[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"time-restricted-eating\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:time-restricted-eating":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,51,84,111,137,168,199,231,257,286,316,341,370,397,417,449],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100053953","early-time-restricted-eating-combined-with-exercise-in-older-adults-100053953",false,"NCT07695961","Early Time-Restricted Eating Combined With Exercise in Older Adults","Effects of Early Time-Restricted Eating Combined With a Multicomponent Exercise Program on Bone Mineral Density, Gait, Balance, and Fall Risk in Healthy Older Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 60 years or older\n* Community-dwelling and generally healthy older adults\n* Sedentary or moderately physically active\n* Stable body weight during the previous 3 months (no intentional weight loss or gain \\>5%)\n* Able to participate in a supervised exercise program\n* Willing to comply with the time-restricted eating protocol and study procedures\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of osteoporosis requiring pharmacological treatment\n* Severe sarcopenia or major mobility limitations preventing safe exercise participation\n* Cognitive impairment or diagnosed dementia affecting ability to follow instructions\n* Presence of uncontrolled chronic diseases affecting bone metabolism (e.g., advanced renal disease, uncontrolled endocrine disorders)\n* Current use of medications affecting bone metabolism (e.g., corticosteroids, anti-osteoporotic drugs)\n* Participation in another structured exercise or dietary intervention program within the past 3 months\n* Any medical condition that contraindicates moderate-intensity exercise\n* Inability to comply with study protocol or follow-up assessments",true,"ALL","60 Years","85 Years",{"count":21,"type":22},44,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial aims to investigate the effects of Early Time-Restricted Eating (eTRE) combined with a multicomponent exercise program on bone health, physical function, and fall risk in healthy older adults.\n\nA total of approximately 44 healthy adults aged 60 years and older will be recruited and randomly assigned to one of two groups. The experimental group will follow an Early Time-Restricted Eating schedule combined with a structured multicomponent exercise program. The control group will not receive any dietary timing intervention or structured exercise program and will continue their usual daily lifestyle.\n\nThe intervention will last for 6 months. Participants in the exercise program will perform supervised sessions including resistance training, balance exercises, aerobic activity, and flexibility exercises. The Early Time-Restricted Eating protocol will involve consuming all daily food intake within an early daytime window while maintaining usual dietary quality and adequate energy and nutrient intake.\n\nThe main outcomes of the study include changes in bone mineral density, gait performance, balance, and fall risk. These outcomes will be measured at baseline and after the intervention period.\n\nThis study will provide evidence on whether combining early time-restricted eating with structured exercise can improve musculoskeletal health and functional ability, and reduce fall risk in older adults.",[28,29,30,31,32],"Nutrition","Health and Wellbeing","Aging","Time Restricted Eating","Bone Health",[31,34,35,36,37],"Exercise Program","Bone Mineral Density","Gait","Balance","NOT_YET_RECRUITING","2026-07-09",{"date":41,"type":42},"2026-07-13","ACTUAL",{"date":44,"type":22},"2026-06-15",{"date":46,"type":22},"2026-12-30",{"name":48,"class":49},"University of Manouba","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":50},"100619511","investigating-the-impact-of-early-time-restricted-eating-on-health-outcomes-and-quality-of-life-in-adults-with-mild-controlled-asthma-compared-to-healthy-adults-100619511","NCT07345572","Investigating the Impact of Early Time-Restricted Eating on Health Outcomes and Quality of Life in Adults With Mild Controlled Asthma Compared to Healthy Adults","Investigating the Impact of Early Time-Restricted Eating on Health Outcomes and Quality of Life in Adults With and Without Asthma","eTRE","Inclusion Criteria:\n\n* Adults between 18 and 65 years old.\n* Control group: individuals without asthma\n* Asthma group: Have already been diagnosed with controlled mild asthma.\n* Not following any diet regimen.\n* Able to read the information pack and give consent in English.\n\nExclusion Criteria:\n\n* Moderate to severe asthma\n* Pregnant\n* Smoking\n* Systemic corticosteroids.\n* History of recent respiratory disease, current chest infection, and collapsed lung.\n* History of recent surgery (last 2 months), including thoracic, abdominal, and eye surgery.\n* Being diagnosed with cardiovascular diseases, e.g., unstable angina, a heart attack, uncontrolled high blood pressure, stroke, and aneurysm.\n* Broken ribs or neck vertebrae.\n* Cancer.\n* History of autoimmune diseases\n* Being diagnosed with an eating disorder.\n* Overnight shift work","18 Years","65 Years",{"count":62,"type":22},36,[25],"This study aims to explore how early time-restricted eating (eTRE) - where all daily meals are eaten within a specific time window - affects health and quality of life in adults. The researchers will compare results between adults with mild, well-controlled asthma and adults without asthma (the control group). Participants can continue to eat their normal food; only the timing of meals will change.",[66,31],"Asthma Management",[68,69,70,71,72,73,74],"Asthma","time restricted eating","inflammatory markers","oxidative stress markers","pulmonary function parameters","quality of life","adherence","2026-02-19",{"date":77,"type":42},"2026-02-20",{"date":79,"type":22},"2026-02-25",{"date":81,"type":22},"2026-07-01",{"name":83,"class":49},"De Montfort University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":16,"sex":92,"minAge":59,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":50},"100552748","time-restricted-eating-among-pregnant-females-with-severe-obesity-100552748","NCT06477120","Time-restricted Eating Among Pregnant Females With Severe Obesity","A Pilot Study of Time-restricted Eating Among Pregnant Females With Severe Obesity","TRE-Preg","Inclusion criteria:\n\n* Female based on sex assigned at birth\n* Preconception body mass index (BMI) 35.0 - 60 kg\u002Fm2\n* Singleton pregnancy\n* Age 18-44 years old\n* 14 - \\\u003C = 20 weeks gestational age\n* Fluency in English to provide consent and complete study procedures\n* Ability to provide informed consent\n* Cleared by study doctor and the obstetrician\u002Fmid-wife provider to participate\n* Access to a smartphone to complete intervention procedures\n\nExclusion criteria:\n\n* Deemed medically high risk\n* Multiple pregnancy (e.g., twins)\n* Type 1 or 2 diabetes mellitus\n* Early gestational diabetes (diagnosed at \\\u003C = to17 weeks gestational age through an oral glucose tolerance test)\n* Currently eating ≤ 12 hours daily\n* Autoimmune disorder (e.g., rheumatoid arthritis)\n* iron deficiency anemia\n* Inflammatory bowel disease\n* Previous spontaneous preterm birth\n* History of bariatric surgery\n* Night shift work\n* Currently incarcerated\n* Eating disorder","FEMALE","44 Years",{"count":95,"type":22},60,[25],"In the United States, a body mass index (BMI) of at least 35.0 kg\u002Fm2 affects about 15% of women of reproductive age. Severe obesity is a significant predictor of adverse perinatal outcomes including gestational diabetes mellitus, pre-eclampsia, premature birth, and at its most severe, fetal death, birth defects and a three-fold greater risk of maternal mortality. Observational studies suggest weight maintenance and even modest body fat loss and altering the maternal metabolic milieu (availability of glucose and lipids) in the gestational period may be important to reducing perinatal health risks among pregnant females with severe obesity. The proposed research aims to assess time-restricted eating in the 2nd and 3rd trimesters of pregnancy to explore the effects on maternal weight, and perinatal health outcomes compared to standard clinical care.",[99,31,100],"Obesity, Morbid","Pregnancy Weight Gain","RECRUITING","2026-01-22",{"date":104,"type":42},"2026-01-23",{"date":106,"type":42},"2024-09-09",{"date":108,"type":22},"2026-11-29",{"name":110,"class":49},"University of Illinois at Chicago",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":50},"100558767","healthy-lifestyles-in-bipolar-disorder-bay-area-study-100558767","NCT06555406","Healthy Lifestyles in Bipolar Disorder: Bay Area Study","Time-restricted Eating as an Adjunctive Intervention for Bipolar Disorder","Inclusion Criteria:\n\n* Meets diagnostic criteria for bipolar I disorder or bipolar II disorder (but not cyclothymia, bipolar disorder Not otherwise specified or bipolar disorder due to another medical condition) assessed by the Diagnostic Interview for Anxiety, Mood, and Obsessive-compulsive and Related Neuropsychiatric Disorders \\[DIAMOND\\])\n* current sleep (insomnia, hypersomnolence) or circadian sleep-wake (delayed phase, advanced phase, irregular sleep-wake, non-24-hour sleep-wake-type) concerns indicated by endorsement of at least some sleep or circadian-related impairment across the screening self-reports or interview\n* Living in an English-speaking country (and one that the researchers have expertise in research procedures and diet)\n* Has been speaking English for at least 10 years, speaks English in the home, or certifies that they are able to understand English well for the study and demonstrates this during the screening interview.\n* Receiving medical care for bipolar disorder (referrals will be provided for those who would like to begin care)\n* Mood-stabilizing medication regimens stable for at least one month\n* \\\u003C 5 kg weight change in the past 3 months\n* Currently eating ≥ 12 hours per day at least twice per week\n* Able to operate the camera function and respond to web-based surveys by phone (loaner phones will be provided as needed)\n* Not engaged in current shift work or have other responsibilities such as providing care that would chronically disrupt their sleep (i.e., \\> 3 h between 22:00 and 05:00 h for at least 1 day\u002Fweek)\n* Able to complete 7 days of dietary logs adequately (e.g., at least 2 entries per day, covering at least a 5-hour eating window) during the baseline period\n* Able to complete screening and baseline questionnaires adequately (e.g., not failing more than 1 attention check item with instructed responding; responding to standard multiple-choice items in a mean of \\\u003C 2 seconds per item). Where individuals respond to more than 14 items in a row with the same response, their answers will be manually reviewed for possible invalidity.\n\nExclusion criteria include the following:\n\n* Current episode of depression, hypomania or mania, or psychosis (assessed by the DIAMOND), Participants with acute mood disorder episodes will be encouraged to seek treatment and to consider the study when symptoms have remitted.\n* Eating disorder diagnosis (by self-report of treatment or diagnosis at any point during their life, Short Eating Disorder Examination Questionnaire (EDE-QS) scores above clinical concern thresholds for eating disorders, or DIAMOND interview of symptoms during adulthood)\n* Past 3-month alcohol use disorder or substance use disorder (assessed by DIAMOND)\n* Active suicidal ideation coupled with plan, intent or attempt history as assessed by Columbia Suicide Severity Rating Scale\n* Conditions that would interfere with ability to take part in the intervention, including pregnancy, breastfeeding, uncorrected hypo or hyperthyroidism, gastrointestinal conditions impairing nutrient absorption\n* Conditions that would confound immune or other study measures, such as HIV, AIDS, lupus, or multiple sclerosis\n* Medications contraindicated for fasting: clozapine, glucose-lowering medications, diabetes-related injections, medications requiring food early morning or late evening, corticosteroids; Glucagon-like peptide-1 (GLP-1) agonists will not be an exclusion criteria if weight stabilized\n* Cognitive deficits as noted during the initial interview or as indicated by low performance on the Orientation Memory Concentration Test- Short Version (weighted score \\\u003C 20)",{"count":119,"type":22},150,[25],"The goal of this clinical trial is to understand how level of adherence with time-restricted eating (TRE) predicts change in diurnal rhythms (as measured using the amplitude of diurnal peripheral clock gene expression), and how those changes predict lower mania and depressive symptoms, and downstream improvements in quality of life. The effects of diurnal amplitude of clock gene expression is expected to remain significant when controlling for change in glucose tolerance and inflammation. Participants will be enrolled who are already receiving medication treatment for bipolar disorder. Participants will complete daily measures of eating, sleep and mood for two weeks, and then will be assigned to follow TRE for eight weeks. Symptoms and Quality of Life will be measured at baseline and during and after the food plan.",[123,31],"Bipolar Disorder",[125,126,127],"sleep","insomnia","circadian rhythms","2026-01-12",{"date":130,"type":42},"2026-01-14",{"date":132,"type":42},"2024-11-22",{"date":134,"type":22},"2029-02-01",{"name":136,"class":49},"University of California, Berkeley",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":50},"100584592","optimization-of-chrononutrition-to-reduce-the-risk-of-disease-in-shift-workers-100584592","NCT06891352","Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers","Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers - The SHIFT Study","SHIFT","Inclusion Criteria:\n\n* Age: 18-70 years\n* BMI ≥ 25 kg\u002Fm2 (or ≥ 23 kg\u002Fm2 for Asian adults)\n* Own a smartphone (Apple iOS or Android OS)\n* Baseline eating window ≥ 14 h\u002Fday\n* Night shift nurses and nursing assistants who are working a 12-hour night shift at least 3 days\u002Fweek.\n* Have been doing night shift work for at least 3 months.\n* Patients on cardiovascular medications (HMG CoA reductase inhibitors (statins), metformin, lipid-modifying drugs (including over-the-counter drugs such as red yeast rice and fish oil), anti-hypertensive, drugs), are allowed\n* If patients have Type 2 Diabetes, they will be included in the study if A1c is less than 9 and they are not on insulin.\n\nExclusion Criteria:\n\n* Insufficient dietary logging on the mCC app is defined as less than 7 of 14 days of baseline of dietary logging with a minimum of 2 items a day, at least 5 hours apart.\n* Type 1 Diabetes or Insulin-dependent Type 2 Diabetes.\n* Use of sulfonylurea or insulin within the last 3 months (due to unknown safety with TRE)\n* Use of medications that are known to cause weight loss such as SGLT2 inhibitors and GLP1 receptor agonists)\n* BMI \\> 50 kg\u002Fm2\n* Change in medications that could impact study outcomes within the past 3 months\n* Change in weight of \\>4kg in the past 3 months\n* Women who are pregnant, breastfeeding, or are trying to become pregnant during the study period. If a participant becomes pregnant during the study, they will be excluded from continuing the study.\n* Systolic BP greater than 160 mmHg and\u002For diastolic BP greater than 110 mmHg at rest\n* Fasting LDL cholesterol greater than 250 mg\u002FdL\n* Fasting triglycerides greater than 500g\u002FdL\n* Active tobacco abuse or illicit drug use or history of treatment for alcohol abuse in the past 5 years.\n* Frequent (more than 4) travel involving a time zone change of more than 3 hours over the 1-year study period\n* Prolonged leave from work (a continuous month or longer) during the study\n* Active treatment for inflammatory and\u002For rheumatologic disease\n* History of a major adverse cardiovascular event within the past year (acute coronary syndrome, percutaneous coronary intervention, coronary artery bypass graft surgery, hospitalization for congestive heart failure, stroke\u002Ftransient ischemic attack)\n* Uncontrolled arrhythmia (i.e. rate-controlled atrial fibrillation\u002Fatrial flutter are acceptable)\n* History of thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (hypothyroidism on a stable dose of thyroid replacement therapy is allowed).\n* History of adrenal disease in the past 5 years\n* History of malignancy undergoing active treatment, except non-melanoma skin cancer, in the past 5 years\n* History of an eating disorder in the past 5 years\n* History of cirrhosis in the past 5 years\n* History of stage 4 or 5 chronic kidney disease or dialysis in the past 5 years\n* History of HIV\u002FAIDs\n* Currently enrolled in weight-loss or weight-management program\n* History of surgical intervention for weight management within the past 2 years, or longer if deemed unsafe following review by medical investigators\n* Uncontrolled psychiatric disorder including prior hospitalization","70 Years",{"count":147,"type":22},180,[25],"In this randomized controlled trial, the investigators will assess the health impacts of optimizing the timing of dietary consumption in nurses and nursing assistants who work night shifts, have a habitual eating window of 14 hours or more, and elevated weight. Participants will be randomized to one of three groups: (1) dietary monitoring, (2) dietary monitoring plus 10-hour daytime time-restricted eating (TRE), or (3) TRE with a low-glycemic snack during night shifts. The study includes a 2-week screening\u002Fbaseline health assessment, with follow-up health assessments at 3-, 6- (primary outcome), and 12 months.",[151,31,152,153],"Night Shift Work","Overweight","Obesity",[155,156,157,158],"Time-Restricted Eating","Night Shift work","Nurses","Nursing Assistants","2025-12-12",{"date":161,"type":42},"2025-12-17",{"date":163,"type":42},"2025-06-02",{"date":165,"type":22},"2029-03-03",{"name":167,"class":49},"Salk Institute for Biological Studies",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":16,"sex":17,"minAge":175,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":180,"conditions":181,"keywords":186,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":50},"100609511","effects-of-hiit-vs-tre-on-type-2-diabetes-risk-100609511","NCT07215533","Effects of HIIT vs. TRE on Type 2 Diabetes Risk","Differential Effects of HIIT vs. TRE on Type 2 Diabetes Risk in Youth and Younger Adults","Inclusion Criteria:\n\n* Adolescents (age 14-17 years old with sex- and race-specific BMI percentile ≥85th) and young adults with overweight and obesity (age 18 to 30 years old with BMI ≥25 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Chronic medical conditions: heart disease, arrhythmias, diabetes, thyroid disease, bleeding disorder, history of pulmonary disease, hypertension, hepatorenal disease, musculoskeletal disorder, neuromuscular\u002Fneurological disease, autoimmune disease, cancer, peptic ulcers, anemia, or chronic infection (HIV).\n* Have taken any heart, pulmonary, thyroid, anti-hyperlipidemic, hypoglycemic, anti- hypertensive, endocrinologic (e.g., thyroid, insulin, etc.), emotional\u002Fpsychotropic (e.g., Prednisone, Ritalin, Adderall), neuromuscular\u002Fneurological, or androgenic medications (anabolic steroids).\n* Have a pacemaker.","14 Years","30 Years",{"count":178,"type":22},40,[25],"The primary aim of this randomized controlled trial is to examine the effects of a 4-week high-intensity interval training (HIIT) and time-restricted eating (TRE) intervention on cardiometabolic biomarkers in adolescents and young adults.",[182,183,184,185],"Obesity and Type 2 Diabetes","Metabolic Diseases","High-intensity Interval Training","Time-restricted Eating",[184,185,153,187,188,189],"Type 2 Diabetes","Youth","Young Adults","2025-10-08",{"date":192,"type":42},"2025-10-10",{"date":194,"type":42},"2024-03-15",{"date":196,"type":22},"2025-12-30",{"name":198,"class":49},"Syracuse University",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":217,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":50},"100596179","lifestyle-for-the-brain-health---time-restricted-eating-and-mindfulness-100596179","NCT07042087","Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness","LIBRA REMIND","Inclusion Criteria:\n\n* Age 60-80 years\n* Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)\n* mini-mental-scale (MMSE) score between 24-30\n* Positive plasma pTau217 biomarker\n* Stable dose of iAChE therapy (if applicable)\n* Ability to participate in a 9-month intervention\n\nExclusion Criteria:\n\n* Stroke or myocardial infarction within the past year\n* Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy)\n* Long-term psychiatric treatment (except well-managed depression)\n* Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy)\n* Severe sensory or motor impairment preventing protocol participation\n* Active cancer treated within the past 5 years\n* Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation)\n* Concurrent participation in another clinical study\n* Unstable iAChE medication regimen\n* Substance or alcohol dependence","80 Years",{"count":208,"type":22},48,[25],"The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.",[212,30,213,214,215,31,216],"Alzheimer Disease","Lifestyle Factors","Cognitive Impairment","Yoga","Diet Modification",[218,219,220,155,221],"Alzheimer's Disease Prevention","Mindfulness-Based Intervention","Cognitive Training","Dietary consultation","2025-06-19",{"date":224,"type":42},"2025-06-27",{"date":226,"type":42},"2024-11-01",{"date":228,"type":22},"2026-12",{"name":230,"class":49},"St. Anne's University Hospital Brno, Czech Republic",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":17,"minAge":237,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":23,"phases":241,"briefSummary":242,"conditions":243,"keywords":245,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":50},"100403681","time-limited-eating-in-adolescents-with-type-2-diabetes-kt2d-100403681","NCT04536480","Time Limited Eating in Adolescents With Type 2 Diabetes (KT2D)","All adolescents with T2D and referred to the endocrinology clinic at CHLA will be screened. Inclusion criteria are: (1) age 12-21 years; (2) Tanner stage III and above; (3) diagnosis of T2D based on the ADA diagnostic guidelines; (4) hemoglobin A1c \\\u003C 9%; and (5) participant must be willing and able to adhere to the assessments, visit schedules, and eating\u002Ffasting periods. To limit confounding factors, individuals will be considered ineligible to participate if they meet any of the following exclusion criteria: (1) previous diagnosis of Prader-Willi Syndrome, brain tumor or hypothalamic obesity; (2) serious developmental or intellectual disability; (3) previous diagnosis or subthreshold symptoms of an eating disorder (anorexia nervosa, bulimia nervosa, binge-eating disorder); (4) parent\u002Fguardian-reported physical, mental of other inability to participate in the assessments (e.g., inability to wear CGM, inability to undergo imaging testing without sedation); (5) previous or planned bariatric surgery; (6) current planned use of an anti-obesity or other diabetes medication (e.g., phentermine, topiramate, orlistat, glucagon-like-peptide-1 agonist, naltrexone, or bupropion); or (7) current participation in other interventional weight loss studies.","12 Years","21 Years",{"count":240,"type":22},100,[25],"To find the effectiveness of a diet plan (Time Limited Eating or TLE) on glycemic control, B-cell function, body fat, and body mass index (BMI) in adolescents with type 2 diabetes.",[244,187,31],"Pediatric Obesity",[246,187,247],"Intermitted-fasting","Time Limited Eating","2025-06-18",{"date":250,"type":42},"2025-06-24",{"date":252,"type":42},"2023-04-15",{"date":254,"type":22},"2027-12-01",{"name":256,"class":49},"Children's Hospital Los Angeles",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":23,"phases":267,"briefSummary":268,"conditions":269,"keywords":274,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":50},"100586172","the-effect-of-time-restricted-eating-on-glycemic-and-proinflammatory-biomarkers-among-prediabetic-obese-jordanian-adults-aged-18-40-years-old-100586172","NCT06911918","The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old","The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old: A Randomized Control Study","Inclusion Criteria:\n\n* IR individuals diagnosed with IR by the physicians as indicated by HOMA-IR score\n* female and male, BMI ≥ 30 to 39.9 kg\u002Fm2\n* age between 18 and 40 years\n* stable weight for 3 months before the beginning of the study\n* sedentary lifestyle\n\nExclusion Criteria:\n\n* previous weight loss surgery\n* pregnancy or intent to become pregnant\n* breastfeeding\n* chronic diseases\n* drug therapies that could interfere with the effectiveness of the dietary intervention (e.g., use of corticosteroids, and anti-diabetic drugs)\n* diabetic type 1 and 2 individuals\n* anyone physically active to reduce the influence of confounding covariates","40 Years",{"count":266,"type":22},120,[25],"Obesity, a global epidemic, significantly contributes to prediabetes, cardiovascular diseases, and other chronic diseases due to its pro-inflammatory nature. This studyl investigates the effects of time-restricted eating (TRE) with calorie restriction (CR), TRE without CR, and CR without TRE on glycemic control and pro-inflammatory biomarkers among prediabetic obese Jordanian adults aged 18-40 years. The study assesses changes in pro-inflammatory biomarkers (IL-1β, TNF-α, IL-6), insulin resistance (HOMA-IR), and body composition over 12 weeks.\n\nParticipants (n=120) will be randomized into four intervention arms: (1) TRE with CR, (2) TRE without CR, (3) CR without TRE, and (4) a control group with no dietary restrictions and no TRE. Biweekly anthropometric assessments will evaluate pro-inflammatory biomarkers and biochemical measures at baseline and the end of the study. The findings will provide insights into the comparative effectiveness of TRE and CR, potentially offering a safe, cost-effective intervention to prevent obesity-induced inflammation, prediabetes, and progression to type 2 diabetes mellitus.",[270,271,31,272,273],"Insulin Resistance","Inflammation Biomarkers","Caloric Restriction","Obesity (Disorder)",[275,270,153,272,276],"Time restricted eating","Inflammation cytokines","2025-03-27",{"date":279,"type":42},"2025-04-04",{"date":281,"type":22},"2025-04-05",{"date":283,"type":22},"2025-11",{"name":285,"class":49},"University of Jordan",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":294,"enrollmentInfo":295,"targetDuration":4,"studyType":23,"phases":297,"briefSummary":299,"conditions":300,"keywords":303,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":50},"100584032","phase-1-time-restricted-eating-in-patients-with-microalbuminuria-100584032","NCT06884059","Time Restricted Eating in Patients With Microalbuminuria","Impact of Time-Restricted Eating (TRE) on Kidney Health (The TREK Study)","TREK","Inclusion Criteria:\n\n1. Age: 18-75 years old\n2. Participants with T2DM with A1c between 6.5 and 9.0 % and on stable doses of medications who are weight-bearing and self-ambulatory.\n3. uACR ( urine albumin creatinine ratio) results ≥ 30 - 300 mg.\n4. Willingness to use smartphone for research procedures (Apple iOS or Android OS)\n5. Baseline eating period ≥12 hours\u002Fday and sufficient logging on the mCC app.\n6. Person of childbearing potential will be given a pregnancy test on study enrollment and asked to use contraception throughout the study.\n7. Post-menopausal and individuals on hormone replacement therapy will be included.\n8. Estimated Glomerular Filtration Rate (EGFR) \\> 45\n9. If participants are on cardiovascular medications (HMG CoA reductase inhibitors (statins), other lipid-modifying drugs, anti-hypertensives) no dose adjustments will be allowed during the study period\n10. Participants on stable doses (consistent dose for ≥3 months) of GLP-1 receptor agonists will be included.\n\nExclusion Criteria:\n\n1. Participants with Type1DM and T2DM who are taking insulin, sulfonylureas, or have an HbA1c \\> 9 %.\n2. Estimated Glomerular Filtration Rate (EGFR) \\\u003C 45\n3. Systolic BP greater than 160 mmHg and\u002For Diastolic BP greater than 110 mmHg (with or without treatment\u002Fmedication)\n4. LDL cholesterol greater than 200 mg\u002FdL\n5. Triglycerides greater than 500 mg\u002FdL\n6. Active tobacco or illicit drug use\n7. Pregnant or breastfeeding individuals.\n8. Currently enrolled in a weight-loss or weight-management program,\n9. Currently on a special or prescribed diet for other reasons (e.g., Celiac disease),\n10. On recently prescribed medication that is meant for weight loss, or has known effect on appetite suppression ( patient on stable dose for 3 months can be enrolled ).\n11. History of eating disorder(s).\n12. History of surgical intervention for weight management (e) active eating disorder.\n13. Chronic kidney disease with an eGFR calculated based on the Modification of Diet in Renal Disease (MDRD) equation \\\u003C50mL\u002Fmin\u002F1.73m2\n14. Treatment for active inflammatory and\u002For rheumatologic disease and cancer.\n15. A major adverse cardiovascular event within the past 6 months such as acute coronary syndrome (ACS), percutaneous coronary intervention, coronary artery bypass graft surgery, hospitalization for congestive heart failure, stroke\u002Ftransient ischemic attack (TIA).\n16. History of Uncontrolled arrhythmia (i.e., rate-controlled atrial fibrillation\u002Fatrial flutter are not exclusion criteria) 18. Liver cirrhosis and\u002For significant alterations in liver function\n17. History of (a) thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (i.e., hypothyroidism on a stable dose of thyroid replacement therapy is not an exclusion), Shift workers with variable (e.g., nocturnal) hours.\n18. Caregivers for dependents requiring frequent nocturnal care\u002Fsleep interruptions.\n19. More than one trip planned to travel to a time zone with greater than a 3-hour difference during study period.\n20. History of major adverse cardiovascular events within the past 1 year (acute coronary syndrome (ACS), percutaneous coronary intervention, coronary artery bypass graft surgery, hospitalization for congestive heart failure, stroke\u002Ftransient ischemic attack (TIA)).\n21. History of thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (i.e., hypothyroidism on a stable dose of thyroid replacement therapy is not an exclusion).\n22. History of adrenal disease.\n23. History of malignancy undergoing active treatment, except non-melanoma skin cancer.\n24. Known history of type I diabetes.\n25. History of stage 4 or 5 chronic kidney disease or requiring dialysis.\n26. History of HIV\u002FAIDS.\n27. Uncontrolled psychiatric disorder (including history of hospitalization for psychiatric illness).","75 Years",{"count":296,"type":22},25,[298],"PHASE1","This is a clinical trial to assess how time-restricted eating (TRE) may improve kidney health and filtration patients with type 2 diabetes and increased protein content in their urine. All participants will be participating in TRE in which they follow a consistent 8-10 hour eating window everyday.",[301,31,302],"Type 2 Diabetes Mellitus (T2DM)","Microalbuminuria",[302,31,304,187,305,306],"Urine Albumin-to-Creatinine Ratio","uACR","Fasting","2025-03-12",{"date":309,"type":42},"2025-03-19",{"date":311,"type":22},"2025-03",{"date":313,"type":22},"2028-02",{"name":315,"class":49},"University of California, San Diego",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":324,"targetDuration":4,"studyType":23,"phases":326,"briefSummary":327,"conditions":328,"keywords":330,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":50},"100530590","healthy-lifestyles-for-bipolar-disorder-100530590","NCT06188754","Healthy Lifestyles for Bipolar Disorder","Time-restricted Eating vs. Mediterranean Diet as Adjunctive Interventions for Bipolar Disorder","HL","Inclusion Criteria:\n\n* meets diagnostic criteria for bipolar I disorder or bipolar II disorder (but not cyclothymia, BD Not otherwise specified or BD due to another medical condition)\n* current sleep (insomnia, hypersomnolence) or circadian sleep-wake (delayed phase, advanced phase, irregular sleep-wake, non-24-hour sleep-wake-type) concerns indicated by endorsement of at least some sleep or circadian-related impairment across the screening self-reports or interview\n\n  * Living in an English-speaking country (and one that we have expertise in research procedures and diet)\n  * Has been speaking English for at least 10 years, speaks English in the home, or certifies that they are able to understand English well for the study and demonstrates this during the screening interview.\n  * Receiving medical care for BD (referrals will be provided for those who would like to begin care)\n  * Mood-stabilizing medication regimens stable for at least one month\n  * \\\u003C 5 kg weight change in the past 3 months\n  * Currently eating ≥ 12 hours per day at least twice per week\n  * Able to operate the camera function and respond to web-based surveys by phone (loaner phones will be provided as needed)\n  * Not engaged in current shift work or have other responsibilities such as providing care that would chronically disrupt their sleep (i.e., \\> 3 h between 22:00 and 05:00 h for at least 1 day\u002Fweek)\n  * Able to complete 7 days of dietary logs adequately (e.g., at least 2 entries per day, covering at least a 5-hour eating window) during the baseline period\n  * Able to complete screening and baseline questionnaires adequately (e.g., not failing more than 1 attention check item with instructed responding; responding to standard multiple-choice items in a mean of \\\u003C 2 seconds per item). Where individuals respond to more than 14 items in a row with the same response, we will manually review for possible invalidity.\n\nExclusion criteria include the following:\n\n* Current episode of depression, hypomania or mania, or psychosis (assessed by the aDiagnostic Interview for Anxiety, Mood, and Obsessive-compulsive and Related Neuropsychiatric Disorders; DIAMOND), Participants with acute mood disorder episodes will be encouraged to seek treatment and to consider the study when symptoms have remitted.\n* Eating disorder diagnosis (by self-report of treatment or diagnosis at any point during their life, Short Eating Disorder Examination Questionnaire (EDE-QS) scores above clinical concern thresholds for eating disorders, or DIAMOND interview of symptoms during adulthood)\n* Past 3-month alcohol use disorder or substance use disorder (assessed by DIAMOND)\n* Active suicidal ideation coupled with plan, intent or attempt history as assessed by Columbia Suicide Severity Rating Scale\n* Conditions that would interfere with ability to take part in the intervention , including pregnancy, breastfeeding, uncorrected hypo or hyperthyroidism, gastrointestinal conditions impairing nutrient absorption,\n* Medical conditions such as HIV, AIDS, lupus, or multiple sclerosis that could confound the assessment of mania or other measures\n* Medications contraindicated for fasting: clozapine, glucose-lowering medications, diabetes-related injections, medications requiring food early morning or late evening, corticosteroids; medications such as semaglutide will not be an exclusion criteria\n* Cognitive deficits as noted during the initial interview or as indicated by low performance on the Short Orientation Memory Concentration Test (\\\u003C 20 on the weighted score).",{"count":325,"type":22},300,[25],"The goal of this clinical trial is to compare the effects of two different healthy lifestyles on outcomes for those with bipolar disorder. The goals are to understand the acceptability of time-restricted eating and the mediterranean diet for those who are already receiving medication treatment for bipolar disorder, and to consider how these two food plans predict changes in manic symptoms, depressive symptoms, and Quality of Life. Participants will complete daily measures of eating, sleep and mood for two weeks, and then will be assigned to follow one of the two food plans for eight weeks. The investigators will measure symptoms and Quality of Life at baseline and during and after the food plan.",[31,329],"Diet, Mediterranean",[331,125,332],"bipolar disorder","circadian rhythm","2025-02-03",{"date":335,"type":42},"2025-02-06",{"date":337,"type":42},"2024-06-05",{"date":339,"type":22},"2029-02-28",{"name":136,"class":49},{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":347,"eligibilityCriteria":348,"healthyVolunteers":16,"sex":17,"minAge":59,"maxAge":349,"enrollmentInfo":350,"targetDuration":4,"studyType":23,"phases":352,"briefSummary":353,"conditions":354,"keywords":356,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":50},"100540979","longitudinal-monitoring-during-intermittent-fasting-protocols-in-obese-adults-100540979","NCT06323889","Longitudinal Monitoring During Intermittent Fasting Protocols in Obese Adults","Longitudinal Monitoring During Different Intermittent Fasting Protocols in Obese Adults - a Randomized Clinical Trial","LIMITFOOD2","Inclusion Criteria:\n\n* Age between 18-50 years, both inclusive\n* Obese, BMI between 30 and 40 kg\u002Fm\\^2 (obesity grade I or II), both inclusive\n* Non-smoker\n* Good knowledge of German or English language\n* Stable weight change (change \\\u003C +\u002F- 3% current bodyweight) for 3 months prior to the study\n* HbA1c \\\u003C 6.5% without glucose lowering medication\n* LDL-cholesterol \\\u003C 4.6mmol\u002Fl without lipid lowering medication\n\nExclusion Criteria:\n\n* Participants who have a fasting period of \\> 12h per day on a regular basis and do not eat at least three main meals per day.\n* Current habitual use of dietary supplements (e.g., vitamins, minerals) and\u002For unwillingness to cease intake of dietary supplements.\n* Antibiotics intake during 3 months prior to the study due to possible interference with metabolic parameters\n* Food intolerances, allergies and sensitivities (severe food allergies) or dietary restrictions (e.g. vegan lifestyle)\n* Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.\n* Diabetes\n* Known alcohol, substance or drug abuse, concomitant medication\n* More than four hours of physical exercise per week\n* Women who are pregnant, breast-feeding or aiming to become pregnant during course of the trial\n* Women and men on hormonal supplementation\n* Women with an irregular menstrual cycle according to the FIGO criteria\n* Therapy with antidepressants within the past 6 months\n* Regular therapy with acetylsalicyclic acid or current medication to regulate blood sugar, blood pressure or lipids\n* Participants likely to fail to comply with the study protocol\n* Participants who do not give informed consent","50 Years",{"count":351,"type":22},90,[25],"LIMITFOOD2 is a randomized clinical intervention study that investigates the effects of two different intermittent fasting protocols compared to a control group on the health of obese adults. A total of 90 participants will be randomized into three equally sized groups: a modified alternate day fasting, a time-restricted eating and a control group, receiving general weight-loss counseling.",[355,153,31],"Intermittent Fasting",[357,358,359,153,360],"Overnutrition","Nutrition Disorders","Body Weight","Longitudinal monitoring","2024-12-17",{"date":363,"type":42},"2024-12-20",{"date":365,"type":42},"2024-09-23",{"date":367,"type":22},"2027-01",{"name":369,"class":49},"University of Zurich",{"id":371,"slug":372,"hasResults":11,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":16,"sex":17,"minAge":377,"maxAge":60,"enrollmentInfo":378,"targetDuration":4,"studyType":23,"phases":380,"briefSummary":381,"conditions":382,"keywords":383,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":50},"100569572","time-restricted-eating-acceptability-efficacy-and-safety-in-obesity-100569572","NCT06695988","Time-restricted Eating Acceptability, Efficacy and Safety in Obesity","Time-restricted Eating Acceptability, Efficacy and Safety in Free-living Adults With Obesity","Inclusion Criteria:\n\n* Age 19 to 65 years\n* Owns a smartphone\n* Apparently healthy\n* BMI ( more than or equal to 25 kg\u002Fm2 ) and high body fat percent (BF%) (≥25% and ≥35% for males and females, respectively)\n* Sedentary lifestyle (less than 150 minutes of self-reported moderate to vigorous activity per week)\n* Self-reported eating interval of ≥12 h per day\n\nExclusion Criteria:\n\n* Diagnosed diabetes mellitus (type I or II), coronary heart disease, heart failure, hypertension, hyperlipidemia, stroke, chronic lung diseases, liver or kidney disease, adrenal diseases, musculoskeletal disorders, uncontrolled thyroid disease (dose changes within the past 3 months), Crohn's disease, Ulcerative Colitis, arthritis, undergoing active cancer treatment except for non-melanoma cancer, uncontrolled psychiatric disorder (a history of hospitalization for psychiatric illness).\n* Currently taking any medication that is meant for, or has a known effect on, appetite\n* On anabolic steroid or hormone replacement therapy\n* Participation in an exercise\u002Fnutrition\u002F weight-loss program within the last 6 months\n* Any history of surgical intervention for weight management\n* Having a ≥5% body weight change during the last 3 months\n* Pregnant or less than 6 months post-partum, breastfeeding, polycystic ovarian syndrome or irregular menstruation\n* missing limbs, have a pacemaker or metal implants,\n* eating disorders or EAT-26 score \\>20\n* Alcohol or drug addiction\n* Current smoker\n* Works night shifts\n* Unable to commit to a 9-week study\n* Not willing to follow study protocol and any other contraindications.\n* Currently following any of the following restrictive diets - Keto\u002Flow carbohydrate\u002F Vegan\u002F Vegetarian\u002F Intermittent fasting\u002F Paleo\u002F Calorie restriction\u002F Any other restrictive diet\n* Participating in another study","19 Years",{"count":379,"type":22},46,[25],"A randomized controlled trial to determine adherence, acceptability and safety of time restricted eating (TRE) in healthy, sedentary, free-living adults with obesity between the ages of 19-65 years when following 16:8 TRE for 8 weeks. This 9-week study includes a baseline week and 8 weeks of the intervention period. Participants are randomly assigned to the TRE or the non-fasting control group. The TRE group will consume calorie containing food and drink only over an 8 hour period and rest of the 16 hour would be fasting. Adherence to TRE and calorie intake are the primary outcomes. Motivators, facilitators and barriers to TRE, hunger and cravings levels, weight bias internalization, body composition (weight, body fat%, fat mass and muscle mass) , Healthy Eating Index (HEI) to assess diet quality, skin carotenoid levels, disordered eating risk, sleep quality, and perceptions of health and well-being are secondary outcomes.",[31],[31,153,384,385,386,387],"Intervention","9 weeks","Randomization","Intermittent fasting","2024-12-03",{"date":390,"type":42},"2024-12-06",{"date":392,"type":42},"2024-06-01",{"date":394,"type":22},"2025-10-31",{"name":396,"class":49},"University of Mississippi, Oxford",{"id":398,"slug":399,"hasResults":11,"nctId":400,"briefTitle":401,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":11,"sex":17,"minAge":237,"maxAge":238,"enrollmentInfo":403,"targetDuration":4,"studyType":23,"phases":404,"briefSummary":405,"conditions":406,"keywords":408,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":50},"100496132","early-vs-late-time-restricted-eating-in-adolescents-with-obesity-el-trea-100496132","NCT05740254","Early vs. Late Time-Restricted Eating in Adolescents With Obesity (EL TREA)","Inclusion Criteria:\n\n* 12-21 years with obesity (BMI\\>95th percentile)\n* participant must be willing and able to adhere to the assessments, visit schedules, and eating\u002Ffasting periods\n* baseline eating window greater than 12 hours.\n\nExclusion Criteria:\n\n* diagnosis of Prader-Willi Syndrome, brain tumor, or diabetes serious intellectual disability\n* previous diagnosis or subthreshold symptoms of an eating disorder (anorexia nervosa, bulimia nervosa, binge-eating disorder)\n* parent\u002Fguardian-reported physical, mental of other inability to participate in the assessments\n* previous bariatric surgery\n* current participation in other interventional weight loss studies.",{"count":266,"type":22},[25],"Determine the effectiveness of how limiting the time you eat within an early or late eating window and fasting for remainder of the day will impact weight loss and body mass index (BMI).",[244,407,31],"Time Restricted Feeding",[153,246,247],"2024-10-19",{"date":411,"type":42},"2024-10-22",{"date":413,"type":42},"2023-03-27",{"date":415,"type":22},"2027-01-01",{"name":256,"class":49},{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":16,"sex":92,"minAge":59,"maxAge":145,"enrollmentInfo":424,"targetDuration":4,"studyType":23,"phases":426,"briefSummary":427,"conditions":428,"keywords":429,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":447,"locationsCount":50},"100555143","time-restricted-eating-and-cognition-100555143","NCT06508255","Time-restricted Eating and Cognition","Time-restricted Eating and Cognition (ChronoBEAT)","Inclusion Criteria:\n\n* right-handed\n* legally competent\n* physically and mentally healthy\n* BMI: 19-35 kg\u002Fm²\n* fluent in reading and speaking German\n\nExclusion Criteria:\n\n* weight change \\>5% of body weight during the last 3 months\n* pregnancy or breastfeeding\n* allergies (inclusion possible after consultation with study doctor)\n* history of cardiovascular disease (myocardial infarction, stroke, hypertension, hypotension) in the last year\n* severe psychiatric condition, including drug addiction and depression\n* impaired renal or liver function\n* dementia or other severely debilitating cognitive disease\n* history of or current eating disorders (e.g., Bulimia nervosa, Anorexia nervosa, Orthorexia nervosa, Binge-Eating disorder)\n* chronic diseases (e.g., Morbus Crohn, Colitis Ulcerosa)\n* metabolic disorders (e.g., metabolic syndrome, diabetes type 1 or 2)\n* hormonal imbalances (e.g., thyroid gland diseases)\n* consuming diseases (e.g., cancer, kachexie) in the last 2 years\n* surgical removal (partial removal) of the digestive organs (e.g., gastrectomy) or history of bariatric surgery\n* Autoimmune conditions or current infection\n* Blood clotting disorders (e.g., haemophilia)\n* Severe anemia\n* severe claustrophobia\n* blood donation four weeks prior to study entry\n* glucocorticoid therapy (oral)\n* anticoagulant medication (inclusion possible if medication can be paused)\n* taking medications that require regular eating\n* any medications or supplements known to affect sleep, circadian rhythms, immune activity or metabolism\n* taking weight loss, lipid or glucose-lowering medications (any medications that affects metabolism) i.e. metformin\n* pacemaker or other electrical implant\n* vaccination during the study course or in the two weeks' prior\n* immunosuppressive premedication\n* currently on a diet\u002Ffasting regime (or within 1 month)\n* professional athletes\n* nicotine consumption\n* drug abuse\n* alcohol consumption per week more than 14 beers (0,3l)\u002F wine (0,125l)\u002F sparkling wine (0,1l)\u002FSchnaps (4cl)\n* shift work\n* poor sleep quality (PSQI score \\> 10 at medical screening)\n* travel across more than one time zone one month before study or during study period\n* non-removable metallic implants\n* fear of blood draw",{"count":425,"type":22},35,[25],"This study aims to investigate how time-restricted eating (TRE), more specifically TRE at different times (early vs late in the day), influences brain activity, behavior, decision-making, food intake, physical activity, the gut microbiome and metabolic processes. The study intervention procedure is a replication of that described in Peters et al. (2021).",[31,355],[430,431,432,433,434,435,436,437,438,439,440],"Time-restricted eating","Time-restricted feeding","Cognition","Decision-making","Behaviour","Brain Activity","Food Intake","Diet","Microbiome","Sleep","Physical Activity","2024-07-17",{"date":443,"type":42},"2024-07-18",{"date":445,"type":42},"2024-05-17",{"date":311,"type":22},{"name":448,"class":49},"German Institute of Human Nutrition",{"id":450,"slug":451,"hasResults":11,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":455,"eligibilityCriteria":456,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":145,"enrollmentInfo":457,"targetDuration":4,"studyType":23,"phases":459,"briefSummary":461,"conditions":462,"keywords":464,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":50},"100519741","early-phase-1-time-restricted-eating-in-sleep-apnea-100519741","NCT06047496","Time Restricted Eating in Sleep Apnea","The Time Restricted Eating in Sleep Apnea Study","TERESA","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form;\n* Stated willingness to comply with all study procedures and availability for the duration of the study;\n* Be of appropriate age (18-70);\n* Own a smartphone (Apple iOS or Android OS);\n* Have a baseline eating period ≥12 hours\u002Fday and sufficient logging on the myCircadianClock app;\n* If participants are on cardiovascular medications (HMG CoA reductase inhibitors (statins), other lipid-modifying drugs, anti-hypertensives) no dose adjustments will be allowed during the study period;\n* Have untreated moderate to severe obstructive sleep apnea (OSA, apnea-hypopnea index ≥15 events\u002Fhr); and\n* Agree to adhere to Lifestyle Considerations (see section 5.3) throughout study duration\\]\n\nExclusion Criteria:\n\n* Participants with type 1 or type 2 diabetes mellitus who are taking insulin or sulfonylureas, or any participant with a history of hypoglycemia unawareness\n* OSA with evidence of significant sleepiness, as defined by either a) Epworth Sleepiness Score ≥15, or b) motor vehicle accident due to excessive sleepiness within the past year\n* BMI \\>40 kg\u002Fm2\n* Uncontrolled hypertension\n* Active tobacco or illicit drug use\n* Pregnant or breastfeeding women\n* Currently enrolled in a weight-loss or weight-management program\n* Currently on a special or prescribed diet for other reasons (e.g., Celiac disease)\n* Currently taking any medication that is meant for weight loss, or has known effect on appetite suppression\n* History of eating disorder(s)\n* History of surgical intervention for weight management\n* Chronic kidney disease\n* Treatment for active inflammatory and\u002For rheumatologic disease and cancer\n* Unrevascularized cardiovascular disease\n* Liver cirrhosis and\u002For significant alterations in liver function\n* History of (a) thyroid disease requiring dose titration of thyroid replacement medication(s) within the past 3 months (i.e., hypothyroidism on a stable dose of thyroid replacement therapy is not an exclusion)\n* Shift workers with variable (e.g., occasionally nocturnal) hours\n* Traveling outside the US\n* History of HIV\u002FAIDS\n* Uncontrolled psychiatric disorder\n* Other safety concern based on MD judgement",{"count":458,"type":22},80,[460],"EARLY_PHASE1","Obstructive sleep apnea (OSA) is a highly prevalent disorder that is associated with both cardiovascular and metabolic dysfunction, such as hypertension, increased blood glucose levels and diabetes, obesity, and nonalcoholic fatty liver. While continuous positive airway pressure (CPAP), the best available OSA treatment, has been shown to improve blood pressure in OSA, it does not appear to improve metabolic consequences of OSA, and other therapies for OSA-induced dysmetabolism are needed. Animal models of time restricted eating (TRE) demonstrate an improvement in glucose and lipid metabolism, even in the absence of a reduction of caloric intake. Some human studies have shown an improvement in metabolic dysfunction with TRE, though further well-designed studies are needed. The effects of TRE on metabolic dysfunction in patients with OSA, a population with a high predisposition to metabolic disorder, has never been examined. In this study, we will conduct a randomized clinical trial to assess the feasibility and efficacy of 12 weeks of TRE, versus standard eating (SE), to improve glucose regulation and cardiovascular health of participants with OSA.",[31,463],"Obstructive Sleep Apnea",[465,466,467,468,469,470],"hyperglycemia","intermittent fasting","sleep apnea","weight loss","hyperlipidemia","metabolic syndrome","2024-01-11",{"date":473,"type":42},"2024-01-16",{"date":475,"type":42},"2024-01-05",{"date":477,"type":22},"2028-12",{"name":315,"class":49}]