[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"timing-of-dexamethasone-administration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:timing-of-dexamethasone-administration":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":4},"100568804","phase-4-effect-of-timing-of-dexamethasone-during-induction-on-postoperative-outcomes-100568804",false,"NCT06685991","Effect of Timing of Dexamethasone During Induction on Postoperative Outcomes","Effect of Timing of Dexamethasone Administration During Induction on Postoperative Outcomes: A Triple-Blinded Randomized Controlled Trial","TIDE","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective non cardiac surgery requiring general anesthesia\n* surgery last at least 90 minutes\n* scare of more than 5 cm Able to provide informed consent Eligible for dexamethasone administration as part of routine perioperative care\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to dexamethasone or related corticosteroids\n* History of uncontrolled diabetes mellitus or significant blood glucose management issues, as dexamethasone may affect glucose levels\n* Severe cardiovascular instability or hemodynamic issues contraindicating study participation\n* Patients receiving immunosuppressive therapy or with conditions affecting the immune system, as corticosteroids may alter immune responses\n* Pregnancy or breastfeeding, due to potential risks to the fetus or infant\n* Current or recent (within 30 days) use of other glucocorticoids, which may interfere with study outcomes\n* Patients with psychiatric or cognitive conditions that impair their ability to consent or adhere to study protocols\n* Lack of informed consent","ALL","18 Years","70 Years",{"count":21,"type":22},300,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study aims to investigate how the timing of dexamethasone administration during anesthesia induction affects patient outcomes after surgery. Dexamethasone is commonly used to reduce nausea and inflammation during and after surgery. However, it is not yet known if administering dexamethasone at different times during induction (before, during, or after specific anesthetic drugs) leads to better recovery and fewer postoperative complications.\n\nParticipants will be randomly assigned to one of three groups: one group will receive dexamethasone before fentanyl, another after the muscle relaxant, and a third group will not receive dexamethasone. This approach will help us understand if the timing of dexamethasone affects patient outcomes such as nausea, pain, and recovery quality. The study is triple-blinded, meaning that the participants, care providers, and investigators will not know which group the participants are in, to ensure unbiased results.",[28,29,30,31,32,33],"Postoperative Nausea and Vomiting (PONV)","Postoperative Pain","Inflammatory Response to Wounding","Hyperglycemia Drug Induced","Hypotension on Induction","Timing of Dexamethasone Administration",[35,36,37,38,39,40,41],"Dexamethasone","Timing of Administration","Anesthesia Induction","Randomized Controlled Trial (RCT)","Triple-Blinded Study","Induction Protocol","Postoperative outcomes","NOT_YET_RECRUITING","2024-11-10",{"date":45,"type":46},"2024-11-13","ACTUAL",{"date":48,"type":22},"2024-12-01",{"date":50,"type":22},"2026-01-31",{"name":52,"class":53},"AABDI Mohammed","OTHER"]