[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tics":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,56,82,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100053967","distinguishing-tics-and-functional-tics-using-clinical-neurophysiological-techniques-100053967",false,"NCT07137442","Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Capacity to provide informed consent (self-consent)\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Male or female, aged 18-80\n* Agreement to adhere to Lifestyle Considerations prior to and during the physiological testing visit.\n\nInclusion criteria for patients with functional tics or tics\n\n\\- Diagnosed with functional motor tics or motor tics\n\nInclusion criteria for healthy controls\n\n\\- Have no neurological or psychiatric disorders established by history and physical\u002Fneurological examination\n\nEXCLUSION CRITERIA:\n\n* Self-reported consumption of \\>14 alcoholic drinks\u002Fweek\\* for a man and \\>7 alcoholic drinks\u002Fweek for a woman\n* Use of prescription drugs and other illicit drugs that may suppress tics such as dopamine blocking agents and antipsychotics during a certain time period prior to the\n\nneurophysiological testing session.\\*\\*\n\n* Clinically significant abnormal movements on neurological examination except for tics.\n* Contraindications to EEG or EMG procedures, including skin lesions at electrode sites or hypersensitivity to electrode materials.\n* History of or current brain tumor, stroke, head trauma with loss of consciousness.\n* Epilepsy or seizures in the past 12 months.\n* Have a Baclofen pump, or have neurostimulators for pain.\n* Pregnant women\n* Self-reported current major depression or Beck Depression Inventory II (BDI-II) score \\>19, Generalized Anxiety Disorder 7-item scale (GAD-7) score \\> 9, or any major current psychiatric illness.\n* Presence of any metal in the eye or skull area such as a brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, metal fragments in the eye.\n* Presence of pacemaker, intracardiac lines, implanted pumps or stimulators.\n* Unable to comply with the requirements of the study procedures.\n* Vocal tics only tested with Modified Rush Video-Based Tic Rating Scale.\n* Low Premonitory Urge for Tics Scale (PUTS) score \\\u003C 9 (maximum 36) with low willingness for tics (patient groups only, not applicable in healthy volunteers).\n\n  * Note: 1 standard alcoholic drink is 0.6 ounce (14 grams) of pure alcohol.\n\n    * Note: The certain time period depends on different drugs used. Five half-lives will be selected. The drug is considered effectively eliminated from the body after this time period because the concentration of the drug reaches around 3% of the orininal concentration.","ALL","18 Years","80 Years",{"count":19,"type":20},75,"ESTIMATED","OBSERVATIONAL","Background:\n\nTics are involuntary movements and vocalizations. Some tics are organic: They are related to diagnosed disorders. Sometimes tics have other causes, such as problems with how the brain and body send and receive messages. These are called functional tics. It can be difficult to tell the difference between these 2 types of tics. Doctors need to know more so they can make more accurate diagnoses.\n\nObjective:\n\nTo learn more about the difference between functional and organic tics.\n\nEligibility:\n\nAdults aged 18 to 80 years who have a tic that causes involuntary movements. Healthy volunteers with no tics are also needed.\n\nDesign:\n\nParticipants will have one 4-hour clinic visit. The visit may be done in 1 or 2 days. Participants will refrain from consuming alcohol or caffeine before the visit. They may have a physical exam.\n\nParticipants will wear two types of sensors:\n\nElectromyography (EMG): Adhesive disks with sensors will be attached to the skin above some muscles. These disks will record electricity in the muscles as the participant moves.\n\nElectroencephalography (EEG): Sensors will be placed on the participant s scalp. The sensors may be adhered directly, or the participant may wear an electrode cap. The sensors will detect brain waves.\n\nParticipants will rest while seated in a chair. Their involuntary tics will be monitored with the EMG and EEG. Then they will be asked to make movements to mimic their tics. Healthy volunteers will also rest; then they will be asked to perform movements that mimic tics.\n\nParticipants will have their blink reflex tested. EMG sensors will be placed on the muscles near the eyes. Electrical pulses will be used to stimulate blinking.\n\nParticipants will answer questionnaires about their tics and their health....",[24,25],"Tics","Functional Tics",[24,27,28,29,30],"Functional tics","EEG","Blink Reflex","Pre-pulse inhibition","RECRUITING","2026-07-10",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":20},"2026-07-16",{"date":39,"type":20},"2034-08-01",{"name":41,"class":42},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH",1,{"id":45,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":47,"keywords":48,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":55,"locationsCount":43},"100603509",{"count":19,"type":20},[24,25],[24,27,28,29,30],"2026-07-01",{"date":51,"type":35},"2026-07-02",{"date":53,"type":20},"2026-07-07",{"date":39,"type":20},{"name":41,"class":42},{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":15,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":43},"100568247","phase-2-cbittms-r33-phase-100568247","NCT06678737","CBIT+TMS R33 Phase","Inclusion Criteria:\n\n* Age 12-21 years at time of enrollment.\n* Current chronic motor and\u002For vocal tics, defined as tics for at least 1 year without a tic-free period of more than 3 consecutive months. Tics must not be due to a medical condition or the direct physiological effects of a substance.\n* At least moderate tic severity, defined as a Yale Global Tic Severity Scale total score ≥14 (≥9 for those with motor or vocal tics only).\n* Full scale IQ greater than 70.\n* Child, consenting parent, and adult participant required to have English fluency and literacy to ensure comprehension of study measures and instructions.\n* To increase external validity of findings, we will include participants taking psychotropic medications that have been stable for 6 weeks and expect to remain stable for the approximately 3-week intervention protocol (with the exception of those taking neuroleptic\u002Fantipsychotic medications). Those who previously received tic-specific therapy will be included if they meet the tic severity criterion.\n\nYouth receiving other forms of psychotherapy will be included provided these treatments are not focused on tics. All concurrent treatments will be monitored during the study period.\n\nExclusion Criteria:\n\n* Medical conditions contraindicated or associated with altered TMS risk profile, including history of intracranial pathology, epilepsy or seizure disorders, traumatic brain injury, brain tumor, stroke, implanted medical devices or metallic objects in the head, current pregnancy or girls of childbearing age not using effective contraception, or any other medical condition deemed serious or contraindicated by a study physician.\n* Inability to undergo MRI (e.g., metal in body, claustrophobia, orthodontia)\n* Active suicidality.\n* Previous diagnosis of psychosis or cognitive disability.\n* Substance abuse or dependence within the past year.\n* Concurrent psychotherapy focused on tics.\n* Neuroleptic\u002Fantipsychotic medications.\n* Pregnant according to the medical history or a urine pregnancy test; and menstruating individuals capable of becoming pregnant and not using a highly effective form of contraception (FDA-approved hormonal contraceptive, IUD, tubal ligation)\n* Taking a medication that has not reached stability criterion (same medication and dose for 6 weeks with no planned changes over the intervention period)","12 Years","21 Years",{"count":65,"type":20},60,"INTERVENTIONAL",[68],"PHASE2","Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth 1 and are associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, peer victimization, and a fourfold increased risk of suicide compared to the general population. Large randomized trials have demonstrated the superiority of CBIT over supportive therapy in child and adult patients. However, in these trials, only 52% of children and 38% of adults showed clinically meaningful tic improvement, meaning that 50-60% of patients do not benefit from CBIT. CBIT success relies on an ability to suppress tics that many youth lack. The central aim of CBIT is to enhance voluntary tic suppression. Better tic suppression ability drives CBIT improvement 10 and predicts lower tic burden over the course of illness. During the core CBIT procedure, competing response training, patients learn to inhibit tics by engaging in a competing motor action. However, research shows that many youth lack this fundamental tic suppression ability that CBIT aspires to enhance.\n\nThis study will examine the clinical and neural effects of a treatment combining Comprehensive Behavioral Intervention for Tics (CBIT) and transcranial magnetic stimulation (TMS) to the supplementary motor area (SMA) in young people with tic disorder.",[24,71],"Tourette Syndrome","2026-05-18",{"date":74,"type":35},"2026-05-20",{"date":76,"type":35},"2025-02-27",{"date":78,"type":20},"2030-07-15",{"name":80,"class":81},"University of Minnesota","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":15,"minAge":90,"maxAge":63,"enrollmentInfo":91,"targetDuration":4,"studyType":66,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":43},"100583247","cognitive-psychophysiological-treatment-for-tics-in-young-people-with-tourettes-syndrome-with-or-without-biofeedback-100583247","NCT06873841","Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback","Can the Cognitive-Psychophysiological Treatment of Tics be Optimized Through Biofeedback in Adolescents and Emerging Adults With Tourette Syndrome? - A Randomized Clinical Trial","CoBRa","Inclusion Criteria:\n\n* Have a diagnosis of TS or to experience bothersome tics;\n* Be aged 14 to 21 years inclusive at the start of therapy.\n\nExclusion Criteria:\n\n* Present a sensorimotor impairment;\n* Have a diagnosis of intellectual disability (intelligence quotient below 75);\n* Alcohol or drug abuse;\n* A neurological issue (e.g., hemifacial spasms, Huntington's disease);\n* Change medication one month or less before step 1 and up to step 4 (last measurement time) without informing a member of the research team;\n* Simultaneously receive another intervention for tics (e.g., psychologist, massage therapist) without informing a research team member.","14 Years",{"count":92,"type":20},150,[94],"NA","The goal of this clinical trial is to compare the effectiveness of CoPs therapy with or without the therapeutic component of biofeedback in treating tics in Tourette Syndrome with emerging young adults.\n\nHypotheses:\n\n1. The CoPs+Biofeedback treatment will improve the severity of tics (YGTSS) and the Clinical Global Impression, surpassing the clinical significance threshold of CoPs treatment alone.\n2. We expect that the identified variables (psychosocial, neurocognitive, biological) will predict the improvement of tics.\n\nResearchers will compare if the biofeedback treatment will improve the severity of tics.\n\n* In the pre-test, participants will undergo two interviews, each lasting 3 hours. These interviews will assess (through a battery of tests) the severity of tics as well as the psychosocial, biological, and neurocognitive aspects of functioning. A general assessment of intelligence and executive functions will also be conducted.\n* They will next attend 10 to 12 therapy sessions, with or without biofeedback. (The biofeedback component is explained in more detail in the ''Study Design'' section).\n* The post-test follow-ups consist of two evaluations: one 3 months after the end of the treatment and the other 6 months after. The evaluation will be done using the same battery of tests as during the pre-test interview.",[71,24,97],"Tourette Syndrome in Adolescence",[99,100,101,102,103,24,104],"CoPs","Biofeedback","cognitive-psychophysiological therapy","Tourette","Young adults","Treatment","2025-07-04",{"date":107,"type":35},"2025-07-08",{"date":109,"type":35},"2025-04-15",{"date":111,"type":20},"2029-12",{"name":113,"class":81},"Université du Québec a Montréal",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":15,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":66,"phases":125,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":43},"100579532","investigating-changes-in-premonitory-urges-during-habit-reversal-training-for-tics-100579532","NCT06825520","Investigating Changes in Premonitory Urges During Habit Reversal Training for Tics","Investigating Changes in Premonitory Urges During Habit Reversal Training","Inclusion Criteria:\n\nParticipants who meet criteria for a DSM-5-TR diagnosis of a TD will be recruited to participate in this study. Participants will be eligible for the study if they\n\n1. present with at least three motor and\u002For vocal tics and are interested in receiving treatment,\n2. report experiencing a PU for each of their target tics with a minimum rating of a 4\u002F8 on a subjective rating (i.e., the Urge Thermometer; Silverman \\& Albano, 1996) for each tic,\n3. the targeted tics occur, on average, at least once per minute during a 10-minute direct observation,\n4. are between the ages of 8 and 17\n5. the patient has no planned changes in medication initiation or dosage during their study participation period.\n\nExclusion Criteria:\n\n1. the presence of any comorbid conditions that are considered a primary treatment concern and\u002For could interfere with study participation or treatment (i.e., unmanaged ADHD, OCD, anxiety),\n2. have previously engaged in CBIT or HRT for more than 2 sessions,\n3. a Yale Global Tic Severity Score of 40+ (or 20+ if they present with a primary motor or vocal tic disorder),\n4. suspected (based on clinical presentation) that the tics are better attributed to functional neurological symptom disorder per DSM-5-TR criteria (APA, 2022).","8 Years","17 Years",{"count":124,"type":20},6,[94],"The primary aim of this study is to learn more about premonitory urges (PU) when using Habit Reversal Training (HRT) to treat tics.\n\nThe main focus of this study is to investigate if and when PU change during tic treatment sessions and between tic treatment sessions.\n\nParticipants will:\n\n* Attend 5 study visits (approximately 1 to 1.5 hours each) for an intake, habit reversal training for 3 separate tics, and a post assessment\n* Attend 5 practice sessions (approximately 30 minutes each) over a week for 3 weeks (total 15 practice sessions)\n* Study visits and practice sessions will take place in person and online via secure videoconference",[24,128,129,97],"Tourette Disorder","Tourette Syndrome in Children",[131,132,133,134,135,136],"habit reversal training","tics","tourette","tourette's disorder","Tourette syndrome","treatment for tics","2025-05-21",{"date":139,"type":35},"2025-05-28",{"date":141,"type":35},"2025-02-11",{"date":143,"type":20},"2026-05",{"name":145,"class":81},"University of Utah"]