-of-isolated-dystonia-100463645","NCT05317390","Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia","Inclusion criteria:\n\n1. Males and females of diverse racial and ethnic backgrounds, with age across the lifespan;\n2. Patients will have at least one of the forms of dystonia, including focal dystonia (e.g., laryngeal, cervical, oromandibular, blepharospasm, focal hand, musicians), segmental dystonia, or generalized dystonia;\n3. Patients will have other movement disorders (Parkinson's disease, essential tremor, dyskinesia, myoclonus) and other non-neurological conditions (tic disorders, torticollis, ulnar nerve entrapments, temporomandibular disorders, dysphonia) that mimic dystonic symptoms.\n\nExclusion criteria:\n\n1. Patients who are incapable of giving informed consent;\n2. Patients who are unable to undergo brain MRI due to the presence of certain tattoos and ferromagnetic objects in their bodies (e.g., implanted stimulators, surgical clips, prosthesis, artificial heart valve) that cannot be removed or due to pregnancy or breastfeeding at the time of the study.",true,{"count":136,"type":20},1000,[23],"This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.",[140,141,142,143,144,145,33,146,147,148,149],"Dystonia","Drug Induced Dystonia","Parkinson Disease","Essential Tremor","Dyskinesias","Myoclonus","Torticollis","Ulnar Nerve Entrapment","Temporomandibular Joint Disorders","Dysphonia","2025-11-24",{"date":152,"type":38},"2025-12-02",{"date":154,"type":38},"2022-06-01",{"date":156,"type":20},"2028-04-30",{"name":158,"class":45},"Massachusetts Eye and Ear Infirmary",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":168,"phases":4,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":180},"100446246","adult-tic-disorders-registry-100446246","NCT05090943","Adult Tic Disorders Registry","RegisTICs","Inclusion criteria :\n\n1. Age \\>18 years\n2. Patients with Tic disorders\n3. Given the non-opposition\n\nNon Inclusion criteria\n\n1. No affiliation to a French health social insurance\n2. Significant congenital disorders that may affect understanding of assessments\n3. Patients under guardianship or curatorship",{"count":167,"type":20},450,"OBSERVATIONAL","The purpose of this study is to develop the adult tic disorders registry in order to characterize the relationship between tic severity and tic-related impairment in women compared to men with tic disorders.",[33],"2025-08-27",{"date":173,"type":38},"2025-09-04",{"date":175,"type":38},"2021-12-01",{"date":177,"type":20},"2027-12-01",{"name":179,"class":45},"Assistance Publique - Hôpitaux de Paris",7,{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":16,"minAge":187,"maxAge":90,"enrollmentInfo":188,"targetDuration":4,"studyType":21,"phases":190,"briefSummary":191,"conditions":192,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":46},"100568328","trajectories-of-change-in-tourette-syndrome-100568328","NCT06679790","Trajectories of Change in Tourette Syndrome","Inclusion Criteria:\n\n1. Presence of chronic motor and\u002For vocal tics, defined as tics for at least 1 year without a tic-free period of more than 3 consecutive months. Tics must not be due to a medical condition or the direct physiological effects of a substance.\n2. At least moderate tic severity, defined as a Yale Global Tic Severity Scale44 total score ≥14 (≥9 for those with motor or vocal tics only).\n3. Participants must be fluent in English to ensure comprehension of study measures and instructions.\n\nExclusion Criteria:\n\n1. Previous diagnosis of psychosis or cognitive disability,\n2. IQ \\\u003C 80,\n3. Substance abuse or dependence within the past year.\n4. Current suicidal intent.\n5. Changes in medication in the previous 4 weeks.","12 Years",{"count":189,"type":20},30,[23],"This K23 Career Development Award is designed to provide the training needed for the PI to achieve her long-term career goal of conducting independent, programmatic intervention research in developmental populations. The training will emphasize gaining expertise in higher-intensity, multi-method, within-subject data collection and analysis. This award builds on the PI's emerging experience in tic disorders and pediatric behavioral interventions, and her ability to quickly learn and apply advanced statistical methods. The award will extend the PI's training through the following short-term training goals: 1) multi-method data collection and integration (electronic momentary assessment \\[EMA\\], wearable devices, neurocognitive tasks), 2) leading and designing pediatric clinical trials, 3) managing and analyzing large, multilevel datasets, and 4) career development and contribution to the field. The PI has developed a training plan to accomplish these goals in concert with her mentors, a team of leading experts in the fields of psychiatry and psychology, who will closely monitor training through regular meetings. The highly structured training plan also includes a set of formal coursework and workshops for each training goal to complement the hands-on experience the PI will gain from leading the research project.\n\nThe objective of this proposal is to comprehensively map symptom change across time and during a behavioral intervention for youth with Persistent Tic Disorders (PTDs). PTDs affect approximately 1% of the population, can cause significant disability, have high rates of comorbidity, and are associated with a four-fold increase in suicide risk. Research has established that tic symptoms and their change over time are highly idiographic. However, first-line, evidence-based, existing interventions are \"one-size-fits-all,\" and are only effective for 60% of patients. The current study aims to use advanced statistical methods and a novel theoretical framework to map the stability of tic patterns, along with systemic factors that relate to tic change over time. Study hypotheses, based on the literature and preliminary data, are that a) tic change patterns will be stable before intervention for all participants, b) disruption of stable patterns during the intervention phase will be associated with treatment response, and c) this disruption will depend on the specific driver of tic symptoms pre-intervention. N = 30 youth ages 12-17 with chronic tics will be recruited for the study. There will be three study phases: 1) pre-intervention (4 weeks), 2) intervention (8 weeks), and 3) post-intervention (4 weeks). Before and between each phase, participants will complete 4 traditional assessments to assess symptoms and treatment response. Throughout the 16 weeks of the study, we will collect EMA data focused on factors relevant to tics (4x per day), physiological data from wearable devices (passive, continuous), and neurocognitive task performance and tic video observation (1x per week). Results will inform efforts to develop individualized interventions for individuals with PTDs to improve treatment outcomes.",[26,33],"2025-07-31",{"date":195,"type":38},"2025-08-06",{"date":197,"type":38},"2025-03-31",{"date":199,"type":20},"2029-05-15",{"name":201,"class":45},"University of Minnesota",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":16,"minAge":210,"maxAge":90,"enrollmentInfo":211,"targetDuration":4,"studyType":21,"phases":213,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":241},"100522340","phase-2-sertraline-vs-placebo-in-the-treatment-of-anxiety-in-children-and-adolescents-with-neurodevelopmental-disorders-100522340","NCT06081348","Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders","A Randomized Placebo-Controlled Trial of Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders","CALM","Inclusion Criteria:\n\n1. Outpatients 8-17 years of age, inclusive\n2. Females of child bearing potential who are sexually active and agree to use medically acceptable birth control throughout the study and at least one week post last dose of study drug.\n3. Meet Diagnostic and Statistical Manual of Mental Disorders - DSM-5 criteria for ASD, ADHD, Tic Disorders, or genetic diagnosis of Fragile X, tuberous sclerosis or 22q11 deletions.\n4. Meet DSM-5 criteria for one of the following anxiety disorders: Separation Anxiety Disorder, Social Anxiety Disorder, Agoraphobia, Generalized Anxiety Disorder, or Unspecified Anxiety Disorder, based on expert clinical interview, supported by the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS; Kaufman et al., 2016). Other specified anxiety disorder is included to account for youth with impairing anxiety symptoms who may not meet criteria for one of the other anxiety disorders.\n5. Have a Clinician's Global Impression-Severity for anxiety (CGI-S; Guy, 1976)) score ≥ 4 (moderately ill) (inter-rater reliability will be done prior to initiation of enrollment, using videotapes of interviews and vignettes)\n6. Have at least phrase speech, to allow for some self-report. So that results can be generalized to children and youth with NDD and various levels of ability, no IQ cut-off will be employed. Full-scale IQ (as measured by the Stanford-Binet) is measured to explore its effect on efficacy and safety\\*\n7. If already receiving interventions, must meet the following criteria:\n\n   1. If receiving concomitant medications affecting behaviour, must be on a stable dose during the month prior to screening and will not electively modify ongoing medications for study duration\n   2. If already receiving stable non-pharmacological behavioural interventions, have stable participation during 3 months prior to screening, and will not electively modify ongoing interventions\n8. Ability to complete assessments in English\u002FFrench\n\nExclusion Criteria:\n\n1. Receiving other SSRIs within four weeks of randomization (6 weeks for fluoxetine)\n2. Previous treatment with sertraline, at an adequate dose (at least 100mg for 6 weeks, or lower dose and duration if not well-tolerated), associated with no response or significant-to-the-participant side effects.\n3. Received more than 2 previous appropriate trials of SSRIs with no adequate response\n4. Pregnant females or sexually active females on inadequate contraception\n5. Serious medical condition that, based on Investigator judgment, might interfere with the conduct of the study, confound interpretation of the study results, or endanger participant. In addition diabetic patients on medications for glycemic control will be excluded as sertraline may interfere with glycemic control.\n6. Hypersensitivity to sertraline or any components of its formulation\n7. On Monoamine Oxidase Inhibitors or pimozide (as per product monograph)\n8. On concomitant medications known to significantly increase QT interval where this would result in unacceptable risk per Investigator judgment.\n9. Known congenital QT prolongation\n10. HIV, hepatitis B or C, hemophilia, abnormal blood pressure, substance abuse, immunity disorder, major depressive episode or psychosis (as required by Health Canada)\n11. Unable to tolerate venipuncture\n12. Unable to swallow capsules\n13. Enrolled in another intervention study","8 Years",{"count":212,"type":20},130,[214],"PHASE2","There are currently no approved medications for the treatment of anxiety in children and youth with neurodevelopmental disorders (NDDs), both common and rare. Sertraline, a selective serotonin reuptake inhibitor, has extensive evidence to support its use in children's and youth with anxiety but not within NDDs. More research is needed to confirm whether or not sertraline could help improve anxiety in children and youth with common and rare neurodevelopmental conditions. This is a pilot study, in which we plan to estimate the effect size of reduction in anxiety of sertraline vs. placebo. across rare and common neurodevelopmental disorders, and determine the best measure(s) to be used as a primary transdiagnostic outcome measure of anxiety, as well as diagnosis specific measures in future, larger-scale clinical trials of anxiety in NDDs.",[217,218,219,220,221,222,223,224,33,26,225,226,227,228,229,230,231],"Neurodevelopmental Disorders","Autism","Autism Spectrum Disorder","Fragile X Syndrome","Tuberous Sclerosis","22Q11 Deletion Syndrome","22Q11 Deletion","ADHD","Tourette Syndrome in Children","Tourette Syndrome in Adolescence","ADHD - Combined Type","ADHD Predominantly Inattentive Type","ADHD, Predominantly Hyperactive - Impulsive","Anxiety","Anxiety Disorders","2025-07-14",{"date":234,"type":38},"2025-07-16",{"date":236,"type":38},"2024-09-16",{"date":238,"type":20},"2026-09",{"name":240,"class":45},"Holland Bloorview Kids Rehabilitation Hospital",8,{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":16,"minAge":249,"maxAge":90,"enrollmentInfo":250,"targetDuration":4,"studyType":21,"phases":251,"briefSummary":252,"conditions":253,"keywords":254,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":46},"100469243","mobile-app-assisted-behavioral-treatment-in-children-and-adolescents-with-tics-100469243","NCT05390268","Mobile App-assisted Behavioral Treatment in Children and Adolescents With Tics","Mobile App-assisted Behavioral Treatment (MA-BT) in Children and Adolescents With a Chronic Tic Disorder. Randomized Clinical Trial Evaluating Treatment Response and Satisfaction","Inclusion Criteria:\n\n* a primary diagnosis of a chronic motor\u002Fvocal tics disorder including Tourette syndrome according to the WHO ICD-10 diagnostic criteria and Statistical Manual of Mental Disorders\n* a total tic score higher than 13 on the Yale Global Tic Severity Scale (YGTSS), or above a tic score of 9, if only motor or vocal tics are present\n\nExclusion Criteria:\n\n* psychotic disorder\n* primary severe depression\n* suicidal ideation or attempts\n* primary severe eating disorder\n* IQ below 70 (mental retardation)\n* participation in tic training based on HRT\u002FERP treatment within 6 months","9 Years",{"count":113,"type":20},[23],"Chronic tic disorders are neurodevelopmental disorders affecting 0.5-1% of children and adolescents. Tics present as sudden, rapid, repetitive non-rhythmic movements or vocalizations or a combination. Tics may be extremely distressing in a child's life, but the severity of tics is often variable. The group of children\u002F adolescents with tic disorders are heterogenous when it comes to symptom presentation, comorbid conditions and social status. This places great demands on professionals to offer the right treatment at the right time. The aim of the current project is to make optimal tics training more accessible, including for patients managed in primary care, to make optimal treatment available in the immediate environment, and to ensure increased adherence to treatment.\n\nAs part of this project, an app has been developed and the study aims to evaluate mobile app-assisted behavioral treatment as an efficient and feasible approach that may be a valuable tool together with other treatment approaches. The mobile app-assisted training is based on the manual \"Niks til Tics\", which describes training with a combination of Habit Reversal Training (HRT) and Exposure Response Prevention (ERP) over eight sessions, and a booster session. Both HRT and ERP are known to be effective treatments of tics.\n\nIn this project a randomized controlled superiority trial evaluates the effect of app-assisted training versus an educational approach. Participants are randomized to manualised treatment combining HRT and ERP as app-assisted training, or to psychoeducation. The participants are included according to the same criteria as in a pilot trial, and primary outcome measure is YGTSS at session 8. Furthermore, the change in tics intensity from the first contact to baseline will be included as to evaluate the effect of being admitted and examined at the hospital.\n\nThis project contributes to increased knowledge about tics and tic treatment especially treatment using digital based interventions. An app has been developed for this project and the hypothesis is that a mobile app-assisted tic training program requiring minimal hospital contacts is superior to app-based psychoeducation alone, which is the most likely intervention that these patients will be offered.\n\nThis registration encompasses a project that collects information\u002Fdata for multiple publications. As such, a number of publications are planned including a description of acute outcome, potential predictors, and longterm treatment effect",[33],[255,256,257,258],"tics","children","adolescents","Mobile app-assisted behavioral treatment","2025-02-20",{"date":261,"type":38},"2025-02-21",{"date":263,"type":38},"2022-04-01",{"date":265,"type":20},"2026-12-31",{"name":267,"class":45},"Aarhus University Hospital"]