[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tinnitus-subjective\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tinnitus-subjective":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,55,84,119,149,176,201,224,246],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100576208","tinnitus-patient-preferences-survey-100576208",false,"NCT06782308","Tinnitus Patient Preferences Survey","Inclusion criteria:\n\n* Individuals aged 18 or older suffering from subjective tinnitus\n* Self-reported or healthcare professional-diagnosed chronic (lasting 3 months or longer), subjective, burdensome tinnitus\n\nExclusion criteria:\n\n* Individuals under 18 years of age\n* Healthy volunteers without tinnitus","ALL","18 Years",{"count":18,"type":19},500,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this survey is to assess several aspects related to patient preferences regarding interventions for alleviating tinnitus through invasive electrical brain stimulation (neuromodulation). This survey covers the acceptance of a surgically-placed brain implant, of its associated risks related to the neurosurgical procedure, usability considerations, and the willingness\u002Fability to pay for such a treatment.\n\nNeurosoft Bioelectronics will use the collected patients' feedback and usability preferences data for the development of a novel minimally invasive brain implant aimed at alleviating tinnitus.",[24,25,26,27],"Tinnitus, Subjective","Tinnitus, Bilateral","Tinnitus, Noise Induced","Tinnitus, Hearing Loss, Cochlear Implant Users",[29,30,31,32,33,34,35,36,37,38,39,40,41],"tinnitus","iBCI","brain implant","survey","risks acceptance","user preferences","patient preferences","subjective tinnitus","chronic tinnitus","severe tinnitus","catastrophic tinnitus","invasive neuromodulation","surgical treatment","RECRUITING","2026-04-07",{"date":45,"type":46},"2026-04-08","ACTUAL",{"date":48,"type":46},"2025-01-13",{"date":50,"type":19},"2026-12-30",{"name":52,"class":53},"Nicolas Gninenko","INDUSTRY",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":54},"100623226","bimodal-electrical-sound-stimulation-and-auditory-training-for-chronic-tonal-tinnitus-100623226","NCT07393880","Bimodal Electrical-Sound Stimulation and Auditory Training for Chronic Tonal Tinnitus","Non-Invasively Re-Training the Tinnitus Brain Using Bimodal Electrical-Sound Stimulation (NITESGON-ADT): Protocol for a Prospective, Double-Blind, Randomised Controlled Trial","NITESGON-ADT","Inclusion Criteria:\n\n* Adults aged 18-80 years\n* Continuous subjective tinnitus for \\>3 months and ≤5 years\n* Predominantly tonal tinnitus (unilateral or bilateral)\n* Screening THI score 28-76\n* Minimum Masking Level (MML) 20-80 dB HL\n* No prior tinnitus neuromodulation treatment\n* Able to comply with eight sessions over four weeks and follow-up assessments\n\nExclusion Criteria:\n\n* Objective tinnitus or predominantly somatic tinnitus\n* Pulsatile tinnitus\n* Evidence of conductive hearing loss (abnormal otoscopy or tympanometry)\n* Pure-tone audiometry exclusions: \\>40 dB HL at any frequency 250 Hz-1 kHz OR \\>80 dB HL at any frequency 2-8 kHz in either ear\n* Hearing aid use initiated within the past 90 days\n* Active implantable medical device (e.g., pacemaker, DBS, cochlear implant)\n* LDL \\\u003C30 dB SL at 500 Hz in either ear\n* Diagnosis of temporomandibular joint disorder or occipital neuralgia\n* Severe anxiety (STAI \\>120\u002F160)\n* Cognitive impairment (MMSE \\\u003C25)\n* Severe depressive symptoms (BDI ≥30)\n* Diagnosis of Menière's disease\n* Current pregnancy\n* Involvement in medicolegal cases\n* History of auditory hallucinations\n* Current prescription of central nervous system drugs likely to alter neuromodulatory function (e.g., noradrenergic, dopaminergic, serotonergic, benzodiazepine, cholinergic, or other psychoactive medications)\n* Currently enrolled in another interventional study","80 Years",{"count":65,"type":19},100,"INTERVENTIONAL",[68],"NA","This study tests whether pairing non-invasive stimulation of the greater occipital nerve (NITESGON) with an attentionally demanding auditory frequency discrimination training task reduces tinnitus loudness and tinnitus-related distress. One hundred adults with chronic tonal tinnitus will be randomised to one of four groups in a 2×2 factorial design: real versus sham NITESGON and active versus passive listening during auditory stimulation. Participants complete eight sessions across four weeks, with outcomes assessed at baseline, end of treatment, 28 days post-treatment, and 6 months post-treatment.",[24,71,72],"Tinnitus","Chronic Tinnitus",[71],"2026-04-02",{"date":76,"type":46},"2026-04-03",{"date":78,"type":46},"2026-01-30",{"date":80,"type":19},"2029-01-30",{"name":82,"class":83},"University of Dublin, Trinity College","OTHER",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":15,"minAge":16,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":66,"phases":96,"briefSummary":97,"conditions":98,"keywords":103,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":54},"100628951","multimodal-therapy-for-somatosensory-tinnitus-100628951","NCT07468318","Multimodal Therapy for Somatosensory Tinnitus","Multimodal Therapeutic Approach to Tinnitus Treatment With Focus on Somatosensory Components: A Randomised Controlled Trial Integrating Physiotherapy, Structured Exercise Program, and Psychological Intervention","SOMATIN","Inclusion Criteria:\n\n* Age 18-70 years (inclusive)\n* Chronic subjective tinnitus present for ≥6 months\n* Tinnitus Handicap Inventory (THI) score ≥18 points (indicating at least mild tinnitus handicap)\n* Positive somatosensory modulation test: ability to reproducibly modulate tinnitus (change in loudness, pitch, or quality) through at least one of the following manoeuvres:\n* Jaw movements (mouth opening, lateral excursion, protrusion, clenching)\n* Neck movements (flexion, extension, rotation, lateral flexion)\n* Pressure on specific head\u002Fneck muscles\n* Eye movements or shoulder elevation\n* Willing and able to attend all study sessions over 28 weeks\n* Adequate cognitive capacity to understand study procedures and complete questionnaires in the Czech language\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Audiological\u002FENT Exclusions:\n* Objective or pulsatile tinnitus\n* Active ear pathology requiring treatment:\n* Acute otitis media or externa\n* Chronic suppurative otitis media\n* Cholesteatoma\n* Meniere's disease with recent vertigo attacks (\\\u003C3 months)\n* Suspected retrocochlear pathology:\n* Acoustic neuroma (vestibular schwannoma)\n* Cerebellopontine angle tumor\n* Neurological Exclusions:\n* Neurological disease affecting brainstem or auditory pathways:\n* Multiple sclerosis with brainstem involvement\n* Stroke affecting auditory pathways\n* Brain tumor\n* Epilepsy or active seizure disorder\n* Musculoskeletal Exclusions:\n* Contraindications to manual therapy:\n* Severe cervical spine instability\n* Rheumatoid arthritis with atlantoaxial instability\n* Down syndrome\n* Vertebrobasilar insufficiency\n* Severe osteoporosis with fracture risk\n* Recent cervical spine surgery (\\\u003C6 months)\n* Recent head or neck trauma (\\\u003C3 months)\n* Ongoing physiotherapy or manual therapy for temporomandibular joint or cervical spine (\\\u003C3 months prior to enrollment)\n* Psychiatric Exclusions:\n* Severe psychiatric disorder:\n* Active psychosis\n* Severe depression requiring inpatient treatment\n* Acute suicidal ideation (PHQ-9 item 9 score ≥2)\n* Active substance abuse disorder\n* Other Exclusions:\n* Pregnancy (due to modifications needed in physical examination and treatment)\n* Ongoing litigation or compensation claims related to tinnitus or hearing loss\n* Current participation in another interventional clinical trial\n* Expected change of residence or long-term absence (\\>2 weeks) during the study period\n* Unable or unwilling to comply with study procedures and attend all sessions",true,"70 Years",{"count":95,"type":19},160,[68],"Tinnitus (ringing or buzzing in the ears) affects approximately 10-15% of the adult population and significantly reduces quality of life in many patients. In a substantial proportion of cases, tinnitus is associated with dysfunction of the temporomandibular joint (TMJ) and cervical spine - this subtype is called somatosensory tinnitus.\n\nThis randomised controlled trial investigates the effectiveness of a multimodal intervention combining: (1) physiotherapy targeting TMJ and cervical spine dysfunction, (2) a structured combined exercise program (aerobic + resistance + breathing), and (3) psychological support (cognitive-behavioural psychoeducation) in patients with chronic somatosensory tinnitus.\n\nThe study also examines the acute effects of different types and intensities of physical exercise on tinnitus perception, and performs psychometric validation of Czech-language tinnitus assessment questionnaires.\n\nParticipants (N=160, aged 18-70 years) will be randomly assigned to either the multimodal intervention group (8 weeks, 5 sessions\u002Fweek) or a control group. Follow-up assessments will be conducted at 3, 12, and 24 months. The primary outcome is the change in the Tinnitus Handicap Inventory (THI) score.",[99,26,24,100,101,102,72],"Ear Noise","Headache Other","Temporomandibular Dysfunction","Cervical Migraine Syndrome",[104,29,105,106,107,108],"exercise therapy","multimodal therapy","subjective noise","somatosensory tinnitus","physiotherapy","NOT_YET_RECRUITING","2026-03-11",{"date":112,"type":46},"2026-03-12",{"date":114,"type":19},"2027-01-01",{"date":116,"type":19},"2030-12-31",{"name":118,"class":83},"Charles University, Czech Republic",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":66,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":54},"100598437","noninvasive-therapy-for-tinnitus-100598437","NCT07071480","Noninvasive Therapy for Tinnitus","Noninvasive Therapeutic Hypothermia for Tinnitus","Inclusion Criteria:\n\n* Adults aged 18 years or older at the time of signing the consent form\n* Fluency in English or Spanish\n* Chronic subjective tinnitus for more than 30 days defined as audible at least 75% of waking hours\n* At least mild tinnitus, score ≥18 on the Tinnitus Handicap Inventory (THI)\n\nExclusion Criteria:\n\n* Severe anxiety, score ≥ 15 on the Generalized Anxiety Disorder-7 (GAD-7)\n* Tinnitus described as non-auditory or pulsatile in nature\n* Catastrophic tinnitus, score ≥78 on the THI\n* Tinnitus that is intermittent in nature\n* Abnormal tympanometric findings\n* Presence of conductive component as characterized by air-bone gaps ≥15 dB at two or more consecutive frequencies\n* Otologic pathologies (including, but not limited to): acoustic neuroma\u002F vestibular schwannoma, chronic ear disease, Meniere's disease, documented fluctuating hearing loss, or ototoxicity\n* Temporomandibular joint disorder\n* Those who are currently receiving medical, pharmacologic, or therapeutic intervention for tinnitus or other otologic conditions.\n* Active hearing aid use\n* Dizziness at the time of signing the consent form or at the time of starting the study protocol treatment\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Pregnant women\n* Prisoners",{"count":127,"type":19},40,[68],"The goal of this interventional clinical study is to establish mild therapeutic hypothermia, delivered non-invasively to the structures of the inner ear, as a safe and repeatable therapeutic method for symptomatic relief of tinnitus. The study will assess both objective and subjective measures to address two main aims:\n\n1. Ascertain the benefits of mild therapeutic hypothermia for symptomatic relief of chronic tinnitus in participants using the ReBound hypothermia device.\n2. Ascertain the benefits of mild therapeutic hypothermia for symptom management in chronic tinnitus participants over six months using the ReBound device.\n\nParticipants will wear the ReBound hypothermia device for 30 minutes in a single session. Researchers will compare results from those receiving the therapy to those from a control group (sham therapy). Participants will also use the device in-home for 6 months and monitor their symptoms with online surveys.",[71,24],[29,132,133,36,134,135,136,137,138,139],"ringing","ringing in the ears","constant tinnitus","treatment","symptom reduction","symptom management","tinnitus management","intervention","2026-01-08",{"date":142,"type":46},"2026-01-12",{"date":144,"type":46},"2025-11-24",{"date":146,"type":19},"2027-05-31",{"name":148,"class":53},"Restorear Devices LLC",{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":66,"phases":159,"briefSummary":160,"conditions":161,"keywords":162,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":54},"100583749","neuromodulatory-effects-of-audio-proprio-phonatory-reinforcement-training-on-subjective-tinnitus-demonstrated-by-high-density-electroencephalogram-hd-eeg-100583749","NCT06880367","Neuromodulatory Effects of Audio-proprio-phonatory Reinforcement Training on Subjective Tinnitus, Demonstrated by High-density Electroencephalogram (HD EEG)","PHONACOU","Inclusion Criteria:\n\n* Person who agreed to participate in the study and gave consent\n* Aged ≥ 18 years and \\\u003C 85 years\n* Suffering from subjective tinnitus for more than 3 months\n* Have a score on the THI questionnaire taken at T0 greater than or equal to 38\n* Be equipped with a smartphone compatible with the Siopi application and a computer connection for videoconference sessions\n* Have answered the questionnaires on the Siopi application: THI, VAS-D and associated questions and insomnia severity index\n* Have committed to diligently following the study protocol, including independent training\n* Have agreed not to take other new treatments for tinnitus throughout the duration of the study\n* Able to understand and carry out assessment instructions.\n\nExclusion Criteria:\n\n* Patient suffering from objective tinnitus\n* Current port of white noise generators\n* Patient having consulted phoniatrics more than twice or having participated in more than two sound-mediated workshop sessions\n* Bilateral hearing loss \\> 40 dB uncorrected on an audiogram or having declared serious or severe hearing loss on Siopi questionnaire, with or without prosthetic correction\n* New therapy introduced less than 2 months ago\n* Psychatric disorders causing auditory hallucinations\n* Protected person (under guardianship or curatorship)\n* Person under judicial protection\n* Person deprived of liberty\n* Person not affiliated to a social security system\n* Pregnant or breastfeeding woman\n* Person participating in a drug study","84 Years",{"count":158,"type":19},56,[68],"Our ecological approach to neuromodulation in the field of \"acouphonology\" empowers tinnitus patients to act as their own source of sound stimuli through audio-proprio-phonatory reinforcement (APPR). By engaging in self-phonations, individuals uncoverthe vast potential for sound production, which can effectively mask their tinnitus or induce residual inhibition, all without relying on external sources.\n\nThis clinical study aims to illustrate the positive impact of audio-proprio-phonatory reinforcement training on individuals suffering from chronic subjective tinnitus. This will be further supported and quantified through high-definition electroencephalography (HD EEG) as we explore the relationship between changes in connectivity within specific brain regions and the varying degrees of response to the therapeutic protocol.",[24],[163,164,165,166],"Subjective tinnitus","neuromodulation","audio-proprio-phonatory reinforcement","high-density electroencephalogram","2025-12-22",{"date":169,"type":46},"2025-12-30",{"date":171,"type":46},"2025-03-18",{"date":173,"type":19},"2028-09-18",{"name":175,"class":83},"Centre Hospitalier Régional d'Orléans",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":66,"phases":186,"briefSummary":187,"conditions":188,"keywords":189,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":54},"100594327","external-therapy-for-tinnitus-management-100594327","NCT07017998","External Therapy for Tinnitus Management","Mild Therapeutic Hypothermia for Tinnitus Management","Inclusion Criteria:\n\n* Adults 18-55 years of age at the time of signing the informed consent form with primary complaint of tinnitus;\n* Suffering from subjective tinnitus for at least 30 days;\n* Tinnitus whose level of severity is defined by Tinnitus Handicap Inventory (THI) values ≥12,\n* Tinnitus is constant in nature (defined as audible at least 75% of waking hours).\n\nExclusion Criteria:\n\n* Very mild tinnitus (THI values \\\u003C12);\n* Tinnitus that is intermittent in nature;\n* Tinnitus described as non-auditory or pulsatile in nature;\n* Individuals with a history of vertigo or fluctuating hearing loss, such as that related to Menière's disease, chronic otitis, vestibular neuritis, neuroma, otosclerosis cholesteatoma, or temporomandibular joint disorder;\n* Individuals with a history of extreme sensitivity to cold or heat, including individuals with a past history of frostbite or Raynaud's Syndrome.\n* Those who are currently receiving medical, pharmacologic, or therapeutic intervention for tinnitus or other otologic conditions, including sound therapy, cognitive behavioral therapy (CBT), Tinnitus Retraining Therapy (TRT), steroid injections, or other treatments;\n* Those who present with a mental health score indicating significant psychological component, per standard of care, based on PHQ-4 score of moderate to severe anxiety\u002Fdepression.\n* Children (under 18 years), incarcerated individuals, adults unable to consent, and psychologically vulnerable participants.","55 Years",{"count":185,"type":19},80,[68],"The goal of this remote interventional clinical study is to investigate the use of mild therapeutic hypothermia devices for the symptomatic relief of chronic tinnitus. The main aims of the study are:\n\n1. Ascertain the effects of MTH in chronic tinnitus patients using questionnaires measuring tinnitus severity and intervention-related change.\n2. Ascertain the comfort and acceptability of the hypothermia device and therapy.\n\nParticipants with chronic tinnitus will wear the mild therapeutic hypothermia therapy devices for a single 30 minute session. Researchers will compare results from those receiving therapy to those from a control group.",[71,24],[29,133,190,137,191,192],"ringing ears","cooling","red light therapy","2025-09-10",{"date":195,"type":46},"2025-09-17",{"date":197,"type":46},"2025-07-16",{"date":199,"type":19},"2026-12-01",{"name":148,"class":53},{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":15,"minAge":208,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":66,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":54},"100577807","efficacy-of-walking-exercise-with-dog-on-tinnitus-complaints-in-sleep-apnea-obstructive-sleep-apnea-100577807","NCT06803095","Efficacy of Walking Exercise With Dog on Tinnitus Complaints in Sleep Apnea (Obstructive Sleep Apnea)","Efficacy of Walking Exercise With Dog on Tinnitus Complaints in Sleep Apnea","Inclusion Criteria:\n\n* obese persons\n* bilateral chronic subjective tinnitus\n* mild obstructive sleep apnea (mild apnea hypopnea index)\n* forty participants\n\nExclusion Criteria:\n\n* body mass index more than 40 kg\u002Fm2.\n* cardiovascular problems\n* hepatorenal probelms\n* autoimmune problems\n* orthopedic probelms","30 Years","45 Years",{"count":127,"type":19},[68],"there is evidence that tinnitus (chronic subjective form) is highly prevalent among patients with obstructive sleep apnea. exercise is recommneded in chronic subjective form) and obstructive sleep apnea. walking with dog increase adherence to walking to maintain continuity of physical activity",[24,214],"Obstructive Sleep Apnea","2025-01-27",{"date":217,"type":46},"2025-01-31",{"date":219,"type":46},"2024-12-12",{"date":221,"type":19},"2025-05-15",{"name":223,"class":83},"Cairo University",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":230,"minAge":231,"maxAge":209,"enrollmentInfo":232,"targetDuration":4,"studyType":66,"phases":233,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":54},"100571121","lifestyle-changes-in-obese-males-with-sexual-dysfunction-and-tinnitus-100571121","NCT06716125","Lifestyle Changes in Obese Males With Sexual Dysfunction and Tinnitus","Inclusion Criteria:\n\n* obese person\n* body mass index less than 40 kg\u002Fm2 and more than 30 kg\u002Fm2\n* males with subjective tinnitus (bilateral presentation from at least 24 weeks).\n* males with sexual dysfunction (erectile dysfunction from at least 24 weeks)\n\nExclusion Criteria:\n\n* cardiac diseased males\n* respiratory diseased males\n* hepatic, musculoskeletal, and hepatic diseased males\n* diabetic males","MALE","35 Years",{"count":127,"type":19},[68],"obese male usually complain subjective tinnitus that may affect their sexual function.",[236,24,237],"Obesity","Erectile Dysfunction","2024-11-28",{"date":240,"type":46},"2024-12-04",{"date":242,"type":46},"2024-11-06",{"date":244,"type":19},"2025-04-06",{"name":223,"class":83},{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":66,"phases":256,"briefSummary":257,"conditions":258,"keywords":266,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":4},"100471348","efficacy-of-transcutaneous-vagus-nerve-stimulation-paired-with-tailor-made-notched-music-therapy-versus-tailor-made-notched-music-training-for-chronic-subjective-tinnitus-100471348","NCT05417711","Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus","Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus: A Multicenter, Randomized, Double-blind, Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with tinnitus as the main complaint: the patients subjectively feel the sound in the ear or deep part of the head without internal or external sound stimulation, and therefore seek medical treatment\n* Chronic (≥ 6 months) and tonal tinnitus\n* Age 18-60\n* Tinnitus frequency is 125-8000 Hz\n* Hearing threshold at each frequency shall not exceed 70 dB HL\n\nExclusion Criteria:\n\n* Patients with conductive deafness, history of middle ear surgery, pulsatile tinnitus caused by vascular distortion and tinnitus caused by Meniere disease\n* History of head trauma, central nervous system diseases, mental diseases and drug abuse","60 Years",{"count":255,"type":19},388,[68],"This clinical study is a prospective, multicenter, randomized, controlled, double-blind clinical study. Sun Yat Sen Memorial Hospital of Sun Yat sen University was the central unit, and Nanjing First Hospital, Sun Yat Sen people's Hospital, Guanfzhou Panyu central Hospital and Zhuhai integrated traditional Chinese and Western medicine hospital were the cooperative units. In this study, 388 patients with chronic subjective tinnitus were recruited. In view of chronic subjective tinnitus, a common ear disease, the study gave the patients three months of treatment with transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy or tailor-made notched music training alone. By comparing the changes of subjective scale scores related to tinnitus before and after treatment in patients receiving two different therapies, such as THI, VAS, BAI, BDI, PSQI, to evaluate the efficacy of the two therapies, so as to judge whether transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy is better than tailor-made notched music training alone. In addition, the study will continue to follow up the patients after the treatment for one year to observe the difference in the long-term sustained efficacy of the two therapies. This clinical study will also evaluate the two therapies from the perspective of compliance and safety, and explore the factors that affect the efficacy of the two therapies.",[24,259,260,261,262,263,264,265],"Vagus Nerve Stimulation","Music Therapy","Double-Blind Method","Female","Male","Humans","Treatment Outcome",[267,268,269,270,271],"Chronic subjective tinnitus","Tailor-made notched music training","Vagus nerve stimulation","Electroencephalogram","Clinical trial","2023-11-22",{"date":274,"type":46},"2023-11-27",{"date":276,"type":19},"2023-11-23",{"date":278,"type":19},"2026-09-01",{"name":280,"class":83},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University"]