[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tick-borne-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tick-borne-diseases":62},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,78,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100546657","navigating-pregnancy-and-parenthood-with-lyme-disease-100546657",false,"NCT06397794","Navigating Pregnancy and Parenthood With Lyme Disease","Mixed Methods Study on Navigating Pregnancy and Parenthood With Lyme Disease","Inclusion Criteria:\n\n* Over 18 years of age and reside in the United States or Canada\n* Diagnosed with acute Lyme disease, PTLDS, and\u002For Chronic Lyme by a health care provider while they were pregnant OR PTLDS\u002FCL prior to becoming pregnant with ongoing symptoms during pregnancy\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Live outside of the United States or Canada\n* Never been diagnosed with Lyme disease by a medical provider\n* Never been pregnant\n* Never given birth to a liveborn infant\n* Previously participated in a qualitative study about their experience with Lyme disease\n* Do not want to agree to having their interviews audio recorded","FEMALE","18 Years",{"count":19,"type":20},30,"ESTIMATED","OBSERVATIONAL","This is a mixed methods study exploring the experiences of pregnancy and parenting among participants with Lyme disease. Eligible participants will have been diagnosed with Lyme disease (LD), post-treatment Lyme disease syndrome (PTLDS), and\u002For chronic Lyme (CL) either during or before a prior pregnancy. Participants will complete quantitative surveys on topics such as their medical history, their child(ren)'s development, and demographic information. They will then participate in a qualitative interview where they will be asked about their experiences with pregnancy and with parenting their child(ren) in the context of their condition.",[24,25,26,27,28,29,30],"Lyme Disease","Post Treatment Lyme Disease","Chronic Lyme Disease","Tick-Borne Infections","Tick-Borne Diseases","Pregnancy Complications","Parenting","RECRUITING","2026-06-15",{"date":34,"type":35},"2026-06-17","ACTUAL",{"date":37,"type":35},"2024-03-20",{"date":39,"type":20},"2026-12",{"name":41,"class":42},"Children's National Research Institute","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":43},"100442078","phase-1-human-immune-response-to-ixodes-scapularis-tick-bites-100442078","NCT05036707","Human Immune Response to Ixodes Scapularis Tick Bites","Investigating the Human Immune Response to Ixodes Scapularis Tick Bites","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Stated willingness to comply with all study procedures and availability for the duration of the study.\n2. Age 18 years or older.\n3. In good general health as evidenced by medical history.\n4. No history of TBD.\n5. No known tick bite.\n6. Serum IgE level within Clinical Center Department of Laboratory Medicine normal range.\n\n   https:\u002F\u002Fccinternal2.cc.nih.gov\u002FLTGRA\u002FUL\u002Fpublic\\_labtest\\_detail.aspx?next\\_flg=Y\\&test\\_id=4731\\&id\\_order=53\n7. Serum tryptase level within Clinical Center Department of Laboratory Medicine normal range.\n\n   https:\u002F\u002Fccinternal2.cc.nih.gov\u002FLTGRA\u002FUL\u002Fpublic\\_labtest\\_detail.aspx?next\\_flg=Y\\&test\\_id=1157\\&id\\_order=1\n8. For participants of child-bearing potential: use of effective contraception for at least 1 month prior to tick placement, and agreement to use such a method during study participation and for an additional 3 months after the removal of the last ticks. Types of contraception include abstinence, surgical methods (sterilization, implants, intrauterine device, partner with vasectomy), hormonal methods (birth control pill, patch, ring, injection), or barrier methods (diaphragm plus spermicide, male condom plus spermicide)\n9. For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner.\n10. Agree to not participate in other clinical studies requiring investigational interventions for the duration of the study.\n11. Minimum hemoglobin of 13.0 g\u002FdL for males and 12 g\u002FdL for females\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. History of forming large thick scars (keloids) after skin injuries.\n2. History of excessive bleeding after cuts or procedures.\n3. History of taking anticoagulants in the past 28 days.\n4. History of allergic reaction to lidocaine.\n5. History of allergic reaction to tape, adhesive bandages, or dressings.\n6. Inability to maintain the dressing for any reason.\n7. Pregnancy or lactation.\n8. Treatment with another investigational drug or other intervention within the past 30 days.\n9. Oral or intravenous (IV) steroids in the 2 weeks prior to each tick placement procedure (topical, nasal, inhaled, intra-articular, and replacement doses of steroids are not exclusions).\n10. History of reactions to mammalian meat, IgE- mediated food allergies, urticaria or anaphylaxis. Mild pollen-food allergy syndrome is not an exclusion.\n11. History of systemic allergic reaction to venom (bee, wasps and other Hymenoptera stings).\n12. History of clinically significant drug allergies.\n13. History of moderate to severe atopy asthma, atopic dermatitis, allergic rhinitis.\n14. Active severe skin disease, uncontrolled diabetes, cancer other than non-melanoma skin cancers, autoimmune disease requiring immunosuppressive therapy, or history of human immunodeficiency virus (HIV), chronic viral hepatitis, or syphilis.\n15. Refusal to allow storage of samples and data for future usage..\n16. Any other condition that, in the opinion of the investigator, would make the patient unsuitable for enrollment or could interfere with the patient participating in and completing the study.\n\nExclusion of Select Populations:\n\nChildren:\n\nChildren are excluded from this protocol as there is no direct benefit to the participants, the risk from the skin biopsies is small but above minimal, the procedure is invasive and can be stressful for children, and there is concern over their ability to maintain the LeFlap dressing.\n\nPregnant and breastfeeding women:\n\nPregnant and breastfeeding women are excluded from trial participation as there is no direct benefit to the participants.\n\nAdults who lack capacity to consent:\n\nAdults lacking decision-making capacity to provide informed consent are excluded at screening as there is no direct benefit to the participants.\n\nEnrolled participants who permanently lose the ability to consent during participation will be monitored for safety but will have no additional research procedures performed.",true,"ALL","99 Years",{"count":55,"type":20},60,"INTERVENTIONAL",[58,59],"PHASE1","PHASE2","Background:\n\nEach year, the number of cases of tick-borne diseases increases. The deer tick (Ixodes scapularis) is the vector of at least 7 pathogens that cause human diseases, including Lyme disease. Researchers want to learn more to help them develop vaccines against ticks in the future.\n\nObjective:\n\nTo learn how people s bodies, particularly the skin, respond to tick bites.\n\nEligibility:\n\nHealthy adults aged 18 years and older who have no known history of a tick-borne disease or tick bite exposure.\n\nDesign:\n\nParticipants will be screened with a medical history, physical exam, and blood tests.\n\nParticipants will have 2 skin punch biopsies of healthy skin. For this, a sharp instrument will be used to remove a round plug of skin about the size of a pencil eraser. Participants will then have 10 clean laboratory-bred ticks placed at 2 different sites on their skin (20 ticks total). The ticks will be removed from the first site 1 day after placement and from the second site 2-4 days after placement. Participants will complete symptom diary cards. They will answer questions about itching at the tick feeding sites. They will give blood samples. Photos will be taken of the tick feeding sites. Skin punch biopsies will be collected at the sites of the tick bites.\n\nParticipants will repeat the tick feeding procedures 2 times, each 2-8 weeks apart. For the 2nd and 3rd procedures, 10 clean laboratory-bred ticks will be placed at 1 site. The ticks will be removed 2-3 days after tick placement. They will have telephone follow-up visits after each procedure.\n\nAfter the final tick removal, participants will have follow-up visits in 4-6 weeks and again in 3 months. They will give blood samples and discuss how they are feeling.\n\nParticipation will last about 5-7 months.",[62,63,24],"Tick-borne Diseases","Tick Resistance",[65,66,67,24],"Tick Immunity","Tick-borne diseases","Vaccines","2026-05-05",{"date":70,"type":35},"2026-05-06",{"date":72,"type":35},"2022-02-28",{"date":74,"type":20},"2028-06-30",{"name":76,"class":77},"National Institute of Allergy and Infectious Diseases (NIAID)","NIH",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":51,"sex":52,"minAge":86,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":21,"phases":4,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":109},"100576109","swetick---a-prospective-multicenter-study-of-tick-borne-diseases-in-sweden-100576109","NCT06781008","SWEtick - a Prospective Multicenter Study of Tick-borne Diseases in Sweden","Emerging Tick-borne Diseases in Children and Adults in Sweden (SWEtick): a Prospective Multicenter Study for Improved Patient Management","SWEtick","Inclusion Criteria in TBD and Non-TBD groups:\n\n* Clinical suspicion of tick-borne disease (physician's assessment based on medical history, symptoms, clinical findings and sometimes laboratory results)\n\nExclusion Criteria:\n\n* Incapacitated to understand the study information and make decisions (adults and adolescents \\>15 years)","1 Year",{"count":88,"type":20},600,"6 Months","The purpose of the SWEtick project is to increase the knowledge of the various clinical presentations of emerging tick-borne diseases (eTBD), to assess their importance for human health, to develop and validate laboratory methods for diagnosis of eTBD, and to develop recommendations for knowledge-driven management of patients with suspected eTBD within the Swedish healthcare system.",[28],[93,94,95,96,97,98],"Clinical","Prospective","Multicenter","Observational","Longitudinal","Cohort","2026-03-03",{"date":101,"type":35},"2026-03-05",{"date":103,"type":35},"2023-09-01",{"date":105,"type":20},"2035-12",{"name":107,"class":108},"Region Jönköping County","OTHER_GOV",12,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":52,"minAge":118,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":56,"phases":121,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":43},"100544878","insights-into-tick-borne-diseases-a-study-from-an-endemic-area-of-northern-italy-100544878","NCT06374615","Insights Into Tick-Borne Diseases: a Study From an Endemic Area of Northern Italy","Insights Into Tick-Borne Diseases: a Prospective Study From an Endemic Area of Northern Italy","TICKTOC","Inclusion Criteria:\n\n* all individuals aged \\> 8 years presenting for tick removal.\n* Individuals providing signed informed consent.\n\nExclusion Criteria:\n\n* tick not available for analysis","8 Years",{"count":120,"type":20},384,[122],"NA","This is a monocentric, experimental, non-pharmacological and non-device no profit study.\n\nThe study is experimental because all the visits and blood withdrawals foreseen by the protocol do not fall within the normal clinical practice.",[28],"2024-04-16",{"date":127,"type":35},"2024-04-18",{"date":129,"type":35},"2024-03-25",{"date":131,"type":20},"2029-03",{"name":133,"class":42},"IRCCS Sacro Cuore Don Calabria di Negrar"]