[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tidal-volume\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tidal-volume":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100638113","height-measurement-procedures-influence-the-risk-of-ventilator-induced-lung-injury-in-ards-100638113",false,"NCT07595926","Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDS","SIZE-ARDS","Inclusion Criteria:\n\n* Adult patient\n* Mechanical ventilation on volumetric mode\n* Sedated and curarized patient\n* Diagnosis of ARDS according to the Berlin criteria\n* Diagnosis of ARDS \\\u003C 48 hours\n* Signed informed consent\n* Affiliation with a social security or health insurance scheme\n\nExclusion Criteria:\n\n* Patient opposing the use of his\u002Fher data for research purposes.\n* Contraindication to placement of an esophageal balloon catheter (e.g., esophageal fistula, esophageal varices).\n* Contraindication to strict supine positioning for height measurement (e.g., proven or suspected intracranial hypertension with intracranial pressure \\>18 mmHg).\n* Impossibility of measuring height with the reference method (stadiometer) due to deformity or amputation of both lower limbs.\n* Patient under guardianship or curatorship, or deprived of liberty.\n* Pregnant or postpartum patient, or patient currently breastfeeding.","ALL","18 Years",{"count":19,"type":20},39,"ESTIMATED","INTERVENTIONAL",[23],"NA","Acute respiratory distress syndrome is characterized by heterogeneous lung injury, with dependent regions often collapsed and non-dependent regions relatively well-aerated, forming the so called \"baby lung.\" Mechanical ventilation, while essential, can induce additional lung injury (VILI) via overdistension (baro\u002Fvolutrauma) or repetitive alveolar collapse (atelectrauma). Protective ventilation strategies with low tidal volumes (VT 6-8 mL\u002Fkg predicted body weight, PBW) reduce mortality, but their efficacy relies on accurate PBW estimation, which is derived from patient height. In critical care, height measurement is often challenging, and common methods such as visual estimation or tape measurement can be inaccurate, leading to inappropriate VT settings and increased risk of lung stress and VILI. Alternative methods, including heel-to-knee distance and laser measurement, may offer more precise PBW estimation, yet their impact on lung mechanics in ARDS remains unexplored. This study addresses the knowledge gap by evaluating whether differences in height measurement methods significantly affect lung stress, tidal volume distribution, and ventilatory mechanics in ARDS patients.\n\nPatients' heights will be measured using five methods (stadiometer, visual, tape, laser, heel-to knee). Corresponding PBW and tidal volumes (VT = 6 mL\u002Fkg PBW) will be calculated and applied in randomized order, each for 30 minutes. Lung stress, ventilatory mechanics, gas exchange, and regional ventilation distribution will be assessed for each VT setting, preceded by a short alveolar recruitment maneuver. During the study, continuous monitoring of hemodynamics and oxygenation will be performed.\n\nVentilatory parameters including plateau pressure, driving pressure, and transpulmonary pressures will be recorded. Electrical impedance tomography will assess regional tidal volume distribution. Each patient's participation is limited to approximately two hours with no further follow-up.",[26,27,28,29,30],"Acute Respiratory Distress Syndrome","Ventilator-Induced Lung Injury","Tidal Volume","Predicted Body Weight","Height",[32,33,34,35,36],"acute respiratory distress syndrome","ventilator-induced lung injury","tidal volume","predicted body weight","height","NOT_YET_RECRUITING","2026-05-12",{"date":40,"type":41},"2026-05-19","ACTUAL",{"date":43,"type":20},"2026-05",{"date":45,"type":20},"2028-05",{"name":47,"class":48},"Centre Hospitalier Universitaire, Amiens","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":62,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":5},"100622297","modern-technologies-in-lower-respiratory-tract-infections-in-children-100622297","NCT07381790","Modern Technologies in Lower Respiratory Tract Infections in Children","Modern Technologies for Individual Risk Stratification in Infant Lower Respiratory Tract Infections","MoT-LRTI","Inclusion Criteria:\n\n* clinical diagnosis of lower respiratory tract infection\n* with tachypnea and\u002For\n* wheezing\n* Retractions\n* Respiratory difficulties\n\nExclusion Criteria:\n\n* Severe Congenital heart disease (not ASD, small VSD, PDA)\n* Cystic fibrosis and PCD\n* Neuromuscular diseases and other diseases with reduced airway clearance\n* Severe malacia, diagnosed by bronchoscopy by time of T0.\n* Foreign body inhalation\n* Pneumothorax\n* Pleural effusion (with need of invasive interventions)\n* Bronchopulmonary dysplasia or GA \\\u003C32 weeks\n* Caretaker not able to communicate in Norwegian or English\n* Weight \\\u003C3 kg","0 Days","24 Months",{"count":61,"type":20},200,"1 Year","OBSERVATIONAL","Lower respiratory tract infections (LRTIs) are a significant cause of childhood morbidity and mortality globally, particularly in low-income countries. In Norway, LRTIs is a leading cause of hospitalization among infants, representing a great socioeconomic burden.\n\nBronchiolitis, a viral infection, is the main representation of LRTIs in infants. It affects the small airways, causing breathing- and feeding difficulties. Today, treatment relies on subjective evaluations, lacking objective measures for assessment. This increases the risk of both under- and over treating patients. In the long term, bronchiolitis increases risk of asthma, but it is unknown who the high-risk patients for chronic lung disease are.\n\nLung ultrasonography (LUS) has emerged as a promising tool for assessing bronchiolitis severity and progression of the disease. The investigators will explore its use to improve diagnostic accuracy and treatment decisions, and develop AI-driven scoring tools for novel technology.\n\nAdditionally, tidal breathing flow volume loops (TBFVL) offer a non-invasive method for evaluating airway obstruction in infants, with the potential to assess severity of bronchiolitis, treatment efficacy and post-infection lung function.\n\nIn this project the investigators will combine the use of these modern technologies to improve treatment and follow-up of infants with LRTIs.\n\nThe main aim for this observational study is to assess the utility of lung ultrasonography (LUS) and tidal flow volume loops (TBFVL) in infant lower respiratory tract infections (LRTIs) for individual risk stratification in acute and chronic settings. This aims to refine the management of bronchiolitis, identifying high-risk patients for chronic lung disease to tailor treatment and follow-up protocols.\n\nThe project has three secondary objectives.\n\n1. To assess correlation between LUS and TBFVL findings with clinical score at admission, length of stay, need of respiratory support and ICU admissions.\n2. To assess duration of symptoms following acute bronchiolitis and evaluate the use of LUS and TBFVL in objectively examine post-infectious sequela.\n3. To evaluate the long-term impact of bronchiolitis on lung function through clinical follow-up after a 12 month period.\n\nLower respiratory tract infections (LRTIs) stand as the leading cause of hospitalization, while asthma is the leading cause of chronic lung disease among children in Nordic countries. The project seeks to improve risk stratification and treatment protocols in both acute and chronic settings.\n\nIn the acute setting, the project endeavors to prognosticate individual patient outcomes, thereby individualize treatment and mitigating unnecessary hospital admissions, use of respiratory support and antibiotic administration. Additionally there is potential of more aggressive treatment to selected patients. The study aims to improve the understanding of pathophysiological processes of LRTIs in infants, providing objective metrics to evaluate disease severity and individualize treatment.\n\nThe investigators aim to validate the utility, validity, and simplicity of handheld ultrasound devices as bedside diagnostic tools for this common disease, alongside affirming the value of tidal flow volume loops (TBFVL) in acute and chronic settings to assess airway obstruction in infants. Combining these modern technologies, evaluating affliction of both the parenchyme and the airways will probide a new perspective in treatment of LRTIs. In addition the project will strive to develop novel technology with AI-driven scoring tools of LUS.\n\nFurthermore, the project aims to examine the trajectory of symptoms post-LRTI and facilitate the early identification of patients with high-risk of chronic lung disease. Early detection of asthma and other chronic lung diseases holds the potential to improve outcomes and mitigate the need for hospitalization, thus easing both economic and emotional burdens associated with the disease.\n\nFor caregivers, the lack of information concerning symptom duration and risk of future disease represents a significant knowledge gap. The project aims to address this, by examining post-infection symptom duration and identifying high-risk cohorts predisposed to chronic lung disease. This has the potential to both improve information, personalize follow-up and reduce hospital readmissions.",[66,67,68,28,69,70],"Bronchiolitis Acute","Lower Respiratory Tract and Lung Infections","Pediatric Lung Ultrasound","Pediatric Lung Diagnosis","Pediatric Asthma",[72,73,74,75],"pediatric","lung ultrasound","lower respiratory tract infections","tidal-flow volume loops","RECRUITING","2026-01-26",{"date":79,"type":41},"2026-02-02",{"date":81,"type":41},"2025-12-15",{"date":83,"type":20},"2029-06-30",{"name":85,"class":86},"Helse Møre og Romsdal HF","OTHER_GOV"]