[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"tissue-transglutaminase-antibody\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:tissue-transglutaminase-antibody":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100627819","small-bowel-ultrasound-and-antibody-levels-in-celiac-disease-activity-100627819",false,"NCT07453589","Small Bowel Ultrasound and Antibody Levels in Celiac Disease Activity","Ultrasound Small Bowel Patterns and Tissue Transglutaminase Antibody Levels in Celiac Disease Activity","Inclusion Criteria:\n\n* Patients aged ≥2 years with suspected celiac disease based on clinical symptoms (chronic diarrhea, abdominal distention, weight loss, failure to thrive).\n* Newly diagnosed celiac disease patients with positive tTG antibodies and\u002For duodenal biopsy confirmation.\n* Previously diagnosed celiac disease patients on gluten-free diet requiring follow-up assessment.\n* Patients with first-degree relatives with celiac disease undergoing screening.\n* Patients who provide informed consent (or parental consent for minors).\n\nExclusion Criteria:\n\n* Previous small bowel surgery or resection.\n* Inflammatory bowel disease (Crohn's disease, ulcerative colitis).\n* Small bowel obstruction from other causes.\n* IgA deficiency (requires alternative antibody testing).\n* Patients on immunosuppressive therapy.\n* Pregnancy.\n* Poor quality ultrasound images due to excessive bowel gas or obesity.\n* Refusal to participate in the study.",true,"ALL","2 Years",{"count":20,"type":21},140,"ESTIMATED","OBSERVATIONAL","This observational study aims to evaluate the relationship between small bowel ultrasound findings and tissue transglutaminase (tTG) antibody blood levels in assessing celiac disease activity. The traditional gold standard for diagnosing and monitoring celiac disease involves an invasive duodenal biopsy. Researchers want to determine if combining a painless, non-invasive small bowel ultrasound with tTG antibody blood tests can accurately predict disease severity and monitor a patient's response to a gluten-free diet.\n\nThe study will enroll 140 participants aged 2 years and older, including newly diagnosed patients, patients currently on a gluten-free diet, and a control group. All participants will undergo a clinical assessment, blood tests for tTG antibodies, and a high-resolution small bowel ultrasound. Newly diagnosed patients will also undergo an upper gastrointestinal endoscopy and biopsy to confirm their diagnosis. Researchers will score the ultrasound severity based on factors like bowel wall thickness and compare it to the antibody levels. A cohort of patients will be monitored over time with serial assessments at baseline, 6 months, and 12 months.",[25,26,27,28],"Celiac Disease","Ultrasound","Tissue Transglutaminase Antibody","Small Bowel Ultrasonography",[30,31,32,33,34],"Celiac disease","Small bowel ultrasonography","Tissue transglutaminase","Gluten-free diet","Duodenal biopsy","NOT_YET_RECRUITING","2026-03-02",{"date":38,"type":39},"2026-03-06","ACTUAL",{"date":41,"type":21},"2026-04",{"date":43,"type":21},"2027-05",{"name":45,"class":46},"Assiut University","OTHER"]